Miyagawa, Naoko

写真a

Affiliation

School of Medicine, Department of Preventive Medicine and Public Health （Shinanomachi）

Position

Instructor
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Books 【 Display / hide 】

  • 最新臨床高血圧学－高血圧治療の最前線－ Ⅹ特論 ４減塩社会への取り組み

    株式会社 日本臨床社, 2014

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Papers 【 Display / hide 】

  • Coffee and Metabolic Phenotypes: A Cross-sectional Analysis of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study

    Takeshi Watanabe, Kokichi Arisawa, Tien Van Nguyen, Masashi Ishizu, Sakurako Katsuura-Kamano, Asahi Hishida, Takashi Tamura, Yasufumi Kato, Rieko Okada, Rie Ibusuki, Chihaya Koriyama, Sadao Suzuki, Takahiro Otani, Teruhide Koyama, Satomi Tomida, Kiyonori Kuriki, Naoyuki Takashima, Naoko Miyagawa, Kenji Wakai, Keitaro Matsuo

    Nutrition, Metabolism and Cardiovascular Diseases （Elsevier BV)   2022.12

    ISSN  0939-4753

  • Relationship between Serum Irisin Levels and MRI-Measured Cerebral Small Vessel Disease in Japanese Men

    Moniruzzaman Mohammad, Kadota Aya, Hisamatsu Takashi, Segawa Hiroyoshi, Kondo Keiko, Torii Sayuki, Miyagawa Naoko, Fujiyoshi Akira, Yano Yuichiro, Watanabe Yoshiyuki, Shiino Akihiko, Nozaki Kazuhiko, Ueshima Hirotsugu, Miura Katsuyuki, on behalf of the SESSA Research Group

    Journal of Atherosclerosis and Thrombosis （Japan Atherosclerosis Society)  advpub （ 0 ）  2022.11

    ISSN  1340-3478

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    <p><b>Aim: </b>Irisin, an exercise-induced myokine, is a potential neurotrophic factor; however, its relationship with cerebral small vessel disease (CSVD) remains unknown. Therefore, we investigated whether serum irisin levels are associated with CSVD in healthy Japanese men.<b> </b></p><p><b>Methods: </b>We analyzed data from 720 men free of stroke and participated in this observational study. Serum irisin levels were measured by enzyme-linked immunosorbent assay. CSVD was assessed on deep and subcortical white matter hyperintensities (DSWMHs), periventricular hyperintensities (PVHs), lacunar infarcts (LIs), and cerebral microbleeds (CMBs) on brain magnetic resonance imaging. We calculated the total CSVD score (ranges 0–4) to express the total CSVD burden. We computed the adjusted odds ratios (ORs), with 95% confidence intervals (CIs), of the total CSVD score and individual CSVD features using logistic regression models according to the quartiles of irisin (reference: Q1).<b> </b></p><p><b>Results: </b>Serum irisin levels were associated with lower ORs of higher (vs. zero or lower score) total CSVD score, with the lowest risk (OR, 0.63; 95% CI, 0.41–0.97) being observed in Q3 compared to Q1 after adjustment of potential covariates. Similar results were obtained for younger adults (＜65 years). Among individual CSVD features, irisin was associated with a reduced risk of LIs in the total sample and PVHs, LIs, and CMBs in younger adults. No relationship was observed in older adults (≥ 65 years).<b> </b></p><p><b>Conclusions: </b>Serum irisin levels were associated with less burden of total CSVD in healthy Japanese men. Serum irisin levels were also related with a reduced risk of PVHs, LIs, and CMBs, but not DSWMHs.</p>

  • Small High-Density Lipoprotein and Omega-3 Fatty Acid Intake Differentiates Japanese and Japanese-Americans: The INTERLIPID Study.

    Yukiko Okami, Queenie Chan, Katsuyuki Miura, Aya Kadota, Paul Elliott, Kamal Masaki, Akira Okayama, Nagako Okuda, Katsushi Yoshita, Naoko Miyagawa, Tomonori Okamura, Kiyomi Sakata, Shigeyuki Saitoh, Masaru Sakurai, Hideaki Nakagawa, Jeremiah Stamler, Hirotsugu Ueshima

    Journal of atherosclerosis and thrombosis （Japan Atherosclerosis Society)  advpub （ 0 ）  2022.11

    ISSN  1340-3478

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    AIM: To identify the most differentiated serum lipids, especially concerning particle size and fractions, between Japanese living in Japan and Japanese-Americans in Hawaii, in the absence of possible genetic confounders, and cross-sectionally examine the associated modifiable lifestyle factors. METHODS: Overall, 1,241 (aged 40-59 years) Japanese living in Japan and Japanese-Americans in Hawaii were included. We quantified 130 serum lipid profiles (VLDL 1-5, IDL, LDL 1-6, high-density lipoprotein [HDL] 1-4, and their subfractions) using Bruker's 1 H-nuclear magnetic resonance spectrometer for the primary outcome. Modifiable lifestyle factors included body mass index (BMI), physical activity, alcohol and smoking habits, and 70 nutrient parameters. We evaluated the different lipids between the groups using partial least squares-discriminant analysis and association between extracted lipids and lifestyle factors using multivariable linear regression analysis. RESULTS: Concentrations of HDL4, HDL with the smallest particle size, were lower in Japanese than in Japanese-Americans of both sexes. Higher fish-derived omega-3 fatty acid intake and lower alcohol intake were associated with lower HDL4 concentrations. A 1% higher kcal intake of total omega-3 fatty acids was associated with a 9.8- mg/dL lower HDL4. Fish-derived docosapentaenoic acid, eicosapentaenoic acid, and docosahexaenoic acid intake were inversely associated with HDL4 concentration. There was no relationship between country, sex, age, or BMI. CONCLUSIONS: Japanese and Japanese-Americans can be differentiated based on HDL4 concentration. High fish intake among the Japanese may contribute to their lower HDL4 concentration. Thus, HDL particle size may be an important clinical marker for coronary artery diseases or a fish consumption biomarker.

  • Effect of diabetes and prediabetes on the development of disability and mortality among middle-aged adult Japanese: a 22-year follow-up of NIPPON DATA90.

    Phap Tran Ngoc Hoang, Aya Kadota, Yano Yuichiro, Harada Akiko, Hayakawa Takehito, Okamoto Shohei, Naoko Miyagawa, Keiko Kondo, Okuda Nagako, Yoshiuni Kita, Akira Okayama, Fujita Yukihiro, Hiroshi Maegawa, Katsuyuki Miura, Tomonori Okamura, Hirotsugu Ueshima

    Journal of diabetes investigation （Journal of Diabetes Investigation)  13 （ 11 ） 1897 - 1904 2022.06

    ISSN  2040-1116

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    AIMS: To examine the association between diabetes and prediabetes at baseline and disability, mortality over a 22-year period among middle-aged adult Japanese. METHODS: Participants consisted of 1,788 adults aged 45 to 64 years at baseline from the cohort study NIPPON DATA90. Disability, defined as having decline in ADL, was assessed by a modified Katz questionnaire at four time points. Disability and death without disability for 22-year follow-up were used as outcomes to test the association with a diagnosis of diabetes or prediabetes at baseline, using multinomial logistic regression. Adjusted odd ratios were obtained from four models that contained appropriate adjustment factors such as age, sex, smoking status, drinking status, body mass index, and cardiovascular risk factors (hypertension, hypercholesterolemia, triglycerides, low serum high-density lipoprotein) at baseline. RESULTS: In the present study, 334 (18.7%) reported at least one disability, and 350 (19.6%) were reported dead without observation of disability during follow-up. Adjusting sex and other risk factors, participants with diabetes and prediabetes had higher risk for disability (OR = 1.43, 95%CI=1.07-1.91 and OR = 1.66, 95%CI=1.10-2.50, respectively) and for mortality (OR = 1.56, 95%CI=1.16-2.08 and OR = 1.77, 95%CI=1.18-2.65, respectively) than individuals with normal glucose tolerance. CONCLUSIONS: In middle-aged Japanese, individuals with diabetes and prediabetes were more likely to be associated with disability and mortality. Our findings suggest that prediabetes and diabetes in middle-aged adults should be paid more attention and requires more intervention to prevent disability and mortality in later life.

  • Association between C-Reactive Protein Levels and Functional Disability in the General Older-Population: The Takashima Study

    Takashima Naoyuki, Nakamura Yasuyuki, Miyagawa Naoko, Kadota Aya, Saito Yoshino, Matsui Kenji, Miura Katsuyuki, Ueshima Hirotsugu, Kita Yoshikuni

    Journal of Atherosclerosis and Thrombosis （Japan Atherosclerosis Society)  advpub （ 0 ） 56 - 65 2022.03

    ISSN  1340-3478

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    AIMS: High-sensitivity C-reactive protein (hsCRP) associates with atherosclerotic diseases such as stroke. However, previous results on the association between hsCRP levels and functional disability were controversial. METHODS: We analyzed 2,610 men and women who did not exhibit functional disability or death within the first 3 years of the baseline survey and those aged 65 years or older at the end of follow-up. The levels of hsCRP were assessed using latex agglutination assay at baseline survey from 2006 to 2014. Functional disability was followed up using the long-term care insurance (LTCI) program until November 1, 2019. Functional disability was defined as a new LTCI program certification. Cox proportional hazards model with competing risk analysis for death was used to evaluate the association between hsCRP levels and future functional disability. RESULTS: During a 9-year follow-up period, we observed 328 cases of functional disability and 67 deaths without prior functional disability incidence. The multivariable-adjusted hazard ratio (HR, 95% confidence interval [CI]) of functional disability in log-transferred hsCRP levels was 1.43 (1.22-1.67) in men and 0.97 (0.81-1.15) in women. When hsCRP level was analyzed as a categorical variable, low hsCRP levels (＜1.0 mg/l) as the reference, the multivariable-adjusted HR (95% CI) of functional disability in high hsCRP levels (≥ 3.0 mg/l) was 2.37 (1.56-3.62). Similar results were observed when stratified by sex, but it was not significant in women. CONCLUSIONS: This study demonstrates that low-grade systemic inflammation to assess hsCRP might predict the future incidence of functional disability, especially in men.

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Reviews, Commentaries, etc. 【 Display / hide 】

  • 一般住民における内臓脂肪の蓄積に関連するメタボロミクスプロファイル　鶴岡メタボロームコホート研究

    宮川 尚子, 原田 成, 飯田 美穂, 桑原 和代, 加藤 寿寿華, 佐田 みずき, 松元 美奈子, 平田 あや, 岡村 智教, 武林 亨

    Journal of Epidemiology ((一社)日本疫学会)  32 ( Suppl.1 ) 164 - 164 2022.01

    ISSN  0917-5040

  • Dietary Intake of Manganese in the Japanese Diet and its Association with Cardiometabolic and Cardiovascular Diseases

    Miyagawa Naoko

    Journal of Atherosclerosis and Thrombosis (Japan Atherosclerosis Society)  29 ( 10 ) 1421 - 1422 2022

    ISSN  13403478

  • 【心疾患と栄養】循環器疾患と食生活

    宮川 尚子, 岡村 智教

    栄養 ((株)ジェフコーポレーション)  36 ( 4 ) 179 - 185 2021.12

    ISSN  2435-4503

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    食生活は内容によって循環器疾患の危険因子にも防御因子にもなりうることが、多くの疫学研究から明らかになっている。脂質やたんぱく質のうち、飽和脂肪酸は循環器疾患のリスクを高め、魚に多く含まれるn-3系不飽和脂肪酸や植物性たんぱく質は循環器疾患の発症に予防的に働くことが報告されている。一方、炭水化物から摂取するエネルギー割合は低すぎても高すぎても死亡リスクが高くなる。食塩は循環器疾患の主要な要因である血圧を上昇させて循環器疾患リスクを高め、反対に野菜や果物は、カリウムなど含まれる様々な栄養素の機能が複合的に作用して高血圧や循環器疾患のリスクを低下させる。これらの循環器疾患に関連する食品を組み合わせて摂取する、健康的な食事パターンをスコア化した食事指標を用いた検討では、指標の遵守度が高いほど循環器疾患リスクが低下していた。食事内容の改善により循環器疾患の予防が期待できるため、摂取する食品の内容や量を適切に選択することが大切である。(著者抄録)

  • 動脈硬化と食事 4 食塩,野菜・果物,長鎖不飽和脂肪酸,炭水化物摂取と動脈硬化性疾患

    宮川尚子, 三浦克之

    動脈硬化予防 16 ( 1 ) 28‐32 2017.03

    ISSN  1347-7056

  • 【動脈硬化と食事】食塩、野菜・果物、長鎖不飽和脂肪酸、炭水化物摂取と動脈硬化性疾患

    宮川 尚子, 三浦 克之

    動脈硬化予防 ((株)メジカルビュー社)  16 ( 1 ) 28 - 32 2017.03

    ISSN  1347-7056

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    動脈硬化性の脳心血管疾患の発症の危険因子である高血圧、糖尿病、脂質異常症の改善・予防は食事との関連が大きいため、食事内容の改善により脳心血管疾患の予防が期待できる。日本人を対象とした疫学研究において、食塩の過剰摂取が血圧上昇と脳心血管疾患リスクを高め、野菜・果物の摂取や魚介類に多く含まれる長鎖多価不飽和脂肪酸の摂取が脳心血管疾患保護的に働くことが報告されている。一方、低炭水化物食は、短期的な体重減少は見込めるが、反対にLDLコレステロール値の上昇を認めるため、長期的な脳心血管疾患保護への影響は未だ明らかではない。国内外の観察研究と介入研究の成果の集積により、栄養素や食品の摂取と動脈硬化性疾患との関連が明らかになりつつある。(著者抄録)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Association between the risk of sarcopenia and estimated protein intake using biomarkers

    2022.04
    -
    2026.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 基盤研究(C), Principal investigator

  • 一般住民における腎機能低下と無症候性脳血管障害の関連

    2019.04
    -
    2022.03

    日本学術振興会, Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, No Setting

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    近年、腎細小血管の解剖学的、機能的類似性から腎機能と無症候性脳血管疾患との関連が指摘され始めており、患者コホートからの報告ではその関連が報告されているが、一般住民からの報告はまだ少なく、その評価は分かれている。本研究では、40歳代から80歳代の850人の健常な日本人一般住民を対象として、腎機能およびその経年変化と無症候性脳血管疾患との関連、およびこの関連への循環器疾患発症因子の介在の程度を明らかにする。無症候性脳血管疾患は脳卒中および認知機能低下指標として注目されているため、本研究で得られた結果は、高齢社会における認知症・脳卒中の早期発見マーカーとして予防に繋がることが期待される。
    本研究は一般地域住民から年齢層化無作為抽出した集団のうち協力が得られた者を対象として、頭部MR画像を用いて評価した無症候性脳血管障害と潜在性動脈硬化指標および危険因子の測定を実施している既存の前向きコホートの成績を用いて、腎機能およびその経年変化と無症候性脳血管疾患の関連を検討するものである。昨年度測定した随時尿中の微量アルブミン、クレアチニン、ナトリウム値をデータベースに突合し、日本人一般集団における尿アルブミン/クレアチニン比(ACR)およびeGFRの経年変化の分布を確認し、無症候性脳血管疾患との関連を検討した。
    新型コロナウイルス感染拡大のため、成果発表の一部が遅延している。
    次年度は最終年度であるため、日本人一般集団における無症候性脳血管疾患と尿アルブミン/クレアチニン比(ACR)およびeGFRの経年変化との関連についてさらに詳細に検討を進める。また、その成果を学会や専門誌で報告する予定である。

  • Association between dietary factors and cognitive impairment in Japanese population(Fostering Joint International Research)

    2016
    -
    2019

    日本学術振興会, Grants-in-Aid for Scientific Research, Miyagawa Naoko, Fund for the Promotion of Joint International Research (Fostering Joint International Research), No Setting

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    This study aimed to identify related factors for low cognitive function in two groups of genetically similar Japanese men exposed to Westernized lifestyles from different starting points in life using cross-sectional data from Japanese-American based in Hawaii and the Japanese based in Japan. Cognitive function was evaluated by participants’ performance on the Cognitive Abilities Screening Instrument (CASI), a validated comprehensive measure of global cognitive function developed for use in cross-cultural and cross-national studies. Older Hawaii-based men were more likely to achieve a low CASI score than were older Japan-based men. In the present study, lower cognitive function among older Japanese men was mostly explained by the differences in educational attainment between the cohorts.

  • Gut microbiota and sublinical atherosclerosis in general population

    2015.04
    -
    2018.03

    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Arima Hisatomi, OHNO Seiko, MIYAGAWA Naoko, KADOWAKI Takashi, OKAMI Yukiko, Grant-in-Aid for Scientific Research (B), No Setting

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    The aim of the present analysis is to investigate the association between gut microbiota and coronary artery calcification (CAC) in general Japanese men. Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) is a prospective cohort study of randomly selected men from a general Japanese population. This analysis included 669 participants who completed a follow-up examination including analysis of gut microbiota. After adjustment for age, BMI, total cholesterol, HDL cholesterol, HbA1c, smoking, alcohol intake, regular exercise, and use of medication to treat hypertension, dyslipidemia or diabetes, frequency of Lactobacillus was associated with lower risks of coronary artery calcification (odd ratio 0.84 per 1SD [9%] increase, 95%CI 0.70-1.00) while there were no clear relationships for Bifidobacterium, Bacteroides, Prevotella or Clostridium. Lactobacillus appears to be associated with lower prevalence of CAC in a general population of Japanese men.

  • The effect of dietary habits on structural and functional assessment of brain in a Japanese population

    2015.04
    -
    2018.03

    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Miyagawa Naoko, Grant-in-Aid for Young Scientists (B), No Setting

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    The aim of the project is to investigate association of cognitive ability which is defined by structural and functional assessment of brain with dietary habits. Measures of total intracranial volume, white matter hyperintensity volume and so on were obtained with magnetic resonance imaging. Assessments of functional cognitive abilities was used Cognitive Abilities Screening Instrument (CASI). Cross-sectional analysis suggested a positive association of vegetable intake with CASI score and a negative association of vegetable intake with white matter hyperintensity volume.

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