Papers - Sakamoto, Michiie

Proposal of histological criteria for intraepithelial atypical/proliferative biliary epithelial lesions of the bile duct in hepatolithiasis with respect to cholangiocarcinoma:Preliminary report based on interobserver agreement

Yoh Z,Aishima S,Ajioka Y,Haratake J,Kage M,Kondo F,Nimura Y,Sakamoto M,Sasaki M,Shimamatsu K,Wakasa K,Young N.P,Ming F.C,Atomi Y,Nakanuma Y:

Pathology international. 55   180-188, 2005

Research paper (scientific journal), Joint Work

Overexpression of cortactin is involved in motility and metastasis of hepatocellular carcinoma

Chuma, M., Sakamoto, M., Yasuda, J., Fujii, G., Nakanishi, K., Tsuchiya, A., Ohta, T., Asaka, M. and Hirohashi, S.

Journal of Hepatology 41 ( 4 ) 629 - 636 2004.10

ISSN  0168-8278

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Background/Aims: The molecular basis of the metastasis of hepatocellular carcinoma (HCC) is not fully understood. The aim of this study was to elucidate the crucial genes involved in metastasis of HCC.

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Orthotopic Transplantation Models of Pancreatic Adenocaricinoma Derived From Cell Lines and Primary Tumors and displaying barying metastatic activity;

Panayiotis L DVN,Kanetaka K,Takamura M,Shibata T,Sakamoto M,Hirohashi S:

pancreatic cancer orthotopic models 29 ( 3 ) 2004 2004.10

Research paper (scientific journal), Joint Work

Expression profiling in hepatocellular carcinoma with intrahepatic metastasis: identification of high-mobility group I(Y) protein as a molecular marker of hepatocellular carcinoma metastasis

Chuma, M., Saeki, N., Yamamoto, Y., Ohta, T., Asaka, M., Hirohashi, S. and Sakamoto, M.

Keio J Med 53 ( 2 ) 90 - 7 2004.06

ISSN  0022-9717

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Hepatocellular carcinoma (HCC) is one of the most common and aggressive human malignancies. Its high mortality rate is mainly a result of intra-hepatic metastases. To investigate the detailed genetic mechanisms in cancer metastasis, we compared the expression profiles of 20 HCCs with intrahepatic metastasis and 10 HCCs without intrahepatic metastasis using an oligonucleotide array. Of the approximately 12,600 genes that were analyzed, we identified 34 genes whose expression levels were significantly correlated with intrahepatic metastasis (P<0:05). Of these genes, we further investigated the expression of high-mobility group I(Y) [HMG-I(Y)] protein. Real-time quantitative reverse transcription polymerase chain reaction (RT-PCR) confirmed that HMG-I(Y) was upregulated in HCC with intrahepatic metastasis, compared to its level in HCC without intrahepatic metastasis. Further immunohistochemical examination of HMG-I(Y) revealed a significant overexpression in HCC with intrahepatic metastasis, compared with that in HCC without intrahepatic metastasis (P<0:05). These results indicate that the molecular signatures of HCC with intrahepatic metastasis and of HCC without intrahepatic metastasis are clearly different. HMG-I(Y) expression was associated with intrahepatic metastasis and may be a predictive marker of HCC intrahepatic metastasis.

Can the life span of human marrow stromal cells be prolonged by bmi-1 E6,E7and/or telomerase without affecting cardiomyogenic defferentiation ;

Takeda Y,Mori T,Imabayashi H,Kiyono T,Gojo S,Miyoshi S,Hida N,Ita M,Segawa S,Ogawa S,Sakamoto M,Nkamura S,Umezawa A:

J.Gene Med. 0   833-845 2004.06

Research paper (scientific journal), Single Work

肝門部胆管癌進展様式の病理学的特徴：肝門部胆管癌の進展度診断−画像でどこまでわかるか：

SAKAMOTO MICHIIE

医学書院  2004.05

Research paper (scientific journal), Joint Work

Clinical significance of dysadherin expression in gastric cancer patients;

'Shimada Y, Yamasaki S, Hashimoto Y, Ito T, Kawamura J, Soma T, Ino Y, Nakamnishi Y, Sakamoto Michiie, Hirohashi Setsuo, Imamura M'

clinical cancer research 2818 ( 10 ) 2818-2823 2004.04

Research paper (scientific journal), Single Work

肝細胞癌の多段階発癌とフェノタイプ、

SAKAMOTO MICHIIE

肝胆膵 48 ( 4 ) 2004 2004.04

Research paper (scientific journal), Joint Work

肝細胞癌の病理　肝細胞性結節性病変の鑑別を中心に　：

SAKAMOTO MICHIIE

臨床放射線 49 ( 11 )  2004

Research paper (scientific journal), Joint Work

Pedunculated　 angiomyolipoma of the liver with a predominant pelioid pattern

'Akatsu Tomotaka, Sakamoto Michiie, Shimazu M, Kitajima Masaki'

Virchows Archiv    444;467-469 2004

Research paper (scientific journal), Single Work

Tumor angiogenesis in the bone marrow of multiple myeloma patients and its alteration by thalidomide treatment

'Wenlin Du, Hattori Y, Hashiguchi Akinorik, Kondoh Keisuke, Hozumi Nobumichi, Ikeda Y, Sakamoto Michiie, Hata Junichi, Yamada Taketo'

pathology International  ( 54 ) 285-294 2004

Research paper (scientific journal), Single Work

Cusom-shaping system gor bon eregeneration by seeding marrow stromal cells onto a web-like biodegradable hybrid sheet

'Tsuchiya Kouhei, Mori Taisuke, Chen G, Ushida T, Tateishi T, Matsuo T, Sakamoto Michiie, Umezawa Akihiro'

Cell Tissue Research  ( 316 ) 141-153 2004

Research paper (scientific journal), Single Work

5-Aza-2’-deoxycytidine restores the E-cadherin system in E-cadherin-silenced cancer cells and reduces cancer metastasis;

'J-S-Nam, Ino Y, kanai Yae, Sakamoto Michiie, Hirohashi Setsuo'

Clnical&Experimental Metastasis 21   29-56 2004

Research paper (scientific journal), Single Work

Expression profiling in hepatocellular carcinoma with intrahepatic metastasis identification of high-mobility groupⅠ(Y)protein as a molecular marker of hepatocellular carcinoma metastasis

Chuma M,Saeki N,Yamamoto Y,Ohta T,Asaka M,Hirohashi S,Sakamoto M:

Keio Journal of Medicine, l53 ( 2 ) 90-97 2004

Research paper (scientific journal), Joint Work

Can the life span of human marrow stromal cells be prolonged by bmi-1 E6,E7and/or telomerase without affecting cardiomyogenic defferentiation ;J

Takeda Y,Mori T,Imabayashi H,Kiyono T,Gojo S,Miyoshi S,Hida N,Ita M,Segawa S,Ogawa S,Sakamoto M,Nkamura S,Umezawa A:

Gene Med. 6   833-845 2004

Research paper (scientific journal), Joint Work

Lamin 5β3 and γ2 chains are frequently coexpressed in cancer cells;

Akimoto S,Nakanishi Y,Sakamoto M,Kanai Y,Hirohashi S:

Pathology International 54   688-692 2004

Research paper (scientific journal), Joint Work

Dysadherin expression facilitates cell motility and metastatic potential human pancreatic cancer cells;

Shimamura T,Yasuda J,Ino M,Tsuchiya A,Najima A,Sakamoto M,Kanai Y,Hirohashi S:

cancer research 64   6989-6995, 2004

Research paper (scientific journal), Joint Work

Prognostic significance of deysadherin expression in esophageal squamous cell carcinoma;

Shimada Y,Hashimoto Y,Kan T,Kawamura J,Okumura T,Soma T,Kondo K,TerataniN,Watanabe G,Ino Y,Sakamoto M,Hirohashi S,Imamura M:

oncology 67   73-80 2004

Research paper (scientific journal), Joint Work

High-grade dysplasia associated with fundic gland polyposis in a familial adenomatous polyposis patient,with special reference to APC mutation profiles.

Sekine S, Shimoda T, Nimura S, Nakanishi Y, Akasu T, Katai H, Gotoda T, Sakamoto M, Hirohashi S,

Modern Pathology, 17   1421-1426 2004

Research paper (scientific journal), Joint Work

Overexpression of cortactin is involved in motility and metastasis of hepatocellular carcinoma.

Chuma M, Sakamoto M, Yasuda J, Fujii G, Nakanishi K, Tsuchiya A, Ohta T, Asaka M, Hirohashi S,

Journal of Hepatology. 41   626-636 2004

Research paper (scientific journal), Joint Work