Details of a Researcher

HIRATA Aya

写真a

Affiliation: School of Medicine, Department of Preventive Medicine and Public Health （Shinanomachi）

Position: Senior Assistant Professor (Non-tenured)/Assistant Professor (Non-tenured)

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Academic Degrees 【 Display / hide 】

博士（医学）, 慶應義塾大学, 2019.03

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Research Areas 【 Display / hide 】

Epidemiology and preventive medicine

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Books 【 Display / hide 】

Encyclopedia of Cardiovascular Research and Medicine

Douglas B. Sawyer, Ramachandran S. Vasan 編集; Okamura T, Sugiyama D, Hirata T, Kuwabara K, Hirata A [他] 著, Elsevier, Oxford, 2017.12

Scope: Lipids and Cardiovascular Diseases: Epidemiologic Perspectives（分担執筆）
FDA リスク&ベネフィットコミュニケーション: エビデンスに基づく健康・医療に関する指針（共訳）

バルークフィッシュホフ [他] 著, 中山健夫, 杉森裕樹監訳, 平田あや [他] 訳, 丸善出版, 2015.07

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Papers 【 Display / hide 】

Electrocardiographic Left Atrial Abnormality and B-Type Natriuretic Peptide in a General Japanese Population: NIPPON DATA2010

Shoji Satoshi, Kadota Aya, Ueshima Hirotsugu, Okayama Akira, Miura Katsuyuki, for the NIPPON DATA2010 Research Group, Kohsaka Shun, Sawano Mitsuaki, Okamura Tomonori, Hirata Aya, Sugiyama Daisuke, Ohkubo Takayoshi, Nakamura Yasuyuki, Watanabe Makoto

Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ（一般社団法人日本動脈硬化学会) 28 （ 1 ） 34 - 43 2021

ISSN 1340-3478

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Aims: P-wave terminal force in lead V1 (PTFV1) is an electrocardiogram marker of increased left atrial pressure and may be a noninvasive and early detectable marker for future cardiovascular events in the general population compared to serum B-type natriuretic peptide (BNP) concentration. The clinical significance of PTFV1 in the contemporary general population is an area of unmet need. We aimed to demonstrate the correlation between PTFV1 and BNP concentrations in a contemporary representative Japanese population. Methods: Among 2,898 adult men and women from 300 randomly selected districts throughout Japan (NIPPON DATA2010), we analyzed 2,556 participants without cardiovascular disease (stroke, myocardial infarction, and atrial fibrillation). Elevated BNP was defined as a value of ≥ 20 pg/mL based on the definition from the Japanese Circulation Society guidelines. Results: In total, 125 (4.9%) participants had PTFV1. Participants with PTFV1 were older with a higher prevalence of hypertension, major electrocardiographic findings, and elevated BNP concentrations (13.5 [6.9, 22.8] versus 7.8 [4.4, 14.5] pg/mL; P＜0.001). After adjustment for confounders, PTFV1 was correlated with elevated BNP (odds ratio, 1.66; 95% confidence interval, 1.05–2.62; P=0.030). This correlation was consistent among various subgroups and was particularly evident in those aged ＜65 years or those without a history of hypertension. Conclusions: In the contemporary general population cohort, PTFV1 was independently related to high BNP concentration. PTFV1 may be an alternative marker to BNP in identifying individuals at a higher risk of future cardiovascular events in the East Asian population.
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The relationship between serum levels of LOX-1 ligand containing ApoAI as a novel marker of dysfunctional HDL and coronary artery calcification in middle-aged Japanese men

Hirata Aya, Kakino Akemi, Okamura Tomonori, Usami Yoko, Fujita Yoshiko, Kadota Aya, Fujiyoshi Akira, Hisamatsu Takashi, Kondo Keiko, Segawa Hiroyoshi, Sawamura Tatsuya, Miura Katsuyuki, Ueshima Hirotsugu

ATHEROSCLEROSIS 313 20 - 25 2020.11

ISSN 0021-9150
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Estimated 24 h Urinary Sodium-to-Potassium Ratio Is Related to Renal Function Decline: A 6-Year Cohort Study of Japanese Urban Residents

Hattori Hiroko, Hirata Aya, Kubo Sachimi, Nishida Yoko, Nozawa Miki, Kawamura Kuniko, Hirata Takumi, Kubota Yoshimi, Sata Mizuki, Kuwabara Kazuyo, Higashiyama Aya, Kadota Aya, Sugiyama Daisuke, Miyamatsu Naomi, Miyamoto Yoshihiro, Okamura Tomonori

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 17 （ 16 ） 2020.08
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Validity Assessment of Self-reported Medication Use for Hypertension, Diabetes, and Dyslipidemia in a Pharmacoepidemiologic Study by Comparison With Health Insurance Claims

Matsumoto Minako, Okamura Tomonori, Takebayashi Toru, Harada Sei, Iida Miho, Kato Suzuka, Sata Mizuki, Hirata Aya, Kuwabara Kazuyo, Takeuchi Ayano, Sugiyama Daisuke

Ｊｏｕｒｎａｌ　ｏｆ　Ｅｐｉｄｅｍｉｏｌｏｇｙ（日本疫学会) 2020

ISSN 0917-5040

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Background: Although self-reported questionnaires are widely employed in epidemiologic studies, their validity has not been sufficiently assessed. The aim of this study was to evaluate the validity of a self-reported questionnaire on medication use by comparison with health insurance claims and to identify individual determinants of discordance in the Tsuruoka Metabolomics Cohort Study.Methods: Participants were 2,472 community-dwellers aged 37 to 78 years from the Tsuruoka Metabolomics Cohort Study. Information on lifestyle and medications was collected through a questionnaire. Sensitivity and specificity were determined using health insurance claims from November 2014 to March 2016, which were used as a standard. Potential determinants of discordance were assessed using multivariable logistic regression.Results: The self-reported questionnaire on medication use showed high validity. Sensitivity and specificity were 0.95 (95% CI, 0.93–0.96) and 0.97 (95% CI, 0.96–0.98) for antihypertensive medications, 0.94 (95% CI, 0.91–0.97) and 0.98 (95% CI, 0.98–0.99) for diabetes medications, and 0.84 (95% CI, 0.82–0.87) and 0.98 (95% CI, 0.97–0.99) for dyslipidemia medications, respectively. Males without high education and those who currently smoke cigarettes were found to be associated with discordant reporting which affected sensitivity, especially those with medication use for dyslipidemia.Conclusions: In this population-based cohort study, we found that the self-reported questionnaire on medication use was a valid measure to capture regular medication users. Sensitivity for dyslipidemia medications was lower than those for the other medications. Type of medication, sex, education years, and smoking status influenced discordance, which affected sensitivity in self-reporting.
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Physique at Birth and Cardiovascular Disease Risk Factors in Japanese Urban Residents: the KOBE Study

Umemoto Kaori, Kuwabara Kazuyo, Miyazaki Junji, Kadota Aya, Iida Miho, Sugiyama Daisuke, Miyamatsu Naomi, Miyamoto Yoshihiro, Okamura Tomonori, Kubo Sachimi, Nishida Yoko, Higashiyama Aya, Kawamura Kuniko, Kubota Yoshimi, Hirata Takumi, Hirata Aya, Sata Mizuki

Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ（一般社団法人日本動脈硬化学会) 2020

ISSN 1340-3478

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Aim: This study investigated the relationship between birth physique and cardiovascular risk factors in Japanese urban residents aged 40 years and more. Methods: A self-administered questionnaire on birth physique was performed among 624 individuals (165 men and 459 women) who participated in the KOBE study. We examined whether self-reported birth physique and available recorded birth weights matched for 72 participants. Then the association between birth physique and risk factors for all participants was examined by gender. Body size at birth in the questionnaire (large, medium, small) was set as an exposure and laboratory values from the baseline survey (2010-2011) were used as outcomes. Results: Mean (standard deviation) recorded birth weight of 72 participants was 3665 (318), 3051 (300), and 2653 (199) g, in the large, medium, and small group, respectively. In the analysis for all participants, odds ratio for having both hypertension and impaired glucose tolerance were significantly higher in the small versus large birth weight group, which was 7.42 (95% CI 1.75–31.50) for men and 4.44 (95% CI 1.14–17.30) for women after adjusting for age, body mass index, smoking/alcohol/exercise habits, and menstrual status in women. Similar results were observed in participants with recorded birth weight. Conclusions: The present study indicates that individuals with small physique at birth might be at higher risk for hypertension and impaired glucose tolerance in middle age compared to those with large birth weight.
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Reviews, Commentaries, etc. 【 Display / hide 】

【冠動脈疾患のリスク管理のフロントライン】冠動脈疾患イベントリスクをどう評価する?

岡村智教, 平田あや, 桑原和代

循環器ジャーナル ((株)医学書院) 67 ( 4 ) 508 - 515 2019.10

ISSN 2432-3284

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＜文献概要＞Point　・個々のリスクファクターではなく,複数のリスクファクターを組み合わせて冠動脈疾患の発症リスクを包括的に評価する必要がある.・特定健診などでスクリーニングするのは,冠動脈疾患そのものではなく冠動脈疾患を発症する可能性が高いハイリスク者であり,そのためにも包括的リスク評価が重要である.
【動脈硬化の早期診断法と予防対策-健康寿命延伸をめざして】発症予測と絶対リスク

平田あや, 岡村智教

カレントテラピー ((株)ライフメディコム) 36 ( 11 ) 1062 - 1067 2018.11

ISSN 0287-8445
Response to the letter entitled “Extremely high levels of high-density lipoprotein cholesterol and increased risk of cardiovascular mortality” by Dr Kawada

Hirata A., Okamura T.

Journal of Clinical Lipidology (Journal of Clinical Lipidology) 12 ( 6 ) 1551 2018.11

ISSN 19332874
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【脂質代謝異常と循環器疾患】診る　脂質異常症と冠動脈疾患　わが国の疫学研究から

平田あや, 岡村智教

Heart View ((株)メジカルビュー社) 22 ( 7 ) 612 - 618 2018.07

ISSN 1342-6591
【動脈・静脈の疾患(上)-最新の診断・治療動向-】動脈・静脈疾患の疫学　わが国における血管疾患の疫学

平田あや, 岡村智教

日本臨床 ((株)日本臨床社) 75 ( 増刊4 動脈・静脈の疾患(上) ) 37 - 42 2017.05

ISSN 0047-1852

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Presentations 【 Display / hide 】

都市住民における生活習慣と腎機能低下の進行との関連　神戸研究

平田あや, 東山綾, 平田匠, 杉山大典, 桑原和代, 佐田みずき, 西田陽子, 久保佐智美, 久保田芳美, 門田文, 西川智文, 宮松直美, 宮本恵宏, 岡村智教

日本公衆衛生学会総会抄録集, 2019.10, 日本公衆衛生学会
飲酒の有無によるFatty liver indexの脂肪肝診断能に関する検討

平田あや, 杉山大典, 桑原和代, 岡村智教

日本アルコール・薬物医学会雑誌, 2019.08, (一社)日本アルコール・アディクション医学会
日本人一般集団における非空腹時採血の中性脂肪と脳・心血管疾患死亡との関連　NIPPON DATA90

平田あや, 岡村智教, 杉山大典, 平田匠, 大久保孝義, 奥田奈賀子, 喜多義邦, 早川岳人, 門田文, 三浦克之, 岡山明, 上島弘嗣

日本動脈硬化学会総会プログラム・抄録集, 2019.07, (一社)日本動脈硬化学会
地域住民におけるFatty liver indexとCAVIとの関連：鶴岡メタボロームコホート研究

平田あや, 岡村智教, 原田成, 杉山大典, 桑原和代, 佐田みずき, 栗原綾子, 加藤寿寿華, 飯田美穂, 武林亨

第77回日本公衆衛生学会総会, 2018.10
全国9コホート43,407名の統合解析による超高値HDL-Cと動脈硬化性心血管疾患との関連：The EPOCH-JAPAN study

平田あや, 杉山大典, 渡邉至, 玉腰暁子, 磯博康, 小谷和彦, 木山昌彦, 山田美智子, 石川鎮清, 村上義孝, 三浦克之, 上嶋弘嗣, 岡村智教

第50回日本動脈硬化学会総会・学術集会, 2018.06