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Papers - Asoda, Seiji

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国際頭痛分類第3版beta版による三叉神経痛（典型的三叉神経痛と有痛性三叉神経ニューロパチー）の臨床統計的検討

臼田頌，村岡渡，西須大徳，佐藤仁，吉川桃子，莇生田整治，河奈裕正，中川種昭，和嶋浩一

日本口腔顔面痛学会雑誌 10 ( 1 ) 23 - 30 2017

Research paper (scientific journal), Joint Work, Accepted

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小児の下顎骨に生じた歯原性粘液線維腫の1例

佐藤仁, 安居孝純, 軽部健史, 莇生田整治, 河奈裕正, 鬼澤勝弘

日本口腔外科学会雑誌 63 ( 9 ) 467 - 471 2017

Research paper (scientific journal), Joint Work, Accepted

A nationwide survey of bone anchored device for wide edentulous area introduced in public health insurance system in Japan

Asoda S, Kawana H, Kawamoto Y, Tonogi M, Asanami S

Japanese Journal of Maxillo Facial Implants 15 ( 4 ) 265 - 273 2016.12

Research paper (scientific journal), Joint Work, Accepted, ISSN 1347-894X

A case of primary cutaneous adenoid cystic carcinoma

Fukuda R, Usuda S, Asoda S, Funakoshi T

日本臨床皮膚科医学会 (日臨皮会誌) 33 ( 3 ) 389 - 393 2016.07

Research paper (scientific journal), Joint Work, Accepted, ISSN 1349-7758

We report the case of a 66-year-old man who had a left forehead mass for 5 years.　Positron emission tomography-computed tomography（PET-CT）was performed in 2013 because he had tongue cancer，and it revealed cutaneous accumulation at the left forehead; however，the standardized uptake value（SUV）was low and passage was observed. On PET-CT performed in 2015，an increase in cutaneous accumulation was noted，and therefore，skin biopsy was performed. Pathological findings indicated accumulation in luminal structures of various sizes and a cribriform structure from the dermis to the galea aponeurotica. The luminal structures included basophilic cells，which contained basophilic material. Additionally，neuronal invasion was noted. Therefore，he was diagnosed with primary cutaneous adenoid cystic carcinoma，and surgery was
performed. No recurrence has been noted for 5 months following surgery. Adenoid cystic carcinoma often shows neuronal invasion and regional relapse. Therefore，extended resection and a long-term follow-up are needed. Even if the SUV is low，it is important to perform dermatological examinations.

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A case of carcinoma of the maxillary gingiva with insulin-like growth factor II producing non-islet-cell tumor hypoglycemia

Miyashita H, Asoda S, Mori T, Yamada Y, Soma T, Kawana H

Japanese Journal of Oral & Maxillofacial Surgery (Japanese Society of Oral and Maxillofacial Surgeons) 62 ( 9 ) 448 - 453 2016

Research paper (scientific journal), Joint Work, Accepted, ISSN 0021-5163

Abstract:Non-islet-cell tumor hypoglycemia (NICTH), a condition characterized by recurrent episodes of hypoglycemia, rarely occurs in association with oral cancer. Here, we report a case of carcinoma of the maxillary gingiva with NICTH caused by paraneoplastic production of insulin-like growth factor II (IGF-II). A 72-year-old man with a painful swelling in the left maxillary region was referred to our hospital. A mass with induration was observed in the buccal and palatal regions from the first premolar to the second molar. The clinical diagnosis was carcinoma of the maxillary gingiva, and a biopsy revealed squamous cell carcinoma. The patient received concurrent radiation and chemotherapy with cisplatin. Three weeks after the completion of treatment, three episodes of hypoglycemia developed despite normal intake of meals. On the basis of the results of endocrinological examinations, typical diseases causing hypoglycemia, such as insulinoma and adrenal insufficiency, were ruled out. Furthermore, decreased IGF-I levels were found, which indirectly revealed an increase in IGF-II levels. On the basis of these findings, we diagnosed this case as carcinoma of the maxillary gingiva with NICTH. Continuous intravenous glucose infusion was needed for 3 months from the diagnosis of NICTH until death. NICTH should be borne in mind as one of the complications that can occur during treatment of oral cancer.

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A long-term followed-up case of a developing lingual bone defect associated with the sublingual gland

Karube T, Yasui T, Onizawa K, Sato H, Asoda S, Kawana H

Japanese Journal of Oral & Maxillofacial Surgery (Japanese Society of Oral and Maxillofacial Surgeons) 62 ( 6 ) 299 - 303 2016

Research paper (scientific journal), Joint Work, Accepted, ISSN 0021-5163

Abstract:Lingual bone defects are usually asymptomatic local concavities of the lingual cortical bone of the mandible, frequently caused by soft-tissue inclusion. In most cases, the soft tissue is the submandibular gland. Only 7 cases of developing lingual bone defects were previously reported in Japan, but none of these cases involved the sublingual gland. We report a rare case of a developing lingual bone defect associated with the sublingual gland, which we followed up for 21 years. The patient was a 58-year-old man who had a developing lingual bone defect in the anterior right side of the mandible. A panoramic X-ray film showed an oval radiolucent area in the apical region of the lower right canine and first premolar tooth. Moreover, electric pulp testing confirmed that all teeth in the lower-right quadrant were vital. A panoramic X-ray film obtained at a nearby dental clinic demonstrated a radiolucent area 15 years before presentation to our department, and the area showed evidence of gradual expansion. Computed tomography revealed a local concavity in the lingual cortical bone of the right side of the mandible. The concavity measured 13 × 9 mm. The signal intensity of the inner tissue of the bone defect was nearly equivalent to that of the sublingual gland on T1-, T2-weighted magnetic resonance imaging. The suspected clinical diagnosis was a lingual bone defect. We performed an incisional biopsy to rule out a neoplastic lesion, and the histopathological diagnosis was normal sublingual gland tissue. On the basis of these results, the final diagnosis was a developing lingual bone defect associated with the sublingual gland. Two years have elapsed, but there is no swelling or induration in the right sublingual gland. The radiolucent area on the panoramic X-ray film showed decreased radiolucency and increased bone volume. Moreover, computed tomography revealed that the concavity of the bone had shrunk.

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Desmoid-type fibromatosis of the head and neck in children: a case report and review of the literature.

Miyashita H, Asoda S, Soma T, Munakata K, Yazawa M, Nakagawa T, Kawana H

Journal of Medical Case Reports (J Med Case Reports) 10 173 2016

Research paper (scientific journal), Joint Work, Accepted

Background
Desmoid-type fibromatosis is defined as an intermediate tumor that rarely occurs in the head and neck of children. There is no doubt as to the value of complete surgical excision for desmoid-type fibromatosis. However, in pediatric patients, surgeons may often be concerned about making a wide excision because of the potential for functional morbidity. Some studies have reported a lack of correlation between margin status and recurrence. Therefore, we discussed our findings with a focus on the state of surgical margins.

Case presentation
We report an unusual case of a 9-month-old Japanese girl who prior to presenting at our hospital underwent debulking surgery twice with chemotherapy for desmoid-type fibromatosis of the tongue at another hospital. We performed a partial glossectomy and simultaneous reconstruction with local flap and achieved microscopic complete resection. We also reviewed available literature of pediatric desmoid-type fibromatosis in the head and neck.

Conclusions
We described successful treatment for the refractory case of pediatric desmoid-type fibromatosis. The review results showed that some microscopic incomplete resections of tumors in pediatric patients with desmoid-type fibromatosis tended to be acceptable with surgical treatment.

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Auricular malformation treated by placement of an osseointegrated implant-supported epithesis using telenavigation and model simulation

Usuda Shin, Truppe Michael, Kaneko Tsuyoshi, Ogawa Kaoru, Asoda Seiji, Hatazawa Chika, Usuda Sho, Yamada Yuka, Ewers Rolf, Nakagawa Taneaki, Kawana Hiromasa

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 27 ( 1 ) 49 - 55 2015.01

ISSN 2212-5558

We report a case of auricular malformation treated by placement of an osseointegrated implant-supported epithesis using telenavigation and model simulation. A 66-year-old male suffering from auricular malformation and atresia auris of his right ear since birth visited our department in October 2006. The patient desired placement of an ear epithesis supported by osseointegrated implants. Computed tomographic (CT) scans were obtained for use in the navigation system as a prerequisite for the telenavigation and the operative plan was designed in consultation with an overseas oral and maxillofacial surgeon having rich experience in telenavigation surgery. We also constructed a preoperative simulation model and a mirror model of the unaffected left ear based on laser lithography to produce successful operation and symmetrical form of a symmetrical ear epithesis as contrast with identical to that on the left side. The osseointegrated implant surgery was carried out under telenavigation guidance. As a result, safe and accurate positioning of the implants was achieved and a symmetrical and elaborate epithesis could be fabricated.

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A titanium screw-retaining temporary denture on the raw surface muscular flap for the immediate maxillary reconstruction

Miyashita Hidetaka, Asoda Seiji, Horie Nobuyuki, Usuda Shin, Kato Shin, Muraoka Wataru, Yamada Yuka, Yoshikawa Momoko, Hasegawa Toshihiro, Onizawa Katsuhiro, Tanaka Ichiro, Yazawa Masaki, Ogata Hisao, Kishi Kazuo, Tomita Toshiki, Nakagawa Taneaki, Kawana Hiromasa

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 2014.10

ISSN 2212-5558

Objective: In any immediate reconstruction of the maxillofacial defect after total maxillectomy, the defect is often covered with a flap, however, dentures cannot be maintained stably by the flap, because of the high mobility and large amount of displacement of the flap under pressure. Therefore, we developed a method in which a muscle flap is transplanted without creating a skin island in the oral cavity and a denture is immediately fixed with titanium screws, and obtained favorable results. Patients and methods: The subjects were 9 patients who underwent resection for maxillary sinus cancer. In all patients, a free rectus abdominis muscle flap was used for the reconstruction and the raw surface of the muscle tissue was left in the oral cavity without creating a skin island. Dentures that had been made preoperatively were fixed on the remaining palate and alveolus with titanium screws for one month, so that they covered the muscle tissue. Results: Good palatal morphology was formed without hanging down after epithelialization of the surface of the muscle tissue. In comparison with the preoperative levels, the masticatory and conversational functions recovered to 77% and 90%, on average. Conclusions: Our method is considered to be one of the useful reconstruction methods for maxillofacial defects.

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鼻腔内に萌出した逆性過剰歯の1例

鬼澤勝弘, 安居孝純, 軽部健史, 岩崎良太郎, 莇生田整治, 臼田慎, 宮下英高, 小高利絵, 兵藤朋子, 内山公男

日本小児口腔外科学会雑誌, 24 ( 1 ) 45 - 55 2014.06

Research paper (scientific journal), Joint Work, Accepted

抗精神病薬による薬剤性口顎ジストニアの1例

西須大徳, 落合駿介, 鳩貝翔, 佐藤仁, 臼田頌, 村岡渡, 莇生田整治, 河奈裕正, 中川種昭, 和嶋浩一

日本顎関節学会雑誌, 26 ( 1 ) 15 - 19 2014.04

Research paper (scientific journal), Joint Work, Accepted

顎関節症・咀嚼筋痛障害に伴う慢性疼痛へのトラマドール塩酸塩/アセトアミノフェン配合錠の使用経験

佐藤仁, 村岡渡, 西須大徳, 臼田頌, 莇生田整治, 河奈裕正, 中川種昭, 和嶋浩一

日本顎関節学会雑誌, 26 ( 1 ) 9 - 14 2014.04

Research paper (scientific journal), Joint Work, Accepted

Mechanical attachment of soft tissue to dental and maxillofacial implants with mesh structures

Asoda Seiji, Arita Takayuki, Takakuda Kazuo

Journal of Biomedical Materials Research - Part B Applied Biomaterials 101 ( 4 ) 553 - 559 2013.05

Research paper (scientific journal), Joint Work, Lead author, Accepted, ISSN 1552-4973

Soft tissue attachment is a major concern for the improved design of dental and maxillofacial implants. This study evaluated the efficacy of mesh structures for soft tissue attachment in a rat percutaneous model. Four kinds of implant specimens were prepared-TI implants made of titanium cylinders, HA implants of hydroxyapatite-coated titanium, TI-Mesh implants with a titanium mesh covering a groove machined around a titanium cylinder, and similar HA-Mesh implants with a hydroxyapatite-coated mesh. These specimens were implanted percutaneously into the skin tissue of rats. The detachments of the implants were examined during the experimental period of 4 weeks. Survived implants were subjected to mechanical tests for the attachment strength and histological examinations. TI and HA implants demonstrated 0% of survival rates, while TI-Mesh and HA-Mesh showed significantly higher rates of 93.3% and 100% respectively. The attachment strengths were 159 ± 47 kPa in the TI-Mesh and 135 ± 16 kPa in the HA-Mesh. Histological observations revealed that collagen fibers originating from surrounding subcutaneous tissues were anchored to the mesh structures of the TI- and HA-Mesh implants. The results demonstrated the efficacy of the mesh structures for the attachment of soft connective tissues to implants. © 2012 Wiley Periodicals, Inc.

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XCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma

Yoshikawa Momoko, Tsuchihashi Kenji, Ishimoto Takatsugu, Yae Toshifumi, Motohara Takeshi, Sugihara Eiji, Onishi Nobuyuki, Masuko Takashi, Yoshizawa Kunio, Kawashiri Shuichi, Mukai Makio, Asoda Seiji, Kawana Hiromasa, Nakagawa Taneaki, Saya Hideyuki, Nagano Osamu

Cancer Research 73 ( 6 ) 1855 - 1866 2013.03

Joint Work, Accepted, ISSN 0008-5472

The targeting of antioxidant systems that allow stem-like cancer cells to avoid the adverse consequences of oxidative stress might be expected to improve the efficacy of cancer treatment. Here, we show that head and neck squamous cell carcinoma (HNSCC) cells that express variant isoforms of CD44 (CD44v) rely on the activity of the cystine transporter subunit xCT for control of their redox status. xCT inhibition selectively induces apoptosis in CD44v-expressing tumor cells without affecting CD44v-negative differentiated cells in the same tumor. In contrast to CD44v-expressing undifferentiated cells, CD44v-negative differentiated cells manifest EGF receptor (EGFR) activation and rely on EGFR activity for their survival. Combined treatment with inhibitors of xCT-dependent cystine transport and of EGFR resulted in a synergistic reduction of EGFR-expressing HNSCC tumor growth. Thus, xCT-targeted therapy may deplete CD44v-expressing undifferentiated HNSCC cells and concurrently sensitize the remaining differentiating cells to available treatments including EGFR-targeted therapy. © 2012 AACR.

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難治性の口腔内出血に対し直接穿刺による塞栓が有効であった上顎動静脈奇形の1例

秋山武紀, 柴尾俊輔, 冨尾亮介, 小野塚聡, 莇生田整冶, 吉田一成

脳神経血管内治療 7 ( 1 ) 32 - 39 2013.03

Research paper (scientific journal), Joint Work, Accepted

高齢者の頬部に発生した多形型横紋筋肉腫の1例

大山定男, 吉田俊一, 莇生田整治, 内田育宏, 高野正行, 元井亨

日本口腔外科学会雑誌, 59 ( 5 ) 357 - 361 2013

Research paper (scientific journal), Joint Work, Accepted

Oral and maxillofacial tissue penetration of levofloxacin following oral administration of a single 500 mg dose

Asoda Seiji, Iwasaki Ryotaro, Fukaya Chie, Hosaka Yasuo, Usuda Shin, Kawana Hiromasa, Nakagawa Taneaki

Japanese Journal of Chemotherapy 60 ( 6 ) 643 - 645 2012.11

ISSN 1340-7007

We examined the transfer of levofloxacin (LVFX) into serum, gingiva, dental follicles, and mandibular bone following oral administration of a single 500 mg dose of LVFX to 10 subjects, comprising 3 males and 7 females. The mean concentrations 2.0 to 4.5 h after administration in serum, gingiva, dental follicles, and mandibular bone were 4.85 ± 0.82 μg/mL, 7.76 ± 3.21, 7.38 ± 2.04 μg/g, and 2.90 ± 1.94, respectively. The mean ratios of concentrations in gingiva/serum, dental follicle/serum, and mandibular bone/serum were 1.58 ± 0.53, 1.54 ± 0.50, and 0.59 ± 0.35, respectively. The mean LVFX concentrations in gingival tissue, dental follicles and mandibular bone exceeded the MIC for 90% of clinically isolated oral strains of streptococci and most of the anaerobic bacteria. These results indicated that LVFX penetrated well into oral and maxillofacial tissue and that LVFX 500 mg q.d. treatment was as effective as, or more effective than, 100 mg t.i.d. for the clinical treatment of oral infections.

Transoral anterior approach using median mandibular splitting in upper spinal tumor extirpation

Hiromasa Kawana, Shin Kato, Seiji Asoda, Akihiko Koike, Ryotaro Iwasaki, Morio Matsumoto, Kota Watanebe, Yorihisa Imanishi, Kaoru Ogawa, Taneaki Nakagawa

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 114 ( 5 ) 2012.11

ISSN 2212-4403

Objective: Transoral approach from the anterior direction is necessary if an upper spinal tumor is too big to extirpate via the posterior approach alone. To obtain a good anterior view of the surgical field, the mandible, tongue, and soft palate have to be split, and we developed a criterion to select the surgical strategy. Study Design: We indicated a decision-making process of splitting techniques and indications with actual cases and review of literatures. Result: Tumors were located from the level of C1 to the lower part of C3. Computerized tomography and magnetic resonance imaging were important to decide approaches. The orthopedic surgical team invited oral and maxillofacial surgeons team to assist in all transoral anterior approach cases. Conclusions: Vertical splitting of the mandible, incising the skin of the mental region, and splitting the middle of the tongue were combined according to the position of the spinal tumor. © 2012 Elsevier Inc. All rights reserved.

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人工材料と生体軟組織の機械的結合

高久田和夫, 莇生田整治, 有田隆之

生体材料工学研究所年報, 45 27 - 30 2012.03

Joint Work

全身疾患を有する患者の抜歯―医科との対診のポイント

莇生田整治

日本歯科評論 72 ( 6 ) 51 - 60 2012

Single Work

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