論文 - 前田　貴記

Subthreshold vibrotactile noise stimulation immediately improves manual dexterity in a child with developmental coordination disorder: A single-case study

Nobusako S., Osumi M., Matsuo A., Furukawa E., Maeda T., Shimada S., Nakai A., Morioka S.

Frontiers in Neurology （Frontiers in Neurology）  10 （ 717 ） 717 2019年07月

研究論文（学術雑誌）, 共著, 査読有り

　概要を見る

Copyright © 2019 Nobusako, Osumi, Matsuo, Furukawa, Maeda, Shimada, Nakai and Morioka. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Developmental coordination disorder (DCD) is the most common childhood movement disorder. It is characterized by clumsiness of fine and gross motor skills in developing children. Children with DCD have low ability to effectively use tactile information for movements, instead relying on visual information. In addition, children with DCD have deficits in visuo-motor temporal integration, which is important in motor control. These traits subsequently lead to clumsiness of movements. Conversely, however, imperceptible vibrotactile noise stimulation (at 60%-intensity of the sensory threshold) to the wrist provides stochastic resonance (SR) phenomenon to the body, improving the sensory and motor systems. However, the effects of SR have not yet been validated in children with DCD. Thus, we conducted a single case study of a 10-year-old boy with a diagnosis of DCD to investigate the effect of SR on visual dependence, visuo-motor temporal integration, and manual dexterity. SR was provided by vibrotactile noise stimulation (at an intensity of 60% of the sensory threshold) to the wrist. Changes in manual dexterity (during the SR on- and off-conditions) were measured using the manual dexterity test of the Movement Assessment Battery for Children-2nd edition. The point of subjective equality measured by visual or tactile temporal order judgment task served as a quantitative indicator reflecting specific sensory dependence. The delay detection threshold and steepness of delay detection probability curve, which were measured using the delayed visual feedback detection task, were used as quantitative indicators of visuo-motor temporal integration. The results demonstrated alleviated visual dependence and improved visuo-motor temporal integration during the SR on-conditions rather than the SR off-conditions. Most importantly, manual dexterity during the SR on-conditions was significantly improved compared to that during the SR off-conditions. Thus, the present results highlighted that SR could contribute to improving poor movement in children with DCD. However, since this was a single case study, a future interventional study with a large sample size is needed to determine the effectiveness of SR for children with DCD.

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精神病理学と生物学の連繋　―ありうべき方法論―

前田貴記

精神科治療学 34 （ ６ ） 613 - 619 2019年06月

研究論文（学術雑誌）, 単著

主体性の精神医学　精神病理学と生物学とが重なるところ

前田貴記

精神医学 （医学書院）  61 （ 5 ） 507 - 515 2019年05月

研究論文（学術雑誌）, 単著

Predicting anxiety state using smartphone-based passive sensing

Fukazawa Y., Ito T., Okimura T., Yamashita Y., Maeda T., Ota J.

Journal of Biomedical Informatics （Journal of Biomedical Informatics）  93   103151 2019年05月

査読有り,  ISSN  15320464

　概要を見る

© 2019 Elsevier Inc. This study predicts the change of stress levels using real-world and online behavioral features extracted from smartphone log information. Previous studies of stress detection using smartphone data focused on a single feature and did not consider all features simultaneously. We propose a method to extract a co-occurring combination of a user's real-world and online behavioral features by converting raw sensor data into categorical features. We conducted an experiment in which the State Trait Anxiety Inventory (STAI) was used to assess the anxiety-related stress levels of 20 healthy participants. The participants installed a log-collecting application on their smartphones and answered the STAI questions once a day for one month. The proposed method showed an F-score of 74.2%, which is 4.0% higher than the F-score of previous studies (70.2%) that used single non-combined features. The results demonstrate that anxiety-related stress levels can be predicted using combined features extracted from smartphone log data.

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Dysconnectivity of the agency network in schizophrenia: A functional magnetic resonance imaging study

Koreki A., Maeda T., Okimura T., Terasawa Y., Kikuchi T., Umeda S., Nishikata S., Yagihashi T., Kasahara M., Nagai C., Moriyama Y., Den R., Watanabe T., Kikumoto H., Kato M., Mimura M.

Frontiers in Psychiatry （Frontiers in Psychiatry）  10 （ APR ） 171 2019年04月

共著, 査読有り

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Copyright © 2019 Koreki, Maeda, Okimura, Terasawa, Kikuchi, Umeda, Nishikata, Yagihashi, Kasahara, Nagai, Moriyama, Den, Watanabe, Kikumoto, Kato and Mimura. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Background: Self-disturbances in schizophrenia have recently been explained by an abnormality in the sense of agency (SoA). The cerebral structures of SoA in healthy people are considered to mainly include the insula and inferior parietal lobule. In contrast, the functional lesion of aberrant SoA in schizophrenia is not yet fully understood. Considering the recent explanation of establishing SoA from the standpoint of associative learning, the “agency network” may include not only the insula and inferior parietal lobule but also the striatum. We hypothesized that aberrant SoA in schizophrenia is based on a deficit in the “agency network.” Methods: Functional magnetic resonance imaging data were acquired while patients with schizophrenia (n = 15) and matched controls (n = 15) performed our adaptation method of agency attribution task on a trial-by-trial basis to assess participants' explicit experience of the temporal causal relationship between an action and an external event with temporal biases. Analysis of functional connectivity was done using the right supramarginal gyrus and the right middle frontal gyrus as seed regions. Results: In healthy controls, analyses revealed increased activation of the right inferior parietal lobule (mainly the supramarginal gyrus), right insula, and right middle frontal gyrus as an activation of the agency condition. We defined activated Brodmann areas shown in the agency condition of healthy controls as the seed region for connectivity analysis. The connectivity analysis revealed lower connectivity between the head of the left caudate nucleus and right supramarginal gyrus in the patients compared to healthy controls. Conclusions: This dysconnectivity of the agency network in schizophrenia may lead to self-disturbance through deficits in associative learning of SoA. These findings may explain why pathological function of the striatum in schizophrenia leads to self-disturbance.

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Comparison of emotional processing assessed with fear conditioning by interpersonal conflicts in patients with depression and schizophrenia

Tani H., Tada M., Maeda T., Konishi M., Umeda S., Terasawa Y., Mimura M., Takahashi T., Uchida H.

Psychiatry and Clinical Neurosciences （Psychiatry and Clinical Neurosciences）  73 （ 3 ） 116 - 125 2019年03月

査読有り,  ISSN  13231316

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© 2018 The Authors. Psychiatry and Clinical Neurosciences © 2018 Japanese Society of Psychiatry and Neurology Aim: While emotional processing is implicated in various psychiatric illnesses, its differences among diagnoses are unclear. We compared associative learning of social values in patients with depression and schizophrenia by measuring skin conductance response to interpersonal stimuli. Methods: We included 20 female outpatients each with depression and schizophrenia. They underwent Pavlovian conditioning experiments in response to a classical aversive sound, and an interpersonal stimulus that was designed to cause aversive social conditioning with actors’ faces coupled with negative verbal messages. Multiple regression analysis was performed to examine the associations between the degree of conditioned response and the clinical characteristics of the participants. Results: Conditioned responses during the acquisition phase in both conditions were higher in depression compared to schizophrenia. Patients with depression successfully showed fear conditioning in both conditions, and they exhibited slower extinction in the interpersonal condition. The conditioned response during the extinction phase showed a positive association with Emotion Regulation Questionnaire Expressive Suppression score, and a negative association with the Emotion Regulation Questionnaire Cognitive Reappraisal score and the use of antidepressants. Patients with schizophrenia did not become conditioned in either of the conditions. The Positive and Negative Syndrome Scale Negative Syndrome score was negatively associated with the degree of conditioned response during the acquisition phase in the interpersonal condition. Conclusion: Female patients with schizophrenia, especially those who prominently demonstrated negative symptoms, suggested their intrinsic impairments in the associative learning of social context. Antidepressants and adaptive emotional regulation strategy may enhance the extinction learning of aversive social conditioning in depression.

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Physiological Stress Level Estimation Based on Smartphone Logs

Yamamoto N., Ochiai K., Inagaki A., Fukazawa Y., Kimoto M., Kiriu K., Kaminishi K., Ota J., Okimura T., Terasawa Y., Maeda T.

2018 11th International Conference on Mobile Computing and Ubiquitous Network, ICMU 2018 （2018 11th International Conference on Mobile Computing and Ubiquitous Network, ICMU 2018）  2019年02月

査読有り,  ISSN  9784907626341

　概要を見る

© 2018 IPSJ. Recently, inferring the state of people's mental health via passive mobile sensing has attracted significant attention. Previous studies have used the self-assessed stress levels as the ground truth; however, these are subjective measures. In this study, we use a physiologically-assessed stress metric to minimize the effect of participant subjectivity and further estimate it using behavioral features based on the smartphone usage logs. We initially requested the study participants (39 participants) to attach heart rate sensors for 8 hours per day and simultaneously collected continuous heart rate data and smartphone logs for 42 days. Further, we divided the participants into four types via clustering using the behavioral features derived from their smartphone sensor logs and trained each model via supervised learning using the heart rate data as the ground truth. Our results exhibit that the proposed method is more accurate (71%) as compared to the baseline method (54%). This demonstrates that physiologically-assessed stress levels can be estimated based on the implicit features that are gathered from the smartphone logs.

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Analyzing the relationship between cognitive performance and time to find intended mobile app

Ochiai K., Yamamoto N., Hamatani T., Fukazawa Y., Kimoto M., Terasawa Y., Kiriu K., Kaminishi K., Ota J., Okimura T., Maeda T.

UbiComp/ISWC 2018 - Adjunct Proceedings of the 2018 ACM International Joint Conference on Pervasive and Ubiquitous Computing and Proceedings of the 2018 ACM International Symposium on Wearable Computers （UbiComp/ISWC 2018 - Adjunct Proceedings of the 2018 ACM International Joint Conference on Pervasive and Ubiquitous Computing and Proceedings of the 2018 ACM International Symposium on Wearable Computers）     1686 - 1690 2018年10月

ISSN  9781450359665

　概要を見る

© 2018 Association for Computing Machinery. Although mental illness is one of the most serious social problems, stress does not necessarily have a negative effect, on the contrary, an optimal amount of stress can result in individuals being able to perform better in tasks. While there have been several studies on estimating stress level from smartphone usage logs and several effective features were revealed as a result, there are few studies on estimating cognitive performance. Thus, in this paper, we explore several factors affecting the estimation of cognitive performance from smartphone logs. To conduct the analysis, we collected smartphone usage logs and Go/No-Go task data for 6 weeks from 39 participants in the wild. We found that the time to find intended app is related to cognitive performance. This result suggests that measuring the time to find intended app can be the effective feature of estimating cognitive performance from smartphone logs.

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The Readiness Potential Reflects the Reliability of Action Consequence

前田 貴記

Scientific Reports （Scientific Reports）  8 （ 1 ） 11865 2018年08月

研究論文（学術雑誌）, 共著, 査読有り

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© 2018, The Author(s). Humans are capable of associating actions with their respective consequences if there is reliable contingency between them. The present study examined the link between the reliability of action consequence and the readiness potential (RP), which is a negative potential observed from about 1–2 s prior to the onset of an action with electroencephalography. In a condition of constant outcome, the participants’ voluntary action always triggered beep sounds; thus, they were able to perceive the contingency between their action and the sound. In contrast, in a condition of inconstant outcome, the participants’ actions only triggered the sound in half the trials. We found that both the early and late RPs were larger in the condition of constant compared to the condition of inconstant outcome. Our results showed that the RPs preceding the voluntary action reflected the reliability of action consequence. In other words, the action-effect contingency enhanced neural activities prior to the action.

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メンタルヘルスのセルフケアに向けたスマートフォンからのストレス状態推定の取り組み

深澤佑介, 山本直樹, 落合桂一, 稲垣章弥, 木本勝敏, 霧生和樹, 上西康平, 太田順, 沖村宰, 寺澤悠理,前田 貴記

行動変容と社会システム 4 2018年06月

共著

Recognizing whether a person is eating alone or has company by using wearable devices

Kiriu K., Ochiai K., Inagaki A., Yamamoto N., Fukazawa Y., Kimoto M., Okimura T., Terasawa Y., Maeda T., Ota J.

2017 10th International Conference on Mobile Computing and Ubiquitous Network, ICMU 2017 （2017 10th International Conference on Mobile Computing and Ubiquitous Network, ICMU 2017）  2018-January   1 - 2 2018年04月

ISSN  9784907626310

　概要を見る

© 2017 IPSJ. Mental health has received increasing attention in recent years, and a correlation between social interaction during eating and mental health noted. The purpose of this research is to determine if wearable devices can be used to recognize whether a person is eating alone or has company. Using a watch-type device and smartphone, the data, while eating in daily life, was collected. Using this data, we were able to recognize whether a person is eating alone or has company with an accuracy of 96.3%.

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主体性の精神病理学―“自我障害”から症状論・病態論・治療回復論について考える―

前田 貴記

精神科治療学 33 （ 1 ） 5 - 12 2018年

研究論文（学術雑誌）, 単著

統合失調症に特異的な神経認知障害はあるか？

大井　博貴、前田 貴記、是木　明宏、三村　將

精神神経学雑誌 （日本精神神経学会）  120 （ 10 ） 904 - 913 2018年

研究論文（学術雑誌）, 共著

運動主体感に着目したリハビリへのモデル・ベーストアプローチ

前田 貴記、矢野史朗、近藤敏之

日本ロボット学会誌 35 （ 7 ） 16 - 21 2017年

研究論文（その他学術会議資料等）, 共著

自己意識の神経心理学の試み

前田 貴記

高次脳機能研究 （一般社団法人日本高次脳機能障害学会）  36 （ 3 ） 86 - 91 2016年09月

研究論文（学術雑誌）, 単著

神経心理からみた陽性症状.　

前田 貴記、矢野史朗

臨床精神医学　 （アークメディア）  45 （ 8 ） 1009 - 1014 2016年08月

共著

Strength of Intentional Effort Enhances the Sense of Agency.

前田 貴記

Frontier in Psychology    1165 2016年07月

共著

Slow dynamics perspectives on the Embodied-Brain Systems Science

前田 貴記

Neuroscience Research  （ 104 ） 52 - 55 2016年

共著

Conrad, K.　の「統合失調症のはじまり」

野原 博、前田 貴記

精神科治療学 （（株）星和書店）  31 （ 6 ） 723 - 729 2016年

一級症状の特異性について“In aller Bescheidenheit”という表現を巡って．

野原博、＜U>前田 貴記(/)-#HR、鹿島晴雄

精神医学 58 （ 6 ） 528 - 531 2016年