論文 - 坂元　亨宇

Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma.

坂元 亨宇

Cancer Letters . 212   253-259 2004年

研究論文（学術雑誌）, 共著

Squamous cell carcinoma of the liver originating from non-parasitic cysts after a 15 year follow-up:

坂元 亨宇

European journal of gastroentelrology &hepatology 16 （ 10 ）  2004年

研究論文（学術雑誌）, 共著

Squamous cell carcinoma of the liver originating from non-parasitic cysts after a 15 year follow-up:

坂元 亨宇

European journal of gastroentelrology &hepatology 16 （ 10 ）  2004年

研究論文（学術雑誌）, 共著

prognostic signficane of dysadherin expression in Tongue cancer :

坂元 亨宇

Immunohistochemical analysis of 91 casesappl immunohistochem mol morphol 12 （ 4 ）  2004年

研究論文（学術雑誌）, 共著

病理からのフィードバック　肝細胞癌の肉眼型と大腸癌肝細胞転移の進展様式、

柴田　理恵、杜　雯林、坂元　亨宇：

医学書院、 5 （ 3 ）  2004年

研究論文（学術雑誌）, 共著

Expression profiling in multistage hepatocarcinogenesis: Identification of HSP70 as a molecular marker of early hepatocellular carcinoma.

Chuma, M., Sakamoto, M., Hige, S. H., Asaka, M. and Hirohashi, S.

Hepatology 38 （ 4 ） 402a - 402a 2003年10月

ISSN  0270-9139

Proteomic Analysis of Intestinal Epithelial Cells expressing stabilized β-Catenin1;

'Seike M, Kondo T, Mori Y, Gemma A, Kondoh S, Sakamoto M, Yamada Taketo, Hirohashi Setsuo'

Cancer Research 63   4641-4647 2003年08月

研究論文（学術雑誌）, 単著

Late Complication of a large simple cyst of the liver mimicking cystadenocarcinoma after sclerotherapy;

'Takayasu K, Mizuguchi Y, Yamazaki S, Sugiura T, Sato Chise, Sakamoto Michiie'

AJR 181 2003年08月

研究論文（学術雑誌）, 単著

Alpha-Fetoprotein-Producing Caricinoma of the Colon:

'Yachida S, Fukushima N, Nakanishi Y, Akatsu T, Kitamura H, Sakamoto Michiie, Shimoda'

Dis Colon Rectum 46 （ 6 ）  2003年06月

研究論文（学術雑誌）, 単著

'EBP50,a β-Catenin-Associating Protein,Enhances Wnt Signaling and Is Over-expresseed in Hepatocellular Carcinoma'

'Shibata Rie, Chuma M, Kokubu A, Sakamoto Michiie, Hirohashi Setsuo'

Hepatology 0 （ 0 ）  2003年06月

研究論文（学術雑誌）, 単著

Overexpression of orphan G-Protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations

Yamamoto, Y., Sakamoto, M., Fujii, G., Tsuiji, H., Kanetaka, K., Asaka, M. and Hirohashi, S.

Hepatology 37 （ 3 ） 528 - 533 2003年03月

ISSN  0270-9139

　概要を見る

To identify the genes responsible for carcinogenesis and progression of hepatocellular carcinoma (HCC), we screened differentially expressed genes in several human HCC cell lines. Among these genes, Gpr49 was up-regulated in PLC/PRF/5 and HepG2. Gpr49 is a member of the glycoprotein hormone receptor subfamily, which includes the thyroid-stimulating hormone receptor (TSHR). However, Gpr49 remains to be an orphan G-protein-coupled receptor. By real-time quantitative reverse transcriptase polymerase chain reaction (RT-PCR) analysis, overexpression (>3-fold increase compared with the corresponding noncancerous liver tissue) of Gpr49 mRNA was observed in 18 of 38 (47%) HCCs compared with corresponding noncancerous livers. Clinicopathologically, overexpression of Gpr49 was frequently observed in HCC with mutation in beta-catenin exon 3 (14 of 16 cases, 87.5%). Moreover, introduction of mutant beta-catenin into mouse hepatocytes in culture caused up-regulation of the Gpr49 mouse homologue. Therefore, Gpr49 is likely to be a target gene activated by Wnt-signaling in HCC. In conclusion, although much is still unknown, Gpr49 may be critically involved in the development of HCCs with beta-catenin mutations and has the potential to be a new therapeutic target in the treatment of HCC.

• Access to Document (DOI)

性幹細胞（組織幹細胞）の分離，増殖，分化誘導体

橋口明典，坂元亨宇，梅澤明弘

日本臨牀 61 （ 3 ） 390-395 2003年03月

研究論文（学術雑誌）, 共著

Prognostic singnificance of dysadherin expression in advanced colorectal carcinoma

Aoki S, Shimamura T, Shibata T, Nakanishi Y, Moriya Y, Kitajima M, Sakamoto M, Hirohashi S

British journal of cancer 88 （ 5 ） 726-732 2003年03月

研究論文（学術雑誌）, 共著

Dysadherin Overepression in Pancreatic Ductal Adenocarcinoma Reflects Tumor Aggressiveness:Relationship to E-Cadherin Expression

Shimamura Takeshi, Sakamoto Michiie, Ino Yoshinori, Sato Yasuto, Shimada Kazuaki, Kasuge Tohru, Sekihara Hisahiko, Hirohashi Setsuo

Journal of clinical oncology 21 （ 4 ） 659-667 2003年02月

研究論文（学術雑誌）, 共著

A faithful method for PCR-mediated global mRNA amplification and itsintegration into microarray analysis on laster-captured cells

Aoyagi Kazuhiko, Tatsuta Tatsuta, Nishigaki Michiko, Akimoto Chikako, Tanabe Chikako, Omoto Yoko, Hayashi Shin-ichi, Sakamoto Hiromi, Sakamoto Michiie, Yoshida Teruhiko, Terada Masaaki, Sasaki Hiroki

Biochemical and biophysical research communications 300 （ 4 ） 915-920 2003年01月

研究論文（学術雑誌）, 共著

Expression profiling in ovarian clear cell carinoma identification of Hepatocyte nuclear factor-1 β as a Molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma;

'Tsuchiya A, Sakamoto Michiie, Yasuda J, chuma Makoto, Ohta T, Ohki M, Yasugi T, Taketani Y, Hirohashi Setsuo'

American journal of pathology 163 （ 6 ）  2003年

研究論文（学術雑誌）, 単著

Mutation of the DNA metyltransferase(DNMT)1 gene in human colorectal cancers;

'Kanai Yae, Ushijima S, Nakanishi Y, Sakamoto Michiie, Hirohashi Setsuo'

Cancer letters 192   75-82 2003年

研究論文（学術雑誌）, 単著

Primary carcinoma tumor in a polycystic kidney;

'Shibata Rie, Okita Hajime, Shimoda Masayuki, Asakura H, Murai M, Sakamoto Michiie, Hata Junichi'

Pathology international 53   317-322 2003年

研究論文（学術雑誌）, 単著

A case of scleosing hemangioma of the lung presenting as gigantic tumor occupying the left thoracic cavity;

'Shibata Rie, Mukai M, Okada Yasunori, Sakamoto Michiie, Yamauchi T, Kobayashi K'

Virchows Arch 442   409-411 2003年

研究論文（学術雑誌）, 単著

Expression profiling in ovarian clear cell carinoma identification of Hepatocyte nuclear factor-1 β as a Molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma;

'Tsuchiya A, Sakamoto Michiie, Yasuda J, Chuma Makoto, Ohta T, Ohki M, Yasugi T, Taketani Y, Hirohashi Setsuo'

American journal of pathology 163 （ 6 ）  2003年

研究論文（学術雑誌）, 単著