HIRATA Aya

写真a

Affiliation

School of Medicine, Department of Preventive Medicine and Public Health （Shinanomachi）

Position

Senior Assistant Professor (Non-tenured)/Assistant Professor (Non-tenured)
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Academic Degrees 【 Display / hide 】

  • 博士（医学）, 慶應義塾大学, 2019.03

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Research Areas 【 Display / hide 】

  • Life Science / Medical management and medical sociology

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Books 【 Display / hide 】

  • Encyclopedia of Cardiovascular Research and Medicine

    Douglas B. Sawyer, Ramachandran S. Vasan 編集; Okamura T, Sugiyama D, Hirata T, Kuwabara K, Hirata A [他] 著, Elsevier, Oxford, 2017.12

    Scope: Lipids and Cardiovascular Diseases: Epidemiologic Perspectives（分担執筆）

  • FDA リスク&ベネフィット コミュニケーション: エビデンスに基づく健康・医療に関する指針（共訳）

    バルーク フィッシュホフ [他] 著, 中山健夫, 杉森裕樹 監訳, 平田あや [他] 訳, 丸善出版, 2015.07

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Papers 【 Display / hide 】

  • Reliability of urinary charged metabolite concentrations in a large-scale cohort study using capillary electrophoresis-mass spectrometry

    Ishibashi Yoshiki, Harada Sei, Takeuchi Ayano, Iida Miho, Kurihara Ayako, Kato Suzuka, Kuwabara Kazuyo, Hirata Aya, Shibuki Takuma, Okamura Tomonori, Sugiyama Daisuke, Sato Asako, Amano Kaori, Hirayama Akiyoshi, Sugimoto Masahiro, Soga Tomoyoshi, Tomita Masaru, Takebayashi Toru

    SCIENTIFIC REPORTS 11 （ 1 ）  2021.04

    ISSN  2045-2322

  • Electrocardiographic Left Atrial Abnormality and B-Type Natriuretic Peptide in a General Japanese Population: NIPPON DATA2010

    Shoji Satoshi, Kadota Aya, Ueshima Hirotsugu, Okayama Akira, Miura Katsuyuki, for the NIPPON DATA2010 Research Group, Kohsaka Shun, Sawano Mitsuaki, Okamura Tomonori, Hirata Aya, Sugiyama Daisuke, Ohkubo Takayoshi, Nakamura Yasuyuki, Watanabe Makoto

    Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ （一般社団法人 日本動脈硬化学会)  28 （ 1 ） 34 - 43 2021

    ISSN  1340-3478

    　View Summary

    <p><b>Aims: </b>P-wave terminal force in lead V<sub>1</sub> (PTFV<sub>1</sub>) is an electrocardiogram marker of increased left atrial pressure and may be a noninvasive and early detectable marker for future cardiovascular events in the general population compared to serum B-type natriuretic peptide (BNP) concentration. The clinical significance of PTFV<sub>1</sub> in the contemporary general population is an area of unmet need. We aimed to demonstrate the correlation between PTFV<sub>1</sub> and BNP concentrations in a contemporary representative Japanese population.<b> </b></p><p><b>Methods: </b>Among 2,898 adult men and women from 300 randomly selected districts throughout Japan (NIPPON DATA2010), we analyzed 2,556 participants without cardiovascular disease (stroke, myocardial infarction, and atrial fibrillation). Elevated BNP was defined as a value of ≥ 20 pg/mL based on the definition from the Japanese Circulation Society guidelines.<b> </b></p><p><b>Results:</b> In total, 125 (4.9%) participants had PTFV<sub>1</sub>. Participants with PTFV<sub>1</sub> were older with a higher prevalence of hypertension, major electrocardiographic findings, and elevated BNP concentrations (13.5 [6.9, 22.8] versus 7.8 [4.4, 14.5] pg/mL; <i>P</i>＜0.001). After adjustment for confounders, PTFV<sub>1</sub> was correlated with elevated BNP (odds ratio, 1.66; 95% confidence interval, 1.05–2.62; <i>P</i>=0.030). This correlation was consistent among various subgroups and was particularly evident in those aged ＜65 years or those without a history of hypertension.<b> </b></p><p><b>Conclusions: </b>In the contemporary general population cohort, PTFV<sub>1</sub> was independently related to high BNP concentration. PTFV<sub>1</sub> may be an alternative marker to BNP in identifying individuals at a higher risk of future cardiovascular events in the East Asian population.</p>

  • Changes in smoking habits and behaviors following the introduction and spread of heated tobacco products in Japan and its effect on FEV<sub>1</sub> decline: a longitudinal cohort study

    Harada Sei, Ishibashi Yoshiki, Sugiyama Daisuke, Okamura Tomonori, Takebayashi Toru, Sata Mizuki, Matsumoto Minako, Iida Miho, Takeuchi Ayano, Kato Suzuka, Hirata Aya, Kuwabara Kazuyo, Shibuki Takuma

    Ｊｏｕｒｎａｌ　ｏｆ　Ｅｐｉｄｅｍｉｏｌｏｇｙ （日本疫学会)   2021

    ISSN  0917-5040

    　View Summary

    <p>Background: Heated tobacco product (HTP) use in Japan has rapidly increased. Despite this rapid spread, little is known about the health effects of HTP use. We conducted a longitudinal cohort study to investigate the change in smoking habits following the spread of HTP use and its effect on forced expiratory volume in one second (FEV<sub>1</sub>) decline.</p><p>Methods: Participants consisted of a resident population (n=2,612, aged 67.7) with FEV<sub>1</sub> measurement in 2012-2014 and 2018-2019, and a worksite population (n=722, aged 49.3) without FEV<sub>1</sub> data. Participants were categorized as never, past and combustible cigarette-only smokers, and HTP-only and dual users. The association between smoking group and the change in smoking consumption for 5.6 years was examined. Differences in annual FEV<sub>1</sub> change between smoking groups were examined in the resident population.</p><p>Results: Prevalence of HTP-only and dual users in 2018-2019 was 0.8% and 0.6% in the resident population, and 5.0% and 1.9% in the worksite population, respectively. The overall number of tobacco products smoked/used increased in dual users compared to baseline, but not in others. Annual FEV<sub>1</sub> decline in dual users tended to be greater than that in cigarette-only smokers (16 mL/yr [95% CI: -34, 2] after full adjustment). Participants switching to HTP-only use 1.7 years before had a similar FEV<sub>1</sub> decline as cigarette-only smokers.</p><p>Conclusions: HTP use, including dual use, is prevalent even in a rural region of Japan. Dual users appear to smoke/use tobacco products more and have a greater FEV<sub>1</sub> decline. Tobacco policy should consider dual use as high-risk.</p>

  • Relationship Between Non-fasting Triglycerides and Cardiovascular Disease Mortality in a 20-year Follow-up Study of a Japanese General Population: NIPPON DATA90

    Hirata Aya, Kondo Keiko, Miura Katsuyuki, Okayama Akira, Ueshima Hirotsugu, Okamura Tomonori, Hirata Takumi, Sugiyama Daisuke, Ohkubo Takayoshi, Okuda Nagako, Kita Yoshikuni, Hayakawa Takehito, Kadota Aya

    Ｊｏｕｒｎａｌ　ｏｆ　Ｅｐｉｄｅｍｉｏｌｏｇｙ （日本疫学会)   2021

    ISSN  0917-5040

    　View Summary

    <p><b>Background:</b> Non-fasting triglycerides (TG) are considered a better predictor of cardiovascular disease (CVD) than fasting TG. However, the effect of non-fasting TG on fatal CVD events remains unclear. In the present study, we aimed to explore the relationship between non-fasting TG and CVD mortality in a Japanese general population.</p><p><b>Methods:</b> A total of 6,831 participants without a history of CVD, in which those who had a blood sampling over 8 hours or more after a meal were excluded, were followed for 18.0 years. We divided participants into seven groups according to non-fasting TG levels: ≤59 mg/dL, 60–89 mg/dL, 90–119 mg/dL, 120–149 mg/dL, 150–179 mg/dL, 180–209 mg/dL, and ≥210 mg/dL, and estimated the multivariable-adjusted hazard ratios (HRs) of each TG group for CVD mortality after adjusting for potential confounders, including high density lipoprotein cholesterol. Additionally, we performed analysis stratified by age <65 and ≥65 years.</p><p><b>Results:</b> During the follow-up period, 433 deaths due to CVD were detected. Compared with a non-fasting TG of 150–179 mg/dL, non-fasting TG ≥210 mg/dL was significantly associated with increased risk for CVD mortality (HR 1.56: 95% CI, 1.01–2.41). Additionally, lower levels of non-fasting TG were also significantly associated with increased risk for fatal CVD. In participants aged ≥65 years, lower levels of non-fasting TG had a stronger impact on increased risk for CVD mortality, while higher levels of non-fasting TG had a stronger impact in those aged <65 years.</p><p><b>Conclusion:</b> In a general Japanese population, we observed a U-shaped association between non-fasting TG and fatal CVD events.</p>

  • Impact of resting heart rate on cardiovascular mortality according to serum albumin levels in a 24-year follow-up study on a general Japanese population: NIPPON DATA80

    Liu Yiwei, Okayama Akira, Ueshima Hirotsugu, Hirata Aya, Okamura Tomonori, Sugiyama Daisuke, Hirata Takumi, Kadota Aya, Kondo Keiko, Ohkubo Takayoshi, Miura Katsuyuki

    Ｊｏｕｒｎａｌ　ｏｆ　Ｅｐｉｄｅｍｉｏｌｏｇｙ （日本疫学会)   2021

    ISSN  0917-5040

    　View Summary

    <p><b>Background</b></p><p>Elevated resting heart rate (RHR) is associated with an increased risk for cardiovascular disease (CVD) and all-cause mortality. However, the findings of cohort studies differed. Thus, the impact of RHR on CVD mortality might be different according to the background of the population. Therefore, we examined the relationship of RHR and CVD mortality according to serum ALB levels in a Japanese general population.</p><p><b>Methods</b></p><p>In total, 8363 individuals without a history of CVD were followed-up for 24.0 years. The participants were divided into four groups according to the quartiles of RHR (Q1–Q4), and they were further classified into the high and low ALB groups based on a median value of 44 g/L. We estimated the multivariable-adjusted hazard ratios (HRs) of CVD mortality in each RHR group based on ALB levels, and the interaction between RHR and ALB groups on CVD mortality was evaluated.</p><p><b>Results</b></p><p>We found no significant association between RHR and CVD mortality. However, the Q4 of RHR was significantly associated with an increased risk for CVD mortality (HR: 1.27 [95% confidence interval, CI: 1.02–1.57]) in participants with a low ALB level. Meanwhile, the Q4 of RHR was significantly correlated with a decreased risk for CVD morality in those with a high ALB level (HR: 0.61 [95% CI: 0.47–0.79]) after adjusting for covariates. A significant interaction between RHR and ALB for CVD mortality was shown (<i>p</i><0.001).</p><p><b>Conclusions</b></p><p>The impact of RHR on CVD mortality differed according to ALB levels in a general Japanese population.</p>

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Reviews, Commentaries, etc. 【 Display / hide 】

  • 【冠動脈疾患のリスク管理のフロントライン】冠動脈疾患イベントリスクをどう評価する?

    岡村 智教, 平田 あや, 桑原 和代

    循環器ジャーナル ((株)医学書院)  67 ( 4 ) 508 - 515 2019.10

    ISSN  2432-3284

    　View Summary

    ＜文献概要＞Point　・個々のリスクファクターではなく,複数のリスクファクターを組み合わせて冠動脈疾患の発症リスクを包括的に評価する必要がある.・特定健診などでスクリーニングするのは,冠動脈疾患そのものではなく冠動脈疾患を発症する可能性が高いハイリスク者であり,そのためにも包括的リスク評価が重要である.

  • 【動脈硬化の早期診断法と予防対策-健康寿命延伸をめざして】 発症予測と絶対リスク

    平田 あや, 岡村 智教

    カレントテラピー ((株)ライフメディコム)  36 ( 11 ) 1062 - 1067 2018.11

    ISSN  0287-8445

  • 【脂質代謝異常と循環器疾患】 診る　脂質異常症と冠動脈疾患　わが国の疫学研究から

    平田 あや, 岡村 智教

    Heart View ((株)メジカルビュー社)  22 ( 7 ) 612 - 618 2018.07

    ISSN  1342-6591

  • 【動脈・静脈の疾患(上)-最新の診断・治療動向-】 動脈・静脈疾患の疫学　わが国における血管疾患の疫学

    平田 あや, 岡村 智教

    日本臨床 ((株)日本臨床社)  75 ( 増刊4 動脈・静脈の疾患(上) ) 37 - 42 2017.05

    ISSN  0047-1852

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Presentations 【 Display / hide 】

  • 都市住民における生活習慣と腎機能低下の進行との関連　神戸研究

    平田 あや, 東山 綾, 平田 匠, 杉山 大典, 桑原 和代, 佐田 みずき, 西田 陽子, 久保 佐智美, 久保田 芳美, 門田 文, 西川 智文, 宮松 直美, 宮本 恵宏, 岡村 智教

    日本公衆衛生学会総会抄録集, 

    2019.10
    , 

    日本公衆衛生学会

  • 飲酒の有無によるFatty liver indexの脂肪肝診断能に関する検討

    平田 あや, 杉山 大典, 桑原 和代, 岡村 智教

    日本アルコール・薬物医学会雑誌, 

    2019.08
    , 

    (一社)日本アルコール・アディクション医学会

  • 日本人一般集団における非空腹時採血の中性脂肪と脳・心血管疾患死亡との関連　NIPPON DATA90

    平田 あや, 岡村 智教, 杉山 大典, 平田 匠, 大久保 孝義, 奥田 奈賀子, 喜多 義邦, 早川 岳人, 門田 文, 三浦 克之, 岡山 明, 上島 弘嗣

    日本動脈硬化学会総会プログラム・抄録集, 

    2019.07
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    (一社)日本動脈硬化学会

  • 地域住民におけるFatty liver indexとCAVIとの関連：鶴岡メタボロームコホート研究

    平田 あや, 岡村 智教, 原田 成, 杉山 大典, 桑原 和代, 佐田 みずき, 栗原 綾子, 加藤 寿寿華, 飯田 美穂, 武林 亨

    第77回日本公衆衛生学会総会, 

    2018.10

  • 全国9コホート43,407名の統合解析による超高値HDL-Cと動脈硬化性心血管疾患との関連：The EPOCH-JAPAN study

    平田 あや, 杉山 大典, 渡邉 至, 玉腰 暁子, 磯 博康, 小谷 和彦, 木山 昌彦, 山田 美智子, 石川 鎮清, 村上 義孝, 三浦 克之, 上嶋 弘嗣, 岡村 智教

    第50回日本動脈硬化学会総会・学術集会, 

    2018.06

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 脂質に着目した脳・心血管疾患の個別化予防実現のためのゲノム・メタボローム疫学研究

    2022.04
    -
    2024.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 若手研究, Principal investigator

  • 変性リポ蛋白を含む脂質プロフィールと脳・心血管疾患の関連、その規定要因の解明

    2021.04
    -
    2026.03

    Keio University, Grant-in-Aid for Scientific Research (A), No Setting

    　View Summary

    Lectin-like oxidized LDL Receptor (LOX-1)は内皮細胞の変性LDLの受容体であり、変性LDL、変性LDLの催動脈硬化作用はLOX-1を介している可能性がある。本研究では複数のコホート集団の疫学研究で、通常の血中脂質検査に加えて変性LDL、変性HDLと脳・心血管疾患との関連を評価し、病型の決定にこれらの因子がどのように影響しているかを明らかにする。また変性リポ蛋白の生活習慣上の規定要因を血中等のメタボローム解析も含めて検証する。これにより将来、変性リポ蛋白を治療ターゲットにした介入研究への橋渡しが可能となり、創薬や予防方法の開発に発展させることが可能である。

  • 既存健診項目で算出できる脂肪肝指数の健診での実用化に向けた疫学的検討

    2019.08
    -
    2021.03

    研究活動スタート支援, Research grant, Principal investigator

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Awards 【 Display / hide 】

  • 第56回日本循環器病予防学会学術集会 Young Investigator’s Award優秀賞

    2020.12, Fatty liver indexとCAVIの関連における血中アミノ酸の疫学的検討：鶴岡メタボロームコホート研究

  • 第50回日本動脈硬化学会総会・学術集会　最優秀ポスター賞

    2018.07, 全国9コホート43,407名の統合解析による超高値HDL-Cと動脈硬化性心血管疾患との関連：The EPOCH-JAPAN study

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Courses Taught 【 Display / hide 】

  • PUBLIC HEALTH 2 (ADVANCED)

    2022

  • PUBLIC HEALTH 1 (BASIC)

    2022

  • EPIDEMIOLOGY OF NON-COMMUNICABLE DISEASES

    2022

  • EPIDEMIOLOGY AND PREVENTIVE MEDICINE

    2022

  • BIOSTATISTICS AND MEDICAL INFORMATICS

    2022

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Memberships in Academic Societies 【 Display / hide 】

  • 日本動脈硬化学会, 

    2016
    -
    Present

  • 日本疫学会, 

    2016
    -
    Present

  • 日本公衆衛生学会, 

    2016
    -
    Present

  • 日本循環器病予防学会, 

    2015
    -
    Present

  • 日本超音波医学会, 

    2009
    -
    Present
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