HIRATA Aya

写真a

Affiliation

School of Medicine, Department of Preventive Medicine and Public Health （Shinanomachi）

Position

Instructor
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Academic Degrees 【 Display / hide 】

  • 博士（医学）, 慶應義塾大学, 2019.03

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Research Areas 【 Display / hide 】

  • Epidemiology and preventive medicine

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Books 【 Display / hide 】

  • Encyclopedia of Cardiovascular Research and Medicine

    Douglas B. Sawyer, Ramachandran S. Vasan 編集; Okamura T, Sugiyama D, Hirata T, Kuwabara K, Hirata A [他] 著, Elsevier, Oxford, 2017.12

    Scope: Lipids and Cardiovascular Diseases: Epidemiologic Perspectives（分担執筆）

  • FDA リスク&ベネフィット コミュニケーション: エビデンスに基づく健康・医療に関する指針（共訳）

    バルーク フィッシュホフ [他] 著, 中山健夫, 杉森裕樹 監訳, 平田あや [他] 訳, 丸善出版, 2015.07

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Papers 【 Display / hide 】

  • Statin Intolerance Clinical Guide 2018.

    Kajinami K, Tsukamoto K, Koba S, Inoue I, Yamakawa M, Suzuki S, Hamano T, Saito H, Saito Y, Masuda S, Nakayama T, Okamura T, Yamashita S, Kagawa T, Kaneyama J, Kuriyama A, Tanaka R, Hirata A, Statin Intolerance Clinical Guide Working Group; The Japan Society of Hepatology, Japanese Society of Neurology, Japan Atherosclerosis Society, The Japanese Society for the Study of Xenobiotics.

    Journal of atherosclerosis and thrombosis  2019.10

    ISSN  1340-3478

  • Higher serum uric acid level is inversely associated with renal function assessed by cystatin C in a Japanese general population without chronic kidney disease: The KOBE study

    Kubo S, Nishida Y, Kubota Y, Higashiyama A, Sugiyama D, Hirata T, Miyamatsu N, Tanabe A, Hirata A, Tatsumi Y, Kadota A, Kuwabara K, Nishikawa T, Miyamoto Y, Okamura T

    BMC Nephrology （BMC Nephrology)  20 （ 1 ） 117 2019.04

    Research paper (scientific journal), Accepted

    　View Summary

    © 2019 The Author(s). Background: Although several epidemiological studies have suggested that high serum uric acid (SUA) levels are related to a decline in kidney function, only a few studies have investigated using cystatin C to calculate estimated glomerular filtration rate (eGFR). We aimed to clarify the relationship between SUA levels and kidney function assessed by cystatin C in a Japanese general community population without chronic kidney disease (CKD). Methods: We conducted a community-based cross-sectional study that included 1086 healthy participants, aged 40-74 years, without CKD and not undergoing treatment of hyperuricemia, who had participated in the baseline survey of the Kobe Orthopedic and Biomedical Epidemiological (KOBE) study. The preconditions for participation in this study were no past histories of cardiovascular disease or cancer, and not undergoing treatment for diabetes, hypertension, or dyslipidemia. We classified the participants into quartiles stratified by sex according to their SUA level and then examined the relationship with eGFR. The odds ratios for having a low eGFR, defined as the lowest quartile of eGFR (i.e., ≤78.4 mL/min/1. 73m 2 ) was estimated according to SUA quartiles (men, Q1 ≤ 5.0, Q2 5.1-5.9, Q3 6.0-6.6, and Q4 ≥ 6.7; women, Q1 ≤ 3.8, Q2 3.9-4.3, Q3 4.4-4.9, and Q4 ≥ 5.0 mg/dL) after adjustment for age, body mass index, systolic blood pressure, HbA1c, high and low density lipoprotein cholesterol, and smoking and drinking habits. The adjusted mean of each quartile was also calculated. Results: Multivariable-adjusted means of eGFR showed a graded decrease in higher SUA quartiles (men, Q1 90.5, Q2 88.0, Q3 83.5, and Q4 82.0; women, Q1 95.7, Q2 91.3, Q3 89.2, and Q4 86.7). In addition, the multivariable-adjusted odds ratios for having a lower eGFR (95% confidence interval) for each SUA quartile compared with Q1 was Q2 2.29 (0.98, 5.35), Q3 4.94 (2.04, 11.97), and Q4 8.01 (3.20, 20.04) for men, and was Q2 2.20 (1.12, 4.32), Q3 2.68 (1.39, 5.20), and Q4 4.96 (2.62, 9.41) for women. Conclusions: There was a graded inverse relationship between mild elevations in SUA levels and eGFR assessed by cystatin C in an apparently healthy Japanese population without CKD. This association was similar in both men and women.

  • Evaluation of the fatty liver index as an indicator of hepatic steatosis as assessed by the controlled attenuation parameter

    Hirata A, Sugiyama D, Kuwabara K, Okamura T

    Nihon Arukoru Yakubutsu Igakkai zasshi 54 （ 1 ） 15 - 24 2019.02

    Research paper (scientific journal), Accepted,  ISSN  1341-8963

  • Effects of sulfur dioxide on fractional exhaled nitric oxide concentration in the child residents of Miyakejima island

    Iwasawa S, Tsuboi T, Nakano M, Hirata A, Yoshioka N, Suzuki S, Tanaka S, Omae K

    Asian Journal of Atmospheric Environment (in Press) （Asian Journal of Atmospheric Environment)  13 （ 2 ） 145 - 149 2019

    Research paper (scientific journal), Accepted,  ISSN  19766912

    　View Summary

    © 2019 by Asian Journal of Atmospheric Environment. The island of Miyakejima in Japan is subject to ongoing emissions of volcanic gases, including high concentrations of sulfur dioxide (SO2). Annual health checkups on the island, therefore, include the examination of respiratory system parameters. Here, we aimed to investigate the relationship between SO2 exposure and fractional exhaled nitric oxide (FeNO) concentration among children who received health checkups from 2008 to 2014. The subjects were 83 and 31 second-year junior high school students aged 13-14 years who resided on Miyakejima island and an SO2-free reference island, respectively. SO2 concentration in the air was measured at 6 fixed-point monitoring stations. FeNO was examined according to the American Thoracic Society guideline and European Respiratory Society recommendations for standardized procedures. Average concentrations of SO2 on Miyakejima over a period of 3 months prior to each health checkup from 2008 to 2014 were 22.2, 20.6, 8.9, 10.5, 10.7, 4.4 and 8.0 ppb, respectively. Among the Miyakejima students, geometric mean (GM) FeNO concentrations measured at each health checkup from 2008 to 2014 were 28.2, 18.2, 23.6, 35.5, 36.9, 28.1, and 32.1 ppb. The GM FeNO concentration measured from all Miyakejima students across the study period was 28.3 ppb. No clear dose-response relationship was observed. The GM FeNO concentration among the students from the reference island was 27.7 ppb in 2017. No significant difference was observed between the two populations, even when the data was stratified by sex and sensitivity. There was no clear significant difference in GM of FeNO concentration between Miyakejima and control students, when the average concentration of SO2 over a period of 3 months was 22 ppb or less.

  • Association between dyslipidemia and plasma levels of branched-chain amino acids in the Japanese population without diabetes mellitus

    Fukushima K., Harada S., Takeuchi A., Kurihara A., Iida M., Fukai K., Kuwabara K., Kato S., Matsumoto M., Hirata A., Akiyama M., Tomita M., Hirayama A., Sato A., Suzuki C., Sugimoto M., Soga T., Sugiyama D., Okamura T., Takebayashi T.

    Journal of Clinical Lipidology （Journal of Clinical Lipidology)   2019

    ISSN  19332874

    　View Summary

    © 2019 National Lipid Association Background: Branched-chain amino acids (BCAAs) play a key role in energy homeostasis. Objective: We aimed to investigate the association between plasma BCAA levels and dyslipidemia in the Japanese population without diabetes mellitus. Methods: This cross-sectional study included 4952 participants without diabetes mellitus, enrolled in the Tsuruoka Metabolomic Cohort Study. Plasma BCAA levels were measured by capillary electrophoresis–mass spectrometry. Correlations between lipid and BCAA profiles were evaluated by sex-stratified multiple linear regression analyses, after adjusting for confounders. Logistic regression was used to identify associations between BCAAs and metabolic dyslipidemia (MD) defined as triglyceride levels ≥150 mg/dL, high-density lipoprotein cholesterol levels ≤40 mg/dL for men and ≤50 mg/dL for women, or low-density lipoprotein cholesterol (LDL-C) levels ≥140 mg/dL. Results: In both sexes, the levels of individual BCAAs and the total BCAA levels correlated positively with triglyceride levels and negatively with high-density lipoprotein cholesterol levels. Valine, leucine, and total BCAA levels were weakly and positively correlated with LDL-C levels. Increased BCAA levels showed positive associations with MD. However, associations between BCAAs and elevated LDL-C levels were unclear. Furthermore, the associations between BCAA levels and MD regardless of fasting blood sugar (FBS) levels (high or low). Although valine, leucine, and total BCAA levels were weakly associated with elevated LDL-C levels in the high-FBS group, no such association was observed in the low-FBS group. Conclusions: BCAAs might be associated with MD independently of the FBS level and might play an important role in lipid metabolism and dyslipidemia.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • 【冠動脈疾患のリスク管理のフロントライン】冠動脈疾患イベントリスクをどう評価する?

    岡村 智教, 平田 あや, 桑原 和代

    循環器ジャーナル ((株)医学書院)  67 ( 4 ) 508 - 515 2019.10

    ISSN  2432-3284

    　View Summary

    ＜文献概要＞Point　・個々のリスクファクターではなく,複数のリスクファクターを組み合わせて冠動脈疾患の発症リスクを包括的に評価する必要がある.・特定健診などでスクリーニングするのは,冠動脈疾患そのものではなく冠動脈疾患を発症する可能性が高いハイリスク者であり,そのためにも包括的リスク評価が重要である.

  • 【動脈硬化の早期診断法と予防対策-健康寿命延伸をめざして】 発症予測と絶対リスク

    平田 あや, 岡村 智教

    カレントテラピー ((株)ライフメディコム)  36 ( 11 ) 1062 - 1067 2018.11

    ISSN  0287-8445

  • Response to the letter entitled “Extremely high levels of high-density lipoprotein cholesterol and increased risk of cardiovascular mortality” by Dr Kawada

    Hirata A., Okamura T.

    Journal of Clinical Lipidology (Journal of Clinical Lipidology)  12 ( 6 ) 1551 2018.11

    ISSN  19332874

  • 【脂質代謝異常と循環器疾患】 診る　脂質異常症と冠動脈疾患　わが国の疫学研究から

    平田 あや, 岡村 智教

    Heart View ((株)メジカルビュー社)  22 ( 7 ) 612 - 618 2018.07

    ISSN  1342-6591

  • 【動脈・静脈の疾患(上)-最新の診断・治療動向-】 動脈・静脈疾患の疫学　わが国における血管疾患の疫学

    平田 あや, 岡村 智教

    日本臨床 ((株)日本臨床社)  75 ( 増刊4 動脈・静脈の疾患(上) ) 37 - 42 2017.05

    ISSN  0047-1852

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Presentations 【 Display / hide 】

  • 都市住民における生活習慣と腎機能低下の進行との関連　神戸研究

    平田 あや, 東山 綾, 平田 匠, 杉山 大典, 桑原 和代, 佐田 みずき, 西田 陽子, 久保 佐智美, 久保田 芳美, 門田 文, 西川 智文, 宮松 直美, 宮本 恵宏, 岡村 智教

    日本公衆衛生学会総会抄録集, 2019.10, 日本公衆衛生学会

  • 飲酒の有無によるFatty liver indexの脂肪肝診断能に関する検討

    平田 あや, 杉山 大典, 桑原 和代, 岡村 智教

    日本アルコール・薬物医学会雑誌, 2019.08, (一社)日本アルコール・アディクション医学会

  • 日本人一般集団における非空腹時採血の中性脂肪と脳・心血管疾患死亡との関連　NIPPON DATA90

    平田 あや, 岡村 智教, 杉山 大典, 平田 匠, 大久保 孝義, 奥田 奈賀子, 喜多 義邦, 早川 岳人, 門田 文, 三浦 克之, 岡山 明, 上島 弘嗣

    日本動脈硬化学会総会プログラム・抄録集, 2019.07, (一社)日本動脈硬化学会

  • 地域住民におけるFatty liver indexとCAVIとの関連：鶴岡メタボロームコホート研究

    平田 あや, 岡村 智教, 原田 成, 杉山 大典, 桑原 和代, 佐田 みずき, 栗原 綾子, 加藤 寿寿華, 飯田 美穂, 武林 亨

    第77回日本公衆衛生学会総会, 2018.10

  • 全国9コホート43,407名の統合解析による超高値HDL-Cと動脈硬化性心血管疾患との関連：The EPOCH-JAPAN study

    平田 あや, 杉山 大典, 渡邉 至, 玉腰 暁子, 磯 博康, 小谷 和彦, 木山 昌彦, 山田 美智子, 石川 鎮清, 村上 義孝, 三浦 克之, 上嶋 弘嗣, 岡村 智教

    第50回日本動脈硬化学会総会・学術集会, 2018.06

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 既存健診項目で算出できる脂肪肝指数の健診での実用化に向けた疫学的検討

    2019.08
    -
    2021.03

    研究活動スタート支援, Research grant, Principal Investigator

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Awards 【 Display / hide 】

  • 第50回日本動脈硬化学会総会・学術集会　最優秀ポスター賞

    平田あや, 2018.07, 全国9コホート43,407名の統合解析による超高値HDL-Cと動脈硬化性心血管疾患との関連：The EPOCH-JAPAN study

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