論文 - 佐藤　泰憲

A new formula for predicting liver metastasis in patients with colorectal cancer: Immunohistochemical analysis of a large series of 439 surgically resected cases

Ochiai, Hiroki, Nakanishi, Yukihiro, Fukasawa, Yuri, Sato, Yasunori, Yoshimura, Kimio, Moriya, Yoshihiro, Kanai, Yae, Watanabe, Masahiko, Hasegawa, Hirotoshi, Kitagawa, Yuko, Kitajima, Masaki, Hirohashi, Setsuo

ONCOLOGY 75 （ 1-2 ） 32 - 41 2008年

研究論文（学術雑誌）, 共著,  ISSN  0030-2414

• Access to Document (DOI)

Association of SNPs in ABCC1 gene with overall survival in stage IV pancreatic adenocarcinoma patients treated with gemcitabine monotherapy

10. Ueno, H., Sato, Y., Okusaka, T., Furuse, J., Ishii, H., Sekine, A., Nakamura, Y., Kaniwa, N., Sawada, J., Saijo, N

J Clin Oncol  2008年

研究論文（国際会議プロシーディングス）, 共著, 査読有り

Genetic polymorphisms correlate with overall survival (OS) in advanced non-small cell lung cancer (NSCLC) treated with carboplatin (CBDCA) and paclitaxel (PTX)

9. Yamamoto, N., Sato, Y., Tamura, T., Kunitoh, H., Ohe, Y., Katori, N., Sawada, J., Sekine, A., Nakamura, Y., Saijo, N

J Clin Oncol  2008年

研究論文（国際会議プロシーディングス）, 共著, 査読有り

Modified multifactor dimensionality reduction method for detecting gene -gene interactions for an unbalanced sample-size

Sato, Y., Hirose M, Ando H, Suganami H, Hamada C, Yoshimura I, Yoshida T.

ISCB27 2007年

査読有り

The confidence interval of allelic odds ratios under the Hardy-Weinberg disequilibrium

Sato, Yasunori, Suganami, Hideki, Hamada, Chikuma, Yoshimura, Isao, Sakamoto, Hiromi, Yoshida, Teruhiko, Yoshimura, Kimio

JOURNAL OF HUMAN GENETICS 51 （ 9 ） 772 - 780 2006年09月

研究論文（学術雑誌）, 共著,  ISSN  1434-5161

• Access to Document (DOI)

The confidence interval of allelic odds ratios under the Hardy-Weinberg disequilibrium

Sato, Y., Suganami H, Hamada C, Yoshimura I, Sakamoto H, Yoshida T, Yoshimura K

XXIII International Biometric Conference 2006年

研究論文（国際会議プロシーディングス）, 査読有り

Statistical consideration of the identifications for disease-associated SNPs in Whole-genome association study

3. Sato, Y., Suganami, H., Hamada, C., Niki, N., Yoshimura, I., Yoshida, T

26th Annual conference of international society for clinical biostatistics 2005年

研究論文（国際会議プロシーディングス）, 査読有り

Multiple imputation method for SNP typing data in linkage disequilibrium mapping of polygenic traits

2. Sato, Y., Ando, H., Suganami, H., Hamada, C., Yoshimura, I., Yoshida, T. and Yoshimura K

Joint statistical meeting 2005 2005年

研究論文（国際会議プロシーディングス）, 査読有り

Designing a multistage, SNP-based, genome screen for common diseases

Sato, Y., Suganami, H., Hamada, C., Yoshimura, I., Yoshida, T. and Yoshimura, K.

J Hum Genet 49 （ 12 ） 669 - 76 2004年

研究論文（学術雑誌）, 共著,  ISSN  1434-5161

　概要を見る

A genome-wide linkage equilibrium mapping is an emerging strategy to identify risk-modifying genes for common diseases, despite unsettled controversies upon many aspects, including its premises, designs, marker choices and cost benefits. One large-scale attempt in Japan aims to identify disease-associated single nucleotide polymorphisms (SNPs) for five diseases among the Japanese population: Alzheimer's disease, gastric cancer, diabetes, hypertension and asthma. Following an initial screening of c.a. 100,000 SNPs on 940 subjects (five diseases x 188 patients) to select about 2,000 SNPs, we compared which subsequent screening design is more appropriate, and an additional one or two screens to further narrow down any disease-associated SNPs within a fixed total volume of 15,040,000 typings (2,000 SNPs x five diseases x 1,504 subjects, comprising 752 cases and 752 controls). We employed a Monte Carlo simulation to evaluate the probability of identifying truly disease-associated SNPs. The results suggest the single additional stage design (i.e., total two-stage design including the initial screening of 100,000 SNPs) was more practicable for the simple reason that the gain in probability is considered insufficient relative to an associated increase in study complexity in the three-stage design.

• Access to Document (DOI)

Two Step Sampling Design for SNP Screening Scheme in the Millennium Genome Project of Japan

1. Sato, Y., Suganami, H., Hamada, C., Yoshimura, I., Yoshida, T. and Yoshimura K

IBC 2004 XXIInd International Biometric Conference in parallel with ASC 2004 Australian Statistical Conference 2004年

研究論文（国際会議プロシーディングス）, 共著, 査読有り