研究者詳細 - 藤原　広和

論文 - 藤原　広和

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Various patterns of the middle cerebral veins and preservation of venous drainage during the anterior transpetrosal approach

Shibao, S, Toda, M, Fujiwara, H and Yoshida, K

J Neurosurg Aug 28 1 - 8 2015年

【ビギナーのための頭部画像診断-Q&Aアプローチ-】所見別　磁化率強調像、T2*強調像の小さな低信号をみたら、(どのような鑑別を考え)どのようなコメントを書きますか? 【多発性硬化症のパラダイムシフト-病態から治療まで】検査　画像診断

藤原, 広和, 高橋, 秀典, 藤原, 広和 and 百島, 祐貴

画像診断 35 （ 10 ） 1248 - 1249 2015年

ISSN 0285-0524

【多発性硬化症のパラダイムシフト-病態から治療まで】検査　画像診断

高橋, 秀典, 藤原, 広和 and 百島, 祐貴

Clinical Neuroscience 32 （ 11 ） 1249 - 1252 2014年11月

ISSN 0289-0585

【脳血管構築の特異性と認知症】血管性認知症の画像診断

百島, 祐貴 and 藤原, 広和

血管医学 15 （ 1 ） 61 - 67 2014年05月

ISSN 1345-9031

血管性認知症を画像所見のみから診断することは難しい場合が多く、臨床経過、神経症状との対比が重要である。血管性認知症に認められる画像所見は、(1)Binswanger病(大脳白質の虚血性変化)、(2)ラクナ梗塞、(3)多発皮質梗塞、(4)特定の「戦略的部位」の梗塞、(5)出血性病変に大別できる。しかし、純粋な脳血管性認知症は比較的少なく、特に加齢とともにアルツハイマー病など変性認知症との合併が増加する。このほか鑑別すべきものとして、アミロイドアンギオパチー、正常圧水頭症などが重要である。(著者抄録)

【鉄と神経疾患】脳内鉄沈着をきたす疾患の画像診断

百島, 祐貴 and 藤原, 広和

神経内科 79 （ 4 ） 435 - 438 2013年10月

ISSN 0386-9709

【頭蓋底-disease oriented anatomy-】眼窩疾患と頭蓋底【鉄と神経疾患】脳内鉄沈着をきたす疾患の画像診断

藤原, 広和, 百島, 祐貴, 高橋, 秀典, 百島, 祐貴 and 藤原, 広和

画像診断 33 （ 13 ） 1397 - 1407 2013年10月

ISSN 0285-0524

Tandem age-related lumbar and cervical intervertebral disc changes in asymptomatic subjects.

Matsumoto, Morio, Okada, Eijiro, Toyama, Yoshiaki, Fujiwara, Hirokazu, Momoshima, Suketaka and Takahata, Takeshi

European spine journal 22 708 - 13 2013年

PURPOSE: To investigate the frequency of tandem lumbar and cervical intervertebral disc degeneration in asymptomatic subjects. METHODS: We evaluated magnetic resonance imaging (MRI) results from 94 volunteers (48 men and 46 women; mean age 48 years) for age-related intervertebral disc degeneration in the lumbar and cervical spine. RESULTS: MRI indicated degenerative changes in the lumbar spine in 79 subjects (84 %), with decreased disc signal intensity in 74.5 %, posterior disc protrusion in 78.7 %, anterior compression of the dura in 81.9 %, disc space narrowing in 21.3 %, and spinal canal stenosis in 12.8 %. These findings were more common in older subjects at caudal levels. MRI showed degenerative changes in both the lumbar and cervical spine in 78.7 % of the volunteers. CONCLUSIONS: Degenerative findings in both the lumbar and cervical spine, suggesting tandem disc degeneration, was common in asymptomatic subjects. These results provide normative data for evaluating patients with degenerative lumbar and cervical disc diseases.

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Whole-brain CT digital subtraction angiography of cerebral dural arteriovenous fistula using 320-detector row CT.

Fujiwara, Hirokazu, Momoshima, Suketaka, Akiyama, Takenori and Kuribayashi, Sachio

Neuroradiology 55 837 - 43 2013年

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Modic changes of the cervical spine in patients with whiplash injury: a prospective 11-year follow-up study.

Matsumoto, Morio, Ichihara, Daisuke, Okada, Eijiro, Toyama, Yoshiaki, Fujiwara, Hirokazu, Momoshima, Suketaka, Nishiwaki, Yuji and Takahata, Takeshi

Injury 44 819 - 24 2013年

INTRODUCTION: There are few studies on Modic changes of the cervical spine in patients suffering from whiplash. This study compared Modic changes seen in whiplash patients 10 years after the injury with those observed in asymptomatic volunteers. METHODS: This is a follow-up study of 133 patients who suffered whiplash injuries in 1994-1996 and underwent MRI with a superconductive imager (63 men, 70 women, mean age 49.6±15.3 years, mean follow-up 11.4 years). In addition, 223 healthy volunteers who underwent MRI during the same period were included as controls (123 men, 100 women, mean age 50.5±15.0 years, mean follow-up 11.6 years). All participants underwent follow-up MRI. We examined all participants for Modic changes, and investigated relationships between Modic changes and clinical symptoms or potentially related factors. RESULTS: Modic changes were observed in 4 patients (3%) and at 7 intervertebral levels in the initial study, and in 17 patients (12.8%) and at 30 intervertebral levels at the follow-up. Modic Type 2 changes were the most prevalent in the whiplash patients in both the initial and follow-up studies. There was no significant difference in the percentage of whiplash patients versus control subjects with positive Modic changes, either at the initial study or at follow-up. Modic changes were not related to clinical symptoms present at follow-up, but were associated with preexisting disc degeneration. There was no association between Modic changes and the details of the car accident that caused the injury. CONCLUSIONS: While Modic changes became more common in whiplash patients in the 10-year period after the accident, they occurred with a similar frequency in control subjects. We did not find any association between Modic changes and the nature of the car accident in which the whiplash occurred. Modic changes found in whiplash patients may be a result of the physiological ageing process rather than pathological findings relating to the whiplash injury.

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【心原性脳塞栓症と心房細動】脳塞栓症の診断　画像診断

藤原, 広和 and 百島, 祐貴

Clinical Neuroscience 30 （ 11 ） 1250 - 1253 2012年11月

ISSN 0289-0585

Cross-sectional area of the posterior extensor muscles of the cervical spine in whiplash injury patients versus healthy volunteers--10 year follow-up MR study.

Matsumoto, Morio, Ichihara, Daisuke, Okada, Eijiro, Chiba, Kazuhiro, Toyama, Yoshiaki, Fujiwara, Hirokazu, Momoshima, Suketaka, Nishiwaki, Yuji and Takahata, Takeshi

Injury 43 912 - 6 2012年

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Modic changes in the cervical spine: prospective 10-year follow-up study in asymptomatic subjects.

Matsumoto, M, Okada, E, Ichihara, D, Chiba, K, Toyama, Y, Fujiwara, H, Momoshima, S, Nishiwaki, Y and Takahata, T

The Journal of bone and joint surgery. British volume 94 678 - 83 2012年

We conducted a prospective follow-up MRI study of originally asymptomatic healthy subjects to clarify the development of Modic changes in the cervical spine over a ten-year period and to identify related factors. Previously, 497 asymptomatic healthy volunteers with no history of cervical trauma or surgery underwent MRI. Of these, 223 underwent a second MRI at a mean follow-up of 11.6 years (10 to 12.7). These 223 subjects comprised 133 men and 100 women with a mean age at second MRI of 50.5 years (23 to 83). Modic changes were classified as not present and types 1 to 3. Changes in Modic types over time and relationships between Modic changes and progression of degeneration of the disc or clinical symptoms were evaluated. A total of 31 subjects (13.9%) showed Modic changes at follow-up: type 1 in nine, type 2 in 18, type 3 in two, and types 1 and 2 in two. Modic changes at follow-up were significantly associated with numbness or pain in the arm, but not with neck pain or shoulder stiffness. Age (≥ 40 years), gender (male), and pre-existing disc degeneration were significantly associated with newly developed Modic changes. In the cervical spine over a ten-year period, type 2 Modic changes developed most frequently. Newly developed Modic changes were significantly associated with age, gender, and pre-existing disc degeneration.

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Changes in the cross-sectional area of deep posterior extensor muscles of the cervical spine after anterior decompression and fusion: 10-year follow-up study using MRI.

Matsumoto, Morio, Okada, Eijiro, Ichihara, Daisuke, Watanabe, Kota, Chiba, Kazuhiro, Toyama, Yoshiaki, Fujiwara, Hirokazu, Momoshima, Suketaka, Nishiwaki, Yuji, Hashimoto, Takeshi, Iwanami, Akio, Ikegami, Takeshi and Takahata, Takeshi

European spine journal 21 304 - 8 2012年

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Hemorrhagic onset of cerebellar pilocytic astrocytoma in an adult: a case report and review of the literature implying a possible relation of degenerative vascular changes to the massive intratumoral hemorrhage.

Shibao, Shunsuke, Kimura, Tokuhiro, Sasaki, Hikaru, Fujiwara, Hirokazu, Akiyama, Takenori, Ueno, Mari, Shidoh, Satoka and Yoshida, Kazunari

Brain tumor pathology 29 96 - 102 2012年

Pilocytic astrocytoma (PA) is a low-grade astrocytic tumor arising predominantly during the first two decades of life. Hemorrhagic onset of PAs is uncommon, and the etiology of hemorrhage remains unclear. Here we report a case of hemorrhagic onset of cerebellar PA in a 29-year-old man who presented with a week-long history of headache and gait instability. Computed tomography and magnetic resonance imaging revealed a hemorrhagic tumor located in the right cerebellar hemisphere, and total resection was performed. Histological examination showed bipolar glial cell proliferation in a biphasic pattern in a compact area and a loose microcystic area with Rosenthal fibers and eosinophilic granular bodies, indicating PA. Prominent changes in tumor vasculature, including aggregation of sclerotic thick-walled and ectatic thin-walled vessels, was observed, and nodules of thrombi containing complex vascular proliferation suggesting recanalized thrombi formed in partially ruptured vessels were also found. Thus, rupture of these abnormal vessels appeared to be the cause of hemorrhage. Review of the literature revealed that age distribution of patients with hemorrhagic PAs tends to be older than that of patients with general PAs. These findings imply a possibility that degenerative changes in blood vessels in long-standing PAs might be related to the mechanisms of spontaneous intratumoral hemorrhage.

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Posterior cerebral artery dissection on a serial magnetic resonance angiography.

Takenouchi, Toshiki, Shimozato, Sachiko, Fujiwara, Hirokazu, Momoshima, Suketaka and Takahashi, Takao

Brain & development 34 396 - 9 2012年

Posterior cerebral artery (PCA) dissection in children seldom is reported in the literature. This is the second report of acute PCA dissection with infarct occurring in a young child. A serial magnetic resonance angiography demonstrated a delayed and transient narrowing of the arterial caliber, which was consistent with a focal PCA dissection with delayed vascular recanalization. PCA dissection should be included in the causes of infarct in children and a thorough and serial neurovascular imaging should be considered if no cause of stroke is found.

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Cross-sectional area of posterior extensor muscles of the cervical spine in asymptomatic subjects: a 10-year longitudinal magnetic resonance imaging study.

Okada, Eijiro, Matsumoto, Morio, Ichihara, Daisuke, Chiba, Kazuhiro, Toyama, Yoshiaki, Fujiwara, Hirokazu, Momoshima, Suketaka, Nishiwaki, Yuji and Takahata, Takeshi

European spine journal 20 1567 - 73 2011年

There has been no prospective study on age-related changes of the extensor muscles of the cervical spine in healthy subjects. This study was conducted to elucidate any association between the changes in cross-sectional area of the extensor muscles of the cervical spine on MRIs and cervical disc degeneration or the development of clinical symptoms. Sixty-two subjects who underwent MR imaging by a 1.5-Tesla machine between 1993 and 1996 as asymptomatic volunteers in a previous study were recruited again 10 years later for this follow-up study. The mean interval between the studies was 11.0 ± 0.7 years. The cross-sectional areas of the multifidus, semispinalis cervicis, semispinalis capitis, and splenius capitis at C3-C4, C4-C5, and C5-C6 intervertebral levels were measured on T2-weighted axial images using Image J 1.42. The mean cross-sectional areas of the deep extensor muscles were 1,396.8 ± 337.6 mm(2) at the C3-C4 level, 1,514.7 ± 381.0 mm(2) at the C4-C5 level, and 1,542.8 ± 373.5 mm(2) at the C5-C6 level in the previous investigation. The cross-sectional areas were 1,498.7 ± 374.4 mm(2) at the C3-C4 level, 1,569.9 ± 390.9 mm(2) at the C4-C5 level, and 1,599.6 ± 364.3 mm(2) at the 10-year follow-up. An increase in the cross-sectional area of the muscles was more frequently observed in subjects in their tens to thirties in the initial study, while a decrease was more frequently observed in those in their forties and older in the initial study. Disc degeneration was not correlated with a change in extensor muscle volume. Development of shoulder stiffness during follow-up was significantly negatively correlated with a change in the cross-sectional area of the deep extensor muscles.

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Wedging of vertebral bodies at the thoracolumbar junction in asymptomatic healthy subjects on magnetic resonance imaging.

Matsumoto, Morio, Okada, Eijiro, Kaneko, Yasuhito, Ichihara, Daisuke, Watanabe, Kota, Chiba, Kazuhiro, Toyama, Yoshiaki, Fujiwara, Hirokazu, Momoshima, Suketaka, Nishiwaki, Yuji, Hashimoto, Takeshi and Takahata, Takeshi

Surgical and radiologic anatomy : SRA 33 223 - 8 2011年

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Disc degeneration of cervical spine on MRI in patients with lumbar disc herniation: comparison study with asymptomatic volunteers.

Okada, Eijiro, Matsumoto, Morio, Fujiwara, Hirokazu and Toyama, Yoshiaki

European spine journal 20 585 - 91 2011年

An association between progression of cervical disc degeneration and that of lumbar disc degeneration has been considered to exist. To date, however, this association has not yet been adequately studied. Age-related changes in the cervical intervertebral discs were evaluated by magnetic resonance imaging (MRI) in patients with lumbar disc herniation, and compared with the MRI findings of healthy volunteers without lower back pain. The purpose of this study was to clarify whether the prevalence of asymptomatic cervical disc degeneration is higher in patients with lumbar disc herniation than in healthy volunteers. The study was conducted on 51 patients who were diagnosed as having lumbar disc herniation and underwent cervical spine MRI. The patients consisted of 34 males and 17 females ranging in age from 21-83 years (mean 46.9 ± 14.5 years) at the time of the study. The control group was composed of 113 healthy volunteers (70 males and 43 females) aged 24-77 years (mean 48.9 ± 14.7 years), without neck pain or low back pain. The percentage of subjects with degenerative changes in the cervical discs was 98.0% in the lumbar disc herniation group and 88.5% in the control group (p = 0.034). The presence of lumbar disc herniation was associated significantly with decrease in signal intensity of intervertebral disc and posterior disc protrusion in the cervical spine. None of the MRI findings was significantly associated with the gender, smoking, sports activities, or BMI. As compared to healthy volunteers, patients with lumbar disc herniation showed a higher prevalence of decrease in signal intensity of intervertebral disc and posterior disc protrusion on MRI of the cervical spine. The result of this study suggests that disc degeneration appears to be a systemic phenomenon.

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【知っておきたい認知症の臨床と画像】画像診断総論　MRI　MRIによる認知症の鑑別診断

百島, 祐貴 and 藤原, 広和

臨床放射線 55 （ 11 ） 1346 - 1353 2010年10月

ISSN 0009-9252

【神経疾患と鉄沈着】鉄沈着の画像診断

藤原, 広和 and 百島, 祐貴

神経内科 73 （ 2 ） 110 - 116 2010年08月

ISSN 0386-9709

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