KEIO RESEARCHERS INFORMATION SYSTEM

Career 【 Display / hide 】

Career 【 Display / hide 】

• 2018.04

  -

  2022.03

  Astellas Pharma Inc.

• 2022.04

  -

  2025.05

  Keio University, Faculty of Pharmacy, Projected Assistant Professor

• 2025.06

  -

  Present

  Keio University, Faculty of Pharmacy, Assistant Professor

Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 2008.04

  -

  2014.03

  Keio University, 薬学部 薬学科

• 2014.04

  -

  2018.03

  Keio University, 大学院 薬学研究科 薬学専攻

  Doctoral course

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• 博士（薬学）, Keio University, 2018.03

Licenses and Qualifications 【 Display / hide 】

Licenses and Qualifications 【 Display / hide 】

• 薬剤師免許, 2014.05

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Life Science / Immunology

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Dietary soy shapes murine microbiota to consolidate the mucosal IgA response through T follicular helper cells

  Hattori-Muroi K., Maruta H., Takahashi D., Kinashi Y., Hattori K., Kabumoto Y., Fujimura Y., Tsukamoto S., Suzuki K., Oguchi H., Ogihara Y., Kodaira Y., Hayashi E., Takano K., Komiyama S., Morita N., Naganawa-Asaoka H., Oya Y., Saito Y., Ohashi W., Kimura S., Shinkura R., Matsuda T., Hase K.

  bioRxiv  2025.08

  • Access to Document (DOI)

• Sugar and arginine facilitate oral tolerance by ensuring the functionality of tolerogenic immune cell subsets in the intestine

  Nagai M., Okawa T., Nakata K., Takahashi D., Miyajima R., Shiratori H., Yamanaka D., Nakamura A., Oyama C., Takahashi S.I., Toyama-Sorimachi N., Suzuki K., Ohashi W., Dohi T., Kawamura Y.I., Hase K.

  Cell Reports 43 ( 7 )  2024.07

  Accepted

  　View Summary

  Although oral tolerance is a critical system in regulating allergic disorders, the mechanisms by which dietary factors regulate the induction and maintenance of oral tolerance remain unclear. To address this, we explored the differentiation and function of various immune cells in the intestinal immune system under fasting and ad libitum-fed conditions before oral ovalbumin (OVA) administration. Fasting mitigated OVA-specific Treg expansion, which is essential for oral tolerance induction. This abnormality mainly resulted from functional defects in the CX3CR1⁺ cells responsible for the uptake of luminal OVA and reduction of tolerogenic CD103⁺ dendritic cells. Eventually, fasting impaired the preventive effect of oral OVA administration on asthma and allergic rhinitis development. Specific food ingredients, namely carbohydrates and arginine, were indispensable for oral tolerance induction by activating glycolysis and mTOR signaling. Overall, prior food intake and nutritional signals are critical for maintaining immune homeostasis by inducing tolerance to ingested food antigens.

  • Access to Document (DOI)

• A partial agonist for retinoid X receptor mitigates experimental colitis

  Onuki M., Watanabe M., Ishihara N., Suzuki K., Takizawa K., Hirota M., Yamada T., Egawa A., Shibahara O., Nishii M., Fujihara M., Makishima M., Takahashi D., Furusawa Y., Kakuta H., Hase K.

  International Immunology 31 ( 4 ) 251 - 262 2019

  Accepted

  • Access to Document (DOI)

• Intestinal Epithelial Cell-specific Deletion of α-Mannosidase II Ameliorates Experimental Colitis

  Suzuki K., Yamada T., Yamazaki K., Hirota M., Ishihara N., Sakamoto M., Takahashi D., Iijima H., Hase K.

  Cell Structure and Function 43 ( 1 ) 25 - 39 2018

  Lead author, Accepted

  • Access to Document (DOI)

• Therapeutic effect of vitamin D3-containing nanostructured lipid carriers on inflammatory bowel disease

  Zai K., Hirota M., Yamada T., Ishihara N., Mori T., Kishimura A., Suzuki K., Hase K., Katayama Y.

  Journal of Controlled Release 286   94 - 102 2018

  Accepted

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• 炎症性腸疾患におけるα-マンノシダーゼIIの役割の解明(審査報告)

  Suzuki , Koichiro

  (慶應義塾大学大学院薬学研究科)  2017

• 炎症性腸疾患におけるα-マンノシダーゼIIの役割の解明(要約)

  Suzuki , Koichiro

  (慶應義塾大学大学院薬学研究科)  2017

• 炎症性腸疾患におけるα-マンノシダーゼIIの役割の解明(要旨)

  Suzuki , Koichiro

  (慶應義塾大学大学院薬学研究科)  2017

Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• 腸内細菌による発達期における免疫インプリンティング

  鈴木 功一郎, 長谷 耕二

  腸内細菌学雑誌 37 ( 3 ) 149 - 155 2023

  Lead author

  • Access to Document (DOI)

• 腸内細菌叢と次世代の健康

  鈴木 功一郎, 長谷 耕二

  Medical Science Digest 49 ( 8 ) 397 - 400 2023

  Lead author

Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• 母子境界面γδT細胞を誘導する腸内細菌の探索と母子の健康に与える影響の解析

  2024.04

  -

  2026.03

  若手研究, Principal investigator

• 腸内細菌の異常が習慣性流産を誘発するメカニズムの解明

  2022.08

  -

  2024.03

  研究活動スタート支援, Principal investigator

• 既承認薬を用いたアルツハイマー病におけるＥｐｈＢ２の役割の解明と創薬応用

  2015.04

  -

  2018.03

  特別研究員奨励費, Principal investigator

Awards 【 Display / hide 】

Awards 【 Display / hide 】

• Tadamitsu Kishimoto International Travel Award

  2025, Japanese Society for Immunology

Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• BIOTECH-DISCOVERY-BASED MEDICINE AND GENOME INFORMATICS

  2023