Details of a Researcher - Horiguchi, Takashi

Horiguchi, Takashi

写真a

Affiliation: Faculty of Nursing and Medical Care Faculty of Nursing And Medical Care, Division of Acute Pathophysiology Graduate School of Health Management （Shonan Fujisawa）

Position: Professor

Related Websites

https://k-ris.keio.ac.jp/html/100003999_en.html

Contact Address: 新宿区信濃町35　孝養舎　研究室4

Remarks: https://k-ris.keio.ac.jp/html/100003999_en.html

External Links

Other Affiliation 【 Display / hide 】

Department of Neurosurgery, Keio University School of Medicine, Professor

Career 【 Display / hide 】

1990

-

1991.04

慶應義塾大学医学部, 外科学教室, 研修医
1991.05

-

1992.04

川崎市立川崎病院, 脳神経外科, 医員
1992.05

-

1993.04

足利赤十字病院, 脳神経外科, 医員
1993.05

-

1995.04

慶應義塾大学医学部, 外科学教室脳神経外科, 専修医
1995.05

-

1996.04

慶應義塾大学医学部, 外科学教室脳神経外科, 助手

Academic Background 【 Display / hide 】

1981

-

1984.03

慶應義塾高等学校

Other
1984.04

-

1990.03

Keio University, 医学部

University

Academic Degrees 【 Display / hide 】

医学博士, Keio University, 2006.07

Licenses and Qualifications 【 Display / hide 】

医師免許, 1990
日本脳神経外科専門医, 1997
厚労省認定臨床研修指導医, 2006
日本脳卒中学会専門医, 2007
厚労省認定臨床研修プログラム責任者, 2010

Research Areas 【 Display / hide 】

Life Science / Anatomy (Clinical anatomy)
Life Science / Anatomy (microanatomy of brain)
Life Science / Neurosurgery

Research Keywords 【 Display / hide 】

brain microsurgical anatomy
neurotrauma
cerebral blood flow and metabolism
brain tumor surgery
cerebrovascular disease

Research Themes 【 Display / hide 】

micro anatomy of brain and neurosurgical approach,

2006.05

-

Present
long term follow up of skullbase tumor,

2006.05

-

Present
brain protection of cortical spreading depression,

2001.05

-

Present
mechanisms of induced ischemic tolerance in brain,

1995.05

-

Present
temporal profile of protein phosphatase in ischemic brain,

1995.05

-

Present

Books 【 Display / hide 】

必携脳卒中ハンドブック第３版

HORIGUCHI TAKASHI, 診断と治療社, 2017.09

Scope: 慢性硬膜下血腫
神経内科　Clinical Questions & Pearls 脳血管障害

HORIGUCHI TAKASHI, 中外医学社, 2016.10

Scope: case approach くも膜下出血
神経内科　Clinical Questions & Pearls 脳血管障害

HORIGUCHI TAKASHI, 中外医学社, 2016.10

Scope: 急性期の脳浮腫、脳圧上昇はどのように対処すればよいのでしょうか？
神経内科　Clinical Questions & Pearls 頭痛

HORIGUCHI TAKASHI, 中外医学社, 2016.05

Scope: くも膜下出血による頭痛はどのように診断し、治療するのでしょうか？
脳卒中ビジュアルテキスト第4版

HORIGUCHI Takashi, 医学書院, 2015

Scope: 脳出血の外科的治療

Papers 【 Display / hide 】

Role of Surgery in the Management of Intracranial Dural Arteriovenous Fistula

AKIYAMA Takenori, HORIGUCHI Takashi, TAKAHASHI Satoshi, OHIRA Takayuki, AKIYAMA Takekazu, YOSHIDA Kazunari

Surgery for Cerebral Stroke （The Japanese Society on Surgery for Cerebral Stroke) 48 （ 6 ） 420 - 426 2020.11

ISSN 0914-5508

　View Summary

<p></p>Summary: Following technological advances in endovascular therapy, this approach is preferred over　surgery as the mainstay of treatment for dural arteriovenous fistula (dAVF). However, surgery remains important, and its role should be re-evaluated. In this retrospective study, we investigated the outcomes of surgical treatment for dAVF, focusing on the pitfalls of this approach in 101 patients who underwent surgery for dAVF. We analyzed the characteristics of lesions treated surgically, as well as treatment outcomes including the morbidity, AV shunt occlusion, and recurrence rates. The results included 20 patients who underwent only surgical treatment. The surgical morbidity rate was 5%. All AV shunts were extirpated at radical procedures; however, recurrence occurred in one patient. In conclusion, surgery serves as definitive treatment for specific types of dAVF. Careful decision-making regarding an endovascular vs. an open surgical approach is important, together with preparedness to manage the associated challenges, as observed in this case series. <p></p>
- Access to Document (DOI)
Short-Term Spontaneous Resolution of Ruptured Peripheral Aneurysm in Moyamoya Disease

Yamada H., Saga I., Kojima A., Horiguchi T.

World Neurosurgery （World Neurosurgery) 126 247 - 251 2019.06

ISSN 18788750

　View Summary

© 2019 Elsevier Inc. Background: Peripheral aneurysms are known to be a source of intracranial hemorrhage in patients with moyamoya disease. However, the natural history of ruptured peripheral aneurysms remains unclear. Some regress spontaneously, whereas others may rebleed. Direct treatments, such as surgical or intravascular treatment of the peripheral aneurysm, can have a risk of severe neurologic complications owing to the depth of the operative field and the fragility of the parent artery. A careful treatment policy is required. Case Description: In a 29-year-old man with moyamoya disease with intraventricular hemorrhage, rupture of a right anterior choroidal artery aneurysm was diagnosed by cerebral angiography. The aneurysm was approximately 4 mm in size and existed in the plexal segment of the right anterior choroidal artery. Endovascular embolization of the aneurysm was planned. However, repeat angiography 3 weeks after aneurysm diagnosis demonstrated complete resolution of the aneurysm. Such short-term disappearance of an aneurysm is remarkably rare. We believe that the aneurysm was thrombosed for a brief period considering the slow blood flow detected inside the aneurysm during the initial angiography. The patient was discharged with no neurologic deficit and has remained recurrence-free for >1 year. Conclusions: Given that spontaneous resolution of an aneurysm may occur in a short period of time, we suggest that conservative treatment be considered as an option for ruptured peripheral aneurysms associated with moyamoya disease when direct treatment is risky.
- Access to Document (DOI)
Pros and cons of using ORBEYE™ for microneurosurgery

Takahashi S., Toda M., Nishimoto M., Ishihara E., Miwa T., Akiyama T., Horiguchi T., Sasaki H., Yoshida K.

Clinical Neurology and Neurosurgery （Clinical Neurology and Neurosurgery) 174 57 - 62 2018.11

ISSN 03038467

　View Summary

© 2018 Elsevier B.V. Objective: To evaluate the pros and cons of using a newly developed microscope, ORBEYE™, during microneurosurgery. Patients and methods: ORBEYE™ use in 14 microneurosurgical procedures was retrospectively assessed by nine neurosurgeons after the procedure. A questionnaire comprising 20 questions was designed and used for evaluation. Results: Compared with the current gold standard, the binocular microscope, ease of setting up the equipment was scored the highest, whereas ease of conducting surgery in a position of an assistant was scored the lowest. Among characteristics of ORBEYE™ itself, the space-saving feature was scored the highest and was followed by the ability to perform procedures in a comfortable position. The only characteristic that was rated below average was ease of operation in a position of an assistant. Neurosurgeons with greater experience (more than five procedures using ORBEYE™) provided significantly higher scores (p = 0.0196) for characteristics of ORBEYE™ itself compared with neurosurgeon with fewer ORBEYE™ experience. Conclusions: The main benefits of the ORBEYETM are its compact size and freedom from focusing through the eye lens of a conventional binocular microscope. However, it appears to be disadvantageous for operating in a position of an assistant because the surgical field has a rotated view on the monitor from a position of an assistant. Nonetheless, because of certain advantages, we believe the ORBEYE™ could be of additional help to use of conventional binocular microscope at the moment and will facilitate microneurosurgery in the future.
- Access to Document (DOI)
An analysis of the anatomic route of the hypoglossal nerve within the hypoglossal canal using dynamic computed tomography angiography in patients with anterior condylar arteriovenous fistulas

Oishi Y., Akiyama T., Mizutani K., Horiguchi T., Imanishi N., Yoshida K.

Clinical Neurology and Neurosurgery （Clinical Neurology and Neurosurgery) 174 207 - 213 2018.11

ISSN 03038467

　View Summary

© 2018 Elsevier B.V. Objective: The venous outlet of anterior condylar arteriovenous fistulas (AC-AVFs) often empties into the anterior condylar vein (ACV). Hypoglossal nerve palsy is one of the major complications after transvenous embolization (TVE) for the AC-AVF within the hypoglossal canal. However, no studies have investigated the route of the hypoglossal nerve within the hypoglossal canal in AC-AVF. The aim of the current study is to retrospectively verify the anatomical route of the hypoglossal nerve within its canal using dynamic computed tomography angiography (CTA) in order to facilitate the safe TVE for AC-AVF. Patients and methods: We included five patients with AC-AVF from 2011 to 2017. Dynamic CTA was performed on all patients. When the ACV was well-visualized by dynamic CTA, the hypoglossal nerve could be recognized as a less-intense structure within the surrounding enhanced vasculatures and the nerve route within the canal was analyzed. We also analyzed the location of the fistulas by digital subtraction angiography and cone-beam computed tomography. Results: In all five patients, the filling defect of the hypoglossal nerve ran through the most caudal portion of the hypoglossal canal. The fistulous pouches were located in the hypoglossal canal in three cases, and in the jugular tubercle venous complex in two cases. In all three cases with AC-AVF in the hypoglossal canal, the fistulous pouches were located in the superior wall of the hypoglossal canal, which means superior to the ACV. We performed TVE in four patients and none developed post-therapeutic hypoglossal nerve palsy. Conclusion: In the current study, dynamic CTA is useful for detecting the hypoglossal nerve within the hypoglossal canal. The hypoglossal nerve usually ran the bottom of its canal and the fistulous pouches were usually located at the superior aspect of the canal opposite side to the hypoglossal nerve. Accordingly, the selective embolization within the fistulous pouch located in the superior aspect of the ACV including jugular tubercle venous complex can reduce the risk of hypoglossal nerve palsy.
- Access to Document (DOI)
Preoperative Assessment of Pathologic Subtypes of Meningioma and Solitary Fibrous Tumor/Hemangiopericytoma Using Dynamic Computed Tomography: A Clinical Research Study

Arai N., Mizutani K., Takahashi S., Morimoto Y., Akiyama T., Horiguchi T., Mami H., Yoshida K.

World Neurosurgery （World Neurosurgery) 115 e676 - e680 2018.07

ISSN 18788750

　View Summary

© 2018 Elsevier Inc. Background: Solitary fibrous tumors (SFTs)/hemangiopericytomas (HPCs) are highly vascularized tumors well known for malignant, invasive, and highly vascular features. To date, several studies have reported the preoperative imaging findings of SFTs/HPCs. In this study, computed tomography (CT) tumor values acquired from dynamic CT scan were selected to determine the tumor pathology of highly vascular tumors, such as SFTs/HPCs. Methods: We conducted a retrospective study on patients with pathologically diagnosed meningiomas and SFTs/HPCs who had undergone a dynamic contrast CT scan. We assessed and compared the CT values of these tumors according to the pathology. Results: From a total of 34 patients, 30 patients with meningiomas and 4 patients with HPCs were included. The mean CT values of SFTs/HPCs and angiomatous meningioma were statistically significantly higher than those of the other meningioma subtypes (P = 0.003). We also performed receiver operating characteristic curve analyses to detect an appropriate cutoff point for the CT value to differentiate tumor pathology, and the calculated threshold was 161 Hounsfield units (HU) (sensitivity, 100%; specificity, 75%; area under the curve, 0.87; 95%, CI 0.75–0.99). Conclusions: This study showed that obtaining a CT value is useful in determining highly vascular tumor pathology preoperatively. When considering neurosurgical extra-axial tumor removal, and when the CT value of tumors is >161 HU, then highly vascular tumors such as SFTs/HPCs or angiomatous meningiomas are likely, and this should be considered prior to surgical intervention and for risk assessment.
- Access to Document (DOI)

Papers, etc., Registered in KOARA 【 Display / hide 】

microRNA expression profiling in serum of patients with subarachnoid hemorrhage

Horiguchi, Takashi

科学研究費補助金研究成果報告書 2017
Noninvasive acquisition of ischemic tolerance of brain after spreading depression by transcranial magnetic stimulation

Horiguchi, Takashi

科学研究費補助金研究成果報告書 2009
Postischemic Hypothermia Inhibits the Generation of Hydroxyl Radical following Transient Forebrain Ischemia in Rats

Horiguchi, Tkashi

Journal of the Keio Medical Society （慶應医学会) 83 （ 3 ） 13 2006.09

ISSN 03685179

Reviews, Commentaries, etc. 【 Display / hide 】

【脳卒中:内科医が知っておくべき最新診療】脳卒中急性期治療　高血圧性脳出血

堀口崇

診断と治療 ((株)診断と治療社) 109 ( 5 ) 651 - 654 2021.05

ISSN 0370-999X

　View Summary

＜Headline＞1 高血圧性脳出血急性期においては、可能な限り早期に収縮期血圧を140mmHg未満に低下させ、7日間維持することが推奨される。2 降圧薬としてカルシウム拮抗薬あるいは硝酸薬の微量点滴静注が勧められる。3 高血圧性脳出血に対して外科的治療が推奨される条件は限定されており、また、有効性に関するエビデンスは乏しい。4 近年普及している神経内視鏡的血腫除去術のエビデンス蓄積が待たれる。(著者抄録)
【激動する脳卒中診療-脳卒中・循環器病対策基本法とは?】その他の脳血管障害の診療の動向　慢性硬膜下血腫

堀口崇

Clinical Neuroscience ((株)中外医学社) 38 ( 5 ) 630 - 631 2020.05

ISSN 0289-0585
重症くも膜下出血におけるearly brain injuryに寄与する遺伝子について

荒井信彦, 高橋里史, 小池一成, 柳澤薫, 水谷克洋, 中川慎介, 秋山武紀, 堀口崇, 吉田一成

脳循環代謝 ((一社)日本脳循環代謝学会) 31 ( 1 ) 132 - 132 2019.11

ISSN 0915-9401
くも膜下出血発症後早期に予後を予測し得る因子に関する検討

高橋里史, 秋山武紀, 堀口崇, 吉田一成

脳血管内治療 ((NPO)日本脳神経血管内治療学会) 4 ( Suppl. ) S203 - S203 2019.11

ISSN 2423-9119
外科的血行再建と脳循環　もやもや病バイパス術後早期の脳循環と症候

高橋里史, 堀口崇, 秋山武紀, 吉田一成

脳循環代謝 ((一社)日本脳循環代謝学会) 31 ( 1 ) 89 - 89 2019.11

ISSN 0915-9401

Presentations 【 Display / hide 】

内頚動脈瘤に対する術前３Dシミュレーション

宮澤森太郎、戸田正博、堀口崇、吉田一成、水谷克洋

第30回日本微小脳神経外科解剖研究会 (東京) ,

2016.04
,
Oral presentation (invited, special)
Anteriortranspetrosal approachを用いた錐体斜台部髄膜腫における錐体静脈の温存について

水谷克洋、戸田正博、堀口崇、吉田一成

第30回日本微小脳神経外科解剖研究会 (東京) ,

2016.04
,
Oral presentation (general)
経鼻内視鏡手術シミュレーションと３D画像を用いた傍鞍部手術解剖の解析

若原聡太、戸田正博、堀口崇、吉田一成、菊池亮吾

第30回日本微小脳神経外科解剖研究会 (東京) ,

2016.04
,
Oral presentation (invited, special)
母血管の狭窄に伴い自然血栓化を来たした再発増大を繰り返した破裂中大脳動脈動脈瘤の1例

HORIGUCHI TAKASHI

第41回日本脳卒中学会総会 (札幌) ,

2016.04
,
Poster presentation
頸動脈血栓内膜剥離術の長期治療成績

HORIGUCHI TAKASHI

第45回日本脳卒中の外科学会学術集会 (札幌) ,

2016.04
,
Oral presentation (general)

Research Projects of Competitive Funds, etc. 【 Display / hide 】

くも膜下出血後遅発性脳虚血のマーカー及び治療標的としてのmiRNAスクリーニング

2015.04

-

2018.03

Health and Labour Sciences Research Grants, Research grant, Coinvestigator(s)
磁気刺激を用いた皮質抑制拡散による虚血耐性の獲得

2007

-

2009

Grant-in-Aid for Scientific Research, Research grant, Coinvestigator(s)
救急症病侵襲に対する生体反応ネットワークと体温

1998

-

1999

Grant-in-Aid for Scientific Research, Research grant, Coinvestigator(s)
脳虚血再潅流障害に対する低体温療法のtherapeutic time windowについて

1997

-

1998

Research grant, Principal investigator
血中・虚血後低脳温の脳保護作用機序の検討ならびに低脳温後のre-warmingにおける急性脳腫脹発現に関する研究

1997

-

1998

Research grant, Principal investigator

Courses Taught 【 Display / hide 】

THEORETICAL ISSUES IN ADULT NURSING

2024
SENIOR PROJECT 2

2024
SENIOR PROJECT 1

2024
RISK ASSESSMENT AND MANAGEMENT

2024
PRACTICUM IN ACUTE CARE

2024

Courses Previously Taught 【 Display / hide 】

クルズス

Keio University

2015.04

-

2016.03
,
Lecture

脳血管障害
学生実習

Keio University

2015.04

-

2016.03
,
Laboratory work/practical work/exercise

脳神経外科
診断学

Keio University

2015.04

-

2016.03
,
Lecture

脳血管障害　
anatomy

Keio University

2015.04

-

2016.03
,
Lecture

anatomy of cerebral vessels, meningial membrane, ventricles
統括講義

Keio University

2015.04

-

2016.03
,
Lecture

脳神経外科

Educational Activities and Special Notes 【 Display / hide 】

初期臨床研修プログラム「一貫コース」責任者

2012

-

2021.03

, Special Affairs
日本脳神経外科学会指導医

2011

-

Present

, Special Affairs
卒後臨床研修センター副センター長

2010.09

-

2021.03

, Special Affairs
厚生労働省認定臨床研修プログラム責任者

2010

-

Present

, Special Affairs
慶應義塾大学病院臨床研修指導医養成WSタスクフォース

2008

-

Present

, Special Affairs

Social Activities 【 Display / hide 】

脳卒中リハビリ認定看護　講師

2011.05

-

2019.03
日本損害保険協会医療コース研修　応用コース講師

1998.05

-

Present

Memberships in Academic Societies 【 Display / hide 】

日本脳卒中学会,

1993

-

Present
日本頭蓋底外科学会,

1990

-

Present
日本脳神経外科学会,

1990

-

Present
日本脳神経外科学会コングレス,

1990

-

Present
日本脳卒中の外科学会,

1990

-

Present

Committee Experiences 【 Display / hide 】

2017.01

-

Present

代議員, 日本脳卒中の外科学会
2014

-

Present

代議員, 日本脳卒中学会
2012

-

Present

代議員, 日本脳神経外科学会