論文 - 青木　大輔

Final report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology, on a fact-finding questionnaire on the status of treatment of hereditary breast and ovarian cancer syndrome in Japan

青木 大輔

J Obstet Gynaecol Res 43 （ 9 ） 1377 - 1380 2017年09月

研究論文（学術雑誌）, 共著

New use of microsatellite instability analysis in endometrial cancer

Kunitomi, H., Banno, K., Yanokura, M., Takeda, T., Iijima, M., Nakamura, K., Iida, M., Adachi, M., Watanabe, K., Matoba, Y., Kobayashi, Y., Tominaga, E. and Aoki, D.

Oncol Lett 14 （ 3 ） 3297 - 3301 2017年09月

研究論文（学術雑誌）, 共著,  ISSN  1792-1074

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A Comparison of Dye Versus Fluorescence Methods for Sentinel Lymph Node Mapping in Endometrial Cancer

Yamagami, W., Susumu, N., Kataoka, F., Makabe, T., Sakai, K., Ninomiya, T., Wada, M., Nomura, H., Hirasawa, A., Banno, K., Nakahara, T., Kameyama, K. and Aoki, D.

Int J Gynecol Cancer 27 （ 7 ） 1517 - 1524 2017年09月

研究論文（学術雑誌）, 共著,  ISSN  1048-891X

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治療薬解説　PARP阻害薬

平沢 晃，青木大輔

カレントテラピー 35 （ 9 ） 74 - 77 2017年09月

Drug repositioning of mevalonate pathway inhibitors as antitumor agents for ovarian cancer

青木 大輔

Oncotarget 8 （ 42 ） 72147 - 72156 2017年09月

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Whole-genome sequencing revealed novel prognostic biomarkers and promising targets for therapy of ovarian clear cell carcinoma

Itamochi, H., Oishi, T., Oumi, N., Takeuchi, S., Yoshihara, K., Mikami, M., Yaegashi, N., Terao, Y., Takehara, K., Ushijima, K., Watari, H., Aoki, D., Kimura, T., Nakamura, T., Yokoyama, Y., Kigawa, J. and Sugiyama, T.

Br J Cancer 117 （ 5 ） 717 - 724 2017年08月

研究論文（学術雑誌）, 共著,  ISSN  0007-0920

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Recent advances in the molecular mechanisms of Mayer-Rokitansky-Kuster-Hauser syndrome

Watanabe, K., Kobayashi, Y., Banno, K., Matoba, Y., Kunitomi, H., Nakamura, K., Adachi, M., Umene, K., Kisu, I., Tominaga, E. and Aoki, D.

Biomed Rep 7 （ 2 ） 123 - 127 2017年08月

研究論文（学術雑誌）, 共著,  ISSN  2049-9434

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遺伝性卵巣がん

千代田達幸，平沢 晃，青木大輔

成人病と生活習慣病 47 （ 7 ） 861 - 866 2017年07月

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手術前禁忌薬（経口避妊薬、低用量エストロゲン－プロゲスチン配合薬）に関する医療安全対策

高柳裕子，冨永英一郎，小林佑介，仲村 勝，片岡史夫，平沢 晃，阪埜浩司，田中 守，青木大輔

東京産科婦人科学会会誌 66 （ 3 ） 424 - 428 2017年07月

研究論文（学術雑誌）, 共著

Comparison Between Laparoscopy and Laparotomy in Systematic Para-Aortic Lymphadenectomy for Patients with Endometrial Cancer: A Retrospective Multicenter Study

Tanaka, T., Terai, Y., Hayashi, S., Aoki, D., Miki, M., Kobayashi, E., Kimura, T., Baba, T., Matsumura, N. and Ohmichi, M.

J Gynecol Surg 33 （ 3 ） 105 - 110 2017年06月

研究論文（学術雑誌）, 共著,  ISSN  1042-4067

　概要を見る

Objective: Laparoscopic surgery has been developed worldwide due to its minimal invasion as well as noninferiority, compared with laparotomy. However, whether or not laparoscopic systematic para-aortic lymphadenectomy for endometrial cancer is feasible and has advantages of various clinical factors, such as a short hospital stay, less blood loss, and faster recovery, compared with open surgery has not yet been clarified. The aim of this study was to compare a laparoscopic procedure with laparotomy for para-aortic lymphadenectomy for patients with endometrial cancer. Study Design: This was a retrospective multicenter study of laparoscopic systematic para-aortic lymphadenectomy for endometrial cancer in five institutions. Materials and Methods: The current authors conducted a retrospective multicenter study of laparoscopic systematic para-aortic lymphadenectomy for endometrial cancer. The study involved patients from five institutions in Japan between January 2008 and March 2016. Clinical data were compared with those of a laparotomic procedure performed around the same period. Results: A total of 54 patients in the laparoscopic group and 99 patients in the laparotomic group were analyzed. In the laparoscopic group, 21 patients had stage IA disease, 19 had stage IB disease, 5 had stage II disease, and 9 had stage III disease. In the laparotomic group, 35 patients had stage IA disease, 19 had stage IB disease, 9 had stage II disease, and 36 had stage III disease. There were no significant differences in characteristics between the groups, including age, body mass index, and histologic type. The mean operative time in the laparoscopic group was 483 +/- 102 minutes, while that in the laparotomic group was 481 +/- 106 minutes (p = 0.9). The laparoscopic group had less intraoperative blood loss (143 +/- 253 versus 988 +/- 694 mL; p < 0.01) and shorter hospital stays (8.4 +/- 5.7 versus 16.1 +/- 8.0 days; p < 0.01). The rates of intraoperative complications were not significantly different between the groups. No cases of ileus occurred in the laparoscopic group. Procedures for 2 of the 54 patients in the laparoscopic group were converted to laparotomy. The number of dissected pelvic lymph nodes (31.8 +/- 10.1 versus 39.9 +/- 15.9, p < 0.01) and para-aortic lymph nodes (26.2 +/- 10.9 versus 31.1 +/- 13.2; p = 0.02) were lower in the laparoscopic group than in the laparotomic group. The postoperative minimum level of hemoglobin was higher in the laparoscopic group than in the laparotomic group (10.4 +/- 1.1 g/dL versus 9.9 +/- 1.4 g/dL; p = 0.02). In contrast, the postoperative maximum level of C-reactive protein was lower in the laparoscopic group than in the laparotomic group (6.3 +/- 3.8 mg/dL versus 10.2 +/- 4.9 mg/dL; p < 0.01). The recurrence rate was not significantly different between the groups in the above time period (7.4% versus 14.3%; p = 0.2). Conclusions: Laparoscopic systematic para-aortic lymphadenectomy is feasible and can be substituted for laparotomic procedures for patients with early stage endometrial cancer. ( J GYNECOL SURG 33:105).

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遺伝性乳癌卵巣癌症候群と女性ヘルスケア

平沢 晃，青木大輔

更年期と加齢のヘルスケア 16 （ 1 ） 42 - 45 2017年06月

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Genome-wide DNA methylation sequencing reveals miR-663a is a novel epimutation candidate in CIMP-high endometrial cancer

Yanokura, M., Banno, K., Adachi, M., Aoki, D. and Abe, K.

Int J Oncol 50 （ 6 ） 1934 - 1946 2017年06月

研究論文（学術雑誌）, 共著,  ISSN  1019-6439

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医療機器に生じたトラブル

冨永英一郎，小林佑介，平沢 晃，阪埜浩司，末岡 浩，青木大輔

産婦人科の実際 66 （ 6 ） 767 - 771 2017年06月

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Clinical utility of a self-administered questionnaire for assessment of hereditary gynecologic cancer

Masuda, K., Hirasawa, A., Irie-Kunitomi, H., Akahane, T., Ueki, A., Kobayashi, Y., Yamagami, W., Nomura, H., Kataoka, F., Tominaga, E., Banno, K., Susumu, N. and Aoki, D.

Jpn J Clin Oncol 47 （ 5 ） 473 2017年05月

研究論文（学術雑誌）, 共著,  ISSN  0368-2811

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Clinical utility of a self-administered questionnaire for assessment of hereditary gynecologic cancer

Masuda, K., Hirasawa, A., Irie-Kunitomi, H., Akahane, T., Ueki, A., Kobayashi, Y., Yamagami, W., Nomura, H., Kataoka, F., Tominaga, E., Banno, K., Susumu, N. and Aoki, D.

Jpn J Clin Oncol 47 （ 5 ） 401 - 406 2017年05月

研究論文（学術雑誌）, 共著,  ISSN  0368-2811

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一般病院における家族性腫瘍相談外来とハイリスク外来の開設 －一般病院に求められる家族性腫瘍診療の意義についての考察－

植木有紗，中田さくら，安齋純子，麻薙美香，嶋田恭輔，久保内光一，三須久美子，平沢 晃，阪埜浩司，菅野康吉，小崎健次郎，青木大輔

家族性腫瘍 16 （ 2 ） 38 - 43 2017年05月

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FDG-PET/CTによる転移診断の注意点は？

進 伸幸，片岡史夫，山上 亘，中原理紀，青木大輔

臨床婦人科産科 2017増刊号（産婦人科画像診断トレーニング） 71 （ 4 ） 293 - 297 2017年04月

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Enhanced fucosylation of GA1 in the digestive tracts of X-ray-irradiated mice

Iwamori, M., Tanaka, K., Adachi, S., Aoki, D. and Nomura, T.

Glycoconj J 34 （ 2 ） 163 - 169 2017年04月

研究論文（学術雑誌）, 共著,  ISSN  0282-0080

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Elevated preoperative neutrophil : lymphocyte ratio as a preoperative indicator of mature cystic teratoma with malignant transformation

Nanki, Y., Chiyoda, T., Kataoka, F., Nomura, H., Nakadaira, N., Iwasa, N., Hashimoto, S., Arima, H., Susumu, N. and Aoki, D.

J Obstet Gynaecol Res 43 （ 4 ） 744 - 748 2017年04月

研究論文（学術雑誌）, 共著,  ISSN  1341-8076

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胸水貯留をきたしたホルモン補充周期融解胚移植後の全胞状奇胎の1例

玉川真澄，内田明花，佐藤 佑，片倉慧美，吉政佑之，日原華子，冨里祥子，中林 章，升田博隆，内田 浩，丸山哲夫，田中 守，青木大輔

東京産科婦人科学会会誌 66 （ 2 ） 316 - 321 2017年04月

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