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• 最新臨床高血圧学－高血圧治療の最前線－ Ⅹ特論 ４減塩社会への取り組み

  株式会社 日本臨床社, 2014

Papers 【 Display / hide 】

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• Association of Nonalcoholic Fatty Liver Disease with Arterial Stiffness and its Metabolomic Profiling in Japanese Community-Dwellers

  Hirata Aya, Harada Sei, Iida Miho, Kurihara Ayako, Fukai Kota, Kuwabara Kazuyo, Kato Suzuka, Matsumoto Minako, Sata Mizuki, Miyagawa Naoko, Toki Ryota, Edagawa Shun, Sugiyama Daisuke, Sato Asako, Hirayama Akiyoshi, Sugimoto Masahiro, Soga Tomoyoshi, Tomita Masaru, Okamura Tomonori, Takebayashi Toru

  Journal of Atherosclerosis and Thrombosis （Japan Atherosclerosis Society)  advpub （ 0 ）  2024.02

  ISSN  1340-3478

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  <p><b>Aims: </b>Nonalcoholic fatty liver disease (NAFLD) is known to be associated with atherosclerosis. This study focused on upstream changes in the process by which NAFLD leads to atherosclerosis. The study aimed to confirm the association between NAFLD and the cardio-ankle vascular index (CAVI), an indicator of subclinical atherosclerosis, and explore metabolites involved in both by assessing 94 plasma polar metabolites.<b> </b></p><p><b>Methods: </b>A total of 928 Japanese community-dwellers (306 men and 622 women) were included in this study. The association between NAFLD and CAVI was examined using a multivariable regression model adjusted for confounders. Metabolites commonly associated with NAFLD and CAVI were investigated using linear mixed-effects models in which batch numbers of metabolite measurements were used as a random-effects variable, and false discovery rate-adjusted <i>p</i>-values were calculated. To determine the extent to which these metabolites mediated the association between NAFLD and CAVI, mediation analysis was conducted.<b> </b></p><p><b>Results: </b>NAFLD was positively associated with CAVI (coefficients [95% Confidence intervals (CI)]=0.23 [0.09-0.37]; <i>p</i>=0.001). A total of 10 metabolites were involved in NAFLD and CAVI, namely, branched-chain amino acids (BCAAs; valine, leucine, and isoleucine), aromatic amino acids (AAAs; tyrosine and tryptophan), alanine, proline, glutamic acid, glycerophosphorylcholine, and 4-methyl-2-oxopentanoate. Mediation analysis showed that BCAAs mediated more than 20% of the total effect in the association between NAFLD and CAVI.<b> </b></p><p><b>Conclusions: </b>NAFLD was associated with a marker of atherosclerosis, and several metabolites related to insulin resistance, including BCAAs and AAAs, could be involved in the process by which NAFLD leads to atherosclerosis.</p>

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• The Association of Spot Urine Sodium and Potassium Excretion with Nutrient and Food Intake: NIPPON DATA 2010

  Nakagawa Yumi, Yoshita Katsushi, Miyagawa Naoko, Okami Yukiko, Ohkubo Takayoshi, Okamura Tomonori, Miura Katsuyuki, the NIPPON DATA 2010 Research Group

  The Japanese Journal of Nutrition and Dietetics （The Japanese Society of Nutrition and Dietetics)  82 （ 1 ） 13 - 23 2024.02

  ISSN  00215147

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  <p><b>Objective:</b> This study aimed to examine the association of estimated excretion in 24-h urinary Na (E24h-Na) and K (E24h-K) from spot urine, with nutrient and food intake.</p><p><b>Methods:</b> The participants were 1,504 men and women (the NIPPON DATA2010 study) who participated in the National Health and Nutrition Survey Japan in 2010. They were not diagnosed with serious cardiovascular or kidney disease and not treated for hypertension, diabetes mellitus, or dyslipidemia. Sex-specific analyses were performed. They were divided into four groups based on the median E24h-Na and E24h-K and their nutrient and food intakes were compared.</p><p><b>Results:</b> K intake was higher in the higher K and higher Na excretion groups than in the lower K excretion group. Na and pickles intakes were higher among women in the lower Na excretion group, and vegetable intake was higher than in the lower K excretion group. In the lower K and lower Na excretion groups, K intake was lower than in the higher K excretion group. The lower K and higher Na excretion groups had the highest dietary Na/K ratio among women. The higher K and lower Na excretion groups had the lowest dietary Na/K ratio among women. K, milk, and dairy product intakes were higher in the lower K excretion groups.</p><p><b>Conclusions:</b> E24h-Na and E24h-K were associated with Na and K intake status and K-rich foods intake.</p>

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• Seven-plus hours of daily sedentary time and the subsequent risk of breast cancer: Japan Multi-Institutional Collaborative Cohort Study

  Tomida S., Koyama T., Ozaki E., Takashima N., Morita M., Sakaguchi K., Naoi Y., Nishida Y., Hara M., Hishida A., Tamura T., Okada R., Kubo Y., Otonari J., Ikezaki H., Nakamura Y., Kusakabe M., Tanoue S., Koriyama C., Koyanagi Y.N., Ito H., Suzuki S., Otani T., Miyagawa N., Okami Y., Arisawa K., Watanabe T., Kuriki K., Wakai K., Matsuo K.

  Cancer Science （Cancer Science)  115 （ 2 ） 611 - 622 2024.02

  ISSN  13479032

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  This study aimed to investigate the association between daily sedentary time and the risk of breast cancer (BC) in a large Japanese population. The participants were 36,023 women aged 35–69 years from the Japan Multi-Institutional Collaborative Cohort Study. Cox proportional hazards analysis was used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for BC incidence in relation to time spent sedentarily (categorical variables: <7 and ≥7 hours/day [h/d]). Additionally, the associations of BC incidence to the joint effect of sedentary time with each component of physical activity, such as leisure-time metabolic equivalents (METs), frequency of leisure-time physical activity, and daily walking time, were examined. During 315,189 person-years of follow-up, 554 incident cases of BC were identified. When compared to participants who spent <7 h/d sedentary, those who spent ≥7 h/d sedentary have a significantly higher risk of BC (HR, 1.36; 95% CI, 1.07–1.71). The corresponding HRs among participants who spent ≥7 h/d sedentary with more physical activity, such as ≥1 h/d for leisure-time METs, ≥3 days/week of leisure-time physical activity, and ≥1 h/d of daily walking were 1.58 (95% CI, 1.11–2.25), 1.77 (95% CI, 1.20–2.61), and 1.42 (95% CI, 1.10–1.83), respectively, compared with those who spent <7 h/d sedentary. This study found that spending ≥7 h/d of sedentary time is associated with the risk of BC. Neither leisure-time physical activity nor walking had a BC-preventive effect in those with ≥7 h/d of sedentary time.

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• Association of step counts with cognitive function in apparently healthy middle-aged and older Japanese men.

  Takeshi Shibukawa, Akira Fujiyoshi, Mohammad Moniruzzaman, Naoko Miyagawa, Aya Kadota, Keiko Kondo, Yoshino Saito, Sayaka Kadowaki, Takashi Hisamatsu, Yuichiro Yano, Hisatomi Arima, Ikuo Tooyama, Hirotsugu Ueshima, Katsuyuki Miura

  Preventive medicine reports （Preventive Medicine Reports)  38   102615 - 102615 2024.02

  ISSN  2211-3355

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  BACKGROUND: Increasing physical activity may prevent cognitive decline. Previous studies primarily focused on older adults and used self-reported questionnaires to assess physical activity. We examined the relationship between step count, an objective measure of physical activity, and cognitive function in community-based middle-aged and older Japanese men. METHODS: The Shiga Epidemiological Study of Subclinical Atherosclerosis randomly recruited community-dwelling healthy men aged 40-79 years from Shiga, Japan, and measured their step counts over 7 consecutive days using a pedometer at baseline (2006-2008). Among men who returned for follow-up (2009-2014), we assessed their cognitive function using the Cognitive Abilities Screening Instrument (CASI) score. We restricted our analyses to those with valid 7-day average step counts at baseline and those who remained free of stroke at follow-up (n = 676). Using analysis of covariance, we calculated the adjusted means of the CASI score according to the quartiles of the average step counts. RESULTS: The mean (standard deviation) of age and unadjusted CASI score were 63.8 (9.1) years and 90.8 (5.8), respectively. The CASI score was elevated in higher quartiles of step counts (90.2, 90.4, 90.6, and 91.8 from the lowest to the highest quartile, respectively, [p for trend = 0.004]) in a model adjusted for age and education. Further adjustment for smoking, drinking, and other cardiovascular risk factors resulted in a similar pattern of association (p for trend = 0.005). CONCLUSION: In apparently healthy middle-aged and older Japanese men, a greater 7-day average step count at baseline was associated with significantly higher cognitive function score.

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• Study Profile of the Tsuruoka Metabolomics Cohort Study (TMCS)

  Sei Harada, Miho Iida, Naoko Miyagawa, Aya Hirata, Kazuyo Kuwabara, Minako Matsumoto, Tomonori Okamura, Shun Edagawa, Yoko Kawada, Atsuko Miyake, Ryota Toki, Miki Akiyama, Atsuki Kawai, Daisuke Sugiyama, Yasunori Sato, Ryo Takemura, Kota Fukai, Yoshiki Ishibashi, Suzuka Kato, Ayako Kurihara, Mizuki Sata, Takuma Shibuki, Ayano Takeuchi, Shun Kohsaka, Mitsuaki Sawano, Satoshi Shoji, Yoshikane Izawa, Masahiro Katsumata, Koichi Oki, Shinichi Takahashi, Tsubasa Takizawa, Hiroshi Maruya, Yuji Nishiwaki, Ryo Kawasaki, Akiyoshi Hirayama, Takamasa Ishikawa, Rintaro Saito, Asako Sato, Tomoyoshi Soga, Masahiro Sugimoto, Masaru Tomita, Shohei Komaki, Hideki Ohmomo, Kanako Ono, Yayoi Otsuka-Yamasaki, Atsushi Shimizu, Yoichi Sutoh, Atsushi Hozawa, Kengo Kinoshita, Seizo Koshiba, Kazuki Kumada, Soichi Ogishima, Mika Sakurai-Yageta, Gen Tamiya, Toru Takebayashi

  Journal of Epidemiology （Japan Epidemiological Association)  advpub （ 0 ）  2024.01

  ISSN  0917-5040

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  <p>The Tsuruoka Metabolomics Cohort Study (TMCS) is an ongoing population-based cohort study being conducted in the rural area of Yamagata Prefecture, Japan. This study aimed to enhance the precision prevention of multi-factorial, complex diseases, including non-communicable and aging-associated diseases, by improving risk stratification and prediction measures. At baseline, 11,002 participants aged 35–74 years were recruited in Tsuruoka City, Yamagata Prefecture, Japan, between 2012 and 2015, with an ongoing follow-up survey. Participants underwent various measurements, examinations, tests, and questionnaires on their health, lifestyle, and social factors. This study used an integrative approach with deep molecular profiling to identify potential biomarkers linked to phenotypes that underpin disease pathophysiology and provide better mechanistic insights into social health determinants. The TMCS incorporates multi-omics data, including genetic and metabolomic analyses of 10,933 participants and comprehensive data collection ranging from physical, psychological, behavioral, and social to biological data. The metabolome is used as a phenotypic probe because it is sensitive to changes in physiological and external conditions. The TMCS focuses on collecting outcomes for cardiovascular disease, cancer incidence and mortality, disability, functional decline due to aging and disease sequelae, and the variation in health status within the body represented by omics analysis that lies between exposure and disease. It contains several sub-studies on aging, heated tobacco products, and women's health. This study is notable for its robust design, high participation rate (89%), and long-term repeated surveys. Moreover, it contributes to precision prevention in Japan and East Asia as a well-established multi-omics platform.</p>

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Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• 地域高齢者におけるライフスタイルリスクスコアと機能障害

  宮川 尚子, 高嶋 直敬, 土岐 了大, 原田 成, 武林 亨, 岡村 智教, 門田 文, 三浦 克之, 上島 弘嗣, 喜多 義邦

  日本循環器病予防学会誌 ((一社)日本循環器病予防学会)  58 ( 2 ) 153 - 153 2023.05

  ISSN  1346-6267

• The Ratio of Circulating Eicosapentaenoic Acid to Arachidonic Acid Ratio in the Community-Dwelling Japanese Population

  Miyagawa Naoko

  Journal of Atherosclerosis and Thrombosis (Japan Atherosclerosis Society)  30 ( 6 ) 587 - 588 2023

  ISSN  13403478

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• 一般住民における内臓脂肪の蓄積に関連するメタボロミクスプロファイル　鶴岡メタボロームコホート研究

  宮川 尚子, 原田 成, 飯田 美穂, 桑原 和代, 加藤 寿寿華, 佐田 みずき, 松元 美奈子, 平田 あや, 岡村 智教, 武林 亨

  Journal of Epidemiology ((一社)日本疫学会)  32 ( Suppl.1 ) 164 - 164 2022.01

  ISSN  0917-5040

• Dietary Intake of Manganese in the Japanese Diet and its Association with Cardiometabolic and Cardiovascular Diseases

  Miyagawa Naoko

  Journal of Atherosclerosis and Thrombosis (Japan Atherosclerosis Society)  29 ( 10 ) 1421 - 1422 2022

  ISSN  13403478

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• 【心疾患と栄養】循環器疾患と食生活

  宮川 尚子, 岡村 智教

  栄養 ((株)ジェフコーポレーション)  36 ( 4 ) 179 - 185 2021.12

  ISSN  2435-4503

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  食生活は内容によって循環器疾患の危険因子にも防御因子にもなりうることが、多くの疫学研究から明らかになっている。脂質やたんぱく質のうち、飽和脂肪酸は循環器疾患のリスクを高め、魚に多く含まれるn-3系不飽和脂肪酸や植物性たんぱく質は循環器疾患の発症に予防的に働くことが報告されている。一方、炭水化物から摂取するエネルギー割合は低すぎても高すぎても死亡リスクが高くなる。食塩は循環器疾患の主要な要因である血圧を上昇させて循環器疾患リスクを高め、反対に野菜や果物は、カリウムなど含まれる様々な栄養素の機能が複合的に作用して高血圧や循環器疾患のリスクを低下させる。これらの循環器疾患に関連する食品を組み合わせて摂取する、健康的な食事パターンをスコア化した食事指標を用いた検討では、指標の遵守度が高いほど循環器疾患リスクが低下していた。食事内容の改善により循環器疾患の予防が期待できるため、摂取する食品の内容や量を適切に選択することが大切である。(著者抄録)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• Usefulness of metabolite biomarker as a common pathway for the prevention of non-communicable diseases and frailty

  2023.04

  -

  2028.03

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), No Setting

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  本研究は、開始後10年を経過した地域在住者コホート研究により、若年期から集積する心臓代謝リスクの併存状態（マルチモビディティ）からNCDsおよびフレイル・認知機能低下への移行を媒介する共通代謝経路・代謝バイオマーカーを疫学的に解明・検証した上で、その代謝経路と関連する変容可能な環境要因を明らかにして、中・高齢期の保健・介護予防一体的実施に最適な介入手法の基礎とすることを目的とする。また新型コロナウイルス感染によってその機能がリモデリングされる代謝経路にも焦点をあて、感染の後遺・遷延症状も考慮した地域保健現場での健康支援についても検討する。

• Association between the risk of sarcopenia and estimated protein intake using biomarkers

  2022.04

  -

  2026.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

• 一般住民における腎機能低下と無症候性脳血管障害の関連

  2019.04

  -

  2022.03

  日本学術振興会, Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, No Setting

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  近年、腎細小血管の解剖学的、機能的類似性から腎機能と無症候性脳血管疾患との関連が指摘され始めており、患者コホートからの報告ではその関連が報告されているが、一般住民からの報告はまだ少なく、その評価は分かれている。本研究では、40歳代から80歳代の850人の健常な日本人一般住民を対象として、腎機能およびその経年変化と無症候性脳血管疾患との関連、およびこの関連への循環器疾患発症因子の介在の程度を明らかにする。無症候性脳血管疾患は脳卒中および認知機能低下指標として注目されているため、本研究で得られた結果は、高齢社会における認知症・脳卒中の早期発見マーカーとして予防に繋がることが期待される。
  本研究は一般地域住民から年齢層化無作為抽出した集団のうち協力が得られた者を対象として、頭部MR画像を用いて評価した無症候性脳血管障害と潜在性動脈硬化指標および危険因子の測定を実施している既存の前向きコホートの成績を用いて、腎機能およびその経年変化と無症候性脳血管疾患の関連を検討するものである。昨年度測定した随時尿中の微量アルブミン、クレアチニン、ナトリウム値をデータベースに突合し、日本人一般集団における尿アルブミン/クレアチニン比(ACR)およびeGFRの経年変化の分布を確認し、無症候性脳血管疾患との関連を検討した。
  新型コロナウイルス感染拡大のため、成果発表の一部が遅延している。
  次年度は最終年度であるため、日本人一般集団における無症候性脳血管疾患と尿アルブミン/クレアチニン比(ACR)およびeGFRの経年変化との関連についてさらに詳細に検討を進める。また、その成果を学会や専門誌で報告する予定である。

• Association between dietary factors and cognitive impairment in Japanese population(Fostering Joint International Research)

  2016

  -

  2019

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Miyagawa Naoko, Fund for the Promotion of Joint International Research (Fostering Joint International Research), No Setting

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  This study aimed to identify related factors for low cognitive function in two groups of genetically similar Japanese men exposed to Westernized lifestyles from different starting points in life using cross-sectional data from Japanese-American based in Hawaii and the Japanese based in Japan. Cognitive function was evaluated by participants’ performance on the Cognitive Abilities Screening Instrument (CASI), a validated comprehensive measure of global cognitive function developed for use in cross-cultural and cross-national studies. Older Hawaii-based men were more likely to achieve a low CASI score than were older Japan-based men. In the present study, lower cognitive function among older Japanese men was mostly explained by the differences in educational attainment between the cohorts.

• Gut microbiota and sublinical atherosclerosis in general population

  2015.04

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  2018.03

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Arima Hisatomi, OHNO Seiko, MIYAGAWA Naoko, KADOWAKI Takashi, OKAMI Yukiko, Grant-in-Aid for Scientific Research (B), No Setting

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  The aim of the present analysis is to investigate the association between gut microbiota and coronary artery calcification (CAC) in general Japanese men. Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) is a prospective cohort study of randomly selected men from a general Japanese population. This analysis included 669 participants who completed a follow-up examination including analysis of gut microbiota. After adjustment for age, BMI, total cholesterol, HDL cholesterol, HbA1c, smoking, alcohol intake, regular exercise, and use of medication to treat hypertension, dyslipidemia or diabetes, frequency of Lactobacillus was associated with lower risks of coronary artery calcification (odd ratio 0.84 per 1SD [9%] increase, 95%CI 0.70-1.00) while there were no clear relationships for Bifidobacterium, Bacteroides, Prevotella or Clostridium. Lactobacillus appears to be associated with lower prevalence of CAC in a general population of Japanese men.

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Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• NUTRITION FOR NURSING AND HEALTH CARE

  2024

• NUTRITION FOR NURSING AND HEALTH CARE

  2023