Papers - Sakamoto, Michiie

Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma.

Takamura M,Ichida T,Matsuda Y,Kobayashi M,Yamagiwa S,Genda T,Shioji K,Hashimoto S,Nomoto M,Hatakeyama K,Ajioka Y,Sakamoto M,Hirohashi S,Aoyagi Y:

Cancer Letters . 212   253-259 2004

Research paper (scientific journal), Joint Work

Squamous cell carcinoma of the liver originating from non-parasitic cysts after a 15 year follow-up:

Yagi H,Ueda M,Kawachi S,Tanabe M,Aiura K,Wakabayashi G,Shimazu M,Sakamoto M,kitajima M:

European journal of gastroentelrology &hepatology 16 ( 10 )  2004

Research paper (scientific journal), Joint Work

Squamous cell carcinoma of the liver originating from non-parasitic cysts after a 15 year follow-up:

Yagi H,Ueda M,Kawachi S,Tanabe M,Aiura K,Wakabayashi G,Shimazu M,Sakamoto M,kitajima M:

European journal of gastroentelrology &hepatology 16 ( 10 )  2004

Research paper (scientific journal), Joint Work

prognostic signficane of dysadherin expression in Tongue cancer :

Nanishi Y,Akimoto S,Sato Y,Kanai Y,Sakamoto M,Hirohashi S:

Immunohistochemical analysis of 91 casesappl immunohistochem mol morphol 12 ( 4 )  2004

Research paper (scientific journal), Joint Work

病理からのフィードバック　肝細胞癌の肉眼型と大腸癌肝細胞転移の進展様式、

SAKAMOTO MICHIIE

医学書院、 5 ( 3 )  2004

Research paper (scientific journal), Joint Work

Expression profiling in multistage hepatocarcinogenesis: Identification of HSP70 as a molecular marker of early hepatocellular carcinoma.

Chuma, M., Sakamoto, M., Hige, S. H., Asaka, M. and Hirohashi, S.

Hepatology 38 ( 4 ) 402a - 402a 2003.10

ISSN  0270-9139

Proteomic Analysis of Intestinal Epithelial Cells expressing stabilized β-Catenin1;

'Seike M, Kondo T, Mori Y, Gemma A, Kondoh S, Sakamoto M, Yamada Taketo, Hirohashi Setsuo'

Cancer Research 63   4641-4647 2003.08

Research paper (scientific journal), Single Work

Late Complication of a large simple cyst of the liver mimicking cystadenocarcinoma after sclerotherapy;

'Takayasu K, Mizuguchi Y, Yamazaki S, Sugiura T, Sato Chise, Sakamoto Michiie'

AJR 181 2003.08

Research paper (scientific journal), Single Work

Alpha-Fetoprotein-Producing Caricinoma of the Colon:

'Yachida S, Fukushima N, Nakanishi Y, Akatsu T, Kitamura H, Sakamoto Michiie, Shimoda'

Dis Colon Rectum 46 ( 6 )  2003.06

Research paper (scientific journal), Single Work

'EBP50,a β-Catenin-Associating Protein,Enhances Wnt Signaling and Is Over-expresseed in Hepatocellular Carcinoma'

'Shibata Rie, Chuma M, Kokubu A, Sakamoto Michiie, Hirohashi Setsuo'

Hepatology 0 ( 0 )  2003.06

Research paper (scientific journal), Single Work

Overexpression of orphan G-Protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations

Yamamoto, Y., Sakamoto, M., Fujii, G., Tsuiji, H., Kanetaka, K., Asaka, M. and Hirohashi, S.

Hepatology 37 ( 3 ) 528 - 533 2003.03

ISSN  0270-9139

　View Summary

To identify the genes responsible for carcinogenesis and progression of hepatocellular carcinoma (HCC), we screened differentially expressed genes in several human HCC cell lines. Among these genes, Gpr49 was up-regulated in PLC/PRF/5 and HepG2. Gpr49 is a member of the glycoprotein hormone receptor subfamily, which includes the thyroid-stimulating hormone receptor (TSHR). However, Gpr49 remains to be an orphan G-protein-coupled receptor. By real-time quantitative reverse transcriptase polymerase chain reaction (RT-PCR) analysis, overexpression (>3-fold increase compared with the corresponding noncancerous liver tissue) of Gpr49 mRNA was observed in 18 of 38 (47%) HCCs compared with corresponding noncancerous livers. Clinicopathologically, overexpression of Gpr49 was frequently observed in HCC with mutation in beta-catenin exon 3 (14 of 16 cases, 87.5%). Moreover, introduction of mutant beta-catenin into mouse hepatocytes in culture caused up-regulation of the Gpr49 mouse homologue. Therefore, Gpr49 is likely to be a target gene activated by Wnt-signaling in HCC. In conclusion, although much is still unknown, Gpr49 may be critically involved in the development of HCCs with beta-catenin mutations and has the potential to be a new therapeutic target in the treatment of HCC.

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Prognostic singnificance of dysadherin expression in advanced colorectal carcinoma

Aoki S, Shimamura T, Shibata T, Nakanishi Y, Moriya Y, Kitajima M, Sakamoto M, Hirohashi S

British journal of cancer 88 ( 5 ) 726-732 2003.03

Research paper (scientific journal), Joint Work

性幹細胞（組織幹細胞）の分離，増殖，分化誘導体

Hashiguchi Akinori, Sakamoto Michiie, Umezawa Akihiro

日本臨牀 61 ( 3 ) 390-395 2003.03

Research paper (scientific journal), Joint Work

Dysadherin Overepression in Pancreatic Ductal Adenocarcinoma Reflects Tumor Aggressiveness:Relationship to E-Cadherin Expression

Shimamura Takeshi, Sakamoto Michiie, Ino Yoshinori, Sato Yasuto, Shimada Kazuaki, Kasuge Tohru, Sekihara Hisahiko, Hirohashi Setsuo

Journal of clinical oncology 21 ( 4 ) 659-667 2003.02

Research paper (scientific journal), Joint Work

A faithful method for PCR-mediated global mRNA amplification and itsintegration into microarray analysis on laster-captured cells

Aoyagi Kazuhiko, Tatsuta Tatsuta, Nishigaki Michiko, Akimoto Chikako, Tanabe Chikako, Omoto Yoko, Hayashi Shin-ichi, Sakamoto Hiromi, Sakamoto Michiie, Yoshida Teruhiko, Terada Masaaki, Sasaki Hiroki

Biochemical and biophysical research communications 300 ( 4 ) 915-920 2003.01

Research paper (scientific journal), Joint Work

Overexpression of orphan G-Protein-Coupled Receptor,Gpr49,in human hepatocellular carcinoma with β-catenin mutations

Yamamoto Y, Sakamoto Michiie, Fujii Gen, Tsuiji Hitomi, Kanetaka Kenzo, Asaka Masahiro, Hirohashi Setsuo

Hepatology 37 ( 3 ) 528-533 2003

Research paper (scientific journal), Joint Work

Expression profiling in ovarian clear cell carinoma identification of Hepatocyte nuclear factor-1 β as a Molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma;

'Tsuchiya A, Sakamoto Michiie, Yasuda J, chuma Makoto, Ohta T, Ohki M, Yasugi T, Taketani Y, Hirohashi Setsuo'

American journal of pathology 163 ( 6 )  2003

Research paper (scientific journal), Single Work

Mutation of the DNA metyltransferase(DNMT)1 gene in human colorectal cancers;

'Kanai Yae, Ushijima S, Nakanishi Y, Sakamoto Michiie, Hirohashi Setsuo'

Cancer letters 192   75-82 2003

Research paper (scientific journal), Single Work

Primary carcinoma tumor in a polycystic kidney;

'Shibata Rie, Okita Hajime, Shimoda Masayuki, Asakura H, Murai M, Sakamoto Michiie, Hata Junichi'

Pathology international 53   317-322 2003

Research paper (scientific journal), Single Work

A case of scleosing hemangioma of the lung presenting as gigantic tumor occupying the left thoracic cavity;

'Shibata Rie, Mukai M, Okada Yasunori, Sakamoto Michiie, Yamauchi T, Kobayashi K'

Virchows Arch 442   409-411 2003

Research paper (scientific journal), Single Work