Papers - Oba, Junna

Hair follicle nevus - A dermoscopic approach

Okada, J., Moroi, Y., Tsujita, J., Takahara, M., Urabe, K., Kiryu, H. and Furue, M.

Eur J Dermatol 18 ( 2 ) 185 - 7 2008.03

Research paper (scientific journal), Accepted,  ISSN  1167-1122

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We report the case of a 26-year-old man who presented with small soft nodules with tiny hairs that had been present on his nose since childhood. The nodules were initially diagnosed as melanocytic nevi. However, dermoscopy showed many uniform hair follicles and an interfollicular 'pseudo-pigment network' in the nodules. Histologically, many well-differentiated hair follicles and sebaceous glands were seen in the dermis. Serial sectioning revealed neither central cysts nor a central canal. We therefore diagnosed this case as hair follicle nevus. Dermoscopy is now widely used as a non-invasive, in vivo technique for the diagnosis of pigmented skin lesions. Hair follicle nevus is a very rare disease and this is the first report to demonstrate the manifestation of this clinical entity by dermoscopy.

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Case of adult T-cell leukemia/lymphoma manifesting marked purpura

Okada, J., Imafuku, S., Tsujita, J., Moroi, Y., Urabe, K. and Furue, M.

J Dermatol 34 ( 11 ) 782 - 5 2007.11

Research paper (scientific journal), Accepted,  ISSN  0385-2407

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We present a case of a 62-year-old woman with marked purpura, first appearing on both legs, then spreading over the whole body, including the face. At presentation, the patient was thought to have Henoch-Schonlein purpura. However, a skin biopsy from a purpuric lesion revealed prominent infiltrations of atypical lymphocytes into the papillary dermis and marked extravasation of erythrocytes through the epidermis and upper dermis. Antibody to human T-lymphotropic virus type 1 (HTLV-1) was present in the serum and samples from skin lesions revealed HTLV-1 proviral DNA integration, as well as a clonal T-cell receptor Cbeta1 gene rearrangement. We therefore diagnosed this case as adult T-cell leukemia/lymphoma (ATL), and the purpuric lesions as ATL-specific. Soon after the initiation of chemotherapy, these purpuric lesions began to resolve with pigmentation.

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