Papers - KANAI Yae

Epigenome mapping of human normal purified hepatocytes: personal epigenome variation and genome-epigenome correlation.

Arai E, Miura F, Totoki Y, Yamashita S, Tian Y, Gotoh M, Ojima H, Nakagawa H, Takahashi Y, Nakamura H, Hama N, Kato M, Kimura H, Suzuki Y, Ito T, Shibata T, Kanai Y.

Epigenomics (Epigenomics)  10 ( 7 ) 955 - 979 2018

Research paper (scientific journal), Single Work,  ISSN  17501911

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© 2018 Yae Kanai. Aim: The aim of this study was to reveal the epigenome landscape of human normal hepatocytes. Materials & methods: Cells purified from partial hepatectomy specimens of Japanese patients were subjected to whole-genome bisulfite sequencing using postbisulfite adaptor tagging, chromatin immunoprecipitation sequencing, RNA sequencing and whole-genome sequencing. Results: CHG and CHH methylations were inversely associated with gene expression. Histone modification profiles of personal differentially methylated regions (pDMRs) differed considerably among samples. pDMRs were observed around the transcription start sites of genes whose expression is reportedly regulated by CpG methylation. pDMRs were frequently observed in the vicinity of single-nucleotide variations and insertions/deletions. Conclusion: Genetic variations may induce epigenetic variations, generating individual differences in the phenotypes of normal hepatocytes through variations in expression.

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511 IDENTIFICATION OF CYP2A6 GENE RELATED TO INVASIVE BLADDER CARCINOGENESIS

K Kanemoto, K Fukuta, K Yamada, N Kawai, K Tozawa, Y Kanai, ...

JOURNAL OF UROLOGY 200 (3), e208-e208  2018

SPECIFIC PREDICTION OF DUODENAL TUMOR USING DEMOGRAPHIC AND ENDOSCOPIC CHARACTERISTICS: AN AGE-AND SEX-MATCHED CASE-CONTROL STUDY

H Suzuki, J Matsuzaki, M Shimoda, H Mori, S Fukuhara, Y Kanai, T Kanai

Gastroenterology 154 (6), S664-S665  2018

SPECIFIC PREDICTION OF DUODENAL TUMOR USING DEMOGRAPHIC AND ENDOSCOPIC CHARACTERISTICS: AN AGE-AND SEX-MATCHED CASE-CONTROL STUDY

H Suzuki, J Matsuzaki, M Shimoda, H Mori, S Fukuhara, Y Kanai, T Kanai

Gastroenterology 154 (6), S664-S665  2018

SPECIFIC PREDICTION OF DUODENAL TUMOR USING DEMOGRAPHIC AND ENDOSCOPIC CHARACTERISTICS: AN AGE-AND SEX-MATCHED CASE-CONTROL STUDY

H Suzuki, J Matsuzaki, M Shimoda, H Mori, S Fukuhara, Y Kanai, T Kanai

Gastroenterology 154 (6), S664-S665  2018

SPECIFIC PREDICTION OF DUODENAL TUMOR USING DEMOGRAPHIC AND ENDOSCOPIC CHARACTERISTICS: AN AGE-AND SEX-MATCHED CASE-CONTROL STUDY

H Suzuki, J Matsuzaki, M Shimoda, H Mori, S Fukuhara, Y Kanai, T Kanai

Gastroenterology 154 (6), S664-S665  2018

Somatic mutations in IFN-γ-Signal molecules in human uterine leiomyosarcoma

T Hayashi, T Ichimura, M Kasai, K Sano, S Tonegawa, Y Kanai, ...

 2018

Somatic mutations in IFN-γ-Signal molecules in human uterine leiomyosarcoma

T Hayashi, T Ichimura, M Kasai, K Sano, S Tonegawa, Y Kanai, ...

 2018

Somatic mutations in IFN-γ-Signal molecules in human uterine leiomyosarcoma

T Hayashi, T Ichimura, M Kasai, K Sano, S Tonegawa, Y Kanai, ...

 2018

Somatic mutations in IFN-γ-Signal molecules in human uterine leiomyosarcoma

T Hayashi, T Ichimura, M Kasai, K Sano, S Tonegawa, Y Kanai, ...

 2018

Risk estimation for hepatocellular carcinoma by DNA methylation analysis using high performance liquid chromatography

E Sunamura, T Yotani, F Arai, Y Tian, A Skeda, H Ojima, T Yoshida, ...

CANCER SCIENCE 109, 243-244  2018

Risk estimation for hepatocellular carcinoma by DNA methylation analysis using high performance liquid chromatography

E Sunamura, T Yotani, F Arai, Y Tian, A Skeda, H Ojima, T Yoshida, ...

CANCER SCIENCE 109, 243-244  2018

Risk estimation for hepatocellular carcinoma by DNA methylation analysis using high performance liquid chromatography

E Sunamura, T Yotani, F Arai, Y Tian, A Skeda, H Ojima, T Yoshida, ...

CANCER SCIENCE 109, 243-244  2018

Risk estimation for hepatocellular carcinoma by DNA methylation analysis using high performance liquid chromatography

E Sunamura, T Yotani, F Arai, Y Tian, A Skeda, H Ojima, T Yoshida, ...

CANCER SCIENCE 109, 243-244  2018

Patient Background and Responses in Providing Informed Consent for the National Cancer Center Biobank Project.

T Yamane, S Yamagami, N Yamashita, T Yoshida, K Tobinai, Y Kanai, ...

CANCER SCIENCE 109, 789-789  2018

Patient Background and Responses in Providing Informed Consent for the National Cancer Center Biobank Project.

T Yamane, S Yamagami, N Yamashita, T Yoshida, K Tobinai, Y Kanai, ...

CANCER SCIENCE 109, 789-789  2018

Patient Background and Responses in Providing Informed Consent for the National Cancer Center Biobank Project.

T Yamane, S Yamagami, N Yamashita, T Yoshida, K Tobinai, Y Kanai, ...

CANCER SCIENCE 109, 789-789  2018

Patient Background and Responses in Providing Informed Consent for the National Cancer Center Biobank Project.

T Yamane, S Yamagami, N Yamashita, T Yoshida, K Tobinai, Y Kanai, ...

CANCER SCIENCE 109, 789-789  2018

Novel method for DNA methylation analysis using high‐performance liquid chromatography and its clinical application

T Yotani, Y Yamada, E Arai, Y Tian, M Gotoh, M Komiyama, H Fujimoto, ...

Cancer science 109 (5), 1690-1700  2018

Novel method for DNA methylation analysis using high‐performance liquid chromatography and its clinical application

T Yotani, Y Yamada, E Arai, Y Tian, M Gotoh, M Komiyama, H Fujimoto, ...

Cancer science 109 (5), 1690-1700  2018