研究者詳細 - 寺澤　悠理

論文 - 寺澤　悠理

分割表示 78 件中 1 - 20 件目／全件表示 >>

Paradoxical somatic information processing for interoception and anxiety in alexithymia

Yuri Terasawa, Kentaro Oba, Yuki Motomura, Ruri Katsunuma, Hiroki Murakami, Yoshiya Moriguchi

European Journal of Neuroscience （Wiley） 54 （ 11 ） 8052 - 8068 2021年11月

研究論文（学術雑誌）, 共著, 査読有り, ISSN 0953816X

The concept of alexithymia has garnered much attention in an attempt to understand the psychological mechanisms underlying the experience of feeling an emotion. In this study, we aimed to understand how the interoceptive processing in an emotional context relates to problems of alexithymia in recognizing self-emotions. Therefore, we prepared experimental conditions to induce emotional awareness based on interoceptive information. As such, we asked participants to be aware of interoception under an anxiety-generating situation anticipating pain, having them evaluate their subjective anxiety levels in this context. High alexithymia participants showed attenuated functional connectivity within their ‘interoception network’, particularly between the insula and the somatosensory areas when they focused on interoception. In contrast, they had enhanced functional connectivity between these regions when they focused on their anxiety about pain. Although access to somatic information is supposed to be more strongly activated while attending to interoception in the context of primary sensory processing, high alexithymia individuals were biased as this process was activated when they felt emotions, suggesting they recognize primitive and unprocessed bodily sensations as emotions. The paradoxical somatic information processing may reflect their brain function pathology for feeling emotions and their difficulty with context-dependent emotional control.

Access to Document (DOI)

Effects of insular resection on interactions between cardiac interoception and emotion recognition

Terasawa Y., Motomura K., Natsume A., Iijima K., Chalise L., Sugiura J., Yamamoto H., Koyama K., Wakabayashi T., Umeda S.

Cortex （Cortex） 137 271 - 281 2021年04月

査読有り, ISSN 00109452

The insular cortex is considered an important region for feeling emotions through interoception. Most studies that report the role of the insula in integrating interoception and emotion have used neuroimaging techniques such as functional magnetic resonance imaging (fMRI); however, there are limited neuropsychological studies. The effects of insular lesions on emotion and interoception have not been suitably investigated. In this study, we examined the role of the insular cortex in cardiac interoception and recognizing emotions from facial expressions by comparing them pre- and post-operatively in patients with glial tumors or brain metastases associated with the insular lobe. Although no significant difference in interoceptive accuracy was observed between the two phases, there were significant associations between the changes in interoceptive accuracy and sensitivity to expressions of anger and happiness. An increased error rate in the heartbeat counting task in the post-operation phase was associated with a decreased accuracy in recognizing anger and happiness. Since most patients had left insula lesions, generalizability of the findings to patients with right lesions is a future subject. To the best of our knowledge, this is the first study to examine the change in interoception and emotion after insular resection in humans. The study results indicate that removal of the insula affects the recognition of emotions such as anger and happiness through interoceptive processing.

Access to Document (DOI)

Interoceptive training impacts the neural circuit of the anterior insula cortex

Sugawara A., Katsunuma R., Terasawa Y., Sekiguchi A.

Translational Psychiatry 14 （ 1 ） 206 2024年12月

Interoception is the perception of afferent information that arises from anywhere and everywhere within the body. Recently, interoceptive accuracy could be enhanced by cognitive training. Given that the anterior insula cortex (AIC) is a key node of interoception, we hypothesized that resting functional connectivity (RSFC) from AIC was involved in an effect of interoceptive training. To address this issue, we conducted a longitudinal intervention study using interoceptive training and obtained RSFC using fMRI before and after the intervention. A heartbeat perception task evaluated interoceptive accuracy. Twenty-two healthy volunteers (15 females, age 19.9 ± 2.0 years) participated. After the intervention, interoceptive accuracy was enhanced, and anxiety levels and somatic symptoms were reduced. Also, RSFC from AIC to the dorsolateral prefrontal cortex (DLPFC), superior marginal gyrus (SMG), anterior cingulate cortex (ACC), and brain stem, including nucleus tractus solitarius (NTS) were enhanced, and those from AIC to the visual cortex (VC) were decreased according to enhanced interoceptive accuracy. The neural circuit of AIC, ACC, and NTS is involved in the bottom-up process of interoception. The neural circuit of AIC, DLPFC, and SMG is involved in the top-down process of interoception, which was thought to represent the cognitive control of emotion. The findings provided a better understanding of neural underpinnings of the effect of interoceptive training on somatic symptoms and anxiety levels by enhancing both bottom-up and top-down processes of interoception, which has a potential contribution to the structure of psychotherapies based on the neural mechanism of psychosomatics.

Access to Document (DOI)

The body mirroring thought: The relationship between thought transitions and fluctuations in autonomic nervous activity mediated by interoception.

Sakuragi M, Shinagawa K, Terasawa Y, Umeda S

Consciousness and cognition 125 103770 2024年10月

ISSN 1053-8100

Access to Document (DOI)

内受容感覚と神経心理学

寺澤悠理

神経心理学（日本神経心理学会） 40 （ 1 ） 12 - 19 2024年03月

ISSN 09111085

内受容感覚は，主に身体内部の状態についての感覚である．内臓の活動やそれに関連する感覚や痛みなど，身体内部状態の変化がこの感覚の対象である．この20年ほどの間に急激に認知され，様々な心の機能の根底に存在する要素の一つとして注目を集めるようになってきた．本稿では，内受容感覚の定義，顕在化や動的調整のシステム，神経基盤，評価方法について概説する．

Altered sense of agency in schizophrenia: the aberrant effect of cardiac interoceptive signals.

Koreki A, Terasawa Y, Nuruki A, Oi H, Critchley H, Yogarajah M, Onaya M

Frontiers in psychiatry 15 1441585 2024年

ISSN 1664-0640

Access to Document (DOI)

A case with prosopagnosia and difficulties in recognizing facial expressions caused by fresh cerebral infarction of the right occipital face area

澤木優治, 寺澤悠理, 梅田聡, 本村和也, 山本裕泰, 山本正彦, 山内崇弘

Japanese Journal of Stroke （一般社団法人日本脳卒中学会） 46 （ 6 ） 443 - 452 2024年

ISSN 09120726

広範な陳旧性の左後頭葉梗塞に加え，右後頭葉外側の新規脳梗塞にて熟知相貌に対する相貌失認を呈した症例を報告した．症例は70歳代の右利き男性であった．熟知相貌および表情の認知に困難さを認め，全般性注意機能，処理速度の低下がみられた．全般性認知機能および相貌認知以外の視覚認知機能は保たれていた．相貌失認は左右半球の後頭顔領域，紡錘状回顔領域，前部側頭葉の脳内ネットワークに機能不全が生じたことで発現したと考えられた．老若および性別の判断に関する相貌認知は保たれていた．拡散テンソルトラクトグラフィにより，右半球の下前頭後頭束や下縦束の白質線維が温存されたことが要因であると考えられた．さらに，全般性注意機能および処理速度の向上を図る認知リハビリテーション介入によって，表情認知の改善が得られる可能性が示唆された．

Effect of subconscious changes in bodily response on thought shifting in people with accurate interoception

Sakuragi M., Shinagawa K., Terasawa Y., Umeda S.

Scientific Reports （Scientific Reports） 13 （ 1 ） 16651 2023年12月

Our thought states shift from one state to another from moment to moment. The relationship between the thought shifting and bodily responses is yet to be directly examined. This exploratory study examined the influence of cardiovascular reactivity and interoception—sensing an internal bodily state—on the shifting of thought states. Participants (N = 100, 70 women) completed two tasks: the heartbeat counting task (HCT) and the vigilance task (VT). We assessed their interoceptive accuracy through their performance on the HCT. The VT was a simple sustained attention task in which participants pressed a key when the target stimulus appeared and were asked to report their thoughts. We presented subliminal vibration stimuli to induce alterations in heart rate (i.e., vibration block). Results showed that participants with higher interoceptive accuracy reported more continuation of self-referential thought (about past episodes and future plans regarding themselves) during the vibration block than did those with lower interoceptive accuracy. These results suggest that individuals with higher interoceptive accuracy are more likely to be influenced by their subliminal bodily response, resulting in divergent attention from the task and intermittent self-referential thought.

Access to Document (DOI)

特集アロスタシス-ホメオスタシスを超えて内受容感覚とアロスタシスからみた精神疾患

是木明宏, 寺澤悠理

BRAIN and NERVE （株式会社医学書院） 75 （ 11 ） 1251 - 1257 2023年11月

ISSN 18816096

特集アロスタシス-ホメオスタシスを超えて内受容感覚を媒介とするアロスタシスと感情

寺澤悠理, 是木明宏

BRAIN and NERVE （株式会社医学書院） 75 （ 11 ） 1245 - 1250 2023年11月

ISSN 18816096

Modulation of heartbeat-evoked potential and cardiac cycle effect by auditory stimuli

Tanaka Y., Ito Y., Terasawa Y., Umeda S.

Biological Psychology （Biological Psychology） 182 108637 2023年09月

ISSN 03010511

Interoception has been proposed as a factor that influences various psychological processes (Khalsa et al., 2018). Afferent signals from the cardiovascular system vary across cardiac cycle phases. Heartbeat-evoked potentials (HEP) and event-related potentials (ERP) were measured to examine whether interoceptive signals differed between cardiac cycle phases. Simultaneously, participants performed an auditory oddball task in which the timing of the presenting stimulus was synchronized with the heartbeat. Pure tones were presented at 10 ms (late diastole condition), 200 ms (systole condition), or 500 ms after the R wave (diastole condition). Greater HEP amplitudes were observed when the tone was presented during diastole than during systole or late diastole. ERP showed the same tendency: a greater amplitude was observed during diastole than systole or late diastole. These results suggest that the processing of interoception reflected by HEP and exteroception reflected by ERP share attentional resources when both stimuli coincide. When the tone was presented during systole, attention to the internal state decreased compared with when the tone was presented during diastole, and attention was distributed to both exteroception and interoception. Our study suggests that HEP may be considered an indication of a relative amount of resources to process the interoception.

Access to Document (DOI)

Functional connectivity changes between frontopolar cortex and nucleus accumbens following cognitive behavioral therapy in major depression: A randomized clinical trial

Katayama N., Nakagawa A., Umeda S., Terasawa Y., Shinagawa K., Kikuchi T., Tabuchi H., Abe T., Mimura M.

Psychiatry Research - Neuroimaging （Psychiatry Research - Neuroimaging） 332 111643 2023年07月

ISSN 09254927

Cognitive behavioral therapy (CBT) is a psychotherapy that challenges distorted cognitions; however, the neural mechanisms that underpin CBT remain unclear. Hence, we aimed to assess the treatment-related resting-state functional connectivity (rsFC) changes in the brain regions associated with future thinking and the associations between rsFC changes and clinical improvements. Thirty-eight adult patients with MDD were randomly assigned with equal likelihood to receive 16-week individual CBT or talking control with a 12-month follow-up period. We evaluated the rsFC changes in the frontal regions, nucleus accumbens, amygdala, and limbic structures key to the depression pathophysiology and future thinking with 2 × 2 mixed ANOVA interaction analysis. Pearson's correlation analysis with Bonferroni's correction was also performed to examine the associations with clinical symptoms, such as depression severity and automatic thoughts in follow-up evaluations. Treatment-specific changes include enhancement in frontopolar connectivity with the nucleus accumbens. An increased rsFC was associated with lower negative automatic thoughts postoperatively, together with lower depressive symptoms and higher positive automatic thoughts at follow-up. Conclusively, rsFC changes in the fronto-limbic neural control circuit after CBT, particularly between the frontal pole and nucleus accumbens, may be clinically meaningful functional changes related to the depression recovery process.

Access to Document (DOI)

The effect of cognitive behavioral therapy on future thinking in patients with major depressive disorder: A randomized controlled trial

Amano M., Katayama N., Umeda S., Terasawa Y., Tabuchi H., Kikuchi T., Abe T., Mimura M., Nakagawa A.

Frontiers in Psychiatry （Frontiers in Psychiatry） 14 997154 2023年01月

ISSN 1664-0640

Background: Pessimistic thinking about the future is one of the cardinal symptoms of major depression. Few studies have assessed changes in pessimistic thinking after undergoing cognitive behavioral therapy (CBT). A randomized clinical trial (RCT) was conducted with patients diagnosed with major depressive disorder (MDD) to determine whether receiving a course of CBT affects pessimistic future thinking using a future thinking task. Methods: Thirty-one patients with MDD were randomly assigned to either CBT (n = 16) or a talking control (TC) (n = 15) for a 16-week intervention. The main outcomes were the change in response time (RT) and the ratio of the responses for positive valence, measured by the future thinking task. Secondary outcomes included the GRID-Hamilton Depression Rating Scale, the Beck Depression Inventory-Second Edition (BDI-II), the Dysfunctional Attitude Scale (DAS), and the word fluency test (WFT). Results: Regarding the main outcomes, the CBT group showed reduced RT for the positive valence (within-group Cohen’s d = 0.7, p = 0.012) and negative valence (within-group Cohen’s d = 0.6, p = 0.03) in the distant future condition. The ratio of positive valence responses in both groups for all temporal conditions except for the distant past condition increased within group (distant future: CBT: Cohen’s d = 0.5, p = 0.04; TC: Cohen’s d = 0.8, p = 0.008; near future: CBT: Cohen’s d = 1.0, p < 0.001; TC: Cohen’s d = 1.1, p = 0.001; near past: CBT: Cohen’s d = 0.8, p = 0.005; TC: Cohen’s d = 1.0, p = 0.002). As for secondary outcomes, the CBT group showed greater improvement than the TC group regarding the need for social approval as measured by the DAS (p = 0.012). Conclusion: Patients with MDD who received CBT showed a reduced RT for the positive and negative valence in the distant future condition. RT in the future thinking task for depressed patients may be a potential objective measure for the CBT treatment process. Because the present RCT is positioned as a pilot RCT, a confirmatory trial with a larger number of patients is warranted to elucidate the CBT treatment process that influences future thinking. Clinical trial registration: https://center6.umin.ac.jp/cgi-open-bin/icdr_e/ctr_view.cgi?recptno=R000021028, identifier UMIN000018155.

Access to Document (DOI)

心拍誘発電位から見る内受容感覚と認知機能の関係性

田仲祐登, 寺澤悠理, 梅田聡

自律神経（日本自律神経学会） 60 （ 2 ） 92 - 96 2023年

ISSN 02889250

拍動や呼吸の速さ，胃の痛みなど，自律神経系を含む身体内部の状態は内受容感覚を通して知覚されている．近年，内受容感覚を測定する指標として，脳波における心拍誘発電位（Heartbeat-evoked potentials：HEP）が注目されている．HEPは心電図のR波を基準とした誘発電位であり，主観報告の必要のない，心臓からの求心性信号を反映している時間解像度の高い指標として，注意，感情，自己認識といった心的機能や，精神疾患と関係があることが報告されている．本研究ではHEPが有効な指標であることについて，さまざまな認知機能との関係性に焦点を当てながら概観する．

Word recall process and physiological activation in the tip-of-the-tongue state: Comparison of young and middle-aged groups

Kurosaki Y., Hashimoto R., Funayama M., Terasawa Y., Umeda S.

Consciousness and Cognition （Consciousness and Cognition） 106 103433 2022年11月

ISSN 10538100

To clarify the feeling of knowing a name but not being able to recall it, known as having a “tip-of-the-tongue” (TOT) experience, we proposed a TOT model consisting of three stages combining a face recognition model and autonomic sympathetic nerve activity. Since TOT increases with age, we compared two age groups: young (N = 27, M = 20.4 ± 1.5 years) and middle-aged (N = 29, M = 58.5 ± 8.0 years). Experiment 1 showed that successfully naming low-frequency common names increased the skin conductance response (SCR) value, and the time to reach the maximum SCR value was longer. Experiment 2 was a naming task for face photographs. The younger group showed higher SCR values during successfully naming, while the middle-aged group showed similar SCR values for successfully naming and experiencing TOT. Both groups had the longest time to reach maximum SCR in TOT. In this study, physiological arousal of TOT was not affected by aging.

Access to Document (DOI)

感情認識と島

寺澤悠理

神経心理学（日本神経心理学会） 38 （ 3 ） 209 - 215 2022年09月

ISSN 09111085

島皮質は内受容感覚を介して感情を感じるために重要な領域と考えられている．島皮質が内受容感覚と感情の統合に果たす役割について報告した研究の多くは，脳機能画像研究法によるもので，神経心理学研究は限られている．本研究では，島皮質に関連する腫瘍を有する患者において，摘出手術前と術後に心拍カウント課題と表情認識課題を実施し，感情認識における島皮質の役割について検討した．その結果，手術前後の心拍カウント課題の成績の変化と怒りや喜びの表情に対する感度の変化に有意な関連が見られた．本研究の結果，島周辺領域の切除によって，内受容感覚を介して怒りや幸福などの感情の認識に影響が生じることが示された．

Passive Way of Measuring QOL/Well-Being Levels Using Smartphone Log

Yao W., Kaminishi K., Yamamoto N., Hamatani T., Yamada Y., Kawada T., Hiyama S., Okimura T., Terasawa Y., Maeda T., Mimura M., Ota J.

Frontiers in Digital Health （Frontiers in Digital Health） 4 780566 2022年03月

Research on mental health states involves paying increasing attention to changes in daily life. Researchers have attempted to understand such daily changes by relying on self-reporting through frequent assessment using devices (smartphones); however, they are mostly focused on a single aspect of mental health. Assessing the mental health of a person from various perspectives may help in the primary prevention of mental illness and the comprehensive measurement of mental health. In this study, we used users' smartphone logs to build a model to estimate whether the scores on three types of questionnaires related to quality of life and well-being would increase compared to the previous week (fluctuation model) and whether they would be higher compared to the average for that user (interval model). Sixteen participants completed three questionnaires once per week, and their smartphone logs were recorded over the same period. Based on the results, estimation models were built, and the F-score ranged from 0.739 to 0.818. We also analyzed the features that the estimation model emphasized. Information related to “physical activity,” such as acceleration and tilt of the smartphone, and “environment,” such as atmospheric pressure and illumination, were given more weight in the estimation than information related to “cyber activity,” such as usage of smartphone applications. In particular, in the Positive and Negative Affect Schedule (PANAS), 9 out of 10 top features in the fluctuation model and 7 out of 10 top features in the interval model were related to activities in the physical world, suggesting that short-term mood may be particularly heavily influenced by subjective activities in the human physical world.

Access to Document (DOI)

立位バランストレーニングにおける視覚フィードバックがストレスに対する身体反応に及ぼす影響

出分康太郎, 上西康平, 山本直樹, 濱谷尚志, 荒川大輝, 檜山聡, 沖村宰, 寺澤悠理, 前田貴記, 太田順

精密工学会学術講演会講演論文集（公益社団法人精密工学会） 2022S （ 0 ） 574 - 575 2022年03月

立位時の姿勢情報をフィードバックするトレーニングは，身体所有感の獲得を補助しメンタルヘルスを向上させる可能性がある．本研究では，モニタで提示された目標位置に足圧中心を移動・保持するトレーニングを行った．トレーニングが立位バランスに与える影響を調べるのに加え，ストレス負荷がかかる課題に対する身体的な反応が，トレーニングの有無によってどのように変化するかを比較した．

Cognitive behavioral therapy effects on frontopolar cortex function during future thinking in major depressive disorder: A randomized clinical trial

Katayama N., Nakagawa A., Umeda S., Terasawa Y., Abe T., Kurata C., Sasaki Y., Mitsuda D., Kikuchi T., Tabuchi H., Mimura M.

Journal of Affective Disorders （Journal of Affective Disorders） 298 （ Pt A ） 644 - 655 2022年02月

ISSN 01650327

Background: Despite the importance of Beck's theoretical cognitive model of psychopathology, the neural mechanisms underlying future thinking in cognitive behavioral therapy (CBT) remain elusive. Recent neuroimaging studies have shown that the function of the frontopolar cortex (Brodmann area 10 [BA10]) is associated with future thinking. We hypothesized that, compared with unstructured psychotherapy (talking control: TC), CBT may involve different neural responses in BA10 associated with future thinking. Methods: This randomized clinical trial included 38 adult patients with moderate-to-severe major depressive disorder who underwent up to 16 weeks of CBT or TC with a 6-month follow-up period. We evaluated changes in BA10 activation during distant future thinking using functional magnetic resonance imaging with a future-thinking task. We assessed frontal neurocognitive function and clinical symptoms at baseline and post-treatment. Depression severity and automatic thoughts were assessed at the 6-month follow-up. Results: We found decreased activation in the frontopolar cortex during distant future thinking after CBT (t = 3.00, df=15, p = 0.009) and no changes after TC. Further, the reduction in BA10 activity significantly correlated with changes in frontal cognitive function after the treatment (r = 0.48, p = 0.007), and in positive automatic thought after 6 months of treatments (r = 0.39; p = 0.03). Limitations: Relatively small sample size and homogenous clinical profile could limit the generalizability. Patients received pharmacotherapy including antidepressant. Conclusions: CBT appears to improve frontopolar cortex function during future thinking in a manner distinct from TC. Larger clinical trials are necessary to provide firm evidence whether BA10 activity may serve as a neuro-marker for monitoring successful depression treatment with CBT.

Access to Document (DOI)

「脳」と「身体」と「行動変容」

関口敦, 菅原彩子, 勝沼るり, 寺澤悠理

心身医学（一般社団法人日本心身医学会） 62 （ 3 ） 225 - 229 2022年

ISSN 03850307

近年，心身相関の認知科学的な背景の1つとして「内受容感覚」が注目されてきた．内受容感覚とは，呼吸・心拍・腸管の動きなど身体内部の生理的な状態に対する感覚を指し，ホメオスタシスの維持に必要な機能と考えられている．内受容感覚の障害はさまざまなストレス関連疾患で認められており，「脳」と「身体」をつなぐメカニズムでもある．Damasioらの研究により，リスク行動を選択する際には危険を認知する前に交感神経反応が亢進していることが確認されていることから，「身体」と「行動」の関連も説明可能で，内受容感覚は行動を規定する因子とも考えられる．本稿では，「脳」と「身体」と「行動」の相互連関の因果関係を示した研究として，われわれが行った内受容感覚訓練実験を紹介する．内受容感覚を強化する認知訓練により，不安および身体症状の軽減，行動の変化を観測し，将来的なストレス関連疾患治療への応用が期待された．

　前のページ - 次のページ　

寺澤 悠理

論文 - 寺澤 悠理

寺澤　悠理

論文 - 寺澤　悠理