論文 - 野村　周平

Hypertensive disorders of pregnancy by oocyte donation pregnancy in Japanese women aged 40 years or older: a single-center retrospective cohort study

Gekka Y., Adachi T., Oi R., Nakayama S., Kawana Y., Takeda Y., Nomura S., Ozaki A., Tanimoto T., Sakamoto H., Yamashita T.

Hypertension in Pregnancy （Informa UK Limited）  40 （ 1 ） 36 - 44 2021年

査読有り,  ISSN  10641955

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This study aimed to examine the incidence of hypertensive disorders of pregnancy (HDP) among Japanese women with oocyte donation pregnancy (ODP) aged 40 years or older and estimate whether the women with ODP were more likely to develop HDP than those with autologous oocyte pregnancy (AOP) and spontaneous pregnancy (SP). In our study (N = 1361), the proportions of women who developed HDP were 20.5%, 12.8%, and 7.6% for ODP, AOP, and SP, respectively. After adjustment of covariables, the women with ODP were more likely to develop HDP than those with AOP or SP.

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Analysis of the relationship between the HbA1c screening results and the development and worsening of diabetes among adults aged over 40 years: a 4-year follow-up study of 140 …

S Nomura, H Sakamoto, SK Rauniyar, K Shimada, H Yamamoto, ...

BMC public health 21, 1-11 2021年

Tracking sectoral allocation of official development assistance: a comparative study of the 29 Development Assistance Committee countries, 2011–2018

Nomura S., Sakamoto H., Ishizuka A., Shimizu K., Shibuya K.

Global Health Action （Informa {UK} Limited）  14 （ 1 ） 1903222 - 1903222 2021年

査読有り,  ISSN  1654-9716

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Background: Official development assistance (ODA) is one of the most important means for donor countries to foster diplomatic relations with low- and middle-income countries and contribute to the welfare of the international community. Objective: This study estimated the sectoral allocation of gross disbursements of ODA of the 29 Development Assistance Committee (DAC) member countries of the Organisation for Economic Co-operation and Development (OECD) for the duration of 2011 to 2018, by aid type (bilateral, multilateral, and both aids). Methods: Data from the OECD iLibrary were used. The sector definition was based on the OECD sector classification. For core funding to multilateral agencies that do not specialize in each aid sector, we estimated ODA and its flows based on the OECD methodology for calculating imputed multilateral ODA. Results: For all 29 countries, during the period of 2014–2018 where data were available for all the countries, the sector with the highest average annual ODA contribution was health at 20.34 billion USD (13.21%), followed by humanitarian aid at 18.04 billion (11.72%). Humanitarian aid has increased in the sectoral share rankings in both bilateral and multilateral aid, and the sectoral share for refugees in donor countries has increased in bilateral aid. While the 29 countries show relatively similar trends for sectoral shares, some countries and sectors display unique trends. For instance, infrastructure and energy sectors in bilateral aid of Japan are particularly high accounts for 48.48% of the total bilateral ODA of the country in 2018. Conclusions: This paper evaluated ODA trends by major donors of DAC countries in the pre-COVID-19 pandemic periods. We hope that our estimates will contribute to the review of the strategic decision-making and the effective implementation of future ODA policy discussions in the DAC countries while ensuring transparency.

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Profiling of androgen-dependent enhancer rnas expression in human prostate tumors: Search for malignancy transition markers

Nishimura K., Mori J., Sawada T., Nomura S., Kouzmenko A., Yamashita K., Kanemoto Y., Kurokawa T., Hayakawa A., Tokiwa S., Ochi M., Shimmura H., Kato S.

Research and Reports in Urology （Informa UK Limited）  13   705 - 713 2021年

査読有り

　概要を見る

Introduction: Although the ability of androgens to promote prostate cancer development has been known for decades, the molecular mechanisms of androgen receptor (AR) signaling in the tumorigenesis remain unclear. Enhancer RNAs (eRNAs) transcribed from strong enhancers, or super-enhancers (SEs), have recently emerged as a novel class of regulatory non-coding RNAs (ncRNAs) that facilitate transcription, including that of androgen target genes, through chromatin looping to position enhancers proximate to the promoters. The aim of this study was to assess androgen-dependent transcription in prostate tumors of eRNAs (designated as KLK3eRNAs) from the SE of the KLK3 gene encoding the prostate-specific antigen (PSA) protein, a clinical marker of prostate carcinogenesis. Materials and Methods: The androgen-induced KLK3eRNAs were identified in the LNCaP human prostate cancer cell line. The expressions of these KLK3eRNAs together with KLK3 and AR mRNA transcripts were assessed by qRT-PCR in prostate tumor samples from five prostate cancer patients. Results: Androgen-induced KLK3eRNAs have been identified in the LNCaP cells, and their expression was further analyzed in tumors of prostate cancer patients. Transcripts of the tested KLK3eRNAs have been detected in all clinical samples, but their expression patterns differed between individual tumor specimens. We found a statistically significant correlation between the levels of the KLK3 and AR mRNAs with those of the previously reported KLK3eRNAs, while such correlation was not observed for novel KLK3eRNAs described in our recent report. Conclusion: Presented data suggest that prostate tumor development may associate with epigenetic reorganization in the KLK3 genomic regulatory elements reflected by changes of the KLK3eRNA expression. Our findings support a potential of eRNAs profiling to be used as diagnostic marker.

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Overall health information exposure, its barriers and impacts on attitude toward healthcare among cancer patients. The long-term aftermath of the 2011 triple disaster in Fukushima, Japan: A single institution cross-sectional study

Ozaki A., Murakami M., Nomura S., Sawano T., Tsubokura M., Ono K., Takebayashi Y., Tsukada M., Yamaoka K., Nakata Y., Ohira H.

Health Informatics Journal （SAGE Publications）  27 （ 2 ） 146045822199642 - 146045822199642 2021年

査読有り,  ISSN  14604582

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Disasters can hinder access to health information among cancer patients. However, little is known regarding overall health information exposure (HIE), its barriers and its impacts on attitudes toward healthcare among cancer patients in the long-term aftermath of disasters. The aims of this study were threefold: assess the extent of HIE; identify associations between family composition and a non-engagement with HIE; and examine the effects of HIE on attitudes toward healthcare among local cancer patients—5 years after the 2011 triple disaster (earthquake, tsunami, and nuclear disaster) in Fukushima, Japan. We conducted self-administered surveys with all cancer and non-cancer surgery department outpatients at Minamisoma Municipal General Hospital (MMGH), Minamisoma City, from October 2016 to January 2017. In total, 404 patients (263 cancer patients and 141 non-cancer patients) voluntarily participated in the study. The results revealed that a regular level of HIE occurred among 90.5% of the cancer patients. In cancer patients, family composition was not significantly associated with HIE, and HIE was not associated with attitude toward healthcare. In conclusion, most cancer patients visiting the MMGH surgical department were regularly engaged in HIE.

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Loss of working life years due to mortality, sickness absence, or ill-health retirement: A comprehensive approach to estimating disease burden in the workplace

Inoue Y., Nomura S., Nishiura C., Hori A., Yamamoto K., Nakagawa T., Honda T., Yamamoto S., Eguchi M., Kochi T., Miyamoto T., Okazaki H., Imai T., Nishihara A., Ogasawara T., Sasaki N., Uehara A., Yamamoto M., Shimizu M., Konishi M., Kabe I., Mizoue T., Dohi S.

Journal of Epidemiology （Japan Epidemiological Association）  31 （ 7 ） 403 - 409 2021年

ISSN  09175040

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Background: While much effort has focused on quantifying disease burden in occupational health, no study has simultaneously assessed disease burden in terms of mortality and morbidity. We aimed to propose a new comprehensive method of quantifying the disease burden in the workplace. Methods: The data were obtained from the Japan Epidemiology Collaboration on Occupational Health (J-ECOH) Study, a large-scale prospective study of approximately 80,000 workers. We defined disease burden in the workplace as the number of working years lost among the working population during a 6-year period (April 2012 to March 2018). We calculated the disease burden according to consequences of health problems (ie, mortality, sickness absence [SA], and ill-health retirement) and disease category. We also calculated the age-group-(20–39 and 40–59 years old) and sex-specific disease burden. Results: The largest contributors to disease burden in the workplace were mental and behavioural disorders (47.0 person-years lost per 10,000 person-years of working years; ie, per myriad [proportion]), followed by neoplasms (10.8 per myriad) and diseases of the circulatory system (7.1 per myriad). While mental and behavioural disorders made a greater contribution to SA and ill-health retirement compared to mortality, the latter two disorders were the largest contributors to the disease burden in the workplace due to mortality. The number of working years lost was greater among younger versus older female participants, whereas the opposite trend was observed in males. Conclusions: Our approach is in contrast to those in previous studies that focused exclusively on mortality or morbidity.

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Correction to: Tracking Japan’s development assistance for health, 2012–2016

S Nomura, H Sakamoto, MK Sugai, H Nakamura, K Maruyama-Sakurai, ...

Globalization and Health 17, 1-4 2021年

Progress towards the development of research agenda and the launch of knowledge hub: the WHO thematic platform for health emergency and disaster risk management research …

R Kayano, S Nomura, J Abrahams, Q Huda, EYY Chan, V Murray

International journal of environmental research and public health 18 (9), 4959 2021年

Policy and technical considerations for implementing a risk-based approach to international travel in the context of COVID-19

SL James, D Abate, KH Abate, SM Abay, C Abbafati, N Abbasi, ...

The Lancet 392 (10159), 1789-1858 2021年

Overall health information exposure, its barriers and impacts on attitude toward healthcare among cancer patients. The long-term aftermath of the 2011 triple disaster in …

A Ozaki, M Murakami, S Nomura, T Sawano, M Tsubokura, K Ono, ...

Health Informatics Journal 27 (2), 1460458221996420 2021年

Modelling salt intake reduction with umami substance’s incorporation into Japanese foods: A cross-sectional study

S Tanaka, D Yoneoka, A Ishizuka, M Adachi, H Hayabuchi, T Nishimura, ...

2021年

Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global …

KR Paulson, AM Kamath, T Alam, K Bienhoff, GG Abady, J Abbas, ...

The Lancet 398 (10303), 870-905 2021年

Expected scopes of health emergency and disaster risk management (Health edrm): Report on the expert workshop at the annual conference for the japanese association for disaster …

S Nomura, R Kayano, S Egawa, N Harada, Y Koido

International journal of environmental research and public health 18 (9), 4447 2021年

Excess all-cause deaths during coronavirus disease pandemic, Japan, January–May 2020

T Kawashima, S Nomura, Y Tanoue, D Yoneoka, A Eguchi, CFS Ng, ...

Emerging Infectious Diseases 27 (3), 789 2021年

Tracking development assistance for health and for COVID-19: a review of development assistance, government, out-of-pocket, and other private spending on health for 204 …

AE Micah, IE Cogswell, B Cunningham, S Ezoe, AC Harle, ER Maddison, ...

The Lancet 398 (10308), 1317-1343 2021年

Tracking Japan's development assistance for health, 2012-2016 (vol 16, 32, 2020)

S Nomura, H Sakamoto, MK Sugai, H Nakamura, K Maruyama-Sakurai, ...

GLOBALIZATION AND HEALTH 17 (1) 2021年

Ongoing debate on data governance principles for achieving Universal Health Coverage: a proposal to post-G20 Osaka Summit meetings

Shuhei Nomura, Haruka Sakamoto, Aya Ishizuka, Yasushi Katsuma, Hidechika Akashi, Hiroaki Miyata

Global Health Action （Informa {UK} Limited）  13 （ 1 ） 1859822 - 1859822 2020年12月

筆頭著者, 責任著者, 査読有り,  ISSN  1654-9716

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Reduced burden from major diseases due to an increase in vegetable intake in Japan: projections of disability-adjusted life years, 2017-2040

Tanaka S, Yoneoka D, Ishizuka A, Ueda P, Nakamura K, Uneyama H, Hayashi N, Shibuya K, Nomura S

2020年12月

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Trends in deaths from road injuries during the COVID-19 pandemic in Japan, January to September 2020

Shuhei Nomura, Takayuki Kawashima, Daisuke Yoneoka, Yuta Tanoue, Akifumi Eguchi, Stuart Gilmour, Masahiro Hashizume

Injury Epidemiology （Springer Science and Business Media LLC）  7 （ 66 ） 66 - 66 2020年12月

筆頭著者, 査読有り

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<title>Abstract</title><sec>
<title>Background</title>
In Japan, the latest estimates of excess all-cause deaths through January to July 2020 showed that the overall (direct and indirect) mortality burden from the Coronavirus Disease 2019 (COVID-19) in Japan was relatively low compared to Europe and the United States. However, consistency between the reported number of COVID-19 deaths and excess all-cause deaths was limited across prefectures, suggesting the necessity of distinguishing the direct and indirect consequences of COVID-19 by cause-specific analysis. To examine whether deaths from road injuries decreased during the COVID-19 pandemic in Japan, consistent with a possible reduction of road transport activity connected to Japan’s state of emergency declaration, we estimated the exiguous deaths from road injuries in each week from January to September 2020 by 47 prefectures.


</sec><sec>
<title>Methods</title>
To estimate the expected weekly number of deaths from road injuries, a quasi-Poisson regression was applied to daily traffic fatalities data obtained from Traffic Accident Research and Data Analysis, Japan. We set two thresholds, point estimate and lower bound of the two-sided 95% prediction interval, for exiguous deaths, and report the range of differences between the observed number of deaths and each of these thresholds as exiguous deaths.


</sec><sec>
<title>Results</title>
Since January 2020, in a few weeks the observed deaths from road injuries fell below the 95% lower bound, such as April 6–12 (exiguous deaths 5–21, percent deficit 2.82–38.14), May 4–10 (8–23, 21.05–43.01), July 20–26 (12–29, 30.77–51.53), and August 3–9 (3–20, 7.32–34.41). However, those less than the 95% lower bound were also observed in weeks in the previous years.


</sec><sec>
<title>Conclusions</title>
The number of road traffic fatalities during the COVID-19 pandemic in Japan has decreased slightly, but not significantly, in several weeks compared with the average year. This suggests that the relatively small changes in excess all-cause mortality observed in Japan during the COVID-19 pandemic could not be explained simply by an offsetting reduction in traffic deaths. Considering a variety of other indirect effects, evaluating an independent, unbiased measure of COVID-19-related mortality burden could provide insight into the design of future broad-based infectious disease counter-measures and offer lessons to other countries.


</sec>

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Digitization of the approach to food and nutrition respecting individual health values

Shuhei Nomura, Hiroaki Miyata

Nutrition Reviews （Oxford University Press (OUP)）  78 （ Supplement_3 ） 46 - 48 2020年11月

筆頭著者, 査読有り,  ISSN  0029-6643

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<title>Abstract</title>
Japan’s aging population and increasing medical costs threaten the sustainability of its healthcare system. Society 5.0, Japan’s growth strategy, calls for a paradigm shift in healthcare based on digital technology. Health is a topic of great public concern, and diet and nutrition are at the heart of health. Many different values are used to define health, and Society 5.0 focuses on creating personalized values for different styles of eating and health. Health is already at the core of global business, and Japan, which is ahead of the rest of the world in its super-aging society, has a unique opportunity to be the first to create new business solutions for diet and nutrition.

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