Miyagawa, Naoko

写真a

Affiliation

School of Medicine, Department of Preventive Medicine and Public Health (Shinanomachi)

Position

Senior Assistant Professor (Non-tenured)/Assistant Professor (Non-tenured)
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Books 【 Display / hide 】

  • 最新臨床高血圧学－高血圧治療の最前線－ Ⅹ特論 ４減塩社会への取り組み

    株式会社 日本臨床社, 2014

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Papers 【 Display / hide 】

  • Genome-wide association study of plasma amino acids and Mendelian randomization for cardiometabolic traits

    Toki R., Fushiki S., Kojima S., Sutoh Y., Otsuka-Yamasaki Y., Harada S., Iida M., Hirata A., Miyagawa N., Matsumoto M., Edagawa S., Miyake A., Kuwabara K., Hirayama A., Sugimoto M., Sato A., Amano K., Soga T., Tomita M., Arakawa K., Kinoshita K., Sakurai-Yageta M., Tamiya G., Ohmomo H., Shimizu A., Okamura T., Takebayashi T.

    Scientific Reports 15 ( 1 ) 14569 2025.12

    ISSN  2045-2322

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    Plasma amino acids (AAs) have emerged as promising biomarkers for metabolic disorders, yet their causality remains unclear. We aimed to investigate the genetic determinants of AA levels in a cohort of 10,333 individuals and their causal effects on cardiometabolic traits using Mendelian randomization (MR). Plasma levels of 20 AAs were quantified using capillary electrophoresis mass spectrometry. Genome-wide association studies were conducted using BOLT-LMM and heritability estimation via LDSC analysis. Causal effects of AAs on 11 cardiometabolic traits were examined using two-sample MR analyses. We identified 85 locus-metabolite associations across 43 genes for 18 AAs, including 44 novel loci linked to metabolic genes. Heritability for AAs was estimated at 16%. MR analysis demonstrated cystine to positively associate with systolic blood pressure (SBP) (β = 0.056, SE = 0.010), while serine indicated protective effects on SBP (β = − 0.040, SE = 0.011), diastolic BP (β = − 0.044, SE = 0.010), and coronary artery disease (odds ratio 0.888, SE = 0.028). We identified potentially novel genetic loci associated with AA levels and demonstrated robust causal associations between several AAs and cardiometabolic traits. These findings reinforce the importance of AAs as potential biomarkers and therapeutic targets in cardiometabolic health.

  • Cross-Sectional Association between Sedentary Behavior and Physical Inactivity with Cardiometabolic Risk Factors among Japanese: The NIPPON DATA2010

    Ohashi Mizuki, Miyagawa Naoko, Yanagita Masahiko, Okuda Nagako, Fujiyoshi Akira, Ohkubo Takayoshi, Kadota Aya, Okami Yukiko, Kondo Keiko, Harada Akiko, Okamura Tomonori, Ueshima Hirotsugu, Okayama Akira, Miura Katsuyuki, for the NIPPON DATA2010 Research Group

    Journal of Atherosclerosis and Thrombosis (Japan Atherosclerosis Society)  32 ( 10 ) 1328 - 1346 2025.10

    ISSN  1340-3478

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    <p> <b>Aim:</b> Sedentary behavior and physical inactivity increase the risk of cardiometabolic diseases. It is important to evaluate physical activity in daily life and understand the influence of these factors on cardiometabolic diseases in the Japanese population, which tends to have a prolonged sitting time. We examined the association between sedentary behavior and physical inactivity, characterized by extended television (TV) viewing and low step counts, which are easily monitored and modifiable, and cardiometabolic risk factors in the Japanese population.</p><p><b>Methods:</b> This cross-sectional study included 2,531 Japanese adults (1,087 men and 1,444 women) 20–91 years old, randomly selected throughout Japan. TV viewing was assessed using a self-reported questionnaire, and step counts were measured using pedometers. Cardiometabolic risk factors were determined using physical examinations or blood samples. The association between sedentary behavior and physical inactivity with each risk factor was examined using a cross-sectional analysis with multivariate-adjusted logistic regression models.</p><p><b>Results:</b> In both sexes, longer TV viewing positively correlated with low high-density lipoprotein (HDL) cholesterol and high triglycerides (TG). In women, TV viewing time is associated with obesity and increased abdominal circumference (AC). Conversely, in men, lower step counts were positively associated with obesity and increased AC, low HDL cholesterol, and high TG levels.</p><p><b>Conclusions:</b> The association between prolonged TV viewing and cardiometabolic risk factors was more pronounced in women than in men, whereas the influence of lower step counts was stronger in men than in women. These findings contribute to the improvement of cardiovascular health by monitoring and managing individual screen times and step counts in daily life.</p>

  • Causal relationship between body mass index and insulin resistance: Linear and nonlinear Mendelian randomization study in a Japanese population.

    Ishida N, Harada S, Toki R, Hirata A, Matsumoto M, Miyagawa N, Iida M, Edagawa S, Miyake A, Kuwabara K, Shibuki T, Kato S, Arakawa K, Kinoshita K, Sakurai-Yageta M, Tamiya G, Nagashima K, Muraoka H, Sato Y, Takebayashi T

    Journal of diabetes investigation 16 ( 7 ) 1305 - 1314 2025.04

    ISSN  2040-1116

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    Aims/Introduction: Obesity is a known risk factor for several chronic diseases, including type 2 diabetes mellitus, which results from increased insulin resistance and impaired insulin secretion. However, the association between obesity and insulin resistance in Asian populations has not yet been fully elucidated. Therefore, we aimed to investigate the causal relationship between body mass index (BMI) and glycemic traits using Mendelian randomization (MR). Materials and Methods: We performed individual-level MR analyses using genetic risk scores based on BMI-related variants in 3,745 individuals without diabetes mellitus from a Japanese cohort. We examined heterogeneity through subgroup analyses based on potential modifiers and determined the shape of the causal relationship using nonlinear MR analyses to further assess the impact of BMI on the homeostasis model assessment of insulin resistance (HOMA-IR). Results: MR analyses revealed a significant positive association between BMI and HOMA-IR (β = 0.077; 95% confidence interval, 0.014–0.141; P = 0.016; outcome variable was log-transformed and standardized). Additional analyses revealed heterogeneity among subgroups differentiated by age, sex, lifestyle habits, and cardiometabolic traits. Nonlinear MR analyses suggested a potential J-shaped causal relationship between BMI and HOMA-IR. Conclusions: Our findings demonstrated that obesity and low BMI may contribute to increased insulin resistance. Furthermore, the impact of BMI on insulin resistance could vary owing to effect modification. Managing BMI is crucial in individuals at high risk of increased insulin resistance and may have important implications for preventing type 2 diabetes, especially given the low insulin secretory capacity observed in East Asian populations.

  • Asymptomatic Intracranial Vascular Lesions and Cognitive Function in a General Population of Japanese Men: Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

    Ito T., Fujiyoshi A., Ohkubo T., Shiino A., Shitara S., Miyagawa N., Torii S., Hisamatsu T., Segawa H., Kondo K., Kadota A., Tooyama I., Watanabe Y., Yoshida K., Nozaki K., Miura K.

    Cerebrovascular Diseases    1 - 11 2025

    ISSN  10159770

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    Introduction: Intracranial subclinical vessel diseases are considered important indicators of cognitive impairment. However, a comprehensive assessment of various types of vessel disease, particularly in Asian populations, is lacking. We aimed to compare multiple types of intracranial vessel disease in association with cognitive function among a communitybased Japanese male population. Methods: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) randomly recruited and examined a community-based cohort of Japanese men from Shiga, Japan. We analyzed those who underwent the Cognitive Abilities Screening Instrument (CASI) assessment and cranial magnetic resonance imaging/ angiogram (MRI/MRA) in 2010 2015. Using MRI/MRA, we assessed lacunar infarction, microbleeds, periventricular hyperintensity (PVH), deep subcortical white matter hyperintensity (DSWMH), and intracranial artery stenosis (ICAS). We divided these subclinical cerebrovascular diseases (SCDs) into three categories according to severity. Using linear regression, we calculated the CASI score according to the grade of each vessel disease, adjusted for age and years of education. Results: In the adjusted models, CASI scores were significantly associated with both PVH and DSWMH. Specifically, multivariable-adjusted CASI scores declined across increasing severity categories of DSWMH (91.7, 91.2, and 90.4; p for trend = 0.011) and PVH (91.5, 90.4, and 89.7; p for trend = 0.006). Other SCDs did not show significant associations. In stratified analyses based on the presence or absence of each SCD, both DSWMH and PVH demonstrated significant inverse trends with CASI scores in the absence of lacunar infarcts and microbleeds and in the presence of ICAS. Additionally, among participants with PVH (+), ≥moderate ICAS was significantly associated with lower CASI scores. Conclusion: PVH and DSWMH showed significant dose-response relationships with cognitive function among community-based Japanese men. These findings suggest that white matter lesions may be an important indicator of early cognitive impairment, and severe ICAS may also play a role in those with PVH.

  • Dietary diversity and the risk of metabolic syndrome in a Japanese population: an analysis of baseline cross-sectional data from the J-MICC study

    Htay Z.W., Michihata N., Nakamura Y., Hippo Y., Otonari J., Ikezaki H., Nishida Y., Shimanoe C., Tamura T., Nagayoshi M., Kato Y., Tamada Y., Hishida A., Tanoue S., Nishimoto D., Koyama T., Ozaki E., Kuriki K., Takashima N., Miyagawa N., Katsuura-Kamano S., Watanabe T., Wakai K., Matsuo K.

    European Journal of Clinical Nutrition  2025

    ISSN  09543007

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    Background: With the increasing burden of metabolic syndrome, it is crucial to focus on lifestyle factors to reduce the risk of metabolic syndrome. Objectives: This study aims to quantify the associations between dietary diversity and the risk of metabolic syndrome among the Japanese population. Methods: This study was conducted using baseline data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. The baseline survey was conducted from 2005 to 2014 by recruiting individuals aged 35–69. Information regarding dietary intake and biometric measurements were obtained. Dietary Diversity Score (DDS) was calculated from the data based on the food frequency questionnaire. A multiple logistic regression analysis was conducted to analyze the association between DDS and metabolic syndrome. Results: In total, 75,332 participants were included for analysis. Inverse associations were observed between a high DDS and metabolic syndrome (adjusted odds ratio, 0.83 [95% confidential interval 0.76–0.92]). Likewise, a high DDS was associated with reduced odds of a high body mass index and hypertension. No significant associations were observed between the DDS and serum triglyceride, fasting blood glucose, or high-density lipoprotein cholesterol values. Conclusion: The findings of this study emphasize that dietary diversity has inversed associations with metabolic syndrome. Promoting a diverse and balanced diet can be a potential strategy for mitigating the burden of metabolic syndrome.

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Reviews, Commentaries, etc. 【 Display / hide 】

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • To identify the social and environmental factors associated with the increase in healthy life expectancy using a long-term longitudinal study.

    2025.04
    -
    2028.03

    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), No Setting

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    本研究では健康寿命に影響を与える、中壮年期の危険因子について検討を行うため、2000年代に始めた生活習慣病に関する多目的コホートである高島研究、京都フィールドの二つのコホートを統合し、都市部から地方までを俯瞰できる統合コホートを立ち上げる。具体的には京都フィールドの対象者1000人に対面での追跡調査を行い生活習慣、ADL/QOL、身体・認知機能等の評価を行い、介護保認定状況の追跡調査の同意取得も行う。またこのコホートを用いて健康寿命/機能低下やその要因(脳卒中罹患、身体・認知機能等)に影響を与える要因について解析を行う。

  • Epidemiological study to generate evidence for the introduction of a program to evaluate early stage renal dysfunction in health checkups

    2024.04
    -
    2027.03

    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), No Setting

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    慢性腎臓病(CKD)発症予防には生活習慣の修正による腎機能の回復が可能な早期腎機能障害の段階からの腎機能評価が必要であるが、現行の健診における早期腎機能障害の評価には限界がある。本研究では尿細管障害マーカーを含む複数の腎機能マーカーを用いてこれまで一般集団では十分に検討されてこなかった早期の腎機能障害を精緻に評価し、脳・心血管疾患発症などの複数の疾患アウトカムとの関連を検討することで、腎機能障害に関する多面的なリスク評価を行う。さらに遺伝要因の影響を含めた詳細な規定要因の検証を行い、個人の体質を考慮した次世代型の健診・保健指導導入のためのエビデンスを創出する。

  • Usefulness of metabolite biomarker as a common pathway for the prevention of non-communicable diseases and frailty

    2023.04
    -
    2028.03

    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), No Setting

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    本研究は、開始後10年を経過した地域在住者コホート研究により、若年期から集積する心臓代謝リスクの併存状態（マルチモビディティ）からNCDsおよびフレイル・認知機能低下への移行を媒介する共通代謝経路・代謝バイオマーカーを疫学的に解明・検証した上で、その代謝経路と関連する変容可能な環境要因を明らかにして、中・高齢期の保健・介護予防一体的実施に最適な介入手法の基礎とすることを目的とする。また新型コロナウイルス感染によってその機能がリモデリングされる代謝経路にも焦点をあて、感染の後遺・遷延症状も考慮した地域保健現場での健康支援についても検討する。

  • Association between the risk of sarcopenia and estimated protein intake using biomarkers

    2022.04
    -
    2026.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

  • 一般住民における腎機能低下と無症候性脳血管障害の関連

    2019.04
    -
    2022.03

    日本学術振興会, Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, No Setting

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    近年、腎細小血管の解剖学的、機能的類似性から腎機能と無症候性脳血管疾患との関連が指摘され始めており、患者コホートからの報告ではその関連が報告されているが、一般住民からの報告はまだ少なく、その評価は分かれている。本研究では、40歳代から80歳代の850人の健常な日本人一般住民を対象として、腎機能およびその経年変化と無症候性脳血管疾患との関連、およびこの関連への循環器疾患発症因子の介在の程度を明らかにする。無症候性脳血管疾患は脳卒中および認知機能低下指標として注目されているため、本研究で得られた結果は、高齢社会における認知症・脳卒中の早期発見マーカーとして予防に繋がることが期待される。
    本研究は一般地域住民から年齢層化無作為抽出した集団のうち協力が得られた者を対象として、頭部MR画像を用いて評価した無症候性脳血管障害と潜在性動脈硬化指標および危険因子の測定を実施している既存の前向きコホートの成績を用いて、腎機能およびその経年変化と無症候性脳血管疾患の関連を検討するものである。昨年度測定した随時尿中の微量アルブミン、クレアチニン、ナトリウム値をデータベースに突合し、日本人一般集団における尿アルブミン/クレアチニン比(ACR)およびeGFRの経年変化の分布を確認し、無症候性脳血管疾患との関連を検討した。
    新型コロナウイルス感染拡大のため、成果発表の一部が遅延している。
    次年度は最終年度であるため、日本人一般集団における無症候性脳血管疾患と尿アルブミン/クレアチニン比(ACR)およびeGFRの経年変化との関連についてさらに詳細に検討を進める。また、その成果を学会や専門誌で報告する予定である。

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Courses Taught 【 Display / hide 】

  • NUTRITION FOR NURSING AND HEALTH CARE

    2025

  • BIOSTATISTICS AND MEDICAL INFORMATICS

    2025

  • NUTRITION FOR NURSING AND HEALTH CARE

    2024

  • NUTRITION FOR NURSING AND HEALTH CARE

    2023

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