論文 - 青山 和正
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Ezh2 loss propagates hypermethylation at T cell differentiation-regulating genes to promote leukemic transformation
Wang, C., Oshima, M., Sato, D., Matsui, H., Kubota, S., Aoyama, K., Nakajima-Takagi, Y., Koide, S., Matsubayashi, J., Mochizuki-Kashio, M., Nakano-Yokomizo, T., Bai, J., Nagao, T., Kanai, A., Iwama, A. and Sashida, G.
J Clin Invest 128 ( 9 ) 3872 - 3886 2018年08月
研究論文(学術雑誌), 査読有り, ISSN 0021-9738
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Dual inhibition of EZH1/2 breaks the quiescence of leukemia stem cells in acute myeloid leukemia
S. Fujita, D. Honma, N. Adachi, K. Araki, E. Takamatsu, T. Katsumoto, K. Yamagata, K. Akashi, K. Aoyama, A. Iwama, I. Kitabayashi
Leukemia (Nature Publishing Group) 32 ( 4 ) 855 - 864 2018年04月
研究論文(学術雑誌), 査読有り, ISSN 1476-5551
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Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies
Tanaka, T., Nakajima-Takagi, Y., Aoyama, K., Tara, S., Oshima, M., Saraya, A., Koide, S., Si, S., Manabe, I., Sanada, M., Nakayama, M., Masuko, M., Sone, H., Koseki, H. and Iwama, A.
J Exp Med 214 ( 10 ) 2901 - 2913 2017年10月
研究論文(学術雑誌), 筆頭著者, 査読有り, ISSN 0022-1007
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Enhancement of TGF-β-induced Smad3 activity by c-Abl-mediated tyrosine phosphorylation of its coactivator SKI-interacting protein (SKIP)
Kuki, K., Yamaguchi, N., Iwasawa, S., Takakura, Y., Aoyama, K., Yuki, R., Nakayama, Y., Kuga, T., Hashimoto, Y., Tomonaga, T. and Yamaguchi, N.
Biochem Biophys Res Commun 490 ( 3 ) 1045 - 1051 2017年08月
研究論文(学術雑誌), 査読有り, ISSN 0006-291x
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Dual Inhibition of EZH2 and EZH1 Sensitizes PRC2-Dependent Tumors to Proteasome Inhibition
Rizq, O., Mimura, N., Oshima, M., Saraya, A., Koide, S., Kato, Y., Aoyama, K., Nakajima-Takagi, Y., Wang, C., Chiba, T., Ma, A., Jin, J., Iseki, T., Nakaseko, C. and Iwama, A.
Clin Cancer Res 23 ( 16 ) 4817 - 4830 2017年08月
研究論文(学術雑誌), 査読有り, ISSN 1078-0432
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Hmga2 collaborates with JAK2V617F in the development of myeloproliferative neoplasms
Ueda, K., Ikeda, K., Ikezoe, T., Harada-Shirado, K., Ogawa, K., Hashimoto, Y., Sano, T., Ohkawara, H., Kimura, S., Shichishima-Nakamura, A., Nakamura, Y., Shikama, Y., Mori, T., Mason, P. J., Bessler, M., Morishita, S., Komatsu, N., Shide, K., Shimoda, K., Koide, S., Aoyama, K., Oshima, M., Iwama, A. and Takeishi, Y.
Blood Adv 1 ( 15 ) 1001 - 1015 2017年06月
研究論文(学術雑誌), 査読有り, ISSN 2473-9529
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Histone lysine methyltransferase G9a is a novel epigenetic target for the treatment of hepatocellular carcinoma
Yokoyama, M., Chiba, T., Zen, Y., Oshima, M., Kusakabe, Y., Noguchi, Y., Yuki, K., Koide, S., Tara, S., Saraya, A., Aoyama, K., Mimura, N., Miyagi, S., Inoue, M., Wakamatsu, T., Saito, T., Ogasawara, S., Suzuki, E., Ooka, Y., Tawada, A., Otsuka, M., Miyazaki, M., Yokosuka, O. and Iwama, A.
Oncotarget 8 ( 13 ) 21315 - 21326 2017年03月
研究論文(学術雑誌), 査読有り, ISSN 1949-2553
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Protective role for lipid modifications of Src-family kinases against chromosome missegregation
Honda, T., Soeda, S., Tsuda, K., Yamaguchi, C., Aoyama, K., Morinaga, T., Yuki, R., Nakayama, Y., Yamaguchi, N. and Yamaguchi, N.
Sci Rep 6 38751 - 38751 2016年12月
研究論文(学術雑誌), 査読有り, ISSN 2045-2322
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Possible role of intragenic DNA hypermethylation in gene silencing of the tumor suppressor gene NR4A3 in acute myeloid leukemia.
Ryo Shimizu, Tomoya Muto, Kazumasa Aoyama, Kwangmin Choi, Masahiro Takeuchi, Shuhei Koide, Nagisa Hasegawa, Yusuke Isshiki, Emi Togasaki, Chika Kawajiri-Manako, Yuhei Nagao, Shokichi Tsukamoto, Shio Sakai, Yusuke Takeda, Naoya Mimura, Chikako Ohwada, Emiko Sakaida, Tohru Iseki, Daniel T Starczynowski, Atsushi Iwama, Koutaro Yokote, Chiaki Nakaseko
Leukemia research 50 85 - 94 2016年11月
研究論文(学術雑誌), 査読有り
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Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes
Koide, S., Oshima, M., Takubo, K., Yamazaki, S., Nitta, E., Saraya, A., Aoyama, K., Kato, Y., Miyagi, S., Nakajima-Takagi, Y., Chiba, T., Matsui, H., Arai, F., Suzuki, Y., Kimura, H., Nakauchi, H., Suda, T., Shinkai, Y. and Iwama, A.
Blood 128 ( 5 ) 638 - 49 2016年08月
研究論文(学術雑誌), 査読有り, ISSN 0006-4971
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The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition.
Goro Sashida, Changshan Wang, Takahisa Tomioka, Motohiko Oshima, Kazumasa Aoyama, Akinori Kanai, Makiko Mochizuki-Kashio, Hironori Harada, Kazuya Shimoda, Atsushi Iwama
The Journal of experimental medicine 213 ( 8 ) 1459 - 77 2016年07月
研究論文(学術雑誌), 査読有り
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Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells
Si, S., Nakajima-Takagi, Y., Aoyama, K., Oshima, M., Saraya, A., Sugishita, H., Nakayama, M., Ishikura, T., Koseki, H. and Iwama, A.
PLoS One 11 ( 5 ) e0154561 2016年
研究論文(学術雑誌), 査読有り, ISSN 1932-6203
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c-Abl-mediated tyrosine phosphorylation of JunB is required for Adriamycin-induced expression of p21
Yamaguchi, N., Yuki, R., Kubota, S., Aoyama, K., Kuga, T., Hashimoto, Y., Tomonaga, T. and Yamaguchi, N.
Biochem J 471 ( 1 ) 67 - 77 2015年10月
研究論文(学術雑誌), 査読有り, ISSN 0264-6021
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Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner
Mochizuki-Kashio, M., Aoyama, K., Sashida, G., Oshima, M., Tomioka, T., Muto, T., Wang, C. and Iwama, A.
Blood 126 ( 10 ) 1172 - 83 2015年09月
研究論文(学術雑誌), 査読有り, ISSN 0006-4971
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Gene expression profiling of loss of TET2 and/or JAK2V617F mutant hematopoietic stem cells from mouse models of myeloproliferative neoplasms
Kameda, T., Shide, K., Yamaji, T., Kamiunten, A., Sekine, M., Hidaka, T., Kubuki, Y., Sashida, G., Aoyama, K., Yoshimitsu, M., Abe, H., Miike, T., Iwakiri, H., Tahara, Y., Yamamoto, S., Hasuike, S., Nagata, K., Iwama, A., Kitanaka, A. and Shimoda, K.
Genom Data 4 102 - 8 2015年06月
研究論文(学術雑誌), 査読有り, ISSN 2213-5960
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Overexpression of zinc-finger protein 777 (ZNF777) inhibits proliferation at low cell density through down-regulation of FAM129A
Yuki, R., Aoyama, K., Kubota, S., Yamaguchi, N., Kubota, S., Hasegawa, H., Morii, M., Huang, X., Liu, K., Williams, R., Fukuda, M. N. and Yamaguchi, N.
J Cell Biochem 116 ( 6 ) 954 - 68 2015年06月
研究論文(学術雑誌), 査読有り, ISSN 0730-2312
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Role for Tyrosine Phosphorylation of A-kinase Anchoring Protein 8 (AKAP8) in Its Dissociation from Chromatin and the Nuclear Matrix.
Sho Kubota, Mariko Morii, Ryuzaburo Yuki, Noritaka Yamaguchi, Hiromi Yamaguchi, Kazumasa Aoyama, Takahisa Kuga, Takeshi Tomonaga, Naoto Yamaguchi
The Journal of biological chemistry 290 ( 17 ) 10891 - 904 2015年04月
研究論文(学術雑誌), 査読有り
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c-Abl induces stabilization of histone deacetylase 1 (HDAC1) in a kinase activity-dependent manner
Aoyama, K., Yamaguchi, N., Yuki, R., Morii, M., Kubota, S., Hirata, K., Abe, K., Honda, T., Kuga, T., Hashimoto, Y., Tomonaga, T. and Yamaguchi, N.
Cell Biol Int 39 ( 4 ) 446 - 56 2015年04月
研究論文(学術雑誌), 筆頭著者, 査読有り, ISSN 1065-6995
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Loss of TET2 has dual roles in murine myeloproliferative neoplasms: disease sustainer and disease accelerator
Kameda, T., Shide, K., Yamaji, T., Kamiunten, A., Sekine, M., Taniguchi, Y., Hidaka, T., Kubuki, Y., Shimoda, H., Marutsuka, K., Sashida, G., Aoyama, K., Yoshimitsu, M., Harada, T., Abe, H., Miike, T., Iwakiri, H., Tahara, Y., Sueta, M., Yamamoto, S., Hasuike, S., Nagata, K., Iwama, A., Kitanaka, A. and Shimoda, K.
Blood 125 ( 2 ) 304 - 15 2015年01月
研究論文(学術雑誌), 査読有り, ISSN 0006-4971
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Activation of the prereplication complex is blocked by mimosine through reactive oxygen species-activated ataxia telangiectasia mutated (ATM) protein without DNA damage
Kubota, S., Fukumoto, Y., Ishibashi, K., Soeda, S., Kubota, S., Yuki, R., Nakayama, Y., Aoyama, K., Yamaguchi, N. and Yamaguchi, N.
J Biol Chem 289 ( 9 ) 5730 - 46 2014年02月
研究論文(学術雑誌), 査読有り, ISSN 0021-9258