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Affiliation
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Faculty of Science and Technology, Department of Applied Chemistry Yagami Campus 23-605 (Yagami)
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Position
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Associate Professor
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Related Websites
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Contact Address
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3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa
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External Links
Takahashi, Daisuke
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Career 【 Display / hide 】
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2004.05-2005.03
東京工業大学大学院, 理工学研究科, ２１世紀ＣＯＥプログラム：東京工業大学化学系６専攻 リサーチアシスタント
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2005.04-2006.03
Japan Society for the Promotion of Science (JSPS) , Research Fellow (DC2)
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2006.04-2007.03
Japan Society for the Promotion of Science (JSPS) , Research Fellow (PD)
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2007.04-2008.03
Carlsberg Laboratory, Postdoctoral Fellow
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2008.04-2011.03
Keio University, Department of Applied Chemistry, Faculty of Science and Technology, Research Associate (Non-tenured)
Academic Background 【 Display / hide 】
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1997.04-2001.03
Tokyo Institute of Technology, Faculty of Engineering, Applied chemistry
University, Graduated
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2001.04-2003.03
Tokyo Institute of Technology, Graduate School of Science and Technology, Department of Applied Chemistry
Graduate School, Completed, Master's course
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2003.04-2006.03
Tokyo Institute of Technology, Graduate School of Science and Technology, Department of Applied Chemistry
Graduate School, Completed, Doctoral course
Academic Degrees 【 Display / hide 】
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Ph.D., Tokyo Institute of Technology, Coursework, 2006.03
鎖状鍵中間体を利用するデオキシオリゴ糖の合成と糖鎖マイクロアレイの開発研究
Research Areas 【 Display / hide 】
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Nanotechnology/Materials / Synthetic organic chemistry (Carbohydrate Chemistry)
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Nanotechnology/Materials / Chemical biology (Carbohydrate Chemistry)
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Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules (Synthetic Organic Chemistry)
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Life Science / Bioorganic chemistry (Glycoscience)
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Life Science / Pharmaceutical chemistry and drug development sciences (Structuer-Activity Relationship)
Research Keywords 【 Display / hide 】
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Carbohydrate Chemistry
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Synthetic Organic Chemistry
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Glycosylation Reaction
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Chemical Biology
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Glycosylated Natural Products
Research Themes 【 Display / hide 】
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天然糖脂質の系統的合成と新規化粧品素材の開発研究,
2016.04-Present -
硫酸化糖質の系統的合成と生物活性,
2013.04-Present -
位置及び立体選択的グリコシル化反応の開発,
2013.04-Present
Books 【 Display / hide 】
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Modern Natural Product Synthesis -Overcoming Difficulties
*DAISUKE TAKAHASHI, *Kazunobu Toshima, Springer Nature, 2024.05, Page： 20
Scope: Complex Oligosaccharides Synthesis—Challenges and Tactics, Contact page： 299-318 (Chapter 14) , Accepted
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Advances in Carbohydrate Chemistry and Biochemistry
*DAISUKE TAKAHASHI, *Kazunobu Toshima, Elsevier, 2022.11, Page： 27
Scope: Boron-mediated aglycon delivery (BMAD) for the stereoselective synthesis of 1,2-cis glycosides, Contact page： 79-105 (Chapter 4) , Accepted
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Comprehensive Glycoscience: Second Edition
*DAISUKE TAKAHASHI, *Kazunobu Toshima, Elsevier, 2021.06, Page： 48
Scope: 1,2-cis O-Glycosylation Methods, Contact page： 365-412 , Accepted
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糖鎖の新機能開発・応用ハンドブック
高橋 大介、*戸嶋 一敦, エヌ・ティー・エス, 2015.08
Scope: 標的糖鎖光分解用生体機能分子, pp. 377-379.
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糖鎖の新機能開発・応用ハンドブック
佐々木 要、高橋 大介、*戸嶋 一敦, エヌ・ティー・エス, 2015.08
Scope: 環境調和型グリコシル化反応, pp. 339-342.
Papers 【 Display / hide 】
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Total Synthesis of Kanamycins
Kanae Hosomi, Banjo Imai, Naoto Takemura, Kazuki Senoo, Chigusa Hayashi, Masayuki Igarashi,*Kazunobu Toshima, *DAISUKE TAKAHASHI
CHEMISTRY-A EUROPEAN JOURNAL (Wiley-VCH) e202500685 (9 pages) 2025.04
Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted
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Stereoselective Total Synthesis of α-Galacto-OligosaccharidesUsing Boron-Mediated Aglycon Delivery and Evaluation of their Immune-Enhancing Activities
Jikun Meng, Moeri Sagawa, *Kazunobu Toshima, *DAISUKE TAKAHASHI
CHEMBIOCHEM (Wiley-VCH) 26 e202401059 (6 pages) 2025.04
Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted
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Photo-induced glycosylation using edible polyphenol ellagic acid
Hidenari Shigeta, Satomi Goi, DAISUKE TAKAHASHI, *Kazunobu Toshima
CARBOHYDRATE RESEARCH (Elsevier) 552 109461 (6 pages) 2025.03
Research paper (scientific journal), Joint Work, Accepted
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Creation of a New Macrolide Antibiotic against Non-tuberculous Mycobacterium Using Late-stage Boron-mediated Aglycon Delivery
Yuka Isozaki, Takumi Makikawa, Kosuke Kimura, Daiki Nishihara, Fujino, Yoshikazu Tanaka, Chigusa Hayashi, Yoshimasa Ishizaki, *Masayuki Igarashi, *Takeshi Yokoyama, *Kazunobu Toshima, *DAISUKE TAKAHASHI
SCIENCE ADVANCES (American Association for the Advancement of Science) 11 ( 10 ) eadt2352 (12 pages) 2025.03
Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted
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A novel porphyrin-based theranostic agent activated by cysteine over-expressed in cancer cells shows promise for tumour-targeted monitoring and phototherapy
Fumihisa Ishida, Satoe Moriya, DAISUKE TAKAHASHI, *Kazunobu Toshima
BIOORGANIC & MEDICINAL CHEMISTRY (Elsevier) 121 118131 (9 pages) 2025.02
Research paper (scientific journal), Joint Work, Accepted
Papers, etc., Registered in KOARA 【 Display / hide 】
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Takahashi, Daisuke
科学研究費補助金研究成果報告書 2022
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Challenges in the development of glycoconjugate vaccines against zoonosis based on organic chemistry
Takahashi, Daisuke
科学研究費補助金研究成果報告書 2021
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Takahashi, Daisuke
学事振興資金研究成果実績報告書 (慶應義塾大学) 2020
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Takahashi, Daisuke
学事振興資金研究成果実績報告書 (慶應義塾大学) 2019
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Synthetic and structure-activity relationship studies on a natural glycolipid, terpioside B
Takahashi, Daisuke
学事振興資金研究成果実績報告書 (慶應義塾大学) 2018
Reviews, Commentaries, etc. 【 Display / hide 】
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Boron-mediated aglycon delivery for late-stage modifications: applications in chemical biology and pharmaceutical lead development
Yuka Isozaki, *Kazunobu Toshima, *DAISUKE TAKAHASHI
CHEMISTRY LETTERS (Chemical Society of Japan) 54 ( 5 ) upaf088 (9 pages) 2025.04
Joint Work, Last author, Corresponding author
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高機能性化粧品素材の創製を指向したマンノシルエリスリトールリピッド（MEL）類縁体の合成と構造活性相関研究
孟 継坤, *戸嶋 一敦, *高橋 大介
オレオサイエンス 24 ( 11 ) 475 - 481 2024.11
Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Last author, Corresponding author
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ホウ素媒介アグリコン転移反応の新展開:反応開発,有用糖質合成,およびケミカルバイオロジーへの応用
*高橋 大介, *戸嶋 一敦
有機合成化学協会誌 82 ( 9 ) 856 - 866 2024.09
Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Lead author, Corresponding author
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Total Synthesis of Mannosylerythritol Lipids and Structure-Function Relationship Studies
*DAISUKE TAKAHASHI, Kazunobu Toshima
JOURNAL OF OLEO SCIENCE 73 ( 4 ) 539 - 546 2024.04
Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Lead author, Corresponding author
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Photo-Induced Glycosylations Using Organophotoacids: A New Environmentally Benign Carbohydrate Synthesis
*Kazunobu Toshima, DAISUKE TAKAHASHI, Yuka Isozaki
SYNLETT 35 777 - 788 2023.07
Article, review, commentary, editorial, etc. (scientific journal), Joint Work
Presentations 【 Display / hide 】
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Synthesis of Biologically Active Carbohydrates and Structure-Activity Relationship Studies Toward the Creation of Pharmaceutical Leads
〇DAISUKE TAKAHASHI
The 2025 Gordon Research Conference on Carbohydrates (Holderness School, New Hampshire, USA) ,
2025.06,Oral presentation (invited, special)
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Creation of Pharmaceutical Leads Based on Precise Carbohydrate Synthesis
〇DAISUKE TAKAHASHI
7th Workshop on Radical and Electron Transfer Reactions (Central Park Hotel Songdo, Incheon, Republic of Korea) ,
2025.06,Oral presentation (invited, special)
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精密化学合成を基盤とした糖質医薬開発への挑戦
〇高橋 大介
感染症学教室セミナー (慶應義塾大学医学部) ,
2025.04,Oral presentation (invited, special)
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Synthesis of Useful Carbohydrates and Structure-Activity Relationship Studies Toward the Creation of Carbohydrate-Based Drugs
〇高橋 大介
日本化学会 第105春季年会 (関西大学 千里山キャンパス) ,
2025.03,Oral presentation (invited, special)
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Creation of a New Macrolide Antibiotic against Non-tuberculous Mycobacterium by Late-stage Boron-mediated Aglycon Delivery
〇Yuka Isozaki, Takumi Makikawa, Kosuke Kimura, Daiki Nishihara, Maho Fujino, Yoshikazu Tanaka, Chigusa Hayashi, Yoshimasa Ishizaki, Masayuki Igarashi, Takeshi Yokoyama, Kazunobu Toshima, DAISUKE TAKAHASHI
The 105th CSJ Annual Meeting (Senriyama Campus, Kansai University) ,
2025.03,Oral presentation (general)
Research Projects of Competitive Funds, etc. 【 Display / hide 】
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精密糖鎖合成を基盤とした次世代創薬モダリティーの創出
2025.04-PresentMEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Transformative Research Areas (A), Principal investigator
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⾰新的配糖化技術を基盤とした肺⾮結核性抗酸菌（NTM）症に対する新規 抗菌物質の創製
2024.01-Present公益財団法人シオノギ感染症研究振興財団, 創薬研究助成金, Principal investigator
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ホウ素媒介アグリコン転移を用いた1,2-cis フラノシドの精密化学合成と応用
2023.04-PresentMEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator
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糖脂質型バイオサーファクタントの精密化学合成と構造機能相関による新規高機能性化粧品素材の創製
2022.12-2025.03公益財団法人 コーセーコスメトロジー研究財団, 2022年度コスメトロジー研究助成, Principal investigator
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広域スペクトルを有する抗ウイルス薬開発を目指した創薬標的探索と次世代創薬モダリティの基盤構築
2022.10-2028.03AMED, AMED-CREST, Coinvestigator(s)
Intellectual Property Rights, etc. 【 Display / hide 】
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新規な抗生物質及びその製造方法
Date applied： 特願2023- 90620 2023.06
Patent, Joint
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抗腫瘍剤
Date applied： 特願2014-140761 2014.07
Date announced： 特開2015-38061 2015.02
Date issued： 特許6403317 2018.10
Date registered： 2018.09
Patent, Joint
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ノイラミニダーゼに対する酵素阻害剤
Date applied： 特願2010-022168 2010.02
Date announced： 特開2011-157325 2011.08
Patent, Joint
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糖鎖アレイ及びその製造方法
Date applied： 特願2004-264922 2004.09
Date announced： 特開2006-78418 2006.03
Patent, Joint
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Ｎ-グリコシルアミドの製造方法
Date applied： 特願2003-436790 2003.12
Date announced： 特開2005-187441 2005.07
Patent, Joint
Awards 【 Display / hide 】
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2023 Asian Core Program Lectureship Award
DAISUKE TAKAHASHI, 2023.12, The Organizing Committee of the 16th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-16), Efficient Synthesis of Biologically Active Glycosides by Boron-Mediated Aglycon Delivery and Their Applications in Chemical Biology
Type of Award： Award from international society, conference, symposium, etc.
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Oleomaterial award
Daisuke Takahashi, 2022.08, Japan Oil Chemists' Society Oleomaterial Division, Efficient Total Synthesis of Mannosylerythritol Lipids and Their Structure-Function Studies
Type of Award： Award from Japanese society, conference, symposium, etc.
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The Carbohydrate Research Award 2021
DAISUKE TAKAHASHI, 2021.04, The Editorial Board and Publisher of Carbohydrate Research
Type of Award： Award from publisher, newspaper, foundation, etc.
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Incentive Award in Synthetic Organic Chemistry, Japan (2016)
2017.02, The Society of Synthetic Organic Chemistry, Japan, Precise Synthesis and Chemical Biological Studies of Certain Carbohydrates, and Creation of Artificial Bio-functional Molecules
Type of Award： Award from Japanese society, conference, symposium, etc.
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2016 Incentive Award in the Japanese Society of Carbohydrate Research
2016.09, The Japanese Society of Carbohydrate Research, Target-Selective Synthesis and Photodegradation of Oligosaccharides Utilizing Chemical Properties of Organoboronic Acids
Type of Award： Award from Japanese society, conference, symposium, etc.
Courses Taught 【 Display / hide 】
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SEMINAR IN APPLIED CHEMISTRY
2025
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MOLECULAR LIFE CHEMISTRY 2
2025
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LABORATORY IN SCIENCE
2025
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LABORATORIES IN APPLIED CHEMISTRY D
2025
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INDEPENDENT STUDY ON FUNDAMENTAL SCIENCE AND TECHNOLOGY
2025
Courses Previously Taught 【 Display / hide 】
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Molecular Life Chemistry 1
Keio University
2018.04-2019.03,Autumn Semester, Lecture, Within own ｆaculty, 1h
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Molecular Life Chemistry 2
Keio University
2018.04-2019.03,Autumn Semester, Lecture, Within own ｆaculty, 1h
糖鎖、化学合成、生合成、酵素合成、糖鎖生物学、癌、インフルエンザ
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生体物質化学基礎
Keio University
2018.04-2019.03,Autumn Semester, Lecture, Within own ｆaculty, 1h, 161people
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LABORATORIES IN APPLIED CHEMISTRY D
Keio University
2018.04-2019.03,Autumn Semester, Laboratory work/practical work/exercise, Within own ｆaculty
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SEMINAR IN APPLIED CHEMISTRY
Keio University
2018.04-2019.03,Full academic year
Media Coverage 【 Display / hide 】
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（プレスリリース）選択的な糖修飾法を用いて肺非結核性抗酸菌症の治療薬候補を開発－薬剤耐性菌に有効となる新規抗菌薬開発に期待－
慶應義塾大学・東北大学・微生物化学研究所, 2025.03
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（プレスリリース）新型コロナウイルスの感染を抑制する糖質を開発－COVID-19の重症化を抑える治療薬開発に期待－
慶應義塾大学・大阪大学, 2024.10
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（プレスリリース）糖質β-アラビノフラノシドを精密に合成する新手法の開発－配糖化を簡便に、抗アレルギー剤開発に期待－
慶應義塾大学, 2023.10
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フコイダン、新型コロナに高阻害活性 慶大・阪大が確認
日刊工業新聞 (朝刊30面) , 2021.11
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（プレスリリース）鳥類病原性大腸菌の抗原候補糖鎖を特定－化学合成を駆使したワクチン開発に期待－
慶應義塾大学, 2020.11
Memberships in Academic Societies 【 Display / hide 】
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日本応用糖質科学会、会員,
2023.11-Present -
Japan Oil Chemists' Society, member,
2018.06-Present -
American Chemical Society, member,
2017.11-Present -
FCCA (Forum: Carbohydrates Coming of Age), member,
2012.09-Present -
日本ケミカルバイオロジー学会、会員,
2008-Present
Committee Experiences 【 Display / hide 】
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2023.07-2024.06
日本学術振興会特別研究員等審査会専門委員, 独立行政法人 日本学術振興会
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2023.04-2025.03
日本化学会 代表正会員, 日本化学会
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2023.01-Present
Associate Editor, Trends in Glycoscience and Glycotechnology
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2023.01-Present
TIGGトピック担当幹事, FCCA (Forum: Carbohydrates Coming of Age)
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2023.01-Present
幹事会員, FCCA (Forum: Carbohydrates Coming of Age)