論文 - 前田　貴記

Sense of Agency研究による精神病理学と生物学の連繋 ：統合失調症の病態理解と治療方法確立を目指して

前田貴記、大井博貴

日本生物学的精神医学会誌 36 （ 3 ） in press 2025年09月

妄想知覚において現れる“他者”とは誰れか？：「異質性（Fremdheit）」の浸潤

前田貴記

精神神経学雑誌 in press 2025年

査読有り

Hierarchical analysis of the sense of agency in schizophrenia: motor control, control detection, and self-attribution.

Oi H, Wen W, Chang AY, Uchida H, Maeda T

Schizophrenia 10 （ 1 ） 79 2024年09月

査読有り

　概要を見る

The sense of agency refers to the feeling of initiating and controlling one’s actions and their resulting effects on the external environment. Previous studies have uncovered behavioral evidence of excessive self-attribution and, conversely, a reduction in the sense of agency in patients with schizophrenia. We hypothesize that this apparent paradox is likely to result from impairment in lower-level processes underlying the sense of agency, combined with a higher-level compensational bias. The present study employed three behavioral tasks utilizing the same stimuli and experimental design to systematically evaluate multiple factors that influence the sense of agency, including motor control, sensorimotor processing, and self-attribution. Participants’ real-time mouse movements were combined with prerecorded motions of others in ratios of 30/70, 55/45, or 80/20, with an additional angular bias of either 0° or 90°. Twenty-six patients with schizophrenia and 27 health control volunteers participated in the three tasks. Patients with schizophrenia performed significantly worse in the reaching and control detection tasks than healthy controls. However, their self-attribution in the control judgment task was comparable to that of the healthy controls. Patients with schizophrenia were impaired in motor control components and in the detection of control using sensorimotor information, but their evaluation of agency remained relatively less affected. This underscores the importance of distinguishing between different subcomponents when addressing the abnormal sense of agency in patients with schizophrenia. Subsequent cluster analysis revealed that the combined task performance accurately distinguished between the patients and healthy control participants.

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Developmental changes in the time window for the explicit sense of agency experienced across the lifespan

Nobusako S., Takamura Y., Koge K., Osumi M., Maeda T., Morioka S.

Cognitive Development 72   101503 2024年

査読有り,  ISSN  08852014

　概要を見る

Sense of agency (SoA) is the subjective experience of individuals that they are initiators and controllers of their own actions, but it is not known how the time window for SoA changes developmentally over the lifetime. The present study examined developmental changes in the time window for SoA in school-age children (6–12 years), adolescents (16–18 years), young adults (20–25 years), adults (28–64 years), and older adults (65–83 years). The current results show that the time window for SoA is longer in young adults than in school-age children, adolescents, adults, and older adults, suggesting that young adulthood may be an important period of developmental change in the time window for SoA across the lifespan.

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Aberrant sense of agency induced by delayed prediction signals in schizophrenia: a computational modeling study

Okimura T., Maeda T., Mimura M., Yamashita Y.

Schizophrenia （Schizophrenia）  9 （ 1 ） 72 2023年12月

　概要を見る

Aberrant sense of agency (SoA, a feeling of control over one’s own actions and their subsequent events) has been considered key to understanding the pathology of schizophrenia. Behavioral studies have demonstrated that a bidirectional (i.e., excessive and diminished) SoA is observed in schizophrenia. Several neurophysiological and theoretical studies have suggested that aberrancy may be due to temporal delays (TDs) in sensory-motor prediction signals. Here, we examined this hypothesis via computational modeling using a recurrent neural network (RNN) expressing the sensory-motor prediction process. The proposed model successfully reproduced the behavioral features of SoA in healthy controls. In addition, simulation of delayed prediction signals reproduced the bidirectional schizophrenia-pattern SoA, whereas three control experiments (random noise addition, TDs in outputs, and TDs in inputs) demonstrated no schizophrenia-pattern SoA. These results support the TD hypothesis and provide a mechanistic understanding of the pathology underlying aberrant SoA in schizophrenia.

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統合失調症における自我障害の神経科学的な理解

大井博貴、前田貴記

臨床精神医学　 52 （ 5 ） 519 - 526 2023年05月

共著

“自我”体験の異常のとらえ方

精神科治療学 38 （ 4 ） 421 - 426 2023年04月

スマートフォンログに基づくwell-being 指標と下位尺度の推定

濱谷尚志, 山本直樹, 荒川大輝, 檜山聡, 姚文昊, 上西康平, 太田順, 寺澤悠理, 沖村宰, 前田貴記

情報処理学会論文誌 64 （ 1 ） 134 - 144 2023年

査読有り

Passive Way of Measuring QOL/Well-Being Levels Using Smartphone Log.

Wenhao Yao, Kohei Kaminishi , Naoki Yamamoto, Takashi Hamatani, Yuki Yamada, Takahiro Kawada, Satoshi Hiyama, Tsukasa Okimura, Yuri Terasawa, Takaki Maeda, Masaru Mimura and Jun Ota

Frontiers in digital health （Frontiers in Digital Health）  4   780566 2022年03月

査読有り

　概要を見る

Research on mental health states involves paying increasing attention to changes in daily life. Researchers have attempted to understand such daily changes by relying on self-reporting through frequent assessment using devices (smartphones); however, they are mostly focused on a single aspect of mental health. Assessing the mental health of a person from various perspectives may help in the primary prevention of mental illness and the comprehensive measurement of mental health. In this study, we used users' smartphone logs to build a model to estimate whether the scores on three types of questionnaires related to quality of life and well-being would increase compared to the previous week (fluctuation model) and whether they would be higher compared to the average for that user (interval model). Sixteen participants completed three questionnaires once per week, and their smartphone logs were recorded over the same period. Based on the results, estimation models were built, and the F-score ranged from 0.739 to 0.818. We also analyzed the features that the estimation model emphasized. Information related to “physical activity,” such as acceleration and tilt of the smartphone, and “environment,” such as atmospheric pressure and illumination, were given more weight in the estimation than information related to “cyber activity,” such as usage of smartphone applications. In particular, in the Positive and Negative Affect Schedule (PANAS), 9 out of 10 top features in the fluctuation model and 7 out of 10 top features in the interval model were related to activities in the physical world, suggesting that short-term mood may be particularly heavily influenced by subjective activities in the human physical world.

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時空間的なスマートフォンログ分析に基づく利用者のストレス推定手法

濱谷尚志, 落合桂一, 山本直樹, 深澤佑介, 木本勝敏, 上西康平, 太田順, 寺澤悠理, 沖村宰, 前田貴記

情報処理学会論文誌 62 （ 4 ） 1 - 15 2021年04月

査読有り

Influence of Stochastic Resonance on Manual Dexterity in Children With Developmental Coordination Disorder: A Double-Blind Interventional Study

Nobusako S., Osumi M., Matsuo A., Furukawa E., Maeda T., Shimada S., Nakai A., Morioka S.

Frontiers in Neurology （Frontiers in Neurology）  12   626608 2021年03月

査読有り,  ISSN  1664-2295

　概要を見る

Background: There is increasing evidence that the stochastic resonance (SR) phenomenon provided by subthreshold mechanical noise stimulation improves the sensory-motor system. However, the effect of SR on children with developmental coordination disorder (DCD) is unclear. The purpose of this study was to assess whether SR activated by subthreshold vibrotactile noise stimulation of the wrist influences manual dexterity in children with DCD. Methods: A double-blind interventional study was conducted. Participants were 30 children (age: 9.3 ± 1.44 years, range 6–11 years; 27 male, three female; 25 right-handed, five left-handed) meeting DCD diagnostic criteria in DSM-5. The manual dexterity test was administered the day before SR intervention (baseline-data). SR was elicited using subthreshold vibrotactile noise stimulation at 60% of the vibrotactile threshold measured at the wrist. SR was delivered two times and the manual dexterity test was administered during each SR stimulation block (SR-on condition) and after each SR stimulation block (SR-off), for a total of four measurements. Target outcomes were the component score, the standard score, and the percentile score of the manual dexterity test. Results: The manual dexterity test scores in the SR-on condition were significantly improved compared to scores at the baseline and in the SR-off condition (p < 0.001). Conclusions: The present study showed that subthreshold noise stimulation eliciting SR significantly improved manual dexterity outcomes in children with DCD during stimulation but not after stimulation. Future studies will need to investigate the carry-over effects of SR stimulation.

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Increased visual bias in children with developmental coordination disorder: Evidence from a visual-tactile temporal order judgment task.

Satoshi Nobusako, Michihiro Osumi, Emi Furukawa, Akio Nakai, Takaki Maeda, Shu Morioka

Human Movement Science （Human Movement Science）  75   102743 2020年12月

査読有り,  ISSN  0167-9457

　概要を見る

© 2020 Elsevier B.V. Background: Previous studies have suggested that children with developmental coordination disorder (DCD) rely heavily on vision to perform movements, which may contribute to their clumsy movements. However, few studies have objectively and quantitatively investigated the perceptual biases of children with DCD. Methods: A visual-tactile temporal order judgment (TOJ) task was used to measure and compare the perceptual biases of 19 children with DCD and 19 age- and sex-matched typically developing children. The point of subjective equality, which demonstrates when “visual first” and “tactile first” judgment probabilities are equal (50%), obtained by analyzing the results of the visual-tactile TOJ task, was used as an indicator of perceptual biases. Further, variables (age and manual dexterity in all participants; motor function, autism spectrum disorder and attention-deficit hyperactivity disorder traits, and depressive symptoms in children with DCD) associated with perceptual biases were examined with correlation analysis. Results: Children with DCD had significantly stronger visual bias than typically developing children. Overall correlation analysis showed that increased visual bias was significantly correlated with poor manual dexterity. Conclusion: Children with DCD had a strong visual bias, which was associated with poor manual dexterity.

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Altered sense of agency in children with developmental coordination disorder

Nobusako S., Osumi M., Hayashida K., Furukawa E., Nakai A., Maeda T., Morioka S.

Research in Developmental Disabilities （Research in Developmental Disabilities）  107   103794 2020年10月

査読有り,  ISSN  08914222

　概要を見る

© 2020 Elsevier Ltd Background: There is increasing evidence that children with developmental coordination disorder (DCD) have deficits in sensory-motor integration, but it is unclear whether the sense of agency (SoA) generated by sensory-motor integration is altered. Aims: To investigate whether there is a difference in the time window for SoA between children with DCD and typically developing (TD) children. Methods and Procedures: An agency attribution task was used to quantitatively measure and compare the time window for SoA in 15 children with DCD and 46 children in the TD group. Variables that correlated with the time window for SoA were also examined in both groups of children. Outcomes and Results: The time window for SoA was significantly extended in children with DCD compared to TD children. The time window for SoA in TD children was significantly associated with manual dexterity, whereas the time window for SoA in children with DCD was significantly associated with depressive tendency. Conclusions and Implications: The time window for SoA is altered in children with DCD. The present results suggest that there may be a bidirectional relationship between an internal model deficit and depressive tendency and SoA in children with DCD.

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Statistical Learning Model of the Sense of Agency

Yano S., Hayashi Y., Murata Y., Imamizu H., Maeda T., Kondo T.

Frontiers in Psychology （Frontiers in Psychology）  11   539957 2020年10月

査読有り

　概要を見る

© Copyright © 2020 Yano, Hayashi, Murata, Imamizu, Maeda and Kondo. A sense of agency (SoA) is the experience of subjective awareness regarding the control of one's actions. Humans have a natural tendency to generate prediction models of the environment and adapt their models according to changes in the environment. The SoA is associated with the degree of the adaptation of the prediction models, e.g., insufficient adaptation causes low predictability and lowers the SoA over the environment. Thus, identifying the mechanisms behind the adaptation process of a prediction model related to the SoA is essential for understanding the generative process of the SoA. In the first half of the current study, we constructed a mathematical model in which the SoA represents a likelihood value for a given observation (sensory feedback) in a prediction model of the environment and in which the prediction model is updated according to the likelihood value. From our mathematical model, we theoretically derived a testable hypothesis that the prediction model is updated according to a Bayesian rule or a stochastic gradient. In the second half of our study, we focused on the experimental examination of this hypothesis. In our experiment, human subjects were repeatedly asked to observe a moving square on a computer screen and press a button after a beep sound. The button press resulted in an abrupt jump of the moving square on the screen. Experiencing the various stochastic time intervals between the action execution (button-press) and the consequent event (square jumping) caused gradual changes in the subjects' degree of their SoA. By comparing the above theoretical hypothesis with the experimental results, we concluded that the update (adaptation) rule of the prediction model based on the SoA is better described by a Bayesian update than by a stochastic gradient descent.

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The time window for sense of agency in school-age children is different from that in young adults

Nobusako S., Tsujimoto T., Sakai A., Shuto T., Hashimoto Y., Furukawa E., Osumi M., Nakai A., Maeda T., Morioka S.

Cognitive Development （Cognitive Development）  54 （ 100891 ）  2020年05月

共著, 査読有り,  ISSN  08852014

　概要を見る

© 2020 Elsevier Inc. Is there a difference in sense of agency between children and adults? This study investigated the difference in the time window of sense of agency between school-age children (N = 94, aged 6–12 years) and young adults (N = 30, aged 21–23 years) by using an agency attribution task and international standardized manual dexterity test. The results showed that the time window for sense of agency was significantly shorter in children compared to young adults. In addition, there was a significant correlation between the time window for sense of agency and manual dexterity only in children. The present results suggested that sensory-motor function greatly contributes to sense of agency in school-age children.

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せん妄ともうろう状態の概念

新井脩泰、前田貴記

臨床精神医学 49 （ 3 ） 341 - 346 2020年03月

Manual Dexterity is not Related to Media Viewing but is Related to Perceptual Bias in School-Age Children.

Nobusako S, Tsujimoto T, Sakai A, Shuto T, Furukawa E, Osumi M, Nakai A, Maeda T, Morioka S

Brain sciences （Brain Sciences）  10 （ 2 ） 100 2020年02月

査読有り

　概要を見る

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Although the media can have both negative and positive effects on children’s cognitive and motor functions, its influence on their perceptual bias and manual dexterity is unclear. Thus, we investigated the association between media viewing time, media preference level, perceptual bias, and manual dexterity in 100 school-aged children. Questionnaires completed by children and their parents were used to ascertain media viewing time and preference levels. Perceptual bias and manual dexterity were measured using the visual-tactile temporal order judgment task and Movement Assessment Battery for Children—2nd edition, respectively. There were significant positive correlations between age and media viewing time and between media viewing time and media preference level. There was also a significant negative correlation between visual bias and manual dexterity. Hierarchical multiple regression analysis revealed that increasing visual bias was a significant predictor of decreasing manual dexterity. Further, children with low manual dexterity showed significant visual bias compared to those with high manual dexterity, when matched for age and gender. The present results demonstrated that, in school-aged children, although viewing media was not associated with perceptual bias and manual dexterity, there was a significant association between perceptual bias and manual dexterity.

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Sense of Agency：自己意識の神経心理学

前田貴記

神経心理学 35   178 - 186 2019年12月

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Automated inference of cognitive performance by fusing multimodal information acquired by smartphone

Hamatani T., Ochiai K., Inagaki A., Yamamoto N., Fukazawa Y., Kimoto M., Kiriu K., Kaminishi K., Ota J., Terasawa Y., Okimura T., Maeda T.

UbiComp/ISWC 2019- - Adjunct Proceedings of the 2019 ACM International Joint Conference on Pervasive and Ubiquitous Computing and Proceedings of the 2019 ACM International Symposium on Wearable Computers （UbiComp/ISWC 2019- - Adjunct Proceedings of the 2019 ACM International Joint Conference on Pervasive and Ubiquitous Computing and Proceedings of the 2019 ACM International Symposium on Wearable Computers）     921 - 928 2019年09月

ISSN  9781450368698

　概要を見る

© 2019 Association for Computing Machinery. Recognizing human cognitive performance is important for preserving working efficiency and preventing human error. This paper presents a method for estimating cognitive performance by leveraging multiple information available in a smartphone. The method employs the Go-NoGo task to measure cognitive performance, and fuses contextual and behavioral features to identify the level of performance. It was confirmed that the proposed method could recognize whether cognitive performance was high or low with an average accuracy of 71%, even when only referring to inertial sensor logs. Combining sensing modalities improved the accuracy up to 74%.

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The relationship and difference between delay detection ability and judgment of sense of agency

Osumi M., Nobusako S., Zama T., Yokotani N., Shimada S., Maeda T., Morioka S.

PLoS ONE （PLoS ONE）  14 （ 7 ） e0219222 2019年07月

研究論文（学術雑誌）, 共著, 査読有り

　概要を見る

© 2019 Osumi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Judgment of agency involves the comparison of motor intention and proprioceptive/visual feedback, in addition to a range of cognitive factors. However, few studies have experimentally examined the differences or correlations between delay detection ability and judgment of agency. Thus, the present study investigated the relationship between delay detection ability and agency judgment using the delay detection task and the agency attribution task. Fifty-eight participants performed the delay detection and agency attribution tasks, and the time windows of each measure were analyzed using logistic curve fitting. The results revealed that the time window of judgment of agency was significantly longer than that of delay detection, and there was a slight correlation between the time windows in each task. The results supported a two-step model of agency, suggesting that judgment of agency involved not only comparison of multisensory information but also several cognitive factors. The study firstly revealed the model in psychophysical experiments.

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