Details of a Researcher - Matsumoto, Kazuaki

Papers - Matsumoto, Kazuaki

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Population pharmacokinetic-pharmacodynamic target attainment analysis of sulbactam in patients with impaired renal function: dosing considerations for Acinetobacter baumannii infections.

Yokoyama Yuta, Matsumoto Kazuaki, Ikawa Kazuro, Watanabe Erika, Morikawa Norifumi, Takeda Yasuo.

JOURNAL OF INFECTION AND CHEMOTHERAPY 21 284 - 289 2015.04

Research paper (scientific journal), Joint Work, Accepted, ISSN 1341-321X

Risk factors for ganciclovir-induced thrombocytopenia and leukopenia.

Matsumoto Kazuaki, Shigemi Akari, Ikawa Kazuro, Kanazawa Naoko, Fujisaki Yuko, Morikawa Norifumi, Takeda Yasuo.

BIOLOGICAL & PHARMACEUTICAL BULLETIN 38 235 - 238 2015.02

Research paper (scientific journal), Joint Work, Accepted, ISSN 0918-6158

バンコマイシン塩酸塩点滴静注用製剤の生理食塩液に対する溶解性比較.

松元一明, 黒田裕子, 寺島朝子, 前澤佳代子, 木津純子.

日本環境感染学会誌 30 ( 1 ) 29 - 32 2015.01

Research paper (scientific journal), Joint Work, Accepted

Linezolid dosage in pediatric patients based on pharmacokinetics and pharmacodynamics.

Matsumoto Kazuaki, Shigemi Akari, Takeshita Ayumi, Watanabe Erika, Yokoyama Yuta, Ikawa Kazuro, Morikawa Norifumi, Takeda Yasuo.

JOURNAL OF INFECTION AND CHEMOTHERAPY (SPRINGER JAPAN KK) 21 ( 1-2 ) 70 - 73 2015.01

Research paper (scientific journal), Joint Work, Accepted, ISSN 1341-321X

Linezolid pharmacokinetic profile in pediatric patients has not been fully characterized, and the dose needed to achieve a pharmacokinetic-pharmacodynamic (PK-PD) target has yet to be established because its efficacy is associated with the area under the plasma drug concentration time curve (AUC(24))/minimum inhibitory concentration (MIC) ratio. The present study aimed to define the pharmacokinetic parameters of intravenous linezolid in pediatric patients and assess the rationale for the approved dosage recommendations. Linezolid was safe, tolerated well, and clinically effective for treating Gram-positive bacteria in five pediatric patients (3-11 years). The mean values for the volume of distribution, and total clearance (CL) in a one-compartment model were estimated to be 0.646 +/- 0.239 l/kg and 0.171 +/- 0.068 1/h/kg, respectively (mean +/- S.D.). Based on this analysis, the AUC(24) and trough drug concentration in plasma (C-min) for linezolid doses were predicted to be 175.4 mu g h/ml and 3.4 mu g/ml for 30 mg/kg/day, 204.7 mu g h/ml and 4.3 mu g/ml for 35 mg/kg/day, and 2632 mu g h/ml and 6.2 mu g/ml for 45 mg/kg/day, respectively. Taking into account that AUC(24) should be >= 200 mu g h/ml for MIC of 2.0 mu g/ml (to achieve an AUC(24)/MIC ratio of >= 100) and C-min should be approximately 7 mu g/ml (to avoid thrombocytopenia), we consider the approved dosage of 30 mg/kg/day to be fundamentally rational, but can be underdosed against bacteria with MIC of 2.0 mu g/ml; therefore, a dose of 35-45 mg/kg/day is more appropriate to ensure the efficacy and safety of linezolid in pediatric patients. (C) 2014, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

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カラゲニン足蹠浮腫モデルを用いた各種ケトプロフェンテープ剤の抗炎症効果比較.

松元一明, 河野倫也, 杉山哲也, 坂本靖宜, 島田亜由美, 黒田裕子, 寺島朝子, 前澤佳代子, 木津純子.

医療薬学 40 672 - 676 2014.11

Research paper (scientific journal), Joint Work, Accepted

Factors affecting treatment and recurrence of Clostridium difficile infections.

Matsumoto Kazuaki, Kanazawa Naoko, Shigemi Akari, Ikawa Kazuro, Morikawa Norifumi, Toyoyasu Koriyama, Orita Michiyo, Kawamura Hideki, Tokuda Koichi, Nishi Junichiro, Takeda Yasuo.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (PHARMACEUTICAL SOC JAPAN) 37 ( 11 ) 1811 - 1815 2014.11

Research paper (scientific journal), Joint Work, Accepted, ISSN 0918-6158

The antimicrobial agents vancomycin and metronidazole have been used to treat Clostridium difficile infections (CDIs). However, it remains unclear why patients are at risk of treatment failure and recurrence. Therefore, this study retrospectively examined 98 patients with CDIs who were diagnosed based on the detection of toxin-positive C. difficile to determine the risk factors affecting drug treatment responses and the recurrence of CDI. No significant difference was observed in the cure rate or dosage between the vancomycin and metronidazole groups. The 90-d mortality rate and total number of drugs associated with CDIs, including antiinfective agents used within 2 months before the detection of toxin-positive C. difficile, were significantly lower in the treatment success group than in the failure group. The total number of antiinfective agents and gastric acid-suppressive agents used during CDI therapy was also significantly lower in the success group than in the failure group. The period from the completion of CDI therapy to restarting the administration of anticancer agents and steroids was significantly longer in patients without than in patients with recurrence. These results indicate that the total number of drugs associated with CDIs should be minimized to reduce the risk of CDIs, that not only antibiotics but also gastric acid-suppressive agents should be discontinued during CDI therapy to increase therapeutic efficacy, and that the use of anticancer agents and steroids should be delayed as long as possible after patients are cured by CDI therapy to prevent recurrence.

複合型塩素系除菌・洗浄用製剤の安定性と色調の変化.

木津純子, 高木奏, 黒田裕子, 前澤佳代子, 松元一明, 堀誠治.

日本環境感染学会誌 29 ( 6 ) 411 - 416 2014.11

Research paper (scientific journal), Accepted

Analysis of thrombocytopenic effects and population pharmacokinetics of linezolid: A dosage strategy according to the trough concentration target and renal function in adult patients.

Matsumoto Kazuaki, Shigemi Akari, Takeshita Ayumi, Watanabe Erika, Yokoyama Yuta, Ikawa Kazuro, Morikawa Norifumi, Takeda Yasuo.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (ELSEVIER SCIENCE BV) 44 ( 3 ) 242 - 247 2014.09

Research paper (scientific journal), Joint Work, Accepted, ISSN 0924-8579

The pharmacokinetic/pharmacodynamic (PK/PD) index for the efficacy of linezolid is a 24-h area under the plasma drug concentration-time curve (AUC(24))/minimum inhibitory concentration (MIC) ratio of >= 100. The main adverse event associated with administration of linezolid is thrombocytopenia. Therefore, the aims of the present study were to define PD thresholds that would minimise linezolid-induced thrombocytopenia and to perform a population PK analysis to identify factors influencing the pharmacokinetics of linezolid. Population PK analysis revealed that creatinine clearance (CLCr) significantly affected linezolid pharmacokinetics: the mean parameter estimate of drug clearance (CL; in L/h)= 0.0258 x CLCr + 2.03. A strong correlation (r=0.970) was found between AUC(24) and trough plasma concentrations (C.) [AUC(24)=18.2 x C-min + 134.4]. The Cmin value for AUC(24)=200 (in the case of MIC=2 mu g/mL) was estimated to be 3.6 mu g/mL. Regarding safety, Cmin was a significant predictor of thrombocytopenia during treatment, and its threshold to minimise linezolid-induced thrombocytopenia was 8.2 mu g/mL. A Kaplan-Meier plot revealed that the median time from initiation of therapy to the development of thrombocytopenia was 15 days. Therefore, the target C. range was 3.6-8.2 mu g/mL. The following formula to achieve a target C. in patients with different degrees of renal function was proposed based on these results: initial daily dose (mg/day) = CL x AUC(24) = (0.0258 x CLCr + 2.03) x (18.2 x C-min + 134.4). This recommended initial dosage and subsequent dosage adjustment for the target concentration range should avoid adverse events, thereby enabling effective linezolid-based therapies to be continued. (C) 2014 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

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Pharmacokinetic/pharmacodynamic evaluation of sulbactam against Acinetobacter baumannii in in vitro and murine thigh and lung infection models.

Yokoyama Yuta, Matsumoto Kazuaki, Ikawa Kazuro, Watanabe Erika, Shigemi Akari, Umezaki Yasuhiro, Nakamura Koyo, Ueno Keiichiro, Morikawa Norifumi, Takeda Yasuo.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 43 ( 6 ) 547 - 552 2014.06

Research paper (scientific journal), Joint Work, Accepted, ISSN 0924-8579

Clinical practice guidelines for therapeutic drug monitoring of arbekacin: a consensus review of the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring.

Okada Kenji, Kimura Toshimi, Mikamo Hiroshige, Kasahara Kei, Seki Masafumi, Takakura Shunji, Tokimatsu Issei, Ohmagari Norio, Takahashi Yoshiko, Matsumoto Kazuaki, Igarashi Masahiro, Kobayashi Masahiro, Hamada Yukihiro, Mochizuki Takahiro, Kimura Masao, Nishi Yoshifumi, Tanigawara Yusuke, Takesue Yoshio.

JOURNAL OF INFECTION AND CHEMOTHERAPY (ELSEVIER SCIENCE BV) 20 ( 1 ) 1 - 5 2014.01

Research paper (scientific journal), Joint Work, Accepted, ISSN 1341-321X

Arbekacin (ABK) was approved and widely used in Japan for treatment of patients infected with MRSA, and TDM was introduced in clinical practice. The Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring decided to develop a clinical practice guidelines for TDM of ABK for the following reasons. First, although the daily dose of 150-200 mg was approved in Japan, recent PR-PD studies revealed that higher serum concentration is required to achieve better clinical efficacy and several findings concerning the usefulness of higher dosage regimen have obtained recently. Second, although maximal concentrations that obtained immediately after the end of administration (C-max) was generally adopted, the serum concentration at 1 h after initiation of administration [peak serum concentration (C-peak)] proved to be more suitable as an efficacy indicator of aminoglycosides. Lastly, as ABK is approved only in Japan, no international practice guideline for TDM has not been available in ABK to date. This guideline evaluated the scientific data associated with serum ABK monitoring and provided recommendations based on the available evidence. Potential limitations of this guideline, however, include the findings that few prospective clinical trials of TDM of ABK are available in the treatment of MRSA infections and that most of the published literature describes observational studies. (C) 2013, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

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九州山口地区における基質拡張型βラクタマーゼ産生菌の検出状況と抗菌薬使用状況に関する合同調査.

室高広, 北原隆志, 伊東弘樹, 入江利行, 野中敏治, 藤井裕史, 松元一明, 山崎博史, 柳原克紀, 佐々木均.

日本環境感染学会誌 29 32 - 39 2014.01

Research paper (scientific journal), Joint Work, Accepted

Development of Initial Loading Procedure for Teicoplanin in Critically Ill Patients with Severe Infections.

Matsumoto Kazuaki, Kanazawa Naoko, Watanabe Erika, Yokoyama Yuta, Fukamizu Tomohide, Shimodozono Yoshihiro, Maeda Chiharu, Yasuda Tomotsugu, kakihana Yasuyuki, Ikawa Kazuro, Morikawa Norifumi, Takeda Yasuo.

BIOLOGICAL & PHARMACEUTICAL BULLETIN 36 ( 6 ) 1024 - 1026 2013.06

Research paper (scientific journal), Joint Work, Accepted, ISSN 0918-6158

Practice guidelines for therapeutic drug monitoring of vancomycin: a consensus review of the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring.

Matsumoto Kazuaki, Takesue Yoshio, Ohmagari Norio, Mochizuki Takahiro, Mikamo Hiroshige, Seki Masafumi, Takakura Shunji, Tokimatsu Issei, Takahashi Yoshiko, Kasahara Kei, Okada Kenji, Igarashi Masahiro, Kobayashi Masahiro, Hamada Yukihiro, Kimura Masao, Nishi Yoshifumi, Tanigawara Yusuke, Kimura Toshimi.

JOURNAL OF INFECTION AND CHEMOTHERAPY 19 ( 3 ) 365 - 380 2013.06

Research paper (scientific journal), Joint Work, Accepted, ISSN 1341-321X

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Practice guidelines for therapeutic drug monitoring of voriconazole: a consensus review of the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring.

Hamada Yukihiro, Tokimatsu Issei, Mikamo Hiroshige, Kimura Masao, Seki Masafumi, Takakura Shunji, Ohmagari Norio, Takahashi Yoshiko, Kasahara Kei, Matsumoto Kazuaki, Okada Kenji, Igarashi Masahiro, Kobayashi Masahiro, Mochizuki Takahiro, Nishi Yoshifumi, Tanigawara Yusuke, Kimura Toshimi, Takesue Yoshio.

JOURNAL OF INFECTION AND CHEMOTHERAPY 19 ( 3 ) 381 - 392 2013.06

Research paper (scientific journal), Joint Work, Accepted, ISSN 1341-321X

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大学病院でのICT病棟ラウンドにおける指摘事項の解析.

川村英樹, 折田美千代, 中川彩, 松元一明, 茂見茜里, 郡山豊泰, 西順一郎.

日本環境感染学会誌 28 25 - 28 2013.01

Research paper (scientific journal), Joint Work, Accepted

Pharmacokinetics of ampicillin-sulbactam and the renal function-based optimization of dosing regimens for prophylaxis in patients undergoing cardiovascular surgery.

Yokoyama Yuta, Matsumoto Kazuaki, Yamamoto Hiroyuki, Iguro Yoshifumi, Imoto Yutaka, Ikawa Kazuro, Morikawa Norifumi, Ishida Shiro, Okano Yoshiro, Watanabe Erika, Shimodozono Yoshihiro, Yamada Katsushi, Takeda Yasuo.

JOURNAL OF INFECTION AND CHEMOTHERAPY 18 ( 6 ) 878 - 882 2012.12

Research paper (scientific journal), Joint Work, Accepted, ISSN 1341-321X

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The Development of Appropriate Dosage of Anti-bacterial and Anti-fungal Agents Based on Pharmacokinetics and Pharmacodynamics.

Matsumoto Kazuaki.

YAKUGAKU ZASSHI 132 ( 10 ) 1171 - 1177 2012.10

Research paper (scientific journal), Single Work, Accepted, ISSN 0031-6903

Characterization of the hepatic cellular uptake of alpha(1)-acid glycoprotein (AGP), part 1: A peptide moiety of human AGP is recognized by the hemoglobin beta-chain on mouse liver parenchymal cells.

Nishi Koji, Komori Hisakazu, Kikuchi Mari, Uehara Nao, Fukunaga Naoko, Matsumoto Kazuaki, Watanabe Hiroshi, Nakajou Keisuke, Misumi Shogo, Suenaga Ayaka, Maruyama Toru, Otagiri Masaki.

JOURNAL OF PHARMACEUTICAL SCIENCES (WILEY-BLACKWELL) 101 ( 4 ) 1599 - 1606 2012.04

Research paper (scientific journal), Joint Work, Accepted, ISSN 0022-3549

Human a1-acid glycoprotein (AGP), a serum glycoprotein, is known to have anti-inflammatory activity. We recently reported that AGP was mainly incorporated into the liver in mice via a receptor-mediated pathway, although the mechanism for this was largely unknown. The objective of this study was to identify the specific cellular surface protein that recognizes the peptide moiety of AGP. Pharmacokinetic studies of 111InAGP and 111In recombinant glycan-deficient AGP (rAGP) in mice demonstrated that both AGPs are mainly distributed to the liver and kidney, but hepatic and renal uptake clearance of rAGP was higher than that for AGP. Hepatic uptake of rAGP was inhibited in the presence of 100-fold excess of unlabeled AGP, indicating that the hepatic uptake of rAGP shared a common route with that of AGP and that it recognized the peptide moiety of AGPs. In ligand blotting analyses using crude cellular membrane fraction of mice liver, a band corresponding to a 16 kDa protein was observed to bind to both AGPs. Interestingly, matrix-assisted laser desorption ionizationtime-of-flight mass spectrometry MALDITOF-MS and western blotting analyses indicated that this 16 kDa protein is the hemoglobin beta-chain (HBB). It, therefore, appears that HBB is associated with the hepatic uptake of AGP via a direct interaction with its peptide moiety. (c) 2011 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:15991606, 2012

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Reduction in the incidence of MRSA with use of alcohol-based hand rub solutions and gloves.

Matsumoto Kazuaki, Shigemi Akari, Yaji Keiko, Shimodozono Yoshihiro, Takeda Yasuo, Ikawa Kazuro, Morikawa Norifumi, Miyanohara Hiroaki, Kawamura Hideki, Orita Michiyo, Tokuda Koichi, Nishi Junichiro, Yamada Katsushi.

JOURNAL OF INFECTION AND CHEMOTHERAPY 18 ( 2 ) 269 - 271 2012.04

Research paper (scientific journal), Joint Work, Accepted, ISSN 1341-321X

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抗MRSA薬投与時のTDMの実際.

松元一明, 深水知英, 金澤直子, 日髙伸之介, 棈松和子, 茂見茜里, 下堂薗権洋, 武田泰生.

日本外科感染症学会雑誌 9 113 - 123 2012

Research paper (scientific journal), Joint Work, Accepted, ISSN 1349-5755

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