Details of a Researcher

HIRATA Aya

写真a

Affiliation: School of Medicine, Department of Preventive Medicine and Public Health （Shinanomachi）

Position: Assistant Professor/Senior Assistant Professor

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Career 【 Display / hide 】

2009.04

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2014.03

高槻赤十字病院, 検査部生理機能検査課
2014.04

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2015.03

大阪市立大学医学部附属病院, 中央臨床検査部生理機能検査
2019.04

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2020.09

慶應義塾大学医学部衛生学公衆衛生学教室, 助教
2020.10

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Present

慶應義塾大学医学部衛生学公衆衛生学教室 , 専任講師

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Academic Background 【 Display / hide 】

2005.04

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2009.03

Kyoto University, 医学部, 保健学科検査技術科学専攻

University, Graduated
2011.04

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2013.03

Kyoto University, 大学院医学研究科, 専門職学位課程

Graduate School, Completed, Master's course
2015.04

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2019.03

Keio University, 大学院医学研究科, 博士課程

Graduate School, Completed, Doctoral course

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Academic Degrees 【 Display / hide 】

社会健康医学修士（専門職）, Kyoto University, 2013.03
博士（医学）, 慶應義塾大学, 2019.03

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Research Keywords 【 Display / hide 】

公衆衛生、疫学、循環器疾患、動脈硬化、脂質、脂肪肝

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Books 【 Display / hide 】

Encyclopedia of Cardiovascular Research and Medicine

Douglas B. Sawyer, Ramachandran S. Vasan 編集; Okamura T, Sugiyama D, Hirata T, Kuwabara K, Hirata A [他] 著, Elsevier, Oxford, 2017.12

Scope: Lipids and Cardiovascular Diseases: Epidemiologic Perspectives（分担執筆）
FDA リスク&ベネフィットコミュニケーション: エビデンスに基づく健康・医療に関する指針（共訳）

バルークフィッシュホフ [他] 著, 中山健夫, 杉森裕樹監訳, 平田あや [他] 訳, 丸善出版, 2015.07

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Papers 【 Display / hide 】

The association between sleep parameters and sarcopenia in Japanese community-dwelling older adults

Shibuki Takuma, Iida Miho, Harada Sei, Kato Suzuka, Kuwabara Kazuyo, Hirata Aya, Sata Mizuki, Matsumoto Minako, Osawa Yusuke, Okamura Tomonori, Sugiyama Daisuke, Takebayashi Toru

ARCHIVES OF GERONTOLOGY AND GERIATRICS 109 2023.06

ISSN 0167-4943
- Access to Document (DOI)
Optimal Cut-off Points of Triglycerides for Cardiovascular Disease Prediction in Japanese Population

Hirata Aya

Journal of Atherosclerosis and Thrombosis （Japan Atherosclerosis Society) 30 （ 2 ） 105 - 106 2023.02

ISSN 13403478
- Access to Document (DOI)
- CiNii Research
Fatty liver index predicts the development of hypertension in a Japanese general population with and without dysglycemia

Wu Dan, Hirata Aya, Hirata Takumi, Imai Yukiko, Kuwabara Kazuyo, Funamoto Mika, Sugiyama Daisuke, Okamura Tomonori

HYPERTENSION RESEARCH 2023.01

ISSN 0916-9636
- Access to Document (DOI)
Determinants of salt taste threshold among urban residents: the KOBE study

WAKAKO Minami, SATA Mizuki, KUBOTA Yoshimi, NISHIDA Yoko, KUBO Sachimi, HIGASHIYAMA Aya, HIRATA Takumi, KADOTA Aya, HIRATA Aya, MIYAZAKI Junji, KAWAHARA Mizuki, KUWABARA Kazuyo, SUGIYAMA Daisuke, MIYAMATSU Naomi, MIYAMOTO Yoshihiro, OKAMURA Tomonori

Nihon Koshu Eisei Zasshi(JAPANESE JOURNAL OF PUBLIC HEALTH) （Japanese Society of Public Health) advpub （ 0 ） 2023

ISSN 05461766

　View Summary

Objectives Though having a high salt taste threshold has been associated with hypertension, its exact determinants remains unclear. This study aimed to identify the determinants of salt taste threshold in a community-based population and to determine the relationship between salt taste thresholds and the simultaneous presence of multiple determinants.Methods Of the 1,117 participants of the baseline survey of the Kobe study, a cohort study of healthy urban residents, aged 40-74 years, with no history of cancer or cardiovascular diseases, nor undergoing treatment for hypertension, diabetes, or dyslipidemia, was conducted. Among them, 1,116 underwent the salt taste threshold test, and urine samples were collected to determine their estimated salt intake. The salt taste threshold test was carried out using SALSAVE®, with a salt taste threshold of 0.6% defined as normal, and that of 0.8% or more defined as high. A binomial logistic regression model was used, with high salt taste threshold as the objective variable, and life and family status, education, smoking and alcohol drinking status, intake status of salt dried fish, stress indicators, and daily salt intake (estimated from the urine sample) as the explanatory variables. A binomial logistic regression analysis was conducted, through multivariate analysis using the forced entry method, with factors influencing salt taste threshold as explanatory variables, and salt taste threshold (normal/high) as the objective variable. This analysis was performed excluding the urinary sodium-to-potassium ratio to account for multicollinearity with the estimated daily salt intake.Results The mean age was 60.9±9.0 years for men, and 58.0±8.7 years for women. The salt taste threshold was normal in 80.9% (n=903) of the participants (73.6% [n=251] men and 84.1% [n=652] women), and high in 19.1% (n=213) of the participants (26.3% [n=90] men and 15.9% [n=123] women). Multivariate analysis revealed that smoking habits were significantly associated with a higher salt taste threshold, with an odds ratio (95% confidence interval) of 2.51 (1.33-4.74) for all participants. The odds ratio for a high salt taste threshold was 1.45 (1.03-2.03) for the top 25% estimated daily salt intake group, showing a significant association with a high salt taste threshold. In the analysis by sex, smoking habits were associated with higher salt taste thresholds, while an association with estimated daily salt intake was observed only in men.Conclusion Smoking status and estimated daily salt intake were associated with higher salt taste thresholds in healthy urban residents.
- Access to Document (DOI)
- CiNii Research
Association between visceral fat accumulation and decline in the estimated glomerular filtration rate based on cystatin C in the Japanese urban population: the KOBE study

Tanabe Ayumi, Hirata Aya, Kuwabara Kazuyo, Kubo Sachimi, Higashiyama Aya, Hirata Takumi, Sugiyama Daisuke, Nishida Yoko, Kubota Yoshimi, Kadota Aya, Nishikawa Tomofumi, Miyamatsu Naomi, Miyamoto Yoshihiro, Okamura Tomonori

Endocrine Journal （The Japan Endocrine Society) 70 （ 1 ） 97 - 106 2023

ISSN 09188959

　View Summary

Although metabolic syndrome, including visceral fat accumulation, causes kidney and cardiovascular diseases, the impact of visceral fat accumulation on mild decreased renal function remains unclear. This study examines the association between visceral fat area (VFA) measured by bioimpedance methods and the estimated glomerular filtration rate based on serum cystatin C (eGFRcys) in the Japanese urban population. This community-based cross-sectional study enrolled 952 individuals (287 men, 665 women) who participated in the second follow-up survey of the Kobe Orthopedic and Biomedical Epidemiological (KOBE) study. We compared the multivariate-adjusted means of eGFRcys among VFA quartile groups by gender using the analysis of covariance. Models were adjusted for age, high blood pressure, hypercholesterolemia, glucose intolerance, smoking, and alcohol use, and further adjusted for body mass index (BMI). The highest VFA quartile group had lower eGFRcys than the lowest VFA quartile group after adjusted for cardiometabolic risk factors, except for BMI (93.1 [95% confidence interval (CI), 90.1–96.2] vs. 82.1 [95% CI, 79.1–85.0] in men and 95.8 [95% CI, 94.1–97.5] vs. 89.4 [95% CI, 87.8–90.9] in women). Moreover, further adjustment for BMI revealed a similar result in men (93.5 [95% CI, 89.8–97.2] vs. 81.6 [95% CI, 77.9–85.3]), while no significant association was found in women. This study suggests a significant association between increased VFA levels and lower eGFRcys levels independent of cardiometabolic risk factors, such as glucose intolerance and hypercholesterolemia in men and women, as well as independent of BMI in men.
- Access to Document (DOI)
- CiNii Research

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Reviews, Commentaries, etc. 【 Display / hide 】

【冠動脈疾患のリスク管理のフロントライン】冠動脈疾患イベントリスクをどう評価する?

岡村智教, 平田あや, 桑原和代

循環器ジャーナル ((株)医学書院) 67 ( 4 ) 508 - 515 2019.10

ISSN 2432-3284

　View Summary

＜文献概要＞Point　・個々のリスクファクターではなく,複数のリスクファクターを組み合わせて冠動脈疾患の発症リスクを包括的に評価する必要がある.・特定健診などでスクリーニングするのは,冠動脈疾患そのものではなく冠動脈疾患を発症する可能性が高いハイリスク者であり,そのためにも包括的リスク評価が重要である.
【動脈硬化の早期診断法と予防対策-健康寿命延伸をめざして】発症予測と絶対リスク

平田あや, 岡村智教

カレントテラピー ((株)ライフメディコム) 36 ( 11 ) 1062 - 1067 2018.11

ISSN 0287-8445
【脂質代謝異常と循環器疾患】診る　脂質異常症と冠動脈疾患　わが国の疫学研究から

平田あや, 岡村智教

Heart View ((株)メジカルビュー社) 22 ( 7 ) 612 - 618 2018.07

ISSN 1342-6591
【動脈・静脈の疾患(上)-最新の診断・治療動向-】動脈・静脈疾患の疫学　わが国における血管疾患の疫学

平田あや, 岡村智教

日本臨床 ((株)日本臨床社) 75 ( 増刊4 動脈・静脈の疾患(上) ) 37 - 42 2017.05

ISSN 0047-1852

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Presentations 【 Display / hide 】

都市住民における生活習慣と腎機能低下の進行との関連　神戸研究

平田あや, 東山綾, 平田匠, 杉山大典, 桑原和代, 佐田みずき, 西田陽子, 久保佐智美, 久保田芳美, 門田文, 西川智文, 宮松直美, 宮本恵宏, 岡村智教

日本公衆衛生学会総会抄録集,

2019.10
,
日本公衆衛生学会
都市部住民における推定24時間尿中NaとNa/Kの腎機能低下リスク　神戸研究

服部浩子, 梅本かおり, 野澤美樹, 中越奈津子, 東山綾, 西田陽子, 久保佐智美, 久保田芳美, 平田匠, 宮松直美, 平田あや, 佐田みずき, 桑原和代, 杉山大典, 岡村智教

日本公衆衛生学会総会抄録集,

2019.10
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日本公衆衛生学会
都市住民における出生体重と循環器疾患の危険因子との関連　神戸研究

梅本かおり, 東山綾, 平田匠, 杉山大典, 桑原和代, 平田あや, 佐田みずき, 西田陽子, 久保佐智美, 久保田芳美, 門田文, 西川智文, 宮松直美, 宮本恵宏, 岡村智教

日本公衆衛生学会総会抄録集,

2019.10
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日本公衆衛生学会
健常人における心拍数およびダブルプロダクトの規定要因　神戸研究

中越奈津子, 野澤美樹, 服部浩子, 平田あや, 佐田みずき, 久保佐智美, 東山綾, 西田陽子, 久保田芳美, 平田匠, 宮松直美, 桑原和代, 杉山大典, 岡村智教

日本公衆衛生学会総会抄録集,

2019.10
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日本公衆衛生学会
飲酒の有無によるFatty liver indexの脂肪肝診断能に関する検討

平田あや, 杉山大典, 桑原和代, 岡村智教

日本アルコール・薬物医学会雑誌,

2019.08
,
(一社)日本アルコール・アディクション医学会

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

脂質に着目した脳・心血管疾患の個別化予防実現のためのゲノム・メタボローム疫学研究

2022.04

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2024.03

MEXT,JSPS, Grant-in-Aid for Scientific Research, 若手研究, Principal investigator
変性リポ蛋白を含む脂質プロフィールと脳・心血管疾患の関連、その規定要因の解明

2021.04

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2026.03

Keio University, Grant-in-Aid for Scientific Research (A), No Setting

　View Summary

Lectin-like oxidized LDL Receptor (LOX-1)は内皮細胞の変性LDLの受容体であり、変性LDL、変性LDLの催動脈硬化作用はLOX-1を介している可能性がある。本研究では複数のコホート集団の疫学研究で、通常の血中脂質検査に加えて変性LDL、変性HDLと脳・心血管疾患との関連を評価し、病型の決定にこれらの因子がどのように影響しているかを明らかにする。また変性リポ蛋白の生活習慣上の規定要因を血中等のメタボローム解析も含めて検証する。これにより将来、変性リポ蛋白を治療ターゲットにした介入研究への橋渡しが可能となり、創薬や予防方法の開発に発展させることが可能である。
既存健診項目で算出できる脂肪肝指数の健診での実用化に向けた疫学的検討

2019.08

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2021.03

研究活動スタート支援, Research grant, Principal investigator

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Awards 【 Display / hide 】

第56回日本循環器病予防学会学術集会 Young Investigator’s Award優秀賞

2020.12, Fatty liver indexとCAVIの関連における血中アミノ酸の疫学的検討：鶴岡メタボロームコホート研究
第50回日本動脈硬化学会総会・学術集会　最優秀ポスター賞

2018.07, 全国9コホート43,407名の統合解析による超高値HDL-Cと動脈硬化性心血管疾患との関連：The EPOCH-JAPAN study