Papers - KANAI Yae

ADAM9 is over-expressed in human ovarian clear cell carcinomas and suppresses cisplatin-induced cell death.

Ueno M, Shiomi T, Mochizuki S, Chijiiwa M, Shimoda M, Kanai Y, Kataoka F, Hirasawa A, Susumu N, Aoki D, Okada Y.

Cancer Sci (Cancer Science)  109 ( 2 ) 471 - 482 2018

Research paper (scientific journal), Single Work, Accepted,  ISSN  13479032

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© 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. ADAMs (a disintegrin and metalloproteinases) are involved in various biological events such as cell adhesion, migration and invasion, membrane protein shedding and proteolysis. However, there have been no systematic studies on the expression of ADAMs in human ovarian carcinomas. We therefore examined mRNA expression of all the proteolytic ADAM species including ADAM8, 9, 10, 12, 15, 17, 19, 20, 21, 28, 30, 33 and ADAMDEC1 in human ovarian carcinomas, and found that prototype membrane-anchored ADAM9m, but not secreted isoform ADAM9s, is significantly over-expressed in carcinomas than in control non-neoplastic ovarian tissue. Among the histological subtypes of serous, endometrioid, mucinous and clear cell carcinomas, ADAM9m expression was highest in clear cell carcinomas. Immunohistochemistry showed that all the clear cell carcinoma samples displayed ADAM9m primarily on the carcinoma cell membrane. By immunoblotting, ADAM9m was detected mainly in an active form in the clear cell carcinoma tissues. When two clear cell carcinoma cell lines (RMG-I and TOV21G cell

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511 IDENTIFICATION OF CYP2A6 GENE RELATED TO INVASIVE BLADDER CARCINOGENESIS

K Kanemoto, K Fukuta, K Yamada, N Kawai, K Tozawa, Y Kanai, ...

JOURNAL OF UROLOGY 200 (3), e208-e208  2018

Feasibility of methylome analysis using small amounts of genomic DNA from formalin‐fixed paraffin‐embedded tissue

K Ohara, E Arai, Y Takahashi, Y Fukamachi, N Ito, AM Maeshima, ...

Pathology international 68 (11), 633-635  2018

Feasibility of methylome analysis using small amounts of genomic DNA from formalin‐fixed paraffin‐embedded tissue

K Ohara, E Arai, Y Takahashi, Y Fukamachi, N Ito, AM Maeshima, ...

Pathology international 68 (11), 633-635  2018

Epigenome mapping of human normal purified hepatocytes: personal epigenome variation and genome–epigenome correlation

E Arai, F Miura, Y Totoki, S Yamashita, Y Tian, M Gotoh, H Ojima, ...

Epigenomics 10 (7), 955-979  2018

Epigenome mapping of human normal purified hepatocytes: personal epigenome variation and genome–epigenome correlation

E Arai, F Miura, Y Totoki, S Yamashita, Y Tian, M Gotoh, H Ojima, ...

Epigenomics 10 (7), 955-979  2018

Epigenome mapping of human normal purified hepatocytes: personal epigenome variation and genome–epigenome correlation

E Arai, F Miura, Y Totoki, S Yamashita, Y Tian, M Gotoh, H Ojima, ...

Epigenomics 10 (7), 955-979  2018

ADAM9 is over‐expressed in human ovarian clear cell carcinomas and suppresses cisplatin‐induced cell death

M Ueno, T Shiomi, S Mochizuki, M Chijiiwa, M Shimoda, Y Kanai, ...

Cancer science 109 (2), 471-482  2018

ADAM9 is over‐expressed in human ovarian clear cell carcinomas and suppresses cisplatin‐induced cell death

M Ueno, T Shiomi, S Mochizuki, M Chijiiwa, M Shimoda, Y Kanai, ...

Cancer science 109 (2), 471-482  2018

ADAM9 is over‐expressed in human ovarian clear cell carcinomas and suppresses cisplatin‐induced cell death

M Ueno, T Shiomi, S Mochizuki, M Chijiiwa, M Shimoda, Y Kanai, ...

Cancer science 109 (2), 471-482  2018

511 IDENTIFICATION OF CYP2A6 GENE RELATED TO INVASIVE BLADDER CARCINOGENESIS

K Kanemoto, K Fukuta, K Yamada, N Kawai, K Tozawa, Y Kanai, ...

JOURNAL OF UROLOGY 200 (3), e208-e208  2018

511 IDENTIFICATION OF CYP2A6 GENE RELATED TO INVASIVE BLADDER CARCINOGENESIS

K Kanemoto, K Fukuta, K Yamada, N Kawai, K Tozawa, Y Kanai, ...

JOURNAL OF UROLOGY 200 (3), e208-e208  2018

511 IDENTIFICATION OF CYP2A6 GENE RELATED TO INVASIVE BLADDER CARCINOGENESIS

K Kanemoto, K Fukuta, K Yamada, N Kawai, K Tozawa, Y Kanai, ...

JOURNAL OF UROLOGY 200 (3), e208-e208  2018

Feasibility of methylome analysis using small amounts of genomic DNA from formalin‐fixed paraffin‐embedded tissue

K Ohara, E Arai, Y Takahashi, Y Fukamachi, N Ito, AM Maeshima, ...

Pathology international 68 (11), 633-635  2018

SPECIFIC PREDICTION OF DUODENAL TUMOR USING DEMOGRAPHIC AND ENDOSCOPIC CHARACTERISTICS: AN AGE-AND SEX-MATCHED CASE-CONTROL STUDY

H Suzuki, J Matsuzaki, M Shimoda, H Mori, S Fukuhara, Y Kanai, T Kanai

Gastroenterology 154 (6), S664-S665  2018

SPECIFIC PREDICTION OF DUODENAL TUMOR USING DEMOGRAPHIC AND ENDOSCOPIC CHARACTERISTICS: AN AGE-AND SEX-MATCHED CASE-CONTROL STUDY

H Suzuki, J Matsuzaki, M Shimoda, H Mori, S Fukuhara, Y Kanai, T Kanai

Gastroenterology 154 (6), S664-S665  2018

SPECIFIC PREDICTION OF DUODENAL TUMOR USING DEMOGRAPHIC AND ENDOSCOPIC CHARACTERISTICS: AN AGE-AND SEX-MATCHED CASE-CONTROL STUDY

H Suzuki, J Matsuzaki, M Shimoda, H Mori, S Fukuhara, Y Kanai, T Kanai

Gastroenterology 154 (6), S664-S665  2018

SPECIFIC PREDICTION OF DUODENAL TUMOR USING DEMOGRAPHIC AND ENDOSCOPIC CHARACTERISTICS: AN AGE-AND SEX-MATCHED CASE-CONTROL STUDY

H Suzuki, J Matsuzaki, M Shimoda, H Mori, S Fukuhara, Y Kanai, T Kanai

Gastroenterology 154 (6), S664-S665  2018

Somatic mutations in IFN-γ-Signal molecules in human uterine leiomyosarcoma

T Hayashi, T Ichimura, M Kasai, K Sano, S Tonegawa, Y Kanai, ...

 2018

Somatic mutations in IFN-γ-Signal molecules in human uterine leiomyosarcoma

T Hayashi, T Ichimura, M Kasai, K Sano, S Tonegawa, Y Kanai, ...

 2018