SUZUKI Koichiro

写真a

Affiliation

Faculty of Pharmacy, Department of Pharmaceutical Sciences Division of Biochemistry (Shiba-Kyoritsu)

Position

Research Associate/Assistant Professor/Instructor

Career 【 Display / hide

  • 2018.04
    -
    2022.03

    Astellas Pharma Inc.

  • 2022.04
    -
    2025.05

    Keio University, Faculty of Pharmacy, Projected Assistant Professor

  • 2025.06
    -
    Present

    Keio University, Faculty of Pharmacy, Assistant Professor

Academic Background 【 Display / hide

  • 2008.04
    -
    2014.03

    Keio University, 薬学部 薬学科

  • 2014.04
    -
    2018.03

    Keio University, 大学院 薬学研究科 薬学専攻

    Doctoral course

Academic Degrees 【 Display / hide

  • 博士(薬学), Keio University, 2018.03

Licenses and Qualifications 【 Display / hide

  • 薬剤師免許, 2014.05

 

Research Areas 【 Display / hide

  • Life Science / Immunology

 

Papers 【 Display / hide

  • Dietary soy shapes murine microbiota to consolidate the mucosal IgA response through T follicular helper cells

    Hattori-Muroi K., Maruta H., Takahashi D., Kinashi Y., Hattori K., Kabumoto Y., Fujimura Y., Tsukamoto S., Suzuki K., Oguchi H., Ogihara Y., Kodaira Y., Hayashi E., Takano K., Komiyama S., Morita N., Naganawa-Asaoka H., Oya Y., Saito Y., Ohashi W., Kimura S., Shinkura R., Matsuda T., Hase K.

    bioRxiv  2025.08

  • Sugar and arginine facilitate oral tolerance by ensuring the functionality of tolerogenic immune cell subsets in the intestine

    Nagai M., Okawa T., Nakata K., Takahashi D., Miyajima R., Shiratori H., Yamanaka D., Nakamura A., Oyama C., Takahashi S.I., Toyama-Sorimachi N., Suzuki K., Ohashi W., Dohi T., Kawamura Y.I., Hase K.

    Cell Reports 43 ( 7 )  2024.07

    Accepted

     View Summary

    Although oral tolerance is a critical system in regulating allergic disorders, the mechanisms by which dietary factors regulate the induction and maintenance of oral tolerance remain unclear. To address this, we explored the differentiation and function of various immune cells in the intestinal immune system under fasting and ad libitum-fed conditions before oral ovalbumin (OVA) administration. Fasting mitigated OVA-specific Treg expansion, which is essential for oral tolerance induction. This abnormality mainly resulted from functional defects in the CX3CR1<sup>+</sup> cells responsible for the uptake of luminal OVA and reduction of tolerogenic CD103<sup>+</sup> dendritic cells. Eventually, fasting impaired the preventive effect of oral OVA administration on asthma and allergic rhinitis development. Specific food ingredients, namely carbohydrates and arginine, were indispensable for oral tolerance induction by activating glycolysis and mTOR signaling. Overall, prior food intake and nutritional signals are critical for maintaining immune homeostasis by inducing tolerance to ingested food antigens.

  • A partial agonist for retinoid X receptor mitigates experimental colitis

    Onuki M., Watanabe M., Ishihara N., Suzuki K., Takizawa K., Hirota M., Yamada T., Egawa A., Shibahara O., Nishii M., Fujihara M., Makishima M., Takahashi D., Furusawa Y., Kakuta H., Hase K.

    International Immunology 31 ( 4 ) 251 - 262 2019

    Accepted

  • Intestinal Epithelial Cell-specific Deletion of α-Mannosidase II Ameliorates Experimental Colitis

    Suzuki K., Yamada T., Yamazaki K., Hirota M., Ishihara N., Sakamoto M., Takahashi D., Iijima H., Hase K.

    Cell Structure and Function 43 ( 1 ) 25 - 39 2018

    Lead author, Accepted

  • Therapeutic effect of vitamin D3-containing nanostructured lipid carriers on inflammatory bowel disease

    Zai K., Hirota M., Yamada T., Ishihara N., Mori T., Kishimura A., Suzuki K., Hase K., Katayama Y.

    Journal of Controlled Release 286   94 - 102 2018

    Accepted

display all >>

Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • 腸内細菌による発達期における免疫インプリンティング

    鈴木 功一郎, 長谷 耕二

    腸内細菌学雑誌 37 ( 3 ) 149 - 155 2023

    Lead author

  • 腸内細菌叢と次世代の健康

    鈴木 功一郎, 長谷 耕二

    Medical Science Digest 49 ( 8 ) 397 - 400 2023

    Lead author

Research Projects of Competitive Funds, etc. 【 Display / hide

  • 母子境界面γδT細胞を誘導する腸内細菌の探索と母子の健康に与える影響の解析

    2024.04
    -
    2026.03

    若手研究, Principal investigator

  • 腸内細菌の異常が習慣性流産を誘発するメカニズムの解明

    2022.08
    -
    2024.03

    研究活動スタート支援, Principal investigator

  • 既承認薬を用いたアルツハイマー病におけるEphB2の役割の解明と創薬応用

    2015.04
    -
    2018.03

    特別研究員奨励費, Principal investigator

Awards 【 Display / hide

 

Courses Taught 【 Display / hide

  • BIOTECH-DISCOVERY-BASED MEDICINE AND GENOME INFORMATICS

    2023