Horiguchi, Takashi

写真a

Affiliation

Faculty of Nursing and Medical Care (Shonan Fujisawa)

Position

Professor

External Links

Career 【 Display / hide

  • 1990
    -
    1991.04

    慶應義塾大学医学部, 外科学教室, 研修医

  • 1991.05
    -
    1992.04

    川崎市立川崎病院, 脳神経外科, 医員

  • 1992.05
    -
    1993.04

    足利赤十字病院, 脳神経外科, 医員

  • 1993.05
    -
    1995.04

    慶應義塾大学医学部, 外科学教室脳神経外科, 専修医

  • 1995.05
    -
    1996.04

    慶應義塾大学医学部, 外科学教室脳神経外科, 助手

display all >>

Academic Background 【 Display / hide

  • 1981
    -
    1984.03

    慶應義塾高等学校

    Other

  • 1984.04
    -
    1990.03

    Keio University, 医学部

    University

Academic Degrees 【 Display / hide

  • 医学博士, Keio University, 2006.07

Licenses and Qualifications 【 Display / hide

  • 医師免許, 1990

  • 日本脳神経外科専門医, 1997

  • 厚労省認定臨床研修指導医, 2006

  • 日本脳卒中学会専門医, 2007

  • 日本神経内視鏡学会技術認定医, 2009

display all >>

 

Research Areas 【 Display / hide

  • Neurosurgery

Research Keywords 【 Display / hide

  • brain microsurgical anatomy

  • neurotrauma

  • cerebral blood flow and metabolism

  • brain tumor surgery

  • cerebrovascular disease

display all >>

Research Themes 【 Display / hide

  • micro anatomy of brain and neurosurgical approach, 

    2006.05
    -
    Present

  • long term follow up of skullbase tumor, 

    2006.05
    -
    Present

  • brain protection of cortical spreading depression, 

    2001.05
    -
    Present

  • mechanisms of induced ischemic tolerance in brain, 

    1995.05
    -
    Present

  • temporal profile of protein phosphatase in ischemic brain, 

    1995.05
    -
    Present

display all >>

 

Books 【 Display / hide

  • 必携脳卒中ハンドブック第3版

    HORIGUCHI TAKASHI, 診断と治療社, 2017.09

    Scope: 慢性硬膜下血腫

  • 神経内科 Clinical Questions & Pearls 脳血管障害

    HORIGUCHI TAKASHI, 中外医学社, 2016.10

    Scope: case approach くも膜下出血

  • 神経内科 Clinical Questions & Pearls 脳血管障害

    HORIGUCHI TAKASHI, 中外医学社, 2016.10

    Scope: 急性期の脳浮腫、脳圧上昇はどのように対処すればよいのでしょうか?

  • 神経内科 Clinical Questions & Pearls 頭痛

    HORIGUCHI TAKASHI, 中外医学社, 2016.05

    Scope: くも膜下出血による頭痛はどのように診断し、治療するのでしょうか?

  • 脳卒中ビジュアルテキスト第4版

    HORIGUCHI Takashi, 医学書院, 2015

    Scope: 脳出血の外科的治療

display all >>

Papers 【 Display / hide

  • Role of Surgery in the Management of Intracranial Dural Arteriovenous Fistula

    AKIYAMA Takenori, HORIGUCHI Takashi, TAKAHASHI Satoshi, OHIRA Takayuki, AKIYAMA Takekazu, YOSHIDA Kazunari

    Surgery for Cerebral Stroke (The Japanese Society on Surgery for Cerebral Stroke)  48 ( 6 ) 420 - 426 2020.11

    ISSN  0914-5508

     View Summary

    <p></p>Summary: Following technological advances in endovascular therapy, this approach is preferred over surgery as the mainstay of treatment for dural arteriovenous fistula (dAVF). However, surgery remains important, and its role should be re-evaluated. In this retrospective study, we investigated the outcomes of surgical treatment for dAVF, focusing on the pitfalls of this approach in 101 patients who underwent surgery for dAVF. We analyzed the characteristics of lesions treated surgically, as well as treatment outcomes including the morbidity, AV shunt occlusion, and recurrence rates. The results included 20 patients who underwent only surgical treatment. The surgical morbidity rate was 5%. All AV shunts were extirpated at radical procedures; however, recurrence occurred in one patient. In conclusion, surgery serves as definitive treatment for specific types of dAVF. Careful decision-making regarding an endovascular vs. an open surgical approach is important, together with preparedness to manage the associated challenges, as observed in this case series. <p></p>

  • Short-Term Spontaneous Resolution of Ruptured Peripheral Aneurysm in Moyamoya Disease

    Yamada H., Saga I., Kojima A., Horiguchi T.

    World Neurosurgery (World Neurosurgery)  126   247 - 251 2019.06

    ISSN  18788750

     View Summary

    © 2019 Elsevier Inc. Background: Peripheral aneurysms are known to be a source of intracranial hemorrhage in patients with moyamoya disease. However, the natural history of ruptured peripheral aneurysms remains unclear. Some regress spontaneously, whereas others may rebleed. Direct treatments, such as surgical or intravascular treatment of the peripheral aneurysm, can have a risk of severe neurologic complications owing to the depth of the operative field and the fragility of the parent artery. A careful treatment policy is required. Case Description: In a 29-year-old man with moyamoya disease with intraventricular hemorrhage, rupture of a right anterior choroidal artery aneurysm was diagnosed by cerebral angiography. The aneurysm was approximately 4 mm in size and existed in the plexal segment of the right anterior choroidal artery. Endovascular embolization of the aneurysm was planned. However, repeat angiography 3 weeks after aneurysm diagnosis demonstrated complete resolution of the aneurysm. Such short-term disappearance of an aneurysm is remarkably rare. We believe that the aneurysm was thrombosed for a brief period considering the slow blood flow detected inside the aneurysm during the initial angiography. The patient was discharged with no neurologic deficit and has remained recurrence-free for >1 year. Conclusions: Given that spontaneous resolution of an aneurysm may occur in a short period of time, we suggest that conservative treatment be considered as an option for ruptured peripheral aneurysms associated with moyamoya disease when direct treatment is risky.

  • Pros and cons of using ORBEYE™ for microneurosurgery

    Takahashi S., Toda M., Nishimoto M., Ishihara E., Miwa T., Akiyama T., Horiguchi T., Sasaki H., Yoshida K.

    Clinical Neurology and Neurosurgery (Clinical Neurology and Neurosurgery)  174   57 - 62 2018.11

    ISSN  03038467

     View Summary

    © 2018 Elsevier B.V. Objective: To evaluate the pros and cons of using a newly developed microscope, ORBEYE™, during microneurosurgery. Patients and methods: ORBEYE™ use in 14 microneurosurgical procedures was retrospectively assessed by nine neurosurgeons after the procedure. A questionnaire comprising 20 questions was designed and used for evaluation. Results: Compared with the current gold standard, the binocular microscope, ease of setting up the equipment was scored the highest, whereas ease of conducting surgery in a position of an assistant was scored the lowest. Among characteristics of ORBEYE™ itself, the space-saving feature was scored the highest and was followed by the ability to perform procedures in a comfortable position. The only characteristic that was rated below average was ease of operation in a position of an assistant. Neurosurgeons with greater experience (more than five procedures using ORBEYE™) provided significantly higher scores (p = 0.0196) for characteristics of ORBEYE™ itself compared with neurosurgeon with fewer ORBEYE™ experience. Conclusions: The main benefits of the ORBEYETM are its compact size and freedom from focusing through the eye lens of a conventional binocular microscope. However, it appears to be disadvantageous for operating in a position of an assistant because the surgical field has a rotated view on the monitor from a position of an assistant. Nonetheless, because of certain advantages, we believe the ORBEYE™ could be of additional help to use of conventional binocular microscope at the moment and will facilitate microneurosurgery in the future.

  • An analysis of the anatomic route of the hypoglossal nerve within the hypoglossal canal using dynamic computed tomography angiography in patients with anterior condylar arteriovenous fistulas

    Oishi Y., Akiyama T., Mizutani K., Horiguchi T., Imanishi N., Yoshida K.

    Clinical Neurology and Neurosurgery (Clinical Neurology and Neurosurgery)  174   207 - 213 2018.11

    ISSN  03038467

     View Summary

    © 2018 Elsevier B.V. Objective: The venous outlet of anterior condylar arteriovenous fistulas (AC-AVFs) often empties into the anterior condylar vein (ACV). Hypoglossal nerve palsy is one of the major complications after transvenous embolization (TVE) for the AC-AVF within the hypoglossal canal. However, no studies have investigated the route of the hypoglossal nerve within the hypoglossal canal in AC-AVF. The aim of the current study is to retrospectively verify the anatomical route of the hypoglossal nerve within its canal using dynamic computed tomography angiography (CTA) in order to facilitate the safe TVE for AC-AVF. Patients and methods: We included five patients with AC-AVF from 2011 to 2017. Dynamic CTA was performed on all patients. When the ACV was well-visualized by dynamic CTA, the hypoglossal nerve could be recognized as a less-intense structure within the surrounding enhanced vasculatures and the nerve route within the canal was analyzed. We also analyzed the location of the fistulas by digital subtraction angiography and cone-beam computed tomography. Results: In all five patients, the filling defect of the hypoglossal nerve ran through the most caudal portion of the hypoglossal canal. The fistulous pouches were located in the hypoglossal canal in three cases, and in the jugular tubercle venous complex in two cases. In all three cases with AC-AVF in the hypoglossal canal, the fistulous pouches were located in the superior wall of the hypoglossal canal, which means superior to the ACV. We performed TVE in four patients and none developed post-therapeutic hypoglossal nerve palsy. Conclusion: In the current study, dynamic CTA is useful for detecting the hypoglossal nerve within the hypoglossal canal. The hypoglossal nerve usually ran the bottom of its canal and the fistulous pouches were usually located at the superior aspect of the canal opposite side to the hypoglossal nerve. Accordingly, the selective embolization within the fistulous pouch located in the superior aspect of the ACV including jugular tubercle venous complex can reduce the risk of hypoglossal nerve palsy.

  • Preoperative Assessment of Pathologic Subtypes of Meningioma and Solitary Fibrous Tumor/Hemangiopericytoma Using Dynamic Computed Tomography: A Clinical Research Study

    Arai N., Mizutani K., Takahashi S., Morimoto Y., Akiyama T., Horiguchi T., Mami H., Yoshida K.

    World Neurosurgery (World Neurosurgery)  115   e676 - e680 2018.07

    ISSN  18788750

     View Summary

    © 2018 Elsevier Inc. Background: Solitary fibrous tumors (SFTs)/hemangiopericytomas (HPCs) are highly vascularized tumors well known for malignant, invasive, and highly vascular features. To date, several studies have reported the preoperative imaging findings of SFTs/HPCs. In this study, computed tomography (CT) tumor values acquired from dynamic CT scan were selected to determine the tumor pathology of highly vascular tumors, such as SFTs/HPCs. Methods: We conducted a retrospective study on patients with pathologically diagnosed meningiomas and SFTs/HPCs who had undergone a dynamic contrast CT scan. We assessed and compared the CT values of these tumors according to the pathology. Results: From a total of 34 patients, 30 patients with meningiomas and 4 patients with HPCs were included. The mean CT values of SFTs/HPCs and angiomatous meningioma were statistically significantly higher than those of the other meningioma subtypes (P = 0.003). We also performed receiver operating characteristic curve analyses to detect an appropriate cutoff point for the CT value to differentiate tumor pathology, and the calculated threshold was 161 Hounsfield units (HU) (sensitivity, 100%; specificity, 75%; area under the curve, 0.87; 95%, CI 0.75–0.99). Conclusions: This study showed that obtaining a CT value is useful in determining highly vascular tumor pathology preoperatively. When considering neurosurgical extra-axial tumor removal, and when the CT value of tumors is >161 HU, then highly vascular tumors such as SFTs/HPCs or angiomatous meningiomas are likely, and this should be considered prior to surgical intervention and for risk assessment.

display all >>

Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • 【脳卒中:内科医が知っておくべき最新診療】脳卒中急性期治療 高血圧性脳出血

    堀口 崇

    診断と治療 ((株)診断と治療社)  109 ( 5 ) 651 - 654 2021.05

    ISSN  0370-999X

     View Summary

    <Headline>1 高血圧性脳出血急性期においては、可能な限り早期に収縮期血圧を140mmHg未満に低下させ、7日間維持することが推奨される。2 降圧薬としてカルシウム拮抗薬あるいは硝酸薬の微量点滴静注が勧められる。3 高血圧性脳出血に対して外科的治療が推奨される条件は限定されており、また、有効性に関するエビデンスは乏しい。4 近年普及している神経内視鏡的血腫除去術のエビデンス蓄積が待たれる。(著者抄録)

  • 【激動する脳卒中診療-脳卒中・循環器病対策基本法とは?】その他の脳血管障害の診療の動向 慢性硬膜下血腫

    堀口 崇

    Clinical Neuroscience ((株)中外医学社)  38 ( 5 ) 630 - 631 2020.05

    ISSN  0289-0585

  • 重症くも膜下出血におけるearly brain injuryに寄与する遺伝子について

    荒井 信彦, 高橋 里史, 小池 一成, 柳澤 薫, 水谷 克洋, 中川 慎介, 秋山 武紀, 堀口 崇, 吉田 一成

    脳循環代謝 ((一社)日本脳循環代謝学会)  31 ( 1 ) 132 - 132 2019.11

    ISSN  0915-9401

  • くも膜下出血発症後早期に予後を予測し得る因子に関する検討

    高橋 里史, 秋山 武紀, 堀口 崇, 吉田 一成

    脳血管内治療 ((NPO)日本脳神経血管内治療学会)  4 ( Suppl. ) S203 - S203 2019.11

    ISSN  2423-9119

  • 外科的血行再建と脳循環 もやもや病バイパス術後早期の脳循環と症候

    高橋 里史, 堀口 崇, 秋山 武紀, 吉田 一成

    脳循環代謝 ((一社)日本脳循環代謝学会)  31 ( 1 ) 89 - 89 2019.11

    ISSN  0915-9401

display all >>

Presentations 【 Display / hide

  • 内頚動脈瘤に対する術前3Dシミュレーション

    宮澤森太郎、戸田正博、堀口崇、吉田一成、水谷克洋

    第30回日本微小脳神経外科解剖研究会 (東京) , 2016.04, Oral Presentation(guest/special)

  • Anteriortranspetrosal approachを用いた錐体斜台部髄膜腫における錐体静脈の温存について

    水谷克洋、戸田正博、堀口崇、吉田一成

    第30回日本微小脳神経外科解剖研究会 (東京) , 2016.04, Oral Presentation(general)

  • 経鼻内視鏡手術シミュレーションと3D画像を用いた傍鞍部手術解剖の解析

    若原聡太、戸田正博、堀口崇、吉田一成、菊池亮吾

    第30回日本微小脳神経外科解剖研究会 (東京) , 2016.04, Oral Presentation(guest/special)

  • 母血管の狭窄に伴い自然血栓化を来たした再発増大を繰り返した破裂中大脳動脈動脈瘤の1例

    HORIGUCHI TAKASHI

    第41回日本脳卒中学会総会 (札幌) , 2016.04, Poster (general)

  • 頸動脈血栓内膜剥離術の長期治療成績

    HORIGUCHI TAKASHI

    第45回日本脳卒中の外科学会学術集会 (札幌) , 2016.04, Oral Presentation(general)

display all >>

Research Projects of Competitive Funds, etc. 【 Display / hide

  • くも膜下出血後遅発性脳虚血のマーカー及び治療標的としてのmiRNAスクリーニング

    2015.04
    -
    2018.03

    Health and Labour Sciences Research Grants, 高橋里史, Research grant, Co-investigator

  • 磁気刺激を用いた皮質抑制拡散による虚血耐性の獲得

    2007
    -
    2009

    Grant-in-Aid for Scientific Research, 小林正人, Research grant, Co-investigator

  • 救急症病侵襲に対する生体反応ネットワークと体温

    1998
    -
    1999

    Grant-in-Aid for Scientific Research, 相川直樹, Research grant, Co-investigator

  • 脳虚血再潅流障害に対する低体温療法のtherapeutic time windowについて

    1997
    -
    1998

    Research grant, Principal Investigator

  • 血中・虚血後低脳温の脳保護作用機序の検討ならびに低脳温後のre-warmingにおける急性脳腫脹発現に関する研究

    1997
    -
    1998

    Research grant, Principal Investigator

display all >>

 

Courses Taught 【 Display / hide

  • ADVANCED HUMAN BODY AND PHYSIOLOGY

    2021

  • ADVANCED STUDIES IN HEALTH MANAGEMENT 1

    2021

  • PHYSICAL ASSESSMENT

    2021

  • PATHOPHYSIOLOGY FOR ACUTE CARE

    2021

  • PATHOPHYSIOLOGICAL ISSUES IN ACUTE CARE

    2021

display all >>

Courses Previously Taught 【 Display / hide

  • 急性期病態学

    Keio University, 2015, Major subject, Lecture

    脳神経

  • メディカルプロフェッショナリズム

    Keio University, 2015, Major subject, Lecture

    脳死臓器移植

  • 統括講義

    Keio University, 2015, Major subject, Lecture

    脳神経外科

  • クルズス

    Keio University, 2015, Major subject, Lecture

    脳血管障害

  • 学生実習

    Keio University, 2015, Major subject, Laboratory work/practical work/exercise

    脳神経外科

display all >>

Educational Activities and Special Notes 【 Display / hide

  • 初期臨床研修プログラム「一貫コース」責任者

    2012
    -
    Present

    , Special Affairs

  • 日本脳神経外科学会指導医

    2011
    -
    Present

    , Special Affairs

  • 卒後臨床研修センター副センター長

    2010
    -
    Present

    , Special Affairs

  • 厚生労働省認定臨床研修プログラム責任者

    2010
    -
    Present

    , Special Affairs

  • 慶應義塾大学病院臨床研修指導医養成WSタスクフォース

    2008
    -
    Present

    , Special Affairs

display all >>

 

Social Activities 【 Display / hide

  • 脳卒中リハビリ認定看護 講師

    2011.05
    -
    Present
  • 日本損害保険協会医療コース研修 応用コース講師

    1998.05
    -
    Present

Memberships in Academic Societies 【 Display / hide

  • 日本脳卒中学会, 

    1993
    -
    Present
  • 日本頭蓋底外科学会, 

    1990
    -
    Present
  • 日本脳神経外科学会, 

    1990
    -
    Present
  • 日本脳神経外科学会コングレス, 

    1990
    -
    Present
  • 日本脳卒中の外科学会, 

    1990
    -
    Present

display all >>

Committee Experiences 【 Display / hide

  • 2017.01
    -
    Present

    代議員, 日本脳卒中の外科学会

  • 2014
    -
    Present

    代議員, 日本脳卒中学会

  • 2012
    -
    Present

    代議員, 日本脳神経外科学会