KEIO RESEARCHERS INFORMATION SYSTEM

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• 博士（工学）, Nagoya University, Coursework, 2014.03

Books 【 Display / hide 】

Books 【 Display / hide 】

• Trichloroperoxyacetamidic Acid

  Robert D Bach, Ryosuke Tsutsumi, Daisuke Uraguchi, Takashi Ooi, Wiley, 2018.03

  • Access to Document (DOI)

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Expeditious Access to the B3NO2 Heterocycle Enabling Modular Derivatization.

  Ryosuke Tsutsumi, Nobuaki Kashiwagi, Naoya Kumagai

  The Journal of organic chemistry （Journal of Organic Chemistry)  88 （ 9 ） 6247 - 6251 2023.05

  Research paper (scientific journal), Joint Work, Lead author, Accepted,  ISSN  00223263

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  DATB (1,3-dioxa-5-aza-2,4,6-triborinane) is a unique six-membered heterocycle exhibiting proficient catalytic activity in direct dehydrative amidation. Reported herein is an improved synthetic protocol for DATB derivatives featuring a concise two-step chromatography-free process. Suzuki-Miyaura coupling assembled 2,6-dibromoaniline derivatives and 1,2-phenylenediboronic acid to afford dimeric B-spiroborate salts. Acidic untying of the spiroborates gave rise to the DATB ring system with various substituents.

  • Access to Document (DOI)

• Azo-tagged C4N4 fluorophores: unusual overcrowded structures and their application to fluorescent imaging.

  Miki Kohei, Naoki Takizawa, Ryosuke Tsutsumi, Wei Xu, Naoya Kumagai

  Organic & biomolecular chemistry （Organic and Biomolecular Chemistry)  21 （ 14 ） 2889 - 2893 2023

  Research paper (scientific journal), Joint Work, Accepted,  ISSN  14770520

  　View Summary

  The C4N4 fluorophore is an intense fluorescence emitter featuring a 2,5-diaminopyrimidine core comprising four carbon and four nitrogen atoms. A series of C4N4 derivatives was photochemically dimerized at the 5-amino group, furnishing overcrowded ortho-tetraaryl-substituted diaryl azo compounds with a characteristic skewed structure revealed by X-ray crystallography. The photoquenched azo-C4N4s are useful for fluorescently visualizing cells under hypoxic conditions.

  • Access to Document (DOI)

• Chiral Bipyridine Ligand with Flexible Molecular Recognition Site: Development and Application to Copper‐Catalyzed Asymmetric Borylation of α,β‐Unsaturated Ketones

  Ryosuke Tsutsumi, Rika Taguchi, Masahiro Yamanaka

  ChemCatChem （Wiley)  14 （ 2 ） e202101278 2021.10

  Research paper (scientific journal), Joint Work, Lead author, Accepted,  ISSN  1867-3880

  • Access to Document (DOI)

• Mechanistic insights into entropy-driven 1,2-type Friedel-Crafts reaction with conformationally flexible guanidine-bisthiourea bifunctional organocatalysts

  Katsuhiro Nakano and Tatsuya Orihara and Masaki Kawaguchi and Keisuke Hosoya and Shogo Hirao and Ryosuke Tsutsumi and Masahiro Yamanaka and Minami Odagi and Kazuo Nagasawa

  Tetrahedron （Elsevier {BV})  92   132281 - 132281 2021.07

  Research paper (scientific journal), Joint Work, Accepted

  • Access to Document (DOI)

• Catalyst-Dependent Rate-Determining Steps in Regiodivergent Vinylogous Aza-Morita-Baylis-Hillman Reactions with N-Ts Imines

  Gondo N., Hyakutake R., Fujimura K., Ueda Y., Nakano K., Tsutsumi R., Yamanaka M., Kawabata T.

  Asian Journal of Organic Chemistry （Asian Journal of Organic Chemistry)  11 （ 3 ）  2021

  Research paper (scientific journal), Joint Work, Accepted,  ISSN  21935807

  　View Summary

  Catalyst-controlled vinylogous aza-MBH reactions of vinylcyclopentenone were performed, and it was found that the α-adducts were exclusively obtained by DABCO-catalysis, while the γ-adducts were the major products by DMAP-catalysis. We report here that the rate-determining step of the DABCO-catalyzed α-selective reactions is the Mannich-type C−C bond forming step, while that of the DMAP-catalyzed γ-selective reactions seems to be the β-elimination step.

  • Access to Document (DOI)

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Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• Catalytic asymmetric fluorination using CSF sparingly soluble in organic solvent

  Tsutsumi R.

  Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry (Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry)  78 ( 2 ) 158 - 159 2020

  Article, review, commentary, editorial, etc. (scientific journal), Single Work,  ISSN  00379980

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  Metal fluorides such as KF and CsF are inexpensive and easy-to-handle nucleophilic fluorinating reagents while their insolubility in most organic solvents often causes a problem in their synthetic use. In this review, examples of nucleophilic fluorination promoted by a hydrogen-bonding donor are described. Moreover, a recent research on asymmetric nucleophilic fluorination using a chiral hydrogen-bond donor catalyst is introduced.

  • Access to Document (DOI)

• Cover Feature: Enantioselective Electrophilic Cyanation of Boron Enolates: Scope and Mechanistic Studies (Chem. Eur. J. 64/2018)

  Takaya Nagata, Atsuko Tamaki, Kensuke Kiyokawa, Ryosuke Tsutsumi, Masahiro Yamanaka, Satoshi Minakata

  Chemistry – A European Journal (Wiley)  24 ( 64 ) 16926 - 16926 2018.11

  • Access to Document (DOI)

• 忘れられた反応剤Davis’オキサジリジン

  堤 亮祐, 浦口大輔, 大井貴史

  月刊化学 2013 ( 10 ) 66 - 67 2013.10

  Article, review, commentary, editorial, etc. (scientific journal), Joint Work

Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• Developmemt of metal-bis-2-aminothiazoline catalyzed enantioselective 1,3-dipolar cycloaddition of nitrones with β,γ-unsaturated α-ketoesters

  Shinnosuke Uno, Ryosuke Tsutsumi, Masahiro Yamanaka

  The 101st Annual Meeting of Chemical Society of Japan, 

  2021.03

  , 

  Oral presentation (general)

• Development of asymmetric bromocyclization of sulfonamide using a new chiral bisguanidine organocatalyst

  Takeru Motoyama, Ryosuke Tsutsumi, Masahiro Yamanaka

  The 101st Annual Meeting of Chemical Society of Japan, 

  2021.03

  , 

  Oral presentation (general)

• Asymmetric Borylation of α,β-Unsaturated Carbonyl Compounds by Using Chiral Bipyridine Ligand with Substrate Recognition Site

  Ryosuke Tsutsumi, Rika Taguchi, Kota Hoshi, Masahiro Yamanaka

  The 101st Annual Meeting of Chemical Society of Japan, 

  2021.03

  , 

  Oral presentation (general)

• A Computational Approach to Design a Novel Guanidine-Urea Bifunctional Organocatalyst and Analyze Transition States in Asymmetric epoxidation of 2,3-Disubstituted 1,4-Naphthoquinone Derivatives

  Tatsuya Orihara, Keisuke Hosoya, Ryosuke Tsutsumi, Masahiro Yamanaka, Minami Odagi, Kazuo Nagasawa

  The 100th Annual Meeting of Chemical Society of Japan (千葉県) , 

  2020.03

  , 

  Oral presentation (general)

• Computational Study of Reactions of Aryllithiums with S-arylphenothiazinium Ions

  Tatsuya Morofuji, Tatsuki Yoshida, Ryosuke Tsutsumi, Masahiro Yamanaka, Naokazu Kano

  The 100th Annual Meeting of Chemical Society of Japan (千葉県) , 

  2020.03

  , 

  Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• 特殊ヘテロ環の複合機能化を鍵とするカルボン酸原料を用いる多様な触媒的分子変換

  2023.04

  -

  2026.03

  基盤研究(C), Principal investigator

Intellectual Property Rights, etc. 【 Display / hide 】

Intellectual Property Rights, etc. 【 Display / hide 】

• DOCK1阻害化合物およびその用途

  Date applied： 特願2018-225753  2018.11 

  Patent

Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• STUDY OF MAJOR FIELD (MOLECULAR DESIGN)

  2024

• SEMINAR (MOLECULAR DESIGN)

  2024

• RESEARCH FOR BACHELOR'S THESIS 1

  2024

• PHARMACEUTICAL-ENGLISH SEMINAR

  2024

• ORGANIC SYNTHESIS

  2024

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