KEIO RESEARCHERS INFORMATION SYSTEM

Career 【 Display / hide 】

Career 【 Display / hide 】

• 2016.01

  -

  2025.03

  Helmholtz Zentrum Munich, Institute of Epigenetics and Stem cells, Post doctoral fellow

• 2025.04

  -

  Present

  慶応義塾大学 医学部 坂口光洋記念, エピジェネティクス・幹細胞生物学講座, 准教授

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Life Science / Molecular biology (Epigenetics, Embryogenesis, Chromatin)

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• DNA replication

• Epigenetics

• Chromatin

• Histone modification

• Totipotency

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Papers 【 Display / hide 】

Papers 【 Display / hide 】

• The establishment of nuclear organization in mouse embryos is orchestrated by multiple epigenetic pathways

  Mrinmoy Pal, Tamas Schauer, Adam Burton, Tsunetoshi Nakatani, Federico Pecori, Alicia Hernández-Giménez, Iliya Nadelson, Marc A. Marti-Renom, Maria-Elena Torres-Padilla

  Cell (Elsevier BV)   2025.04

  ISSN  0092-8674

  • Access to Document (DOI)

• RIF1 controls replication timing in early mouse embryos independently of lamina-associated nuclear organization

  Tsunetoshi Nakatani, Tamas Schauer, Mrinmoy Pal, Andreas Ettinger, Luis Altamirano-Pacheco, Julia Zorn, David M. Gilbert, Maria-Elena Torres-Padilla

  Developmental Cell (Elsevier BV)   2025.04

  Lead author,  ISSN  1534-5807

  • Access to Document (DOI)

• Dynamics of replication timing during mammalian development

  Tsunetoshi Nakatani

  Trends in Genetics (Elsevier BV)   2025.03

  Lead author, Corresponding author,  ISSN  0168-9525

  • Access to Document (DOI)

• The transcription factor SRF regulates MERVL retrotransposons and gene expression during zygotic genome activation

  Clara Hermant, Carlos Michel Mourra-Díaz, Marlies E. Oomen, Luis Altamirano-Pacheco, Mrinmoy Pal, Tsunetoshi Nakatani, Maria-Elena Torres-Padilla

  Genes & Development (Cold Spring Harbor Laboratory)  39 ( 7-8 ) 490 - 509 2025.02

  ISSN  0890-9369

  　View Summary

  The regulatory circuitry of cell-specific transcriptional programs is thought to be influenced by transposable elements (TEs), whereby TEs serve as raw material for the diversification and genome-wide distribution of genetic elements that containcis-regulatory activity. However, the transcriptional activators of TEs in relevant physiological contexts are largely unknown. Here, we undertook an evolutionary approach to identify regulators of two main families of MERVL, a major regulator of transcription during early mouse development. Using a combination of phyloregulatory, transcriptomic, and loss-of-function approaches, we demonstrate that SRF is a novel regulator of MERVL and embryonic transcription during zygotic genome activation. By resolving the phylogenetic history of two major MERVL families, we delineate the evolutionary acquisition of SRF and DUX binding sites and show that the acquisition of the SRF site precedes that of DUX. SRF contributes to embryonic transcription through the regulation of MERVLs, which in turn serve as promoters for host genes. Our work identifies new transcriptional regulators and TEs that shape the gene expression programs in early embryos and highlights the process of TE domestication via the sequential acquisition of transcription factor binding sites and coevolution with the host.

  • Access to Document (DOI)

• An atlas of transcription initiation reveals regulatory principles of gene and transposable element expression in early mammalian development

  Marlies E. Oomen, Diego Rodriguez-Terrones, Mayuko Kurome, Valeri Zakhartchenko, Lorenza Mottes, Kilian Simmet, Camille Noll, Tsunetoshi Nakatani, Carlos Michel Mourra-Diaz, Irene Aksoy, Pierre Savatier, Jonathan Göke, Eckhard Wolf, Henrik Kaessmann, Maria-Elena Torres-Padilla

  Cell (Elsevier BV)  188 ( 4 ) 1156 - 1174.e20 2025.02

  ISSN  0092-8674

  • Access to Document (DOI)

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Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• ADVANCED EPIGENETICS AND STEM CELL BIOLOGY

  2025

• EPIGENETICS AND STEM CELL BIOLOGY: PRACTICE

  2025

• EPIGENETICS AND STEM CELL BIOLOGY: SEMINAR

  2025

• EPIGENETICS AND STEM CELL BIOLOGY

  2025