研究者詳細 - 寺澤　悠理

論文 - 寺澤　悠理

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身体症状症と内受容感覚

寺澤悠理

精神科 40 2022年

CiNii Research

未来思考生成における感情的方向性

伊藤友一, 田仲祐登, 辻幸樹, 品川和志, 柴田みどり, 寺澤悠理, 梅田聡

日本認知心理学会発表論文集（日本認知心理学会） 2021 （ 0 ） 47 - 47 2022年

人の思考には時間(過去・未来)，感情(ポジティブ・ネガティブ），社会的(自己・他者)などの多様な方向性がある。先行研究は心拍誘発電位(HEP; heartbeat-evoked potential)を用いて，過去あるいは未来思考時の感情的方向が身体からの求心性信号を受けて規定されることを明らかにしている。しかし，感情的方向が思考生成のどの段階で決まるのかは明らかでない。本研究では，自己や他者の未来について思考する際の感情的方向性の生起時点を明らかにするため，脳波計測実験を行った。課題では，主語・時間・内容の3要素からなる文(例：私は／将来／試験に)を1要素ずつ呈示し，それに合わせて思考した上で，肯定あるいは否定的結末(例：自分が将来試験に受かるか否か)を自由に想像するよう参加者に求めた。結果，主語情報呈示時点のHEPで感情価による振幅の差が認められ，思考生成の最初期時点で身体からの求心性信号を受けて思考の感情的方向が規定されていることが明らかになった。

Temporal changes in attentional resources consumed by mind-wandering that precede awareness: An ERP study

Shinagawa K., Ito Y., Tsuji K., Tanaka Y., Odaka M., Shibata M., Terasawa Y., Umeda S.

Neuroimage: Reports （Neuroimage: Reports） 1 （ 4 ） 2021年12月

査読有り

A relationship between the awareness of mind-wandering (MW) and the disruption of MW because of external stimuli has previously been reported. Attention often fluctuates without external stimuli and such disruptions can spontaneously precede awareness of MW. To elucidate whether changes in attentional resources used by MW exist, we used event-related potentials (ERPs), focusing on the P300 (P3) ERP component as an index of attention to a task. Participants performed a simple task, in which they pressed a key in synchrony with continually presented tones. Moreover, they were asked to stop the response whenever they became aware of their MW. We analyzed the P3 induced by the tones before self-reports of MW using a state–space model that was used for analysis to detect changes over time. The results revealed that the mean amplitude of P3 increased significantly from the third to the second tone before the self-reports; no other clear increasing or decreasing tendencies were observed. We concluded that the attentional resources allocated to the main task returned, suggesting that such awareness requires a decrease in resources to task-unrelated thoughts. These findings highlight a transitional state related to awareness between the MW state and self-reports. Therefore, the state immediately before self-reports should not be defined as merely an MW state when using the self-caught method.

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Decreased activity in the reward network of chronic insomnia patients

Motomura Y., Katsunuma R., Ayabe N., Oba K., Terasawa Y., Kitamura S., Moriguchi Y., Hida A., Kamei Y., Mishima K.

Scientific Reports （Scientific Reports） 11 （ 1 ） 3600 2021年12月

共著, 査読有り

© 2021, The Author(s). In modern society, many people have insomnia. Chronic insomnia has been noted as a risk factor for depression. However, there are few functional imaging studies of the brain on affective functions in chronic insomnia. This study aimed to investigate brain activities induced by emotional stimuli in chronic insomnia patients. Fifteen patients with primary insomnia and 30 age and gender matched healthy controls participated in this study. Both groups were presented images of fearful, happy, and neutral expressions consciously and non-consciously while undergoing MRI to compare the activity in regions of the brain responsible for emotions. Conscious presentation of the Happy-Neutral contrast showed significantly lower activation in the right orbitofrontal cortex of patients compared to healthy controls. The Happy-Neutral contrast presented in a non-conscious manner resulted in significantly lower activation of the ventral striatum, right insula, putamen, orbitofrontal cortex and ventral tegmental area in patients compared to healthy controls. Our findings revealed that responsiveness to positive emotional stimuli were decreased in insomniac patients. Specifically, brain networks associated with rewards and processing positive emotions showed decreased responsiveness to happy emotions especially for non-conscious image. The magnitude of activity in these areas also correlated with severity of insomnia, even after controlling for depression scale scores. These findings suggest that insomnia induces an affective functional disorder through an underlying mechanism of decreased sensitivity in the regions of the brain responsible for emotions and rewards to positive emotional stimuli.

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総説安静時fMRIにおける動的機能結合の臨床応用

品川和志, 寺澤悠理, 梅田聡

BRAIN and NERVE （株式会社医学書院） 73 （ 11 ） 1267 - 1273 2021年11月

ISSN 18816096

The conventional analysis assumes a constant mental state during scanning and assesses the strength of functional connectivity as the average of the entire fMRI data. However, it is suggested that even at rest, functional connectivity may change with time, and the conventional analysis has not been able to fully evaluate its properties. To overcome this limitation, many studies propose an index called dynamic functional connectivity (dFC) or time-varying functional connectivity (TVFC) or the chronnectome. This article reviews the significance and methods of dFC, examples of its application in clinical studies, and its limitations. Finally, we discuss its potential for clinical application.

増大特集脳とからだ Ⅲ.中枢と末梢の相互作用内受容感覚と感情認識-基礎的概念から臨床研究への展開

寺澤悠理

生体の科学（株式会社医学書院） 72 （ 5 ） 457 - 460 2021年10月

ISSN 03709531

増大特集脳とからだ Ⅲ.中枢と末梢の相互作用覚醒下手術による感情認識に関わる島皮質機能の解明-脳とこころの脳神経外科学・認知神経科学の融合型研究

本村和也, 寺澤悠理, 梅田聡

生体の科学（株式会社医学書院） 72 （ 5 ） 461 - 463 2021年10月

ISSN 03709531

Products With High Purchase Frequency Require Greater Inhibitory Control: An Event-Related Potential Study

Tsuji K., Shibata M., Terasawa Y., Umeda S.

Frontiers in Psychology （Frontiers in Psychology） 12 727040 2021年09月

査読有り, ISSN 1664-1078

One’s past behavior influences their present behavior. The effects of such response history have often been tested using response inhibition tasks. Since previous studies have highlighted the effect of immediate action history formed directly before the subsequent response in a laboratory environment, we aimed to elucidate the longer-term effects of response history, using repetitive and habitual consumer behavior in daily life as the response history. We used event-related potentials recorded in a Go/No-go task to investigate brain activity related to inhibitory control, hypothesizing that stimuli with a high frequency of choice in everyday life would elicit stronger inhibition-related activity, that is, the No-go-N2 component. Participants were asked to evaluate the frequency of purchase and use of some products, such as food and drink or social networking services (SNS) in everyday situations. Images of each product were assigned as stimuli in the Go and No-go trials according to the frequency of choice. The results showed that frequently purchased No-go stimuli yielded a larger amplitude of the No-go-N2 component and a negative shift between 200 and 300ms after the presentation of No-go stimuli. The results suggest that frequently chosen products evoke stronger inhibition conflicts and require greater cognitive control to withhold a response. Our findings showed that repeated purchase behavior in daily life forms a response history and has a long-term influence on the inhibition of even simple approaching behaviors, such as button pressing.

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The effect of haptic stimulation simulating heartbeats on the regulation of physiological responses and prosocial behavior under stress: The influence of interoceptive accuracy

Xu M., Tachibana T., Suzuki N., Hoshino E., Terasawa Y., Miki N., Minagawa Y.

Biological Psychology （Biological Psychology） 164 108172 2021年09月

査読有り, ISSN 03010511

Research has discovered the modulatory effect of peripheral stimulation simulating altered bodily signals on emotion. Whether such an effect varies depending on one's interoceptive accuracy (IAc) remains unclear. Therefore, we provided haptic stimulation simulating participants’ slowed-down heartbeats or no stimulation while they engaged in socially stressful tasks to examine whether participants reacted differently depending on their IAc. Results showed that haptic stimulation exhibited the opposite effect on participants with different levels of IAc for both heart rate and heart rate variability (HRV). When receiving the stimulation, participants with higher IAc showed less increased heart rate and more elevated HF than participants with lower IAc. In contrast, in the absence of stimulation, an opposite pattern of response depending on participants’ IAc was observed. The modulatory effect of stimuli and IAc on prosocial behavior was not significant. Individual differences in IAc were shown to affect how one perceives/responds to altered bodily signals.

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Effects of interoceptive accuracy in autonomic responses to external stimuli based on cardiac rhythm

Tanaka Y., Terasawa Y., Umeda S.

PLoS ONE （PLoS ONE） 16 （ 8 August ） e0256914 2021年08月

査読有り

Interoceptive accuracy is an index of the ability to perceive an individual's internal bodily state, including heartbeat and respiration. Individual differences in interoceptive accuracy influence emotional recognition through autonomic nervous activity. However, the precise mechanism by which interoceptive accuracy affects autonomic reactivity remains unclear. Here, we investigated how cardiac reactivity induced by a non-affective external rhythm differed among individuals, using a heartbeat counting task. Because individuals with poor interoceptive accuracy cannot distinguish an external rhythm from their cardiac cycles, it has been hypothesized that the interoceptive effect on heart rate works differently in individuals with good interoceptive accuracy and those with poor interoceptive accuracy. Study participants observed a visual or auditory stimulus presented at a rhythm similar to the participants' resting heart rates. The stimulus rhythm was gradually changed from that of their resting heart rate, and we recorded electrocardiographs while participants were exposed to the stimuli. Individuals with good interoceptive accuracy exhibited a deceleration in heart rate when the rhythm of the auditory stimulus changed. In contrast, in the group with poor interoceptive accuracy, the heart rate decreased only when the stimulus became faster. They were unable to distinguish the rhythm of their own heartbeat from that of the external rhythm; therefore, we propose that such individuals recognize the stimuli at the pace of their heart rate. Individuals with good interoceptive accuracy were able to distinguish their heart rates from the external rhythm. A modality difference was not observed in this study, which suggests that both visual and auditory stimuli help mimic heart rate. These results may provide physiological evidence that autonomic reactivity influences the perception of the internal bodily state, and that interoception and the autonomic state interact to some degree.

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自己と他者に関する未来思考におけるポジティブバイアスの違い

伊藤友一, 田仲祐登, 辻幸樹, 品川和志, 柴田みどり, 寺澤悠理, 梅田聡

日本認知心理学会発表論文集（日本認知心理学会） 2020 （ 0 ） 41 - 41 2021年03月

<p>人の思考には時間（過去/未来），感情（ネガティブ/ポジティブ），自己/他者など様々な方向性があり，特に未来に関する思考のポジティブバイアスが多くの先行研究で示されている。しかしながら，それらは個人的な未来の想像を主な対象としており，他者の未来の想像でも同様のバイアスが生じるのかは明らかでない。本研究では，「私（彼）は／将来／試験に…」のように文手がかりを，主語，時間，内容の順に呈示し，自己または他者の未来について思考するよう参加者に求めた。このとき思考の感情価は参加者が任意に決定した。ポジティブ思考数がネガティブ思考数より多いことを以てポジティブバイアスとし，その傾向が自己に関する思考と他者に関する思考との間で異なるかどうか検討した。その結果，他者の遠い未来を想像するときにより強いポジティブバイアスが生じており，自己-他者間で異なる感情処理がなされていることが示唆された。</p><p></p>

Aberrant Interoceptive Accuracy in Patients with Schizophrenia Performing a Heartbeat Counting Task

Koreki A., Funayama M., Terasawa Y., Onaya M., Mimura M.

Schizophrenia Bulletin Open （Schizophrenia Bulletin Open） 2 （ 1 ） 2021年01月

Introduction: Although self-disturbances and emotional disturbances are common in schizophrenia, there is no integrated understanding to explain these symptoms. Interoception has a crucial role in the development of self and emotion, and interoceptive abnormality could lead to such symptoms. Methods: We compared interoceptive accuracy between controls and patients with schizophrenia. Forty-two patients and 30 healthy controls were recruited and their interoceptive accuracy was assessed using a heartbeat counting task. Participants were instructed to count the number of times they felt their own heartbeat during various measurement periods. Interoceptive accuracy was calculated based on the discrepancy between the number of reported and actual heartbeats during the measurement period. Participants also performed a time estimation task and were instructed to count the number of seconds there were during the same period. Time accuracy was calculated in a similar manner to that for the heartbeat. Participants also completed a questionnaire regarding interoception to assess their subjective experiences. Results: Interoceptive accuracy was significantly lower among patients with schizophrenia than in healthy controls (P =. 017), even after controlling for age, sex, time accuracy, anxiety, depression, educational level, and heart rate (HR). In addition, patients' positive and negative symptoms were significantly associated with their HR-adjusted interoceptive accuracy, especially hallucination. The discrepancy between HR-adjusted interoceptive accuracy and the score of the questionnaire was significantly associated with positive symptoms, especially delusion, but not negative symptoms. Discussion: These findings suggest that patients with schizophrenia have aberrant interoception. Aberrant interoception in schizophrenia could be a novel therapeutic target in future.

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The role of the thalamus in the neurological mechanism of subjective sleepiness: An fmri study

Motomura Y., Kitamura S., Nakazaki K., Oba K., Katsunuma R., Terasawa Y., Hida A., Moriguchi Y., Mishima K.

Nature and Science of Sleep （Nature and Science of Sleep） 13 899 - 921 2021年

査読有り, ISSN 1179-1608

Purpose: The thalamus, the region that forms the attentional network and transmits external sensory signals to the entire brain, is important for sleepiness. Herein, we examined the relationship between activity in the thalamus-seed brain network and subjective sleepiness. Materials and Methods: Fifteen healthy male participants underwent an experiment comprising a baseline evaluation and two successive interventions, a 9-day sleep extension followed by 1-night total sleep deprivation. Pre-and post-intervention tests included the Karolinska sleepiness scale and neuroimaging for arterial spin labeling and functional connectivity. We examined the association between subjective sleepiness and the functional magnetic resonance imaging indices. Results: The functional connectivity between the left or right thalamus and various brain regions displayed a significant negative association with subjective sleepiness, and the functional connectivity between the left and right thalamus displayed a significant positive association with subjective sleepiness. The graph theory analysis indicated that the number of positive functional connectivity related to the thalamus showed a strong negative association with subjective sleepiness, and conversely, the number of negative functional connectivity showed a positive association with subjective sleepiness. Arterial spin labeling analysis indicated that the blood flow in both the left and right thalami was significantly negatively associated with subjective sleepiness. Functional connectivity between the anterior cingulate cortex and salience network areas of the left insular cortex, and that between the anterior and posterior cingulate cortices showed a strong positive and negative association with subjective sleepiness, respectively. Conclusion: Subjective sleepiness and the thalamic-cortical network dynamics are strongly related, indicating the application of graph theory to study sleepiness and consciousness. These results also demonstrate that resting functional connectivity largely reflects the “state” of the subject, suggesting that the control of sleep and conscious states is essential when using functional magnetic resonance imaging indices as biomarkers.

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Effects of interoceptive training on decision making, anxiety, and somatic symptoms

Sugawara A., Terasawa Y., Katsunuma R., Sekiguchi A.

BioPsychoSocial Medicine （BioPsychoSocial Medicine） 14 （ 1 ） 2020年03月

共著, 査読有り, ISSN 17510759

© 2020 The Author(s). Background: Interoception is the perception of afferent information that arises from any point within the body. Individual differences in interoception have been associated with affective processing and decision-making processing. The somatic marker hypothesis summarizes the potential effects of interoception on decision-making processes. According to this theory, individuals with interoceptive dysfunction exhibit disadvantageous decision making. Recently, enhancement of interoceptive accuracy, an element of interoception assessed by objective decision-making tasks, has been demonstrated using biofeedback. Garfinkle et al. developed an interoceptive training task, modified from the heartbeat perception task, which enhanced interoceptive accuracy and reduced anxiety symptoms. The purpose of this study was to determine the effects of interoceptive training on decision-making processes. Based on improvements in interoceptive accuracy, we hypothesized that decision-making scores would change in a manner indicative of increased rationality. Methods: This longitudinal interventional study was performed with interoceptive training. Before and after the intervention, interoceptive accuracy and rationality of decision-making processes were assessed using a heartbeat perception task and rational decision-making tasks, respectively. Fourteen healthy volunteers (nine women; mean age, 21.9 ± 4.5 years) participated. The analysis included data from 12 participants. To detect individual differences in the effects of interoceptive accuracy on rationality of decision making, correlation analysis was conducted on change ratios of the indices of interoceptive accuracy and rationality of decision making. Results: Interoceptive training resulted in significant enhancement of interoceptive accuracy scores and significant reductions in somatic symptom and state anxiety scores. In contrast, interoceptive training did not cause significant changes in decision-making indices. There was a significant positive correlation between change ratios of indices of interoceptive accuracy and rationality of decision making. Conclusions: The results suggested a causal relation between interoception and rationality of decision making. These findings will enhance the understanding of mechanisms underlying alterations of decision-making related to psychotherapy by focusing on interoception. Trial registration: Trial registration number: UMIN000037548.

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Neural and clinical changes of cognitive behavioural therapy versus talking control in patients with major depression: A study protocol for a randomised clinical trial

Katayama N., Nakagawa A., Abe T., Kurata C., Sasaki Y., Mitsuda D., Nakao S., Mizuno S., Ozawa M., Nakagawa Y., Ishikawa N., Umeda S., Terasawa Y., Tabuchi H., Kikuchi T., Mimura M.

BMJ Open （BMJ Open） 10 （ 2 ） 2020年02月

査読有り, ISSN 20446055

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. While major depression causes substantial distress and impairment for affected individuals and society, the effectiveness of cognitive behavioural therapy (CBT) in treating the condition has been established. However, the therapeutic mechanism underlying the efficacy of CBT remains unknown. This study aimed to describe a protocol for a randomised controlled trial that will measure the CBT-induced clinical and neural changes in patients with non-psychotic major depression. Methods and analysis The current study is a 16-week assessor-blinded, randomised, parallel-group trial with a 12-month follow-up as part of usual depression care at an outpatient clinic. Patients aged 20-69 years with major depressive disorder will be randomly assigned to receive either CBT in addition to their usual treatment or talking control in addition to their usual treatment for 16 weeks. The primary outcome is the functional changes in the brain areas that have been associated with future-oriented thinking at 16 weeks; secondary outcomes include changes in functional brain connectivity, severity and changes in the scores of objective and subjective clinical depression symptoms, proportion of responders and remitters and quality of life. The intention-to-treat analysis will be used. Ethics and dissemination All protocols and the informed consent form are compliant with the Ethics Guideline for Clinical Research (Japanese Ministry of Health, Labour and Welfare). Ethical Review Committees at the Keio University School of Medicine have approved the study protocol (version 3, 11 September 2017). We will disseminate research findings to scientific and general audiences through national and international conference presentations as well as lay summaries to the general public, including mental health consumer and publications in international peer-reviewed psychiatry and brain imaging journals. Trial registration number UMIN Clinical Trials Registry (UMIN000018155); Pre-results.

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Altered functional connectivity associated with time discounting in chronic pain

Wakaizumi K., Jabakhanji R., Ihara N., Kosugi S., Terasawa Y., Morisaki H., Ogaki M., Baliki M.

Scientific Reports （Scientific Reports） 9 （ 1 ） 8154 - 8154 2019年12月

研究論文（学術雑誌）, 共著, 査読有り, ISSN 20452322

© 2019, The Author(s). Chronic pain (CP) is a global problem extensively associated with an unhealthy lifestyle. Time discounting (TD), a tendency to assign less value to future gains than to present gains, is an indicator of the unhealthy behaviors. While, recent neuroimaging studies implied overlapping neuro mechanisms underlying CP and TD, little is known about the specific relationship between CP and TD in behavior or neuroscience. As such, we investigated the association of TD with behavioral measures in CP and resting-state brain functional network in both CP patients and healthy subjects. Behaviorally, TD showed a significant correlation with meaningfulness in healthy subjects, whereas TD in patients only correlated with pain intensity. We identified a specific network including medial and dorsolateral prefrontal cortex (PFC) in default mode network (DMN) associated with TD in healthy subjects that showed significant indirect mediation effect of meaningfulness on TD. In contrast, TD in patients was correlated with functional connectivity between dorsolateral PFC (DLPFC) and temporal lobe that mediated the effect of pain intensity on TD in patients. These results imply that TD is modulated by pain intensity in CP patients, and the brain function associated to TD is shifted from a medial to lateral representation within the frontal regions.

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Thalamic volume, resting-state activity, and their association with the efficacy of electroconvulsive therapy

Takamiya A., Kishimoto T., Liang K., Terasawa Y., Nishikata S., Tarumi R., Sawada K., Kurokawa S., Hirano J., Yamagata B., Mimura M.

Journal of Psychiatric Research （Journal of Psychiatric Research） 117 135 - 141 2019年10月

共著, 査読有り, ISSN 00223956

© 2019 Electroconvulsive therapy (ECT) is the most effective antidepressant treatment. Biological predictors of clinical outcome to ECT are valuable. We aimed to examine multimodal magnetic resonance imaging (MRI) data that correlates to the efficacy of ECT. Structural and resting-state functional MRI data were acquired from 46 individuals (25 depressed individuals who received ECT, and 21 healthy controls). Whole-brain grey matter volume (GMV) and fractional amplitude of low frequency fluctuations (fALFF) were investigated to identify brain regions associated with post-ECT Hamilton Depression Rating Scale (HAM-D) total scores. GMV and fALFF values were compared with those in healthy controls using analysis of covariance (ANCOVA). Remission was defined by HAM-D ≤7. A multiple regression analysis revealed that pretreatment smaller GMV in the left thalamus was associated with worse response to ECT (i.e. higher post-ECT HAM-D). Pretreatment higher fALFF in the right anterior insula, and lower fALFF in the left thalamus and the cerebellum were associated with worse outcomes. The left thalamus was identified in both GMV and fALFF analyses. Nonremitters showed significantly smaller thalamic GMV compared to remitters and controls. We found that pretreatment thalamic volume and resting-state activity were associated with the efficacy of ECT. Our results highlight the importance of the thalamus as a possible biological predictor and its role in the underlying mechanisms of ECT action.

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Affective and temporal orientation of thoughts: Electrophysiological evidence

Ito Y., Shibata M., Tanaka Y., Terasawa Y., Umeda S.

Brain Research （Brain Research） 1719 148 - 156 2019年09月

共著, 査読有り, ISSN 00068993

© 2019 Elsevier B.V. The factors that determine the content and valence of spontaneous thoughts have not yet been clarified. In this study, we focused on the effects of bodily states and depression and anxiety traits. Participants performed a past/future thinking task in which three-part sentences including temporal cues were presented in a sequential pattern, for example “in the near future/dreams/will come true”. We measured heartbeat-evoked potentials (HEPs)to assess affective processing, and event-related potentials (ERPs)to assess temporal processing of thoughts that emerged when the temporal cue words were presented. The HEPs predicted thought valence irrespective of personality traits. Larger N400 ERPs were observed in response to past-oriented than to future-oriented words in participants with higher levels of depression, whereas the opposite was the case in participants with higher social anxiety. Our data suggest that afferent signals modulate affective thought-orientations as triggers, and that individuals with depression and anxiety have sensitivity toward temporal information at the neural level.

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Automated inference of cognitive performance by fusing multimodal information acquired by smartphone

Hamatani T., Ochiai K., Inagaki A., Yamamoto N., Fukazawa Y., Kimoto M., Kiriu K., Kaminishi K., Ota J., Terasawa Y., Okimura T., Maeda T.

UbiComp/ISWC 2019- - Adjunct Proceedings of the 2019 ACM International Joint Conference on Pervasive and Ubiquitous Computing and Proceedings of the 2019 ACM International Symposium on Wearable Computers （UbiComp/ISWC 2019- - Adjunct Proceedings of the 2019 ACM International Joint Conference on Pervasive and Ubiquitous Computing and Proceedings of the 2019 ACM International Symposium on Wearable Computers） 921 - 928 2019年09月

研究論文（国際会議プロシーディングス）, 共著, 査読有り, ISSN 9781450368698

© 2019 Association for Computing Machinery. Recognizing human cognitive performance is important for preserving working efficiency and preventing human error. This paper presents a method for estimating cognitive performance by leveraging multiple information available in a smartphone. The method employs the Go-NoGo task to measure cognitive performance, and fuses contextual and behavioral features to identify the level of performance. It was confirmed that the proposed method could recognize whether cognitive performance was high or low with an average accuracy of 71%, even when only referring to inertial sensor logs. Combining sensing modalities improved the accuracy up to 74%.

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Anterior insular cortex stimulation and its effects on emotion recognition

Motomura K., Terasawa Y., Natsume A., Iijima K., Chalise L., Sugiura J., Yamamoto H., Koyama K., Wakabayashi T., Umeda S.

Brain Structure and Function （Brain Structure and Function） 224 （ 6 ） 2167 - 2181 2019年07月

共著, 査読有り, ISSN 18632653

© 2019, Springer-Verlag GmbH Germany, part of Springer Nature. With the objective to investigate the role of the insula in recognizing emotion, we performed direct electrical stimulation over the anterior insular cortex during awake surgery while simultaneously delivering an emotional sensitivity task. We registered 18 consecutive patients with brain tumors associated with the insular lobe, who were undergoing tumor resection. An emotional sensitivity task was employed to measure the patients’ ability to recognize emotions from facial expressions before, during, and after awake surgery. Furthermore, we performed voxel-based lesion symptom mapping (VLSM) to identify the association between relevant brain lesions and emotion recognition. When we performed direct electrical stimulation over the anterior insular cortex during awake surgery, the results showed that the ability to recognize anger was significantly enhanced with the presence of anterior insular stimulation (p < 0.05). Comparing the performance in the emotional sensitivity task before and after surgery, the performance in the anger condition became worse (p < 0.01), but became better in the sadness condition after surgery (p < 0.01). In the case of anger recognition, lower scores in the correct response index were associated with lesions involving the left insula in the VLSM study. Direct electrical stimulation over the anterior insular cortex enhanced anger recognition in patients with insular tumors. In contrast, accuracy of anger recognition was significantly reduced, and sadness was improved, when the performance of emotional sensitivity was compared pre- and post-surgery. Our findings suggest that the insular cortex is involved in changes in emotion recognition, including anger and sadness recognition by modulating arousal level that is closely connected with interoception.

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