論文 - 青木　大輔

妊娠初期における脳瘤の検出を契機にMeckel-Gruber症候群と胎内診断した1例

樋口敦彦，中村加奈子，宮越 敬，春日義雄，松本 直，福武麻里絵，落合大吾，田中 守，青木大輔

東京産科婦人科学会会誌 64 （ 4 ） 591 - 595 2015年10月

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Differential mRNA expression profiling in ovarian endometriotic tissue with versus without leuprolide acetate treatment

Kiba, A., Banno, K., Yanokura, M., Asada, M., Nakayama, Y., Aoki, D. and Watanabe, T.

J Obstet Gynaecol Res 41 （ 10 ） 1598 - 606 2015年10月

ISSN  1447-0756

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脂質異常症治療薬スタチンが抗悪性腫瘍薬となる未来

小林佑介，青木大輔

産科と婦人科 82 （ 10 ） 1125 - 1129 2015年10月

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How do Japanese gynecologists view hormone replacement therapy for survivors of endometrial cancer? Japanese Gynecologic Oncology Group (JGOG) survey

Yokoyama, Y., Ito, K., Takamatsu, K., Takehara, K., Nakanishi, T., Harano, K., Watari, H., Susumu, N., Aoki, D. and Saito, T.

Int J Clin Oncol 20 （ 5 ） 997 - 1004 2015年10月

ISSN  1341-9625

　概要を見る

BACKGROUND: This survey sought to determine Japanese gynecologists' attitudes concerning administering hormone replacement therapy (HRT) for patients after surgery for endometrial cancer (EC). METHODS: Eight hundred and eighty-eight members of the Japanese Gynecologic Oncology Group (JGOG) were asked to respond to an anonymous questionnaire on the JGOG website. The survey asked whether or not HRT was to be administered when surgery was performed (including a hysterectomy and bilateral oophorectomy) to treat EC before or after menopause. If HRT was not to be administered, respondents were asked the reason why. Respondents were presented with the same hypothetical patients that were featured in a previous survey in Germany, and differences in the mindsets of Japanese and German physicians were compared. RESULTS: Responses from 363 individuals (response rate 40.9 %) were analyzed. Seventy-eight percent of physicians considered HRT for patients undergoing surgery before menopause. The most prevalent reason of refusal to prescribe HRT was the risk of EC recurrence. Forty-eight percent of physicians considered HRT for patients undergoing surgery after menopause. The most prevalent reasons of refusal of HRT were its limited benefit and the availability of alternative therapies. Sixty-five percent of Japanese physicians responded that they would administer HRT to patients with low risk of recurrence vs. 46 % of physicians in Germany (P < 0.0002). Forty-nine percent of Japanese physicians approved of prescribing HRT for patients with high risk of recurrence vs. 25 % of physicians in Germany (P < 0.0001). CONCLUSION: Many Japanese gynecologists have a favorable attitude toward prescribing HRT after treatment of EC.

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術後感染症リンパ嚢胞の治療方法に関する検討

田中恒成，冨永英一郎，野上侑哉，仲村 勝，西尾 浩，山上 亘，野村弘行，片岡史夫，田中京子，阪埜浩司，田中 守，青木大輔

東京産科婦人科学会会誌 64 （ 4 ） 571 - 575 2015年10月

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子宮体がんの予防とヘルスケア

進 伸幸，平沢 晃，山上 亘，青木大輔

産婦人科の実際　女性ヘルスケア　集中講義！ 61 （ 10月臨時増刊号 ） 399 - 408 2015年10月

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Polymorphisms of estrogen metabolism-related genes ESR1, UGT2B17, and UGT1A1 are not associated with osteoporosis in surgically menopausal Japanese women

Yokota, M., Hirasawa, A., Makita, K., Akahane, T., Sakai, K., Makabe, T., Horiba, Y., Yamagami, W., Ogawa, M., Iwata, T., Yanamoto, S., Deshimaru, R., Banno, K., Susumu, N. and Aoki, D.

Prz Menopauzalny 14 （ 3 ） 161 - 7 2015年09月

ISSN  1643-8876

　概要を見る

INTRODUCTION: Bilateral salpingo-oophorectomy (BSO) is a risk factor for osteoporosis. Previous studies have reported an association between genetic polymorphisms and the risk of developing osteoporosis. However, the relationship between osteoporosis and genetic polymorphisms in Japanese women treated with BSO is not well understood. To improve the quality of life for post-BSO patients, it is important to determine the genetic factors that influence their risk for osteoporosis. The aim of this study was to investigate the association between gene variations of estrogen metabolism-related genes and osteoporosis in surgically menopausal patients, which may improve their quality of life. MATERIAL AND METHODS: This study included 203 menopausal women treated with BSO because of gynecologic disorders. One hundred and twenty-six women with artificial (surgical) menopause, who had undergone BSO in the premenopausal period, were compared with 77 women with natural menopause, who had undergone BSO in the postmenopausal period. The women were tested for bone mineral density to diagnose osteoporosis. Polymorphisms of estrogen receptor 1 (ESR1) and UDP-glucuronosyl transferase (UGT) genes UGT2B17 and UGT1A1 were analyzed, and their association with bone mass and osteoporosis was statistically evaluated. RESULTS: No significant association was found between osteoporosis and polymorphisms in ESR1, UGT2B17, or UGT1A1 in both groups, suggesting that BSO might be a more significant physiological factor in influencing bone mass density compared to genetic variations. CONCLUSIONS: These results suggest that the ESR1, UGT2B17, and UGT1A1 polymorphisms are not genetic factors affecting osteoporosis in postmenopausal Japanese women.

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High Expression of p62 Protein Is Associated with Poor Prognosis and Aggressive Phenotypes in Endometrial Cancer

Iwadate, R., Inoue, J., Tsuda, H., Takano, M., Furuya, K., Hirasawa, A., Aoki, D. and Inazawa, J.

Am J Pathol 185 （ 9 ） 2523 - 33 2015年09月

ISSN  1525-2191

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A surgical technique using the ovarian vein in non-human primate models of potential living-donor surgery of uterus transplantation

Kisu, I., Banno, K., Mihara, M., Hara, H., Umene, K., Adachi, M., Nogami, Y. and Aoki, D.

Acta Obstet Gynecol Scand 94 （ 9 ） 942 - 8 2015年09月

ISSN  1600-0412

Prevalence and differentiation of hereditary breast and ovarian cancers in Japan

Nakamura, S., Takahashi, M., Tozaki, M., Nakayama, T., Nomizu, T., Miki, Y., Murakami, Y., Aoki, D., Iwase, T., Nishimura, S., Yamauchi, H., Ohsumi, S., Baba, S. and Shimizu, T.

Breast Cancer 22 （ 5 ） 462 - 8 2015年09月

共著,  ISSN  1880-4233

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Intratumoral CD8+ Lymphocyte Infiltration as a Prognostic Factor and Its Relationship With Cyclooxygenase 2 Expression and Microsatellite Instability in Endometrial Cancer

Suemori, T., Susumu, N., Iwata, T., Banno, K., Yamagami, W., Hirasawa, A., Sugano, K., Matsumoto, E. and Aoki, D.

Int J Gynecol Cancer 25 （ 7 ） 1165 - 72 2015年09月

ISSN  1525-1438

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ⅠB1期への広汎性子宮頸部摘出術

田中京子，青木大輔

臨床婦人科産科 69 （ 9 ） 826 - 830 2015年09月

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遺伝性乳癌・卵巣癌

平沢 晃，増田健太，青木大輔

臨床画像 31 （ 10 増刊号 ） 220 - 221 2015年09月

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東京都の子宮頸がん検診の精度管理について

青木 大輔

東京都医師会雑誌 68 （ 8 ） 15 - 18 2015年09月

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家族性腫瘍としての子宮内膜癌

阪埜浩司，入江晴子，青木大輔

日本臨床　家族性腫瘍学－家族性腫瘍の最新研究動向－ 73 （ 増刊号6 ） 467 - 470 2015年08月

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子宮頸癌に対する同時化学放射線療法後に生じた晩期有害事象の検討

早乙女啓子，西尾 浩，宮内安澄，村山真治，菅 裕佳子，仲村 勝，森定 徹，岩田 卓，田中京子，冨永英一郎，田中 守，青木大輔

東京産科婦人科学会会誌 64 （ 3 ） 349 - 353 2015年07月

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Absence of lactobacilli containing glycolipids with the alpha-galactose epitope and the enhanced fucosylation of a receptor glycolipid GA1 in the digestive tracts of immune-deficient scid mice

Iwamori, M., Tanaka, K., Adachi, S., Aoki, D. and Nomura, T.

J Biochem 158 （ 1 ） 73 - 82 2015年07月

ISSN  1756-2651

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BRCA1/2遺伝子変死保持者に対するリスク低減卵管卵巣摘出術とサーベイランス

平沢 晃，増田健太，青木大輔

産科と婦人科 82 （ 6 ） 639 - 642 2015年06月

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Effects of chemotherapy on patients with recurrent cervical cancer previously treated with concurrent chemoradiotherapy: a retrospective multicenter survey in Japan

青木 大輔

Int J Clin Oncol 20 （ 3 ） 561 - 565 2015年06月

研究論文（学術雑誌）, 共著

CT画像より得られた膀胱側腔、直腸側腔の画像情報をもとに考察した広汎子宮全摘出術

仲村 勝，西尾 浩，森定 徹，岩田 卓，田中京子，今西宣晶，陣崎雅弘，相磯貞和，藤井多久磨，青木大輔

産婦人科手術 26   71 - 78 2015年06月

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