論文 - 坂元　亨宇

A solid pseudopapilary tumor arising from the greater omentum followed by multiple metastases with increasing malignant potential

坂元 亨宇

J Gastroenterol 41   276-181 2006年

研究論文（学術雑誌）, 共著

「膵癌の病理学的特性—分子機構の解明—」

福間　真理子、山崎　剣、坂元　亨宇

画像診断 26 （ 1 ）  2006年

研究論文（学術雑誌）, 共著

坂元　亨宇　「早期肝細胞癌の病理診断—臨床へのメッセージ」

坂元 亨宇

消化器画像　医学書院 8 （ 1 ）  2006年

研究論文（学術雑誌）, 単著

「2.肝癌の前癌病変・境界病変」

柴田　理恵、杜　雯林　坂元　亨宇

臨床消化器内科 21 （ 7 ）  2006年

研究論文（学術雑誌）, 単著

「胆管浸潤型管内胆管癌の臨床病理学的特徴」

尾島　英智、坂元　亨宇

管内胆管癌　消化器画像　医学書院 7 （ 6 ）  2005年11月

研究論文（学術雑誌）, 共著

Multistep and multicentric development of hepatocellular carcinoma: histological analysis of 980 resected nodules

Oikawa, T., Ojima, H., Yamasaki, S., Takayama, T., Hirohashi, S. and Sakamoto, M.

Journal of Hepatology 42 （ 2 ） 225 - 229 2005年02月

ISSN  0168-8278

　概要を見る

Background/Aims: Histological observations support the concept of multistep and multicentric development of hepatocellular carcinoma (HCC) in cases of chronic liver disease. However, the relationship between the incidence of such a modality of development of HCC and the type of background liver disease has not been fully investigated.

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Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepatocellular carcinoma

Nakanishi, K., Sakamoto, M., Yamasaki, S., Todo, S. and Hirohashi, S.

Cancer 103 （ 2 ） 307 - 12 2005年01月

ISSN  0008-543X

　概要を見る

BACKGROUND: Patients with hepatocellular carcinoma (HCC) who showed early massive disease recurrence due to hematogenous intrahepatic metastasis after curative resection had a poor prognosis. The authors previously reported that Akt phosphorylation was correlated with hematogenous intrahepatic metastasis, using HCC cell lines. METHODS: The authors analyzed clinicopathologic features and the status of selected biologic markers, including phosphorylated Akt, to identify risk factors for early disease recurrence and poor prognosis in HCC. In the current series, 49 postoperative patients developed intrahepatic disease recurrence within 6 months (Group 1) and 86 patients remained disease recurrence free > 3 years after resection (Group 2). Group 1 was further divided into 2 subgroups: 19 patients who died of disease recurrence within a year after resection (Group 1A) and 27 patients who survived > 1 year (Group 1B). RESULTS: Using univariate analysis, the risk factors for early disease recurrence were tumor size, macroscopic classification, tumor differentiation, microscopic capsule infiltration, microscopic portal vein (MPV) invasion, microscopic intrahepatic metastasis (MIM), and positive immunostaining for phosphorylated Akt, Ki-67, and p53 (P < 0.05). The risk factors for poor prognosis were the number of intrahepatic metastases, tumor differentiation, and positive immunostaining for phosphorylated Akt and Ki-67 (P < 0.05). Multivariate analysis revealed that the risk factors for early disease recurrence were MPV invasion, MIM, and positive immunostaining for phosphorylated Akt, and that the risk factors for poor prognosis were positive immunostaining for phosphorylated Akt and Ki-67 (P < 0.05). CONCLUSIONS: The current clinical study showed the critical involvement of Akt phosphorylation in the aggressiveness of HCC. The potential benefits of surgery should be assessed carefully in patients with any of these risk factors.

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Akt Phosphorylation is risk factor for early disease recurrence and poor prognosis in hepatocellular caricinoma ;

坂元 亨宇

cancer 103 （ 2 ）  2005年01月

研究論文（学術雑誌）, 共著

肝腫瘍の術中迅速診断　肝生検診断Ⅰ−腫瘍性疾患−

坂元 亨宇

病理と臨床・別刷 23 （ 2 ）  2005年

研究論文（学術雑誌）, 単著

Multistep and multicentric development of hepatocellular carcinoma:histological analysis of 980 resected nodules .

坂元 亨宇

Journal of Hepatology 42   225-229 2005年

研究論文（学術雑誌）, 共著

Extramedullary myeloid tumor (EMMT)of the gallbladder .

坂元 亨宇

J Clin Pathol . 58   211-213 2005年

研究論文（学術雑誌）, 共著

Spontaneous rupture of a mass-forming type peripheral cholangiocarcinoma:

坂元 亨宇

Journal of Gastroenterology and Hepatology. 20   162-168 2005年

研究論文（学術雑誌）, 共著

Combination of hTERT and bimi-1,E6,or E7,induces prolongation of the life span of bone marrow stromal cells from an elderly donor without affecting their neurogenic protential:

坂元 亨宇

molecular and cellular biology. 25 （ 12 ） 5182-5195 2005年

研究論文（学術雑誌）, 共著

Extramedullary myeloid tumor (EMMT)of the gallbladder .

坂元 亨宇

J Clin Pathol . 58   211-213 2005年

研究論文（学術雑誌）, 共著

Proposal of histological criteria for intraepithelial atypical/proliferative biliary epithelial lesions of the bile duct in hepatolithiasis with respect to cholangiocarcinoma:Preliminary report based on interobserver agreement

坂元 亨宇

Pathology international. 55   180-188, 2005年

研究論文（学術雑誌）, 共著

Primary bone carcinosarcoma:Chondrosarcoma and squamous cell carcinoma with keratin pearl formation:

坂元 亨宇

Pathology International 55   504-409 2005年

研究論文（学術雑誌）, 共著

Long-term survival of intrahepatic cholangiocarcinoma with hilar lymph node metastasis anda portal vein invovment:

坂元 亨宇

hepato-gastroenterology 52   606-609 2005年

研究論文（学術雑誌）, 共著

Clinical and pathologic signigicance of activation of signal transducer and activator of transcription 3 in prostate cancer:

坂元 亨宇

urology. 66 （ 3 ）  2005年

研究論文（学術雑誌）, 共著

Domain-specific function of ShcC docking protein in neuroblastoma cells:

坂元 亨宇

oncogene. 24   3206-3215. 2005年

研究論文（学術雑誌）, 共著

Fukusato T,Fukushima J,Shiga J,Takahashi Y,Nakano Interobserver variation in the hitopathological assessment of nonalcoholic steatohepatitis;

坂元 亨宇

Hepatology Research 33   122-127, 2005年

研究論文（学術雑誌）, 共著