Papers - Asoda, Seiji

Osteonecrosis development by tooth extraction in zoledronate treated mice is inhibited by active vitamin D analogues, anti-inflammatory agents or antibiotics

Soma T., Iwasaki R., Sato Y., Kobayashi T., Ito E., Matsumoto T., Kimura A., Miyamoto K., Matsumoto M., Nakamura M., Morita M., Asoda S., Kawana H., Nakagawa T., Miyamoto T.

Scientific Reports 12 ( 1 ) 19 2022.01

Research paper (scientific journal), Joint Work, Accepted

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Model-Free Detection of Penetration and Automatic Stop Control in Dental Implant Surgery Based on Differential Value of Torque

Kido Y., Kawana H., Asoda S., Nozaki T., Murakami T.

2022 IEEE 17th International Conference on Advanced Motion Control (AMC)    144 - 149 2022

Research paper (international conference proceedings), Joint Work, Accepted

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Clinical value of entire-circumferential intraoperative frozen section analysis for the complete resection of superficial squamous cell carcinoma of the tongue

Asoda S., Miyashita H., Soma T., Munakata K., Yamada Y., Yasui Y., Kudo Y., Usuda S., Hasegawa T., Nakagawa T., Kawana H.

Oral Oncology  ( 123 ) 105629 2021.12

Research paper (scientific journal), Joint Work, Lead author, Accepted

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Diagnosing trigeminal neuralgia based on clinical diagnostic reasoning in elderly patient

Usuda S., Muraoka W., Asoda S., Horie N., Nakagawa T. and Ouchi T.

Bulletin of Tokyo Dental College (東京歯科大学欧文紀要編集部)  62 ( 4 ) 253 - 260 2021.11

Research paper (bulletin of university, research institution), Joint Work, Accepted

Oral hamartoma with advanced elevation of tongue

Yamada Y., Okita H., Nakagawa T., Asoda S.

BMJ Case Reports 14 ( 10 )  2021.10

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

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Undifferentiated Carcinoma of the Mandible Detected Simultaneously with the Liver: A case report

Asoda S., Morita M., Soma T., Sato H., Hasegawa T., Nakagawa T., Hashiguchi A., Kawana H.

Oral and Maxillofacial Surgery Cases 7 ( 3 ) 100228 2021.09

Research paper (scientific journal), Joint Work, Lead author, Accepted

Development of a microsurgery-assisted robot for high-precision thread traction and tension control, and confirmation of its applicability

Hangai S, Nozaki T, Soma T, Miyashita H, Asoda S, Yazawa M, Sato K, Kawana H, Ohnishi K, Kobayashi E

The International Journal of Medical Robotics and Computer Assisted Surgery (The International Journal of Medical Robotics and Computer Assisted Surgery)  17 ( 2 ) 2205 2021.04

Joint Work, Accepted

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Background: Microsurgery requires high skills for suturing using fragile threads, often within narrow surgical fields. Precise tension is required for good healing and to avoid the risk of thread breakage.

Methods: To meet the demands, we developed a novel assist robot utilizing high-precision sensorless haptic technology. The robot adopts a cable-driven mechanism to maintain a distance from the surgical area and enhances compatibility with surgical equipment such as microscopes. The robot performance was verified through in vitro and in vivo experiments using a rat model.

Results: The realization of precise tension control was confirmed in both experiments. In particular, in the in vivo experiments, the developed robot succeeded to produce a knot with an accurate tension of 0.66% error.

Conclusions: The developed robot can realize to control traction force precisely. This technology might open up the window for a full assist robot for microsurgery with haptic feeling.

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Influence of prostate cancer status on the prevalence of medication-related osteonecrosis of the jaw.

Yasui T, Kimura M, Nagamine H, Yajima S, Karube T, Sato H, Asoda S, Hara S, Onizawa K

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology (Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)  131 ( 3 ) 312 - 318 2021.03

Accepted

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Objective: The aim of this study was to evaluate the risk of osteonecrosis of the jaw (ONJ) in patients with prostate cancer, particularly the relationship between prostate cancer progression and ONJ development.

Study design: This single-center, retrospective, observational study included 113 patients who received zoledronic acid or denosumab for prostate cancer with bone metastasis between January 2012 and March 2020. The risk of ONJ was evaluated regarding age; antiresorptive drugs; duration of antiresorptive treatment; prostate cancer status, including castration-resistant prostate cancer (CRPC) and prostate-specific antigen level; chemotherapy; radium-223 treatment; corticosteroid treatment; diabetes mellitus; and dental extractions.

Results: Overall, 28 patients had ONJ; 10 patients received zoledronic acid and 18 patients received denosumab. Multiple logistic regression analysis demonstrated that CRPC (odds ratio = 6.01; 95% confidence interval, 1.76-20.05; P = .004) and dental extractions (odds ratio = 12.40; 95% confidence interval, 3.42-44.70; P < .001) were significantly associated with ONJ. In addition, antiresorptive treatment lasting more than 1 year partially mediated between CRPC and development of ONJ.

Conclusion: CRPC and dental extraction are risk factors for developing ONJ, and antiresorptive treatment lasting more than 1 year is a partial mediator between CRPC and ONJ.

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下唇軟部組織に発生した微小な類上皮肉腫の1例

小川千晴, 臼田慎, 宮下英高, 莇生田整治, 内田育宏, 元井亨, 寺尾保信, 大山定男

Journal of Japan Society for Oral Tumors (Japanese Society of Oral Oncology)  33 ( 3 ) 113 - 118 2021

Research paper (scientific journal), Joint Work, Accepted

Giant peripheral ossifying fibroma with coincidental squamous cell carcinoma: A case report

Karube T., Munakata K., Yamada Y., Yasui Y., Yajima S., Horie N., Kawana H., Mikami S., Nakagawa T., Asoda S.

Journal of Medical Case Reports  ( 15 ) 599 2021

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

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Epidermoid cyst arising in the mandibular ramus: A case report

Homma F., Karube T., Usuda S., Endo T., Asoda S., Kizu H.

International Journal of Case Reports and Images 12   101271Z01FH2021 2021

Research paper (scientific journal), Joint Work, Accepted

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Remote Oral Imaging Diagnosis Using an Ultra-High-Definition Video Microscope in the COVID-19 Era

Kawana H., Asoda S., Kobayashi E.,

Oral Surgery 6 ( 10 ) 1111  2021

Research paper (scientific journal), Joint Work, Accepted

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重粒子線治療の晩期有害事象として神経障害性疼痛を生じた1例

佐藤仁, 村岡　渡, 中山詩織，莇生田整治, 嶋根俊和，中川種昭

Japanese Journal of Orofacial Pain (Japanese Society of Orofacial Pain)  13 ( 1 ) 97 - 103 2021

Research paper (scientific journal), Joint Work, Accepted

症例をどう見るか？　上顎洞内を占拠した歯原性角化嚢胞について

神崎晶, 莇生田整治, 宗像花楠子

Journal of Otolaryngology, Head and Neck Surgery 37 ( 5 ) 1139 - 1146 2021

Research paper (scientific journal), Joint Work

顔面痛を主訴に来院したメトトレキサート関連リンパ増殖性疾患の１例

浅野崇浩, 矢島祥助, 安井真梨子, 落合駿介, 遠藤友樹, 吉川桃子, 西須大徳, 佐藤 仁, 黄地健仁, 莇生田整冶, 臼田頌, 中川種昭, 村岡渡

Japanese Journal of Orofacial Pain (Japanese Society of Orofacial Pain)  13 ( 1 ) 69 - 77 2021

Research paper (scientific journal), Joint Work, Accepted

Tooth extraction in mice administered zoledronate increases inflammatory cytokine levels and promotes osteonecrosis of the jaw

Soma T., Iwasaki R., Sato Y., Kobayashi T., Nakamura S., Keneko Y., Ito E., Okada H., Watanabe H., Miyamoto K., Matsumoto M., Nakamura M., Asoda S., Kawana H., Nakagawa T., Miyamoto T.

Journal of Bone and Mineral Metabolism 39   372 - 384 2020.11

Joint Work, Accepted

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Introduction
Osteonecrosis of the jaw (ONJ) occurring after invasive dental treatment often adversely affects patients’ activities of daily living. Long-term administration of strong anti-bone resorptive agents such as bisphosphonates prior to invasive dental treatment is considered an ONJ risk factor; however, pathological mechanisms underlying ONJ development remain unclear.

Materials and Methods
We developed an ONJ mouse model in which a tooth is extracted during treatment with the bisphosphonate zoledronate.

Results
We observed induction of apoptosis in osteocytes, resulting in formation of empty lacunae in jaw bones at sites of tooth extraction but not in other bones of the same mice. We also observed elevated levels of inflammatory cytokines such as TNFα, IL-6 and IL-1 in jaw bone at the extraction site relative to other sites in zoledronate-treated mice. We also report that treatment in vitro with either zoledronate or an extract from Porphyromonas gingivalis, an oral bacteria, promotes expression of inflammatory cytokines in osteoclast progenitor cells. We demonstrate that gene-targeting of either TNFα, IL-6 or IL-1 or treatment with etanercept, a TNFα inhibitor, or a neutralizing antibody against IL-6 can antagonize ONJ development caused by combined tooth extraction and zoledronate treatment.

Conclusions
Taken together, the cytokine storm induced by invasive dental treatment under bisphosphonate treatment promotes ONJ development due to elevated levels of inflammatory cytokine-producing cells. Our work identifies novel targets potentially useful to prevent ONJ.

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Clear Cell Carcinoma in the Retromolar Area: A Case Report

Yasui Y, Asoda S, Soma T, Miyashita H, Hasegawa T, Ouchi T, Karube T, Yasui T, Onizawa K, Nakagawa T, Kawana H

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology (J Oral Maxillofac Surg Med Pathol)  32 ( 6 ) 507 - 513 2020.11

Joint Work, Accepted

広範囲顎骨支持型装置を用いて咬合再建したランゲルハンス細胞組織球症の1例

宗像花楠子, 宮下英高, 堀江伸行, 森田麻友, 小高利絵, 莇生田整治, 内田育宏, 中川種昭, 河奈裕正

日本顎顔面インプラント学会誌 (日本顎顔面インプラント学会)  19 ( 1 ) 19 - 25 2020.04

Research paper (scientific journal), Joint Work, Accepted

Auricular osseointegrated implant treatment: Basic technique and application of computer technology

Kawana H, Usuda S, Asoda S, Kaneko T, Ogawa K, Itamiya T, Fuchigami K, Nagata K, Kitami R, Kimoto K, Truppe M

Applied Sciences (Appl. Sci)  10 ( 14 ) 4922 2020

Joint Work, Accepted

Vertical Displacement in Unilateral Extension Base Flexible Removable Dentures

Horie N, Ouchi T, Nishiyama R, Usuda S, Morikawa S, Asoda S, Nakagawa T

Bulletin of Tokyo Dental College (Tokyo Dental College)  60 ( 4 ) 233 - 239 2019.12

Research paper (bulletin of university, research institution), Joint Work, Accepted