Reviews, Commentaries, etc. - Soga, Tomoyoshi

肝炎のバイオマーカーを発見

Soga, T.

BTJジャーナル (Nikkei Business Publications, Inc.)   ( 5 ) 3 - 5 2006.05

Article, review, commentary, editorial, etc. (scientific journal), Single Work

Metabolomics：System for genome interacting with environments through chemical substances

Nishioka, T., Terabe, S., Soga, T., Matsuda, K., Fujita, Y.

PROTEIN, NUCLEIC ACID AND ENZYME (KYORITSU SHUPPAN )  50 ( 16 ) 2198 - 2203 2005.12

Article, review, commentary, editorial, etc. (scientific journal), Joint Work

赤血球代謝の低酸素応答とその生理機能の解明にむけて-メタボロ－ム解析と細胞シミュレーションによるアプローチ

Kinoshita, A., Nakayama, Y., Soga, T., Tomita, M. Suematsu, M.

Vascular Biology & Medicine (Medical Review Co.,Ltd.)  6 ( 6 ) 83 - 90 2005.12

Article, review, commentary, editorial, etc. (scientific journal), Joint Work

CE-MSを用いたメタボローム測定へのアプローチ

Soga, T., Kakazu, Y.

Farumashia (The Pharmaceutical Society of Japan)  41 ( 11 ) 1053 - 1058 2005.11

Article, review, commentary, editorial, etc. (scientific journal), Joint Work

メタボロ－ム解析技術と創薬研究への応用

Ohkishi, H., Soga, T., Tomita, M.

Molecular Medicine (Nakayama Shoten)  42 ( 11 ) 1249 - 1256 2005.10

Article, review, commentary, editorial, etc. (scientific journal), Joint Work

CE-MSを用いたメタボローム解析

Nishioka, T., Soga, T.

JOURNAL OF MEDICAL TECHNOLOGY (Igaku-Shoin Ltd.)  49 ( 9 ) 1015 - 1020 2005.09

Article, review, commentary, editorial, etc. (scientific journal), Joint Work

CE-MSによるメタボロームの測定および同定

Soga, T., Kakazu, Y.

MEDCHEM NEWS (Division of Medicinal Chemistry, The Pharmaceutical Society of Japan)  15 ( 3 ) 15 - 17 2005.08

Article, review, commentary, editorial, etc. (scientific journal), Joint Work

メタボロ－ム解析の進展と創薬への応用

Ohkishi, H., Soga, T., Tomita, M.

Experimental Medicine (Yodosha)  23 ( 4 ) 141 - 148 2005.02

Article, review, commentary, editorial, etc. (scientific journal), Joint Work

LC/イオントラップMSによる大腸菌メタボローム解析システムの開発

Kato, N., Soga, T.

Bunseki (The Japan Society Analytical Chemistry)   ( 11 ) 658 - 660 2004.11

Article, review, commentary, editorial, etc. (scientific journal), Joint Work

メタボロミクス解析システム

Suzuki, H., Awazuhara, M., Soga, T., Yamazaki, Y., Saito, K.

PROTEIN, NUCLEIC ACID AND ENZYME (KYORITSU SHUPPAN CO., LTD.)  49 ( 11 ) 1893 - 1899 2004.08

Article, review, commentary, editorial, etc. (scientific journal), Joint Work

メタボロミクスの現状と展望

Saito, K., Soga, T., Tomita, M., Fukusaki, E.,

BIOINDUSTRY (CMC Publishing Co.,Ltd.)   ( 7 ) 6 - 18 2004.06

Article, review, commentary, editorial, etc. (scientific journal), Joint Work

ダイナミックな生命現象のメタボローム解析技術

Soga, T., Sato, S., Nishioka, T.

CELL TECHNOLOGY (Shujunsha)  22 ( 12 ) 1337 - 1341 2003.12

Article, review, commentary, editorial, etc. (scientific journal), Joint Work,  ISSN  02873796

CE-MSによるメタボローム解析

Soga, T.

Inflammation & Immunity (SENTAN IGAKU-SHA)  11 ( 6 ) 690 - 699 2003.10

Article, review, commentary, editorial, etc. (scientific journal), Single Work

メタボローム解析-代謝物質の網羅的化学分析法の開発

Ueno, Y., Soga, T., Tomita, M.

Journal of Clinical and Experimental Medicine（IGAKU NO AYUMI） (Ishiyaku Pub,Inc.)  206 ( 3 ) 226 - 227 2003.07

Article, review, commentary, editorial, etc. (scientific journal), Joint Work,  ISSN  0039-2359

キャピラリー電気泳動による無機陰イオン、有機酸、アミノ酸および糖の一斉分析法

Soga, T.

Bunseki (The Japan Society Analytical Chemistry)   ( 9 ) 454 - 459 2001.09

Article, review, commentary, editorial, etc. (scientific journal), Single Work

　View Summary

キャピラリー電気泳動による無機陰イオン、有機酸、アミノ酸および糖類の一斉分析方法を開発し、測定原理、応用例を解説した。

Study on simultaneous determination methods for anions by capillary electrophoresis.

Soga, T.

BUNSEKI KAGAKU (The Japan Society Analytical Chemistry)  49 ( 8 ) 645 - 646 2000.08

Article, review, commentary, editorial, etc. (scientific journal), Single Work,  ISSN  0525-1931

キャピラリー電気泳動による無機陰イオン,有機酸,アミノ酸および糖の一斉分析法

Soga, T.

Seibutsu-kogaku Kaishi (The Society for Biotechnology, Japan)  78 ( 5 ) 174 - 175 2000.05

Article, review, commentary, editorial, etc. (scientific journal), Single Work,  ISSN  0919-3758

Analysis of various organic acids in silage using capillary electrophoresis method.

Ishiguro, E., Hibino, H., Soga, T., Yanai, H., Sawada, H.

Animal-husbandry (YOKENDO)  54 ( 5 ) 588 - 590 2000.05

Article, review, commentary, editorial, etc. (scientific journal), Joint Work,  ISSN  0009-3874

New Method for Sugar Analysis Using HPLC

Soga, T.

A technical journal on food chemistry & chemicals (FOOD CHEMICALS NEWSPAPER INC.)  7 ( 12 ) 44 - 48 1991.12

Article, review, commentary, editorial, etc. (scientific journal), Single Work,  ISSN  0911-2286

SGLT2 inhibition eliminates senescent cells and alleviates pathological aging

Katsuumi G., Shimizu I., Suda M., Yoshida Y., Furihata T., Joki Y., Hsiao C.L., Jiaqi L., Fujiki S., Abe M., Sugimoto M., Soga T., Minamino T.

Nature Aging (Nature Aging)   2024

　View Summary

It has been reported that accumulation of senescent cells in various tissues contributes to pathological aging and that elimination of senescent cells (senolysis) improves age-associated pathologies. Here, we demonstrate that inhibition of sodium–glucose co-transporter 2 (SGLT2) enhances clearance of senescent cells, thereby ameliorating age-associated phenotypic changes. In a mouse model of dietary obesity, short-term treatment with the SGLT2 inhibitor canagliflozin reduced the senescence load in visceral adipose tissue and improved adipose tissue inflammation and metabolic dysfunction, but normalization of plasma glucose by insulin treatment had no effect on senescent cells. Canagliflozin extended the lifespan of mice with premature aging even when treatment was started in middle age. Metabolomic analyses revealed that short-term treatment with canagliflozin upregulated 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside, enhancing immune-mediated clearance of senescent cells by downregulating expression of programmed cell death-ligand 1. These findings suggest that inhibition of SGLT2 has an indirect senolytic effect by enhancing endogenous immunosurveillance of senescent cells.

• Access to Document (DOI)