KEIO RESEARCHERS INFORMATION SYSTEM

Books 【 Display / hide 】

Books 【 Display / hide 】

• 最新臨床高血圧学－高血圧治療の最前線－ Ⅹ特論 ４減塩社会への取り組み

  株式会社 日本臨床社, 2014

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Association between awareness of limiting food intake and all-cause mortality: A cohort study in Japan.

  Nishimoto D, Ibusuki R, Shimoshikiryo I, Shibuya K, Tanoue S, Koriyama C, Takezaki T, Oze I, Ito H, Hishida A, Tamura T, Kato Y, Tamada Y, Nishida Y, Shimanoe C, Suzuki S, Nishiyama T, Ozaki E, Tomida S, Kuriki K, Miyagawa N, Kondo K, Arisawa K, Watanabe T, Ikezaki H, Otonari J, Wakai K, Matsuo K

  Journal of epidemiology  2023.11

  ISSN  0917-5040

  • Access to Document (DOI)

• Metabolomics profiles alterations in cigarette smokers and heated tobacco product users.

  Harada S, Ohmomo H, Matsumoto M, Sata M, Iida M, Hirata A, Miyagawa N, Kuwabara K, Kato S, Toki R, Edagawa S, Sugiyama D, Sato A, Hirayama A, Sugimoto M, Soga T, Tomita M, Shimizu A, Okamura T, Takebayashi T

  Journal of epidemiology  2023.11

  ISSN  0917-5040

  • Access to Document (DOI)

• Association of Arterial Stiffness and Atherosclerotic Burden With Brain Structural Changes Among Japanese Men.

  Nazar M Azahar, Yuichiro Yano, Aya Kadota, Akihiko Shiino, Ali H Syaifullah, Naoko Miyagawa, Keiko Kondo, Mohammad Moniruzzaman, Sayuki Torii, Hiroyoshi Segawa, Takashi Hisamatsu, Akira Fujiyoshi, Kazuhiko Nozaki, Ikuo Tooyama, Hirotsugu Ueshima, Katsuyuki Miura

  Journal of the American Heart Association （Journal of the American Heart Association)  12 （ 11 ） e028586 2023.06

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  Background Little is known regarding whether arterial stiffness and atherosclerotic burden are each independently associated with brain structural changes. Simultaneous assessments of both arterial stiffness and atherosclerotic burden in associations with brain could provide insights into the mechanisms of brain structural changes. Methods and Results Using data from the SESSA (Shiga Epidemiological Study of Subclinical Atherosclerosis), we analyzed data among 686 Japanese men (mean [SD] age, 67.9 [8.4] years; range, 46-83 years) free from history of stroke and myocardial infarction. Brachial-ankle pulse wave velocity and coronary artery calcification on computed tomography scans were measured between March 2010 and August 2014. Brain volumes (total brain volume, gray matter, Alzheimer disease signature and prefrontal) and brain vascular damage (white matter hyperintensities) were quantified using brain magnetic resonance imaging from January 2012 through February 2015. In multivariable adjustment models including mean arterial pressure, when brachial-ankle pulse wave velocity and coronary artery calcification were entered into the same models, the β (95% CI) for Alzheimer disease signature volume for each 1-SD increase in brachial-ankle pulse wave velocity was -0.33 (-0.64 to -0.02), and the unstandardized β (95% CI) for white matter hyperintensities for each 1-unit increase in coronary artery calcification was 0.68 (0.05-1.32). Brachial-ankle pulse wave velocity and coronary artery calcification were not statistically significantly associated with total brain and gray matter volumes. Conclusions Among Japanese men, higher arterial stiffness was associated with lower Alzheimer disease signature volumes, whereas higher atherosclerotic burden was associated with brain vascular damage. Arterial stiffness and atherosclerotic burden may be independently associated with brain structural changes via different pathways.

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• Circulating plasma phospholipid fatty acid levels as a biomarker of habitual dietary fat intake: The INTERMAP/INTERLIPID Study.

  Naoko Miyagawa, Akira Sekikawa, Katsuyuki Miura, Rhobert W Evans, Nagako Okuda, Akira Fujiyoshi, Katsushi Yoshita, Queenie Chan, Yukiko Okami, Aya Kadota, Bradley Willcox, Kamal Masaki, Beatriz Rodriguez, Kiyomi Sakata, Hideaki Nakagawa, Shigeyuki Saitoh, Akira Okayama, Lewis H Kuller, Paul Elliott, Jeremiah Stamler, Hirotsugu Ueshima

  Journal of clinical lipidology （Journal of Clinical Lipidology)  17 （ 1 ） 131 - 141 2023

  Research paper (scientific journal), Joint Work, Lead author, Accepted,  ISSN  19332874

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  BACKGROUND: Accurate assessment of fat intake is essential to examine relationships between diet and disease risk. However, estimating individual intakes of fat quantity by dietary assessment is difficult. OBJECTIVE: We assessed the association of plasma phospholipid fatty acid levels with dietary intake of fatty acids in the INTERMAP/INTERLIPID study, conducted with a standardized protocol. METHODS: The study participants were 1339 men and women ages 40-59 years from five Japanese populations one from Hawaii; four from Japan. Fatty acid intake was estimated from four standardized 24-hour dietary recalls. Plasma phospholipid fatty acid composition was analyzed by gas chromatography. We illustrated the relationship between intake and circulating fatty acid levels using Spearman's rank-correlation coefficients, mean, and median values. RESULTS: Spearman's rank-correlation coefficients between intake (g/d) and circulating fatty acid levels (µg/ml) were -0.03 to 0.21 for saturated fatty acids and monounsaturated fatty acids and -0.04 to 0.32 for trans fatty acids. The coefficients for essential n-3 and n-6 fatty acids were moderate to high, especially for eicosapentaenoic acid (EPA), 0.60; docosahexaenoic acid (DHA), 0.41; and EPA+DHA, 0.51. The circulating levels and intake of marine-derived n-3 fatty acids showed a linear association, at least for the intake of EPA+DHA up to 2.1 g/d. CONCLUSION: We observed high correlation between intake and circulating levels of marine-derived n-3 fatty acids in participants from Japanese and Japanese-American populations with high and low fish intake. Plasma phospholipid marine-derived n-3 fatty acid measurements are a simple and reliable biomarker for assessing dietary intake.

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• Coffee and Metabolic Phenotypes: A Cross-sectional Analysis of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study

  Takeshi Watanabe, Kokichi Arisawa, Tien Van Nguyen, Masashi Ishizu, Sakurako Katsuura-Kamano, Asahi Hishida, Takashi Tamura, Yasufumi Kato, Rieko Okada, Rie Ibusuki, Chihaya Koriyama, Sadao Suzuki, Takahiro Otani, Teruhide Koyama, Satomi Tomida, Kiyonori Kuriki, Naoyuki Takashima, Naoko Miyagawa, Kenji Wakai, Keitaro Matsuo

  Nutrition, Metabolism and Cardiovascular Diseases （Elsevier BV)  33 （ 3 ） 620 - 630 2022.12

  ISSN  0939-4753

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  Background and aims: To date, the relationship between coffee consumption and metabolic phenotypes has hardly been investigated and remains controversial. Therefore, the aim of this cross-sectional study is to examine the associations between coffee consumption and metabolic phenotypes in a Japanese population. Methods and results: We analyzed the data of 26,363 subjects (aged 35–69 years) in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. Coffee consumption was assessed using a questionnaire. Metabolic Syndrome (MetS) was defined according to the Joint Interim Statement Criteria of 2009, using body mass index (BMI) instead of waist circumference. Subjects stratified by the presence or absence of obesity (normal weight: BMI <25 kg/m2; obesity: BMI ≥25 kg/m2) were classified by the number of MetS components (metabolically healthy: no components; metabolically unhealthy: one or more components) other than BMI. In multiple logistic regression analyses adjusted for sex, age, and other potential confounders, high coffee consumption (≥3 cups/day) was associated with a lower prevalence of MetS and metabolically unhealthy phenotypes both in normal weight (OR 0.83, 95% CI 0.76–0.90) and obese subjects (OR 0.83, 95% CI 0.69–0.99). Filtered/instant coffee consumption was inversely associated with the prevalence of MetS and metabolically unhealthy phenotypes, whereas canned/bottled/packed coffee consumption was not. Conclusion: The present results suggest that high coffee consumption, particularly filtered/instant coffee, is inversely associated with the prevalence of metabolically unhealthy phenotypes in both normal weight and obese Japanese adults.

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Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• 地域高齢者におけるライフスタイルリスクスコアと機能障害

  宮川 尚子, 高嶋 直敬, 土岐 了大, 原田 成, 武林 亨, 岡村 智教, 門田 文, 三浦 克之, 上島 弘嗣, 喜多 義邦

  日本循環器病予防学会誌 ((一社)日本循環器病予防学会)  58 ( 2 ) 153 - 153 2023.05

  ISSN  1346-6267

• The Ratio of Circulating Eicosapentaenoic Acid to Arachidonic Acid Ratio in the Community-Dwelling Japanese Population

  Miyagawa Naoko

  Journal of Atherosclerosis and Thrombosis (Japan Atherosclerosis Society)  30 ( 6 ) 587 - 588 2023

  ISSN  13403478

  • Access to Document (DOI)
  • CiNii Research

• 一般住民における内臓脂肪の蓄積に関連するメタボロミクスプロファイル　鶴岡メタボロームコホート研究

  宮川 尚子, 原田 成, 飯田 美穂, 桑原 和代, 加藤 寿寿華, 佐田 みずき, 松元 美奈子, 平田 あや, 岡村 智教, 武林 亨

  Journal of Epidemiology ((一社)日本疫学会)  32 ( Suppl.1 ) 164 - 164 2022.01

  ISSN  0917-5040

• Dietary Intake of Manganese in the Japanese Diet and its Association with Cardiometabolic and Cardiovascular Diseases

  Miyagawa Naoko

  Journal of Atherosclerosis and Thrombosis (Japan Atherosclerosis Society)  29 ( 10 ) 1421 - 1422 2022

  ISSN  13403478

  • Access to Document (DOI)
  • CiNii Research

• 【心疾患と栄養】循環器疾患と食生活

  宮川 尚子, 岡村 智教

  栄養 ((株)ジェフコーポレーション)  36 ( 4 ) 179 - 185 2021.12

  ISSN  2435-4503

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  食生活は内容によって循環器疾患の危険因子にも防御因子にもなりうることが、多くの疫学研究から明らかになっている。脂質やたんぱく質のうち、飽和脂肪酸は循環器疾患のリスクを高め、魚に多く含まれるn-3系不飽和脂肪酸や植物性たんぱく質は循環器疾患の発症に予防的に働くことが報告されている。一方、炭水化物から摂取するエネルギー割合は低すぎても高すぎても死亡リスクが高くなる。食塩は循環器疾患の主要な要因である血圧を上昇させて循環器疾患リスクを高め、反対に野菜や果物は、カリウムなど含まれる様々な栄養素の機能が複合的に作用して高血圧や循環器疾患のリスクを低下させる。これらの循環器疾患に関連する食品を組み合わせて摂取する、健康的な食事パターンをスコア化した食事指標を用いた検討では、指標の遵守度が高いほど循環器疾患リスクが低下していた。食事内容の改善により循環器疾患の予防が期待できるため、摂取する食品の内容や量を適切に選択することが大切である。(著者抄録)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• Usefulness of metabolite biomarker as a common pathway for the prevention of non-communicable diseases and frailty

  2023.04

  -

  2028.03

  Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), No Setting

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  本研究は、開始後10年を経過した地域在住者コホート研究により、若年期から集積する心臓代謝リスクの併存状態（マルチモビディティ）からNCDsおよびフレイル・認知機能低下への移行を媒介する共通代謝経路・代謝バイオマーカーを疫学的に解明・検証した上で、その代謝経路と関連する変容可能な環境要因を明らかにして、中・高齢期の保健・介護予防一体的実施に最適な介入手法の基礎とすることを目的とする。また新型コロナウイルス感染によってその機能がリモデリングされる代謝経路にも焦点をあて、感染の後遺・遷延症状も考慮した地域保健現場での健康支援についても検討する。

• Association between the risk of sarcopenia and estimated protein intake using biomarkers

  2022.04

  -

  2026.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, 基盤研究(C), Principal investigator

• 一般住民における腎機能低下と無症候性脳血管障害の関連

  2019.04

  -

  2022.03

  日本学術振興会, Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, No Setting

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  近年、腎細小血管の解剖学的、機能的類似性から腎機能と無症候性脳血管疾患との関連が指摘され始めており、患者コホートからの報告ではその関連が報告されているが、一般住民からの報告はまだ少なく、その評価は分かれている。本研究では、40歳代から80歳代の850人の健常な日本人一般住民を対象として、腎機能およびその経年変化と無症候性脳血管疾患との関連、およびこの関連への循環器疾患発症因子の介在の程度を明らかにする。無症候性脳血管疾患は脳卒中および認知機能低下指標として注目されているため、本研究で得られた結果は、高齢社会における認知症・脳卒中の早期発見マーカーとして予防に繋がることが期待される。
  本研究は一般地域住民から年齢層化無作為抽出した集団のうち協力が得られた者を対象として、頭部MR画像を用いて評価した無症候性脳血管障害と潜在性動脈硬化指標および危険因子の測定を実施している既存の前向きコホートの成績を用いて、腎機能およびその経年変化と無症候性脳血管疾患の関連を検討するものである。昨年度測定した随時尿中の微量アルブミン、クレアチニン、ナトリウム値をデータベースに突合し、日本人一般集団における尿アルブミン/クレアチニン比(ACR)およびeGFRの経年変化の分布を確認し、無症候性脳血管疾患との関連を検討した。
  新型コロナウイルス感染拡大のため、成果発表の一部が遅延している。
  次年度は最終年度であるため、日本人一般集団における無症候性脳血管疾患と尿アルブミン/クレアチニン比(ACR)およびeGFRの経年変化との関連についてさらに詳細に検討を進める。また、その成果を学会や専門誌で報告する予定である。

• Association between dietary factors and cognitive impairment in Japanese population(Fostering Joint International Research)

  2016

  -

  2019

  日本学術振興会, Grants-in-Aid for Scientific Research, Miyagawa Naoko, Fund for the Promotion of Joint International Research (Fostering Joint International Research), No Setting

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  This study aimed to identify related factors for low cognitive function in two groups of genetically similar Japanese men exposed to Westernized lifestyles from different starting points in life using cross-sectional data from Japanese-American based in Hawaii and the Japanese based in Japan. Cognitive function was evaluated by participants’ performance on the Cognitive Abilities Screening Instrument (CASI), a validated comprehensive measure of global cognitive function developed for use in cross-cultural and cross-national studies. Older Hawaii-based men were more likely to achieve a low CASI score than were older Japan-based men. In the present study, lower cognitive function among older Japanese men was mostly explained by the differences in educational attainment between the cohorts.

• Gut microbiota and sublinical atherosclerosis in general population

  2015.04

  -

  2018.03

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Arima Hisatomi, OHNO Seiko, MIYAGAWA Naoko, KADOWAKI Takashi, OKAMI Yukiko, Grant-in-Aid for Scientific Research (B), No Setting

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  The aim of the present analysis is to investigate the association between gut microbiota and coronary artery calcification (CAC) in general Japanese men. Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) is a prospective cohort study of randomly selected men from a general Japanese population. This analysis included 669 participants who completed a follow-up examination including analysis of gut microbiota. After adjustment for age, BMI, total cholesterol, HDL cholesterol, HbA1c, smoking, alcohol intake, regular exercise, and use of medication to treat hypertension, dyslipidemia or diabetes, frequency of Lactobacillus was associated with lower risks of coronary artery calcification (odd ratio 0.84 per 1SD [9%] increase, 95%CI 0.70-1.00) while there were no clear relationships for Bifidobacterium, Bacteroides, Prevotella or Clostridium. Lactobacillus appears to be associated with lower prevalence of CAC in a general population of Japanese men.

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Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• NUTRITION FOR NURSING AND HEALTH CARE

  2023