Papers - Sakamoto, Michiie

A solid pseudopapilary tumor arising from the greater omentum followed by multiple metastases with increasing malignant potential

Hibi T,Ojima H,Sakamoto Y,Kosuge T,Shimada K,Sano T,Sakamoto M,Kitajima M,Yamasaki S:

J Gastroenterol 41   276-181 2006

Research paper (scientific journal), Joint Work

「膵癌の病理学的特性—分子機構の解明—」

SAKAMOTO MICHIIE

画像診断 26 ( 1 )  2006

Research paper (scientific journal), Joint Work

坂元　亨宇　「早期肝細胞癌の病理診断—臨床へのメッセージ」

SAKAMOTO MICHIIE

消化器画像　医学書院 8 ( 1 )  2006

Research paper (scientific journal), Single Work

「2.肝癌の前癌病変・境界病変」

SAKAMOTO MICHIIE

臨床消化器内科 21 ( 7 )  2006

Research paper (scientific journal), Single Work

「胆管浸潤型管内胆管癌の臨床病理学的特徴」

SAKAMOTO MICHIIE

管内胆管癌　消化器画像　医学書院 7 ( 6 )  2005.11

Research paper (scientific journal), Joint Work

Multistep and multicentric development of hepatocellular carcinoma: histological analysis of 980 resected nodules

Oikawa, T., Ojima, H., Yamasaki, S., Takayama, T., Hirohashi, S. and Sakamoto, M.

Journal of Hepatology 42 ( 2 ) 225 - 229 2005.02

ISSN  0168-8278

　View Summary

Background/Aims: Histological observations support the concept of multistep and multicentric development of hepatocellular carcinoma (HCC) in cases of chronic liver disease. However, the relationship between the incidence of such a modality of development of HCC and the type of background liver disease has not been fully investigated.

• Access to Document (DOI)

Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepatocellular carcinoma

Nakanishi, K., Sakamoto, M., Yamasaki, S., Todo, S. and Hirohashi, S.

Cancer 103 ( 2 ) 307 - 12 2005.01

ISSN  0008-543X

　View Summary

BACKGROUND: Patients with hepatocellular carcinoma (HCC) who showed early massive disease recurrence due to hematogenous intrahepatic metastasis after curative resection had a poor prognosis. The authors previously reported that Akt phosphorylation was correlated with hematogenous intrahepatic metastasis, using HCC cell lines. METHODS: The authors analyzed clinicopathologic features and the status of selected biologic markers, including phosphorylated Akt, to identify risk factors for early disease recurrence and poor prognosis in HCC. In the current series, 49 postoperative patients developed intrahepatic disease recurrence within 6 months (Group 1) and 86 patients remained disease recurrence free > 3 years after resection (Group 2). Group 1 was further divided into 2 subgroups: 19 patients who died of disease recurrence within a year after resection (Group 1A) and 27 patients who survived > 1 year (Group 1B). RESULTS: Using univariate analysis, the risk factors for early disease recurrence were tumor size, macroscopic classification, tumor differentiation, microscopic capsule infiltration, microscopic portal vein (MPV) invasion, microscopic intrahepatic metastasis (MIM), and positive immunostaining for phosphorylated Akt, Ki-67, and p53 (P < 0.05). The risk factors for poor prognosis were the number of intrahepatic metastases, tumor differentiation, and positive immunostaining for phosphorylated Akt and Ki-67 (P < 0.05). Multivariate analysis revealed that the risk factors for early disease recurrence were MPV invasion, MIM, and positive immunostaining for phosphorylated Akt, and that the risk factors for poor prognosis were positive immunostaining for phosphorylated Akt and Ki-67 (P < 0.05). CONCLUSIONS: The current clinical study showed the critical involvement of Akt phosphorylation in the aggressiveness of HCC. The potential benefits of surgery should be assessed carefully in patients with any of these risk factors.

• Access to Document (DOI)

Akt Phosphorylation is risk factor for early disease recurrence and poor prognosis in hepatocellular caricinoma ;

Nakanishi K,Sakamoto M,Yamasaki S,Todo S,Hirohashi S:

cancer 103 ( 2 )  2005.01

Research paper (scientific journal), Joint Work

Long-term survival of intrahepatic cholangiocarcinoma with hilar lymph node metastasis anda portal vein invovment:

Akatsu T,Shimazu M,Kawachi S,Tanabe M,Aiura K,Wakabayashi S,Ueda M,Sakamoto M,Kitajima M:

hepato-gastroenterology 52   606-609 2005

Research paper (scientific journal), Joint Work

Clinical and pathologic signigicance of activation of signal transducer and activator of transcription 3 in prostate cancer:

Horinaga M,Okita H,Nakashima J,Kanao K,Sakamoto M,Murai M:

urology. 66 ( 3 )  2005

Research paper (scientific journal), Joint Work

Domain-specific function of ShcC docking protein in neuroblastoma cells:

Miyake I,Hakomori Y,Misu Y,Nakadate H,Matsuura N,Sakamoto M,Sakai R:

oncogene. 24   3206-3215. 2005

Research paper (scientific journal), Joint Work

Fukusato T,Fukushima J,Shiga J,Takahashi Y,Nakano Interobserver variation in the hitopathological assessment of nonalcoholic steatohepatitis;

T,Maeyama S,Masayuki U,Ohbu M,Matsumoto T,Matsumoto K,Hano H,Sakamoto M,Kondo F,Komatsu S,Ishikawa T,Ohtake H,Takikawa H,Yoshimura K,Liver disease working group-kanto;

Hepatology Research 33   122-127, 2005

Research paper (scientific journal), Joint Work

Genetic profile of hepatocellular carcinoma revealed by array-based comparative genomic hybridization:Identification of genetic indicators to predict patient outcome:

Katoh H,Shibata T,Kokubu A,Ojima H,P.Loukopoulos,Kanai Y,Kosuge T,Fukayama M,Kondo T,Sakamoto m,Hosoda F,Ohiki M,Imoto I,Inazawa J,Hirohashi S;

Journal hepatology. 43   863-874. 2005

Research paper (scientific journal), Joint Work

肝腫瘍の術中迅速診断　肝生検診断Ⅰ−腫瘍性疾患−

SAKAMOTO MICHIIE

病理と臨床・別刷 23 ( 2 )  2005

Research paper (scientific journal), Single Work

Primary bone carcinosarcoma:Chondrosarcoma and squamous cell carcinoma with keratin pearl formation:

Shiraishi J,Mukai M,Yabe H,Shibata R,Yamada T,Miura K,Anazawa Morioka H,Sakamto M:

Pathology International 55   504-409 2005

Research paper (scientific journal), Joint Work

Multistep and multicentric development of hepatocellular carcinoma:histological analysis of 980 resected nodules .

Oikawa T,Ojima H,Yamazaki S,Takayama T,Hirohashi S,Sakamoto M:

Journal of Hepatology 42   225-229 2005

Research paper (scientific journal), Joint Work

Extramedullary myeloid tumor (EMMT)of the gallbladder .

Ojima H,Hasegawa T,Matsuo Y,Sakamoto M:

J Clin Pathol . 58   211-213 2005

Research paper (scientific journal), Joint Work

Spontaneous rupture of a mass-forming type peripheral cholangiocarcinoma:

Akatsu T,Ueda M,Shimazu M,Kawauchi S,Tanabe M,Aiura K,Wakabayashi G,Sakamoto M,Matsuo R:

Journal of Gastroenterology and Hepatology. 20   162-168 2005

Research paper (scientific journal), Joint Work

Combination of hTERT and bimi-1,E6,or E7,induces prolongation of the life span of bone marrow stromal cells from an elderly donor without affecting their neurogenic protential:

Mori T,Kiyono T,Imabayashi H,Takeda Y,Tsuchiya K,Miyoshi S,Makino H,Matsumoto K,Saito H,Ogawa S,Sakamoto M,Hata J,Umezawa A:

molecular and cellular biology. 25 ( 12 ) 5182-5195 2005

Research paper (scientific journal), Joint Work

Extramedullary myeloid tumor (EMMT)of the gallbladder .

Ojima H,Hasegawa T,Matsuo Y,Sakamoto M:

J Clin Pathol . 58   211-213 2005

Research paper (scientific journal), Joint Work