SUZUKI Koichiro

写真a

Affiliation

Faculty of Pharmacy, Department of Pharmaceutical Sciences Division of Biochemistry ( Shiba-Kyoritsu )

Position

Research Associate/Assistant Professor/Instructor

Career 【 Display / hide 】

  • 2015.04
    -
    2018.03

    日本学術振興会特別研究員DC1

  • 2018.04
    -
    2022.03

    Astellas Pharma Inc.

  • 2022.04
    -
    2025.05

    Keio University, Faculty of Pharmacy, Projected Assistant Professor

  • 2025.06
    -
    Present

    Keio University, Faculty of Pharmacy, Assistant Professor

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Academic Background 【 Display / hide 】

  • 2008.04
    -
    2014.03

    Keio University, 薬学部 薬学科

  • 2014.04
    -
    2018.03

    Keio University, 大学院 薬学研究科 薬学専攻

    Doctoral course

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Academic Degrees 【 Display / hide 】

  • 博士（薬学）, Keio University, 2018.03

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Licenses and Qualifications 【 Display / hide 】

  • 薬剤師免許, 2014.05

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Research Areas 【 Display / hide 】

  • Life Science / Immunology

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Papers 【 Display / hide 】

  • M cell-dependent commensal uptake confers encephalitogenic phenotypes on γδT17 cells in Peyer's patches

    Komiyama S, Kodaira Y, Maeda R, Sugiura Y, Suzuki K, Saeki A, Kinashi Y, Oguchi H, Takano K, Onawa S, Matsui A, Sasaki E, Hattori-Muroi K, Kimura S, Fujimura Y, Ka Y, Ogura T, Hanaoka K, Ito M, Watarai H, Kaisho T, Udagawa N, Takahashi D, Hase K

    Proc Natl Acad Sci U S A 123 ( 2 ) e2506550123 2026.01

    Research paper (scientific journal), Accepted

  • Dietary soy shapes murine microbiota to consolidate the mucosal IgA response through T follicular helper cells

    Hattori-Muroi K., Maruta H., Takahashi D., Kinashi Y., Hattori K., Kabumoto Y., Fujimura Y., Tsukamoto S., Suzuki K., Oguchi H., Ogihara Y., Kodaira Y., Hayashi E., Takano K., Komiyama S., Morita N., Naganawa-Asaoka H., Oya Y., Saito Y., Ohashi W., Kimura S., Shinkura R., Matsuda T., Hase K.

    bioRxiv  2025.08

  • Monoclonal humanized monovalent antibody blocking therapy for anti-NMDA receptor encephalitis

    Kanno A., Kito T., Maeda M., Yamaki S., Amano Y., Shimomura T., Anisimova M., Kanazawa N., Suzuki K., Razai A., Mihara T., Kubo K., Shimada T., Nakamura K., Nomura N., Kondo Y., Okimoto A., Sugiyama A., Park D., Stein I., Petshow S., Vandendoren V., Bilic S., Kazimi R., Eastman V., Snipas S.J., Mitchell M., Maurer M., Jefson M., Lichter J., Yamajuku D., Shirai H., Adachi M., Hoeppner D.J., Kubo S., Zito K., Iizuka T., Flynn P., Matsumoto M.

    Nature Communications 16 ( 1 ) 5292 2025.06

    Research paper (scientific journal), Accepted

    　View Summary

    Anti-NMDA receptor (NMDAR) encephalitis is a devastating disease with severe psychiatric and neurological symptoms believed to be caused by pathogenic autoantibodies that bind to the N-terminal domain (NTD) of the NMDAR GluN1 subunit (GluN1-NTD) crosslinking adjacent NMDARs and driving their internalization. Here we describe ART5803, a humanized monovalent antibody, as a potential therapy for anti-NMDAR encephalitis. ART5803 binds with a high affinity (K<inf>D</inf> = 0.69 nM) to GluN1-NTD without affecting NMDAR activity or inducing internalization. ART5803 blocks NMDAR internalization induced by patients’ pathogenic autoantibodies, and restores NMDAR function. A marmoset animal model was developed using sustained intracerebroventricular (ICV) administration of a human pathogenic autoantibody to evoke behavioral and motor abnormalities. ART5803 ICV infusion or peripheral injections rapidly reversed these abnormalities. These data, together with the pharmacokinetic profile in cynomolgus monkeys, indicate a therapeutic potential for intravenous (IV)-administered ART5803 as a fast-acting and efficacious option for anti-NMDAR encephalitis.

  • Sugar and arginine facilitate oral tolerance by ensuring the functionality of tolerogenic immune cell subsets in the intestine

    Nagai M., Okawa T., Nakata K., Takahashi D., Miyajima R., Shiratori H., Yamanaka D., Nakamura A., Oyama C., Takahashi S.I., Toyama-Sorimachi N., Suzuki K., Ohashi W., Dohi T., Kawamura Y.I., Hase K.

    Cell Reports 43 ( 7 ) 114490 2024.07

    Research paper (scientific journal), Accepted

    　View Summary

    Although oral tolerance is a critical system in regulating allergic disorders, the mechanisms by which dietary factors regulate the induction and maintenance of oral tolerance remain unclear. To address this, we explored the differentiation and function of various immune cells in the intestinal immune system under fasting and ad libitum-fed conditions before oral ovalbumin (OVA) administration. Fasting mitigated OVA-specific Treg expansion, which is essential for oral tolerance induction. This abnormality mainly resulted from functional defects in the CX3CR1<sup>+</sup> cells responsible for the uptake of luminal OVA and reduction of tolerogenic CD103<sup>+</sup> dendritic cells. Eventually, fasting impaired the preventive effect of oral OVA administration on asthma and allergic rhinitis development. Specific food ingredients, namely carbohydrates and arginine, were indispensable for oral tolerance induction by activating glycolysis and mTOR signaling. Overall, prior food intake and nutritional signals are critical for maintaining immune homeostasis by inducing tolerance to ingested food antigens.

  • A partial agonist for retinoid X receptor mitigates experimental colitis

    Onuki M., Watanabe M., Ishihara N., Suzuki K., Takizawa K., Hirota M., Yamada T., Egawa A., Shibahara O., Nishii M., Fujihara M., Makishima M., Takahashi D., Furusawa Y., Kakuta H., Hase K.

    International Immunology 31 ( 4 ) 251 - 262 2019

    Research paper (scientific journal), Accepted

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • 腸内細菌による発達期における免疫インプリンティング

    鈴木 功一郎, 長谷 耕二

    腸内細菌学雑誌 37 ( 3 ) 149 - 155 2023

    Article, review, commentary, editorial, etc. (scientific journal), Lead author

  • 腸内細菌叢と次世代の健康

    鈴木 功一郎, 長谷 耕二

    Medical Science Digest 49 ( 8 ) 397 - 400 2023

    Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Lead author

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Presentations 【 Display / hide 】

  • Maternal microbiome deficiency induces behavioral abnormalities in offspring

    Suzu Masuhara, Koichiro Suzuki, Hinata Sugiyama, Wakana Ohashi, Koji Hase

    [International presentation]  The Early-Life Nexus: Molecular Keys to Health and Disease (東京) , 

    2025.11
    , 

    Poster presentation

  • 絶食時の骨髄ニッチにおけるCXCL13産生細胞の特性と制御機構の解析

    大川 拓眞、永井 基慈、中田 一彰、土肥 多惠子、河村 由紀、藤田 進也、田久保 圭誉、鈴木 功一郎、長谷 耕二

    [Domestic presentation]  第10回日本骨免疫学会 (沖縄) , 

    2025.06
    , 

    Poster presentation

  • Maternal gut microbiota induces γδT cells at the maternal-fetal interface to prevent pathogen-associated intrapartum complications

    Koichiro Suzuki, Takahiro Yamada, Yusuke Kinashi, Seiga Komiyama, Yuyo Ka, Kayo Tomiyama, Nanako Ushio-Watanabe, Yoshifumi Nishikawa, Koji Hase

    [International presentation]  International Symposium on Perinatal and Early Life Immunity (フライブルク) , 

    2025.04
    , 

    Oral presentation (general)

  • 炎症性腸疾患モデルマウスにおけるムチン糖鎖構成単糖投与の効果

    沖本 香菜子, 鈴木 功一郎, 森田 達也, 長谷 耕二

    [Domestic presentation]  日本薬学会第145年会 (福岡) , 

    2025.03
    , 

    Oral presentation (general)

  • Maternal gut microbiota induces γδT cells at the maternal-fetal interface for immunosurveillance

    Koichiro Suzuki, Takahiro Yamada, Yusuke Kinashi, Seiga Komiyama, Yuyo Ka, Kayo Tomiyama, Nanako Ushio-Watanabe, Yoshifumi Nishikawa, Koji Hase

    [Domestic presentation]  第53回 日本免疫学会学術集会 (長崎) , 

    2024.12
    , 

    Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 記憶B細胞の形成、生存、活性化および分化におけるFcμRの役割と分子機構の解明

    2025.04
    -
    2028.03

    Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Coinvestigator(s)

    　View Summary

    記憶B細胞（memory B cells, MBC）は、ウイルスや細菌の二次感染に対する生体防御において決定的な役割を果たす。MBCの形成はワクチンの有効性を評価する重要な指標でもある。しかし、MBCの形成、長期生存、活性化及び形質細胞への分化を制御する分子機構はまだ十分に解明されていない。申請者らは最近、IgM受容体（FcμR）欠損マウスにおいてMBCが機能不全を呈することを見出した。即ち、FcμRが液性免疫の記憶応答に重要な役割を果たしていることが示唆された。本研究ではFcμRがMBCの形成、長期生存、活性化、形質細胞分化に果たす役割と分子機構を解明する。

  • 母子境界面γδT細胞を誘導する腸内細菌の探索と母子の健康に与える影響の解析

    2024.04
    -
    2026.03

    Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Principal investigator

    　View Summary

    子宮・脱落膜など母子境界面の免疫系は妊娠の維持や胎児の発育に重要であり、全身の免疫系の中でも極めてユニークな特質を有している。申請者は母子境界面免疫系に豊富に存在するγδ（ガンマ・デルタ）T細胞の誘導に母体の腸内細菌が必須であることを見出した。しかしながら、その誘導メカニズムや母子境界面におけるγδT細胞の役割については不明である。そこで本研究では、①母子境界面のγδT細胞を誘導する責任細菌の特定、②その誘導メカニズムの解明、③妊娠中の母子の健康に果たすγδT細胞の役割の解明を目指す。本研究から得られる成果は、免疫系の制御を介して母子の健康を左右する腸内細菌の発見につながる可能性がある。

  • Investigating the Involvement of Dysbiosis in Idiopathic Recurrent Pregnancy Loss

    2022.08
    -
    2024.03

    Grants-in-Aid for Scientific Research, Suzuki Koichiro, Grant-in-Aid for Research Activity Start-up, Principal investigator

    　View Summary

    In this study, we administered various antibiotics with different spectra to mice and evaluated their effects on fetal resorption, gut microbiota, and the immune system of the uterus and the decidua. While some antibiotics did not affect the incidence of fetal resorption, administration of a specific antibiotic to pregnant female mice resulted in a significant increase in fetal resorption. In the intestines of mice administered with the antibiotic that induced fetal resorption, there was an increased abundance of Citrobacter and Enterococcus. Additionally, changes were observed in certain subsets of immune cells in the uterus and the decidua.

  • 既承認薬を用いたアルツハイマー病におけるＥｐｈＢ２の役割の解明と創薬応用

    2015.04
    -
    2018.03

    特別研究員奨励費, Principal investigator

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Awards 【 Display / hide 】

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Courses Taught 【 Display / hide 】

  • BIOTECH-DISCOVERY-BASED MEDICINE AND GENOME INFORMATICS

    2023

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