Reviews, Commentaries, etc. - Soga, Tomoyoshi

キャピラリー電気泳動による無機陰イオン,有機酸,アミノ酸および糖の一斉分析法

Soga, T.

Seibutsu-kogaku Kaishi (The Society for Biotechnology, Japan)  78 ( 5 ) 174 - 175 2000.05

Article, review, commentary, editorial, etc. (scientific journal), Single Work,  ISSN  0919-3758

Analysis of various organic acids in silage using capillary electrophoresis method.

Ishiguro, E., Hibino, H., Soga, T., Yanai, H., Sawada, H.

Animal-husbandry (YOKENDO)  54 ( 5 ) 588 - 590 2000.05

Article, review, commentary, editorial, etc. (scientific journal), Joint Work,  ISSN  0009-3874

New Method for Sugar Analysis Using HPLC

Soga, T.

A technical journal on food chemistry & chemicals (FOOD CHEMICALS NEWSPAPER INC.)  7 ( 12 ) 44 - 48 1991.12

Article, review, commentary, editorial, etc. (scientific journal), Single Work,  ISSN  0911-2286

SGLT2 inhibition eliminates senescent cells and alleviates pathological aging

Katsuumi G., Shimizu I., Suda M., Yoshida Y., Furihata T., Joki Y., Hsiao C.L., Jiaqi L., Fujiki S., Abe M., Sugimoto M., Soga T., Minamino T.

Nature Aging (Nature Aging)   2024

　View Summary

It has been reported that accumulation of senescent cells in various tissues contributes to pathological aging and that elimination of senescent cells (senolysis) improves age-associated pathologies. Here, we demonstrate that inhibition of sodium–glucose co-transporter 2 (SGLT2) enhances clearance of senescent cells, thereby ameliorating age-associated phenotypic changes. In a mouse model of dietary obesity, short-term treatment with the SGLT2 inhibitor canagliflozin reduced the senescence load in visceral adipose tissue and improved adipose tissue inflammation and metabolic dysfunction, but normalization of plasma glucose by insulin treatment had no effect on senescent cells. Canagliflozin extended the lifespan of mice with premature aging even when treatment was started in middle age. Metabolomic analyses revealed that short-term treatment with canagliflozin upregulated 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside, enhancing immune-mediated clearance of senescent cells by downregulating expression of programmed cell death-ligand 1. These findings suggest that inhibition of SGLT2 has an indirect senolytic effect by enhancing endogenous immunosurveillance of senescent cells.

• Access to Document (DOI)