Papers - KANAI Yae

Human amniotic fluid stem cells have a unique potential to accelerate cutaneous wound healing with reduced fibrotic scarring like a fetus

Fukutake M., Ochiai D., Masuda H., Abe Y., Sato Y., Otani T., Sakai S., Aramaki-Hattori N., Shimoda M., Matsumoto T., Miyakoshi K., Kanai Y., Kishi K., Tanaka M.

Human Cell (Human Cell)  32 ( 1 ) 51 - 63 2019.01

Joint Work,  ISSN  09147470

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© 2018, Japan Human Cell Society and Springer Japan KK, part of Springer Nature. Adult wound healing can result in fibrotic scarring (FS) characterized by excess expression of myofibroblasts and increased type I/type III collagen expression. In contrast, fetal wound healing results in complete regeneration without FS, and the mechanism remains unclear. Amniotic fluid cells could contribute to scar-free wound healing, but the effects of human amniotic fluid cells are not well characterized. Here, we determined the effect of human amniotic fluid stem cells (hAFS) on FS during wound healing. Human amniotic fluid was obtained by amniocentesis at 15–17 weeks of gestation. CD117-positive cells were isolated and defined as hAFS. hAFS (1 × 10 6 ) suspended in PBS or cell-free PBS were injected around wounds created in the dorsal region of BALB/c mice. Wound size was macroscopically measured, and re-epithelialization in the epidermis, granulation tissue area in the dermis and collagen contents in the regenerated wound were histologically analyzed. The ability of hAFS to engraft in the wound was assessed by tracking hAFS labeled with PKH-26. hAFS fulfilled the minimal criteria for mesen

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Primary Peritoneal Low-grade Serous Carcinoma in a Patient with Lynch Syndrome: A Case Report

Makiuchi S., Yoshida H., Ishikawa M., Kojima N., Kanai Y., Kato T.

International Journal of Gynecological Pathology (International Journal of Gynecological Pathology)  39 ( 4 ) 327 - 332 2019

Joint Work,  ISSN  02771691

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Copyright © 2019 The Author(s). Lynch syndrome (LS) is an autosomal dominant disease caused by a germline mutation in DNA mismatch repair genes which increases the risk of several cancers such as endometrial and colorectal cancers. However, there are only a few reports of peritoneal malignancies in patients with LS. Herein, we report the first case of a primary peritoneal lowgrade serous carcinoma in a woman with LS and provide a literature review of peritoneal malignancies in patients with LS. The patient was a 72-yr-old gravid 2 para 2 Japanese woman with a germline mutation in MLH1. She had a history of colon cancer and endometrial cancer and was treated with total hysterectomy and bilateral salpingo-oophorectomy 14 yr ago. During the follow-up, peritoneal nodules were detected by abdominal computed tomography which were surgically resected. Pathologic examination revealed a low-grade serous carcinoma with cells positive for BerEP4, MOC31, CEA, and WT-1 and negative for BAP1, PAX8, MLH1, and PMS2, by immunohistochemistry. This case report and literature review show that peritoneal low-grade serous carcinoma can occur in patients with LS and that LS-related cancers usually prece

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Prognosis method for renal cell cancer

Y Kanai, E Arai, Y Nemoto, T Yotani

US Patent App. 15/756,812  2019

Prognosis method for renal cell cancer

Y Kanai, E Arai, Y Nemoto, T Yotani

US Patent App. 15/756,812  2019

Prognosis method for renal cell cancer

Y Kanai, E Arai, Y Nemoto, T Yotani

US Patent App. 15/756,812  2019

Prognosis method for renal cell cancer

Y Kanai, E Arai, Y Nemoto, T Yotani

US Patent App. 15/756,812  2019

Physiological Functions of LMP2/β1i in the Female Reproductive System

T Hayashi, K Sano, T Ichimura, G Gur, H Aburatani, Y Kanai, D Zharhary, ...

 2019

Physiological Functions of LMP2/β1i in the Female Reproductive System

T Hayashi, K Sano, T Ichimura, G Gur, H Aburatani, Y Kanai, D Zharhary, ...

 2019

Assessment of homologous recombination deficiency phenotype in breast cancers in adolescents and young adults in the clinical setting

T Watanabe, T Honda, H Totsuka, M Yoshida, M Tanioka, K Shiraishi, ...

 2019

Assessment of homologous recombination deficiency phenotype in breast cancers in adolescents and young adults in the clinical setting

T Watanabe, T Honda, H Totsuka, M Yoshida, M Tanioka, K Shiraishi, ...

 2019

Assessment of homologous recombination deficiency phenotype in breast cancers in adolescents and young adults in the clinical setting

T Watanabe, T Honda, H Totsuka, M Yoshida, M Tanioka, K Shiraishi, ...

 2019

Assessment of homologous recombination deficiency phenotype in breast cancers in adolescents and young adults in the clinical setting

T Watanabe, T Honda, H Totsuka, M Yoshida, M Tanioka, K Shiraishi, ...

 2019

乳頭状腎細胞癌

Arai Eri, KANAI Yae

病理と臨床臨時増刊号「肉眼病理　症例から探る鑑別のヒント」 37   253 - 255 2019

Accepted

集合管癌

Arai Eri, KANAI Yae

病理と臨床臨時増刊号「肉眼病理　症例から探る鑑別のヒント」 37   259 - 261 2019

Accepted

精巣胚細胞腫瘍の転移

Arai Eri, KANAI Yae

病理と臨床臨時増刊号「肉眼病理　症例から探る鑑別のヒント」 37   299 - 301 2019

Accepted

精巣胚細胞腫瘍

Arai Eri, KANAI Yae

病理と臨床臨時増刊号「肉眼病理　症例から探る鑑別のヒント」 37   294 - 296 2019

Accepted

精巣悪性リンパ腫

Arai Eri, KANAI Yae

病理と臨床臨時増刊号「肉眼病理　症例から探る鑑別のヒント」 37   297 - 298 2019

Accepted

嫌色素細胞がんとオンコサイトーマ

Arai Eri, KANAI Yae

病理と臨床臨時増刊号「肉眼病理　症例から探る鑑別のヒント」 37   256 - 258 2019

Accepted

The functional analysis of miR-200 family in renal cell carcinoma

Gotoh Masahiro, Arai Eri, Yoshida Teruhiko, Kanai Yae

CANCER SCIENCE 109   446 - 446 2018.12

Joint Work,  ISSN  1349-7006

Accumulation of tumor associated macrophages by miR-27b regulated CSF1 in renal cell carcinoma

Matsumoto Daichi, Tanaka Keiyu, Arai Eri, Kanai Yae, Ohta Shigeki, Kawakami Yutaka

CANCER SCIENCE 109   1192 - 1192 2018.12

Joint Work,  ISSN  1349-7006