Miyagawa, Naoko

写真a

Affiliation

School of Medicine, Department of Preventive Medicine and Public Health (Shinanomachi)

Position

Instructor
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Books 【 Display / hide 】

  • 最新臨床高血圧学－高血圧治療の最前線－ Ⅹ特論 ４減塩社会への取り組み

    株式会社 日本臨床社, 2014

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Papers 【 Display / hide 】

  • Validity assessment of self-reported medication use in a pharmacoepidemiologic study by comparison with prescription record review

    YAJIMA Rina, MATSUMOTO Minako, IIDA Miho, HARADA Sei, SHIBUKI Takuma, HIRATA Aya, KUWABARA Kazuyo, MIYAGAWA Naoko, NAKAMURA Tomonori, OKAMURA Tomonori, TAKEBAYASHI Toru

    Nihon Koshu Eisei Zasshi(JAPANESE JOURNAL OF PUBLIC HEALTH) (Japanese Society of Public Health)  71 ( 8 ) 430 - 437 2024.08

    ISSN  0546-1766

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    <p><b>Objectives</b>　Although self-reported questionnaires are widely used to collect information on medication use in epidemiological studies, their validity for studies involving older adults has not been sufficiently assessed. This study evaluated the validity of self-reported medication use using questionnaires in comparison with drug notebooks.</p><p><b>Methods</b>　The study enrolled 370 older community dwellers who participated in an aging sub-study survey of the Tsuruoka Metabolomics Cohort Study between April 2019 and March 2021. Medication use was assessed by comparing self-reported questionnaire data with drug notebook records. We analyzed medications used for hypertension, dyslipidemia, myocardial infarction, angina, diabetes, rheumatism, osteoporosis/metabolic bone disease, constipation, anxiety/depression, dementia, asthma, allergy, thrombosis, and thyroid disease. Moreover, gastrointestinal (GI) medications, steroids, and antipyretic analgesics were assessed, and data on injectable medications for osteoporosis/metabolic bone disease was collected. Using drug notebook records, we identified regular medication users by assessing whether they had received oral medication prescriptions covering over 28 days and took the medication within the 90 days preceding the day of their survey. To define medication categories, we used Anatomical Therapeutic Chemical (ATC) classification codes. Sensitivity, specificity, and kappa statistics were calculated for each medication using drug notebooks as standards. Those who did not bring their drug notebooks on the day of the survey were defined as non-medication users.</p><p><b>Results</b>　The mean age (standard deviation) of the 370 participants (146 men and 224 women) was 73.3 (4.0) years. The sensitivity and specificity for each medication were as follows: hypertension (0.97, 0.97), dyslipidemia (0.93, 0.98), myocardial infarction (0.24, 0.99), diabetes (0.94, 1.00), rheumatism (1.00, 1.00), osteoporosis/metabolic bone disease (0.82, 0.99), constipation (0.71, 0.98), GI conditions (0.63, 0.97), anxiety/depression (0.36, 1.00), dementia (0.67, 1.00), asthma (0.67, 0.98), allergy (0.57, 0.99), thrombosis (0.88, 0.98), steroids (0.80, 0.99), thyroid disease (1.00, 1.00) and antipyretic analgesics (0.75, 0.96).</p><p><b>Conclusions</b>　Although sensitivity and specificity differed by medication categories, the results of our population-based cohort study suggested that self-reported questionnaires on medication use among older adults are valid, especially for medications with high sensitivity (≥ 0.8).</p>

  • Evaluation of Medication Adherence Among Prevalent Users in Hypertension, Dyslipidemia, and Diabetes Using Health Insurance Claims: A Population-Based Cohort Study in Japan

    Matsumoto M., Harada S., Ikuta H., Iida M., Kato S., Sata M., Shibuki T., Ishibashi Y., Miyagawa N., Hisamatsu M., Hirata A., Kuwabara K., Takeuchi A., Sugiyama D., Suzuki S., Nakamura T., Okamura T., Takebayashi T.

    Pharmacoepidemiology and Drug Safety 33 ( 8 ) e5855 2024.08

    ISSN  10538569

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    Purpose: Hypertension (HT), dyslipidemia (DL), and diabetes mellitus (DM) are major risk factors for cardiovascular diseases. Despite the wide availability of medications to reduce this risk, poor adherence to medications remains an issue. The aim of this study is to evaluate medication adherence of prevalent users in these disease medications (HT, DL, DM) using claims data. Factors associated with non-adherence were also examined. Methods: Of 7538 participants of the Tsuruoka Metabolomics Cohort Study, 3693 (HT: 2702, DL: 2112, DM: 661) were identified as prevalent users of these disease medications. Information on lifestyle was collected through a questionnaire. Adherence was assessed by a proportion of days covered (PDC) and participants with PDC ≥0.8 were defined as adherent. Predictors of non-adherence were determined by performing multivariable logistic regression. Results: Medication adherence differed by treatment status. Among those without comorbidities, those with HT-only showed the highest adherence (90.2%), followed by those with DM-only (81.2%) and those with DL-only (80.8%). Factors associated with non-adherence in each medication group were skipping breakfast and poor understanding of medications among those with HT medications, females, having comorbidities, having a history of heart disease, and drinking habit among those with DL medications, and good sleep quality and skipping breakfast among those with DM medications. Conclusion: While participants showed high medication adherence, differences were observed across medication groups. The identified predictors of non-adherence could help target those in need of adherence support.

  • Association between consumption of small fish and all-cause mortality among Japanese: the Japan Multi-Institutional Collaborative Cohort Study.

    Chinatsu Kasahara, Takashi Tamura, Kenji Wakai, Yudai Tamada, Yasufumi Kato, Yoko Kubo, Rieko Okada, Mako Nagayoshi, Asahi Hishida, Nahomi Imaeda, Chiho Goto, Jun Otonari, Hiroaki Ikezaki, Yuichiro Nishida, Chisato Shimanoe, Isao Oze, Yuriko N Koyanagi, Yohko Nakamura, Miho Kusakabe, Daisaku Nishimoto, Ippei Shimoshikiryo, Sadao Suzuki, Miki Watanabe, Etsuko Ozaki, Chie Omichi, Kiyonori Kuriki, Naoyuki Takashima, Naoko Miyagawa, Kokichi Arisawa, Sakurako Katsuura-Kamano, Kenji Takeuchi, Keitaro Matsuo

    Public health nutrition 27 ( 1 ) e135 - 40 2024.05

    ISSN  13689800

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    OBJECTIVE: Although small fish are an important source of micronutrients, the relationship between their intake and mortality remains unclear. This study aimed to clarify the association between intake of small fish and all-cause and cause-specific mortality. DESIGN: We used the data from a cohort study in Japan. The frequency of the intake of small fish was assessed using a validated food frequency questionnaire. The hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and cause-specific mortality according to the frequency of the intake of small fish by sex were estimated using a Cox proportional hazard model with adjustments for covariates. SETTING: The Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. PARTICIPANTS: A total of 80,802 participants (34,555 males and 46,247 females), aged 35-69 years. RESULTS: During a mean follow-up of 9.0 years, we identified 2,482 deaths including 1,495 cancer-related deaths. The intake of small fish was statistically significantly and inversely associated with the risk of all-cause and cancer mortality in females. The multivariable-adjusted HRs (95% CIs) in females for all-cause mortality according to the intake were 0.68 (0.55-0.85) for intakes 1-3 times/month, 0.72 (0.57-0.90) for 1-2 times/week, and 0.69 (0.54-0.88) for ≥3 times/week, compared with the rare intake. The corresponding HRs (95% CIs) in females for cancer mortality were 0.72 (0.54-0.96), 0.71 (0.53-0.96), and 0.64 (0.46-0.89), respectively. No statistically significant association was observed in males. CONCLUSIONS: Intake of small fish may reduce the risk of all-cause and cancer mortality in Japanese females.

  • Association of Nonalcoholic Fatty Liver Disease with Arterial Stiffness and its Metabolomic Profiling in Japanese Community-Dwellers

    Hirata Aya, Harada Sei, Iida Miho, Kurihara Ayako, Fukai Kota, Kuwabara Kazuyo, Kato Suzuka, Matsumoto Minako, Sata Mizuki, Miyagawa Naoko, Toki Ryota, Edagawa Shun, Sugiyama Daisuke, Sato Asako, Hirayama Akiyoshi, Sugimoto Masahiro, Soga Tomoyoshi, Tomita Masaru, Okamura Tomonori, Takebayashi Toru

    Journal of Atherosclerosis and Thrombosis (Japan Atherosclerosis Society)  advpub ( 0 ) 1031 - 1047 2024.02

    ISSN  1340-3478

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    <p><b>Aims: </b>Nonalcoholic fatty liver disease (NAFLD) is known to be associated with atherosclerosis. This study focused on upstream changes in the process by which NAFLD leads to atherosclerosis. The study aimed to confirm the association between NAFLD and the cardio-ankle vascular index (CAVI), an indicator of subclinical atherosclerosis, and explore metabolites involved in both by assessing 94 plasma polar metabolites.<b> </b></p><p><b>Methods: </b>A total of 928 Japanese community-dwellers (306 men and 622 women) were included in this study. The association between NAFLD and CAVI was examined using a multivariable regression model adjusted for confounders. Metabolites commonly associated with NAFLD and CAVI were investigated using linear mixed-effects models in which batch numbers of metabolite measurements were used as a random-effects variable, and false discovery rate-adjusted <i>p</i>-values were calculated. To determine the extent to which these metabolites mediated the association between NAFLD and CAVI, mediation analysis was conducted.<b> </b></p><p><b>Results: </b>NAFLD was positively associated with CAVI (coefficients [95% Confidence intervals (CI)]=0.23 [0.09-0.37]; <i>p</i>=0.001). A total of 10 metabolites were involved in NAFLD and CAVI, namely, branched-chain amino acids (BCAAs; valine, leucine, and isoleucine), aromatic amino acids (AAAs; tyrosine and tryptophan), alanine, proline, glutamic acid, glycerophosphorylcholine, and 4-methyl-2-oxopentanoate. Mediation analysis showed that BCAAs mediated more than 20% of the total effect in the association between NAFLD and CAVI.<b> </b></p><p><b>Conclusions: </b>NAFLD was associated with a marker of atherosclerosis, and several metabolites related to insulin resistance, including BCAAs and AAAs, could be involved in the process by which NAFLD leads to atherosclerosis.</p>

  • The Association of Spot Urine Sodium and Potassium Excretion with Nutrient and Food Intake: NIPPON DATA 2010

    Nakagawa Yumi, Yoshita Katsushi, Miyagawa Naoko, Okami Yukiko, Ohkubo Takayoshi, Okamura Tomonori, Miura Katsuyuki, the NIPPON DATA 2010 Research Group

    The Japanese Journal of Nutrition and Dietetics (The Japanese Society of Nutrition and Dietetics)  82 ( 1 ) 13 - 23 2024.02

    ISSN  00215147

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    <p><b>Objective:</b> This study aimed to examine the association of estimated excretion in 24-h urinary Na (E24h-Na) and K (E24h-K) from spot urine, with nutrient and food intake.</p><p><b>Methods:</b> The participants were 1,504 men and women (the NIPPON DATA2010 study) who participated in the National Health and Nutrition Survey Japan in 2010. They were not diagnosed with serious cardiovascular or kidney disease and not treated for hypertension, diabetes mellitus, or dyslipidemia. Sex-specific analyses were performed. They were divided into four groups based on the median E24h-Na and E24h-K and their nutrient and food intakes were compared.</p><p><b>Results:</b> K intake was higher in the higher K and higher Na excretion groups than in the lower K excretion group. Na and pickles intakes were higher among women in the lower Na excretion group, and vegetable intake was higher than in the lower K excretion group. In the lower K and lower Na excretion groups, K intake was lower than in the higher K excretion group. The lower K and higher Na excretion groups had the highest dietary Na/K ratio among women. The higher K and lower Na excretion groups had the lowest dietary Na/K ratio among women. K, milk, and dairy product intakes were higher in the lower K excretion groups.</p><p><b>Conclusions:</b> E24h-Na and E24h-K were associated with Na and K intake status and K-rich foods intake.</p>

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Reviews, Commentaries, etc. 【 Display / hide 】

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Epidemiological study to generate evidence for the introduction of a program to evaluate early stage renal dysfunction in health checkups

    2024.04
    -
    2027.03

    Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), No Setting

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    慢性腎臓病(CKD)発症予防には生活習慣の修正による腎機能の回復が可能な早期腎機能障害の段階からの腎機能評価が必要であるが、現行の健診における早期腎機能障害の評価には限界がある。本研究では尿細管障害マーカーを含む複数の腎機能マーカーを用いてこれまで一般集団では十分に検討されてこなかった早期の腎機能障害を精緻に評価し、脳・心血管疾患発症などの複数の疾患アウトカムとの関連を検討することで、腎機能障害に関する多面的なリスク評価を行う。さらに遺伝要因の影響を含めた詳細な規定要因の検証を行い、個人の体質を考慮した次世代型の健診・保健指導導入のためのエビデンスを創出する。

  • Usefulness of metabolite biomarker as a common pathway for the prevention of non-communicable diseases and frailty

    2023.04
    -
    2028.03

    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), No Setting

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    本研究は、開始後10年を経過した地域在住者コホート研究により、若年期から集積する心臓代謝リスクの併存状態（マルチモビディティ）からNCDsおよびフレイル・認知機能低下への移行を媒介する共通代謝経路・代謝バイオマーカーを疫学的に解明・検証した上で、その代謝経路と関連する変容可能な環境要因を明らかにして、中・高齢期の保健・介護予防一体的実施に最適な介入手法の基礎とすることを目的とする。また新型コロナウイルス感染によってその機能がリモデリングされる代謝経路にも焦点をあて、感染の後遺・遷延症状も考慮した地域保健現場での健康支援についても検討する。

  • Association between the risk of sarcopenia and estimated protein intake using biomarkers

    2022.04
    -
    2026.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

  • 一般住民における腎機能低下と無症候性脳血管障害の関連

    2019.04
    -
    2022.03

    日本学術振興会, Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, No Setting

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    近年、腎細小血管の解剖学的、機能的類似性から腎機能と無症候性脳血管疾患との関連が指摘され始めており、患者コホートからの報告ではその関連が報告されているが、一般住民からの報告はまだ少なく、その評価は分かれている。本研究では、40歳代から80歳代の850人の健常な日本人一般住民を対象として、腎機能およびその経年変化と無症候性脳血管疾患との関連、およびこの関連への循環器疾患発症因子の介在の程度を明らかにする。無症候性脳血管疾患は脳卒中および認知機能低下指標として注目されているため、本研究で得られた結果は、高齢社会における認知症・脳卒中の早期発見マーカーとして予防に繋がることが期待される。
    本研究は一般地域住民から年齢層化無作為抽出した集団のうち協力が得られた者を対象として、頭部MR画像を用いて評価した無症候性脳血管障害と潜在性動脈硬化指標および危険因子の測定を実施している既存の前向きコホートの成績を用いて、腎機能およびその経年変化と無症候性脳血管疾患の関連を検討するものである。昨年度測定した随時尿中の微量アルブミン、クレアチニン、ナトリウム値をデータベースに突合し、日本人一般集団における尿アルブミン/クレアチニン比(ACR)およびeGFRの経年変化の分布を確認し、無症候性脳血管疾患との関連を検討した。
    新型コロナウイルス感染拡大のため、成果発表の一部が遅延している。
    次年度は最終年度であるため、日本人一般集団における無症候性脳血管疾患と尿アルブミン/クレアチニン比(ACR)およびeGFRの経年変化との関連についてさらに詳細に検討を進める。また、その成果を学会や専門誌で報告する予定である。

  • Association between dietary factors and cognitive impairment in Japanese population(Fostering Joint International Research)

    2016
    -
    2019

    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Miyagawa Naoko, Fund for the Promotion of Joint International Research (Fostering Joint International Research), No Setting

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    This study aimed to identify related factors for low cognitive function in two groups of genetically similar Japanese men exposed to Westernized lifestyles from different starting points in life using cross-sectional data from Japanese-American based in Hawaii and the Japanese based in Japan. Cognitive function was evaluated by participants’ performance on the Cognitive Abilities Screening Instrument (CASI), a validated comprehensive measure of global cognitive function developed for use in cross-cultural and cross-national studies. Older Hawaii-based men were more likely to achieve a low CASI score than were older Japan-based men. In the present study, lower cognitive function among older Japanese men was mostly explained by the differences in educational attainment between the cohorts.

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Courses Taught 【 Display / hide 】

  • NUTRITION FOR NURSING AND HEALTH CARE

    2024

  • NUTRITION FOR NURSING AND HEALTH CARE

    2023

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