Papers - KANAI Yae

Feasibility of methylome analysis using small amounts of genomic DNA from formalin‐fixed paraffin‐embedded tissue

K Ohara, E Arai, Y Takahashi, Y Fukamachi, N Ito, AM Maeshima, ...

Pathology international 68 (11), 633-635  2018

Feasibility of methylome analysis using small amounts of genomic DNA from formalin‐fixed paraffin‐embedded tissue

K Ohara, E Arai, Y Takahashi, Y Fukamachi, N Ito, AM Maeshima, ...

Pathology international 68 (11), 633-635  2018

Feasibility of methylome analysis using small amounts of genomic DNA from formalin‐fixed paraffin‐embedded tissue

K Ohara, E Arai, Y Takahashi, Y Fukamachi, N Ito, AM Maeshima, ...

Pathology international 68 (11), 633-635  2018

Epigenome mapping of human normal purified hepatocytes: personal epigenome variation and genome–epigenome correlation

E Arai, F Miura, Y Totoki, S Yamashita, Y Tian, M Gotoh, H Ojima, ...

Epigenomics 10 (7), 955-979  2018

Epigenome mapping of human normal purified hepatocytes: personal epigenome variation and genome–epigenome correlation

E Arai, F Miura, Y Totoki, S Yamashita, Y Tian, M Gotoh, H Ojima, ...

Epigenomics 10 (7), 955-979  2018

Epigenome mapping of human normal purified hepatocytes: personal epigenome variation and genome–epigenome correlation

E Arai, F Miura, Y Totoki, S Yamashita, Y Tian, M Gotoh, H Ojima, ...

Epigenomics 10 (7), 955-979  2018

ADAM9 is over‐expressed in human ovarian clear cell carcinomas and suppresses cisplatin‐induced cell death

M Ueno, T Shiomi, S Mochizuki, M Chijiiwa, M Shimoda, Y Kanai, ...

Cancer science 109 (2), 471-482  2018

ADAM9 is over‐expressed in human ovarian clear cell carcinomas and suppresses cisplatin‐induced cell death

M Ueno, T Shiomi, S Mochizuki, M Chijiiwa, M Shimoda, Y Kanai, ...

Cancer science 109 (2), 471-482  2018

ADAM9 is over‐expressed in human ovarian clear cell carcinomas and suppresses cisplatin‐induced cell death

M Ueno, T Shiomi, S Mochizuki, M Chijiiwa, M Shimoda, Y Kanai, ...

Cancer science 109 (2), 471-482  2018

511 IDENTIFICATION OF CYP2A6 GENE RELATED TO INVASIVE BLADDER CARCINOGENESIS

K Kanemoto, K Fukuta, K Yamada, N Kawai, K Tozawa, Y Kanai, ...

JOURNAL OF UROLOGY 200 (3), e208-e208  2018

511 IDENTIFICATION OF CYP2A6 GENE RELATED TO INVASIVE BLADDER CARCINOGENESIS

K Kanemoto, K Fukuta, K Yamada, N Kawai, K Tozawa, Y Kanai, ...

JOURNAL OF UROLOGY 200 (3), e208-e208  2018

511 IDENTIFICATION OF CYP2A6 GENE RELATED TO INVASIVE BLADDER CARCINOGENESIS

K Kanemoto, K Fukuta, K Yamada, N Kawai, K Tozawa, Y Kanai, ...

JOURNAL OF UROLOGY 200 (3), e208-e208  2018

Somatic mutations in IFN-γ-Signal molecules in human uterine leiomyosarcoma

T Hayashi, T Ichimura, M Kasai, K Sano, S Tonegawa, Y Kanai, ...

 2018

SPECIFIC PREDICTION OF DUODENAL TUMOR USING DEMOGRAPHIC AND ENDOSCOPIC CHARACTERISTICS: AN AGE-AND SEX-MATCHED CASE-CONTROL STUDY

H Suzuki, J Matsuzaki, M Shimoda, H Mori, S Fukuhara, Y Kanai, T Kanai

Gastroenterology 154 (6), S664-S665  2018

SPECIFIC PREDICTION OF DUODENAL TUMOR USING DEMOGRAPHIC AND ENDOSCOPIC CHARACTERISTICS: AN AGE-AND SEX-MATCHED CASE-CONTROL STUDY

H Suzuki, J Matsuzaki, M Shimoda, H Mori, S Fukuhara, Y Kanai, T Kanai

Gastroenterology 154 (6), S664-S665  2018

SPECIFIC PREDICTION OF DUODENAL TUMOR USING DEMOGRAPHIC AND ENDOSCOPIC CHARACTERISTICS: AN AGE-AND SEX-MATCHED CASE-CONTROL STUDY

H Suzuki, J Matsuzaki, M Shimoda, H Mori, S Fukuhara, Y Kanai, T Kanai

Gastroenterology 154 (6), S664-S665  2018

SPECIFIC PREDICTION OF DUODENAL TUMOR USING DEMOGRAPHIC AND ENDOSCOPIC CHARACTERISTICS: AN AGE-AND SEX-MATCHED CASE-CONTROL STUDY

H Suzuki, J Matsuzaki, M Shimoda, H Mori, S Fukuhara, Y Kanai, T Kanai

Gastroenterology 154 (6), S664-S665  2018

Hyaluronan binding protein involved in hyaluronan depolymerization(HYBID)はヒアルロン酸代謝を介して内軟骨性骨形成を制御する

下田 将之, 吉田 浩之, 水野 早希子, 弘實 透, 堀内 圭輔, 吉野 雄太, 原 英彰, 金井 弥栄, 井上 紳太郎, 石島 旨章, 岡田 保典

日本結合組織学会学術大会プログラム・抄録集 (日本結合組織学会)  49回   42 - 42 2017.06

Accepted

長管骨形成に関わるHYBIDの役割解析

下田 将之, 吉田 浩之, 水野 早希子, 堀内 圭輔, 吉野 雄太, 原 英彰, 金井 弥栄, 井上 紳太郎, 石島 旨章, 岡田 保典

日本病理学会会誌 ((一社)日本病理学会)  106 ( 1 ) 307 - 307 2017.03

Accepted,  ISSN  0300-9181

Genes involved in development and differentiation are commonly methylated in cancers derived from multiple organs: A single-institutional methylome analysis using 1007 tissue specimens.

Ohara K, Arai E, Takahashi Y, Ito N, Shibuya A, Tsuta K, Kushima R, Tsuda H, Ojima H, Fujimoto H, Watanabe SI, Katai H, Kinoshita T, Shibata T, Kohno T, Kanai Y.

Carcinogenesis (OXFORD UNIV PRESS)  38 ( 3 ) 241 - 251 2017

Accepted,  ISSN  01433334

　View Summary

The aim of this study was to clarify the significance of DNA methylation alterations shared by cancers derived from multiple organs. We analyzed single-institutional methylome data by single-CpG-resolution Infinium assay for 1007 samples of non-cancerous tissue (N) and corresponding cancerous tissue (T) obtained from lung, stomach, kidney, breast and liver. Principal component analysis revealed that N samples of each organ showed distinct DNA methylation profiles, DNA methylation profiles of N samples of each organ being inherited by the corresponding T samples and DNA methylation profiles of T samples being more similar to those of N samples in the same organ than those of T samples in other organs. In contrast to such organ and/or carcinogenetic factor-specificity of DNA methylation profiles, when compared with the corresponding N samples, 231 genes commonly showed DNA hypermethylation in T samples in four or more organs. Gene ontology enrichment analysis showed that such commonly methylated genes were enriched among '' transcriptional factors '' participating in development and/or differentiation, which reportedly show bivalent histone modification in embryonic stem cells. Pyrosequencing and quantitative reverse transcription-PCR revealed an inverse correlation between DNA methylation levels and mRNA expression levels of representative commonly methylated genes, such as ALX1, ATP8A2, CR1 and EFCAB1, in tissue samples. These data suggest that disruption of the differentiated state of precancerous cells via alterations of expression, independent of differences in organs and/or carcinogenetic factors, may be a common feature of DNA methylation alterations during carcinogenesis in multiple organs.

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