KONDO Shingo

写真a

Affiliation

Faculty of Pharmacy, Department of Pharmacy Social Pharmacy (Shiba-Kyoritsu)

Position

Research Associate/Assistant Professor/Instructor

Contact Address

1-5-30 shibakoen, Minato-ku, Tokyo
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Career 【 Display / hide 】

  • 2017.04
    -
    2019.03

    Medical Hospital, Tokyo Medical and Dental University, Department of Pharmacy, pharmacist

  • 2019.04
    -
    2023.03

    慶應義塾大学薬学部, 化学療法学講座, 助教

  • 2023.04
    -
    Present

    慶應義塾大学薬学部, Social Pharmacy, 助教

  • 2023.04
    -
    Present

    慶應義塾大学薬学部附属薬局, 非常勤薬剤師

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Academic Background 【 Display / hide 】

  • 2013.04
    -
    2017.03

    Keio University

    Graduate School, Completed, Doctoral course

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Academic Degrees 【 Display / hide 】

  • Doctor（Pharmacy）, Keio University, Coursework, 2017.03

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Licenses and Qualifications 【 Display / hide 】

  • Pharmacist license, 2013.07

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Papers 【 Display / hide 】

  • Loneliness and analgesic overuse among low-dose estrogen-progestin users in Japan

    Fujimoto T., Iwata H., Kobayashi N., Kondo S., Yamaura K.

    BMC Women S Health 25 ( 1 ) 422 2025.12

    　View Summary

    Purpose: Loneliness is related to menstrual disorders and medication use. Loneliness and pain are related and may be associated with analgesic use. The aim of this study was to investigate the prevalence of concomitant analgesic use and overuse, and to clarify factors associated with loneliness and analgesic overuse among women who are low-dose estrogen-progestin (LEP) users. Methods: Women in their 20s and 30s were randomly selected from a research company’s web panel (Macromill, Inc.) and LEP users were screened. The survey included analgesic concomitant use days per month and the Three-Item Loneliness Scale (TIL). Logistic regression analysis was performed with high TIL score (≥ 6) and analgesic use ≥ 10 days per month as the objective variables. Results: A total of 516 valid responses from LEP users were analyzed. Among them, 64.1% reported concomitant analgesic use on ≥ 1 day per month, 11.2% on ≥ 10 days per month, and 45.7% had high TIL score. High TIL score was significantly associated with concomitant analgesic use on ≥ 1 day per month (odds ratio [OR] 1.76, 95% confidence interval [95%CI] 1.18–2.63, p = 0.006). Concomitant analgesic use on ≥ 10 days per month was significantly associated with endometriosis (OR 5.25, 95%CI 2.15–12.81, p < 0.001) and concomitant analgesic use for low back pain (OR 4.67, 95%CI 1.65–13.18, p = 0.04). Conclusions: To our knowledge, this is the first detailed study to investigate concomitant analgesic use and overuse among LEP users. Loneliness was found to be prevalent in this population and was associated with concomitant analgesic use, potentially reflecting underlying patterns of frequent or habitual analgesic intake. Furthermore, concomitant analgesic overuse was linked to conditions such as endometriosis and low back pain, underscoring the importance of medication monitoring that takes into account both loneliness and the self-recording of menstrual symptoms. Greater attention by healthcare professionals to the psychosocial context of concomitant analgesic overuse and loneliness may facilitate more meaningful patient dialogue and contribute to improved quality of life.

  • Use of Dysphagia-Inducing Drugs and Risk of Aspiration Pneumonia: A Cross-Sectional Analysis Using a Japanese Claims Database.

    Hayashi N, Yoshida M, Maida N, Kondo S, Ogawa M, Iwata H, Kobayashi N, Yamaura K

    Drugs - real world outcomes  2025.09

    ISSN  2199-1154

  • Sex Differences in Electrolyte Disturbances Among Diuretic Users According to Renal Function and Age.

    Maida N., Kondo S., Hayashi N., Iwata H., Kobayashi N., Yamaura K.

    Drug safety 48 ( 10 ) 1149 - 1159 2025.06

    ISSN  0114-5916

    　View Summary

    Introduction: Diuretics are widely used in Japan for the treatment of hypertension and heart failure. Electrolyte disturbance is a common adverse reaction to diuretics and may be life-threatening. Previous studies have shown that diuretic-induced electrolyte disturbance is more common in women. Electrolyte balance is regulated by the kidneys, and renal function tends to decline with advancing age. Objective: The aim of this study was to identify patients at high risk of adverse reactions to diuretics, considering the effects of sex, renal function, and age on susceptibility to diuretic-induced electrolyte disturbance. Methods: Claims data for 67,135 patients on diuretics in Japan were sourced from DeSC Healthcare, Inc. The data covered the period from April 2020 to March 2021. Results: Analysis of patient numbers using the chi-squared test showed that hyperkalemia was more common in men than in women (326 vs. 271; p = 0.003) and that hypokalemia was more common in women than in men (413 vs. 285; p < 0.001). Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for women considering age and renal function (estimated glomerular filtration rate [eGFR]). In elderly patients aged ≥ 75 years, the odds of developing hypokalemia in women compared to men were 1.47 (95% CI 1.13–1.91) for eGFR 60–30 mL/min/1.73 m<sup>2</sup> and 2.05 (95% CI 1.08–4.10) for eGFR < 30 mL/min/1.73 m<sup>2</sup>. Conclusion: Among women aged ≥ 75 years, those in lower eGFR groups (60–30 and < 30) had higher odds of hypokalemia compared to men. These data highlight the importance of monitoring for adverse reactions to diuretics, particularly hypokalemia, in elderly women with low eGFR.

  • Prescription Trends and Contributing Factors of Medications Causing Xerostomia in Elderly Patients

    Kondo Shingo, Sano Kunihiro, Hayashi Naoko, Fujishima Seitaro, Iwata Hiroki, Kobayashi Noriko, Yamaura Katsunori

    Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) (Japanese Society of Pharmaceutical Health Care and Sciences)  51 ( 6 ) 355 - 365 2025.06

    ISSN  1346342X

    　View Summary

    <p>Xerostomia is a syndrome characterized by subjective or objective findings of oral dryness. One quarter of the elderly population suffers from xerostomia owing to a decline in salivary secretion function with age and problems with oral closure. Additionally, many ethical drugs have xerostomia listed as an adverse drug reaction. Xerostomia reduces the self-cleansing action of the mouth and can cause problems in maintaining oral health. In this study, we created a list of drugs associated with xerostomia from these package inserts. Then, electronic medical record data from Keio University Hospital were analyzed to investigate prescribing trends among elderly patients and to identify patient characteristics associated with these drugs. Patients who received continuous prescriptions from April 2019 to March 2020 were included in this study based on age, prescribed drugs, and associated diseases. Among the 575 patients analyzed, 464 (80.7％) were prescribed at least one xerostomia-inducing medication. Compared with the early-stage elderly, a significantly higher proportion of late-stage elderly patients received these medications (<i>P</i> < 0.001) and had multiple prescriptions (<i>P</i> < 0.001). Logistic regression analysis examined the presence and multiple prescriptions of xerostomia-inducing drugs, showing significant associations with late-stage elderly patients and polypharmacy. The most common conditions among patients prescribed xerostomia-inducing drugs were endocrine, nutritional, metabolic, cardiovascular, and gastrointestinal diseases. Accordingly, vasodilators, peptic ulcer drugs, and hyperlipidemic drugs were frequently prescribed to these patients. The results suggest that the risk of xerostomia should be a point of consideration when prescribing multiple medicines to elderly patients.</p>

  • Practical training reduces aspiration-linked gaps in pressure ulcer education for pharmacy students

    Kondo Shingo, Mima Ririka, Okui Rira, Iwata Hiroki, Kawamoto Yoshiko, Kobayashi Noriko, Furuta Katsunori, Yamaura Katsunori

    Drug Discoveries & Therapeutics (International Research and Cooperation Association for Bio & Socio-Sciences Advancement)  advpub ( 0 ) 90 - 95 2025.04

    ISSN  1881-7831

    　View Summary

    <p>Expectations for pharmacists' contribution and involvement in pressure ulcer pharmacotherapy are growing. This study aimed to not only clarify the effects of incorporating practical training on the use of topical medications into clinical preparatory education but also examine the relationship between students' aspiration—or lack thereof—to pursue a career as a pharmacist. The percentage of positive responses to the questionnaire survey on knowledge, skills, and attitudes toward pressure ulcer treatment was significantly higher after the lecture than before and highest after the practical training. In addition, students who aspired to become pharmacists tended to provide a higher percentage of positive responses after the lecture. However, the gap between aspiring and non-aspiring pharmacists tended to narrow after practical training. These results suggest that incorporating practical training on pressure ulcer treatment into lectures improves students' knowledge, skills, and attitudes toward its treatment. Including practical training in pressure ulcer education may compensate for the difference in the educational effect of lectures between students who aspire to become pharmacists and those who do not, thereby improving the educational effect for the latter.</p>

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • ヒスチジン異化はメトトレキサート感受性の主要な決定因子である

    近藤 慎吾

    ファルマシア (公益社団法人日本薬学会)  55 ( 7 ) 702 2019.07

    Book review, literature introduction, etc., Single Work

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Presentations 【 Display / hide 】

  • 新型コロナウイルス感染症第7波自宅療養者における一般用医薬品の適正使用の実態と課題

    藤本卓磨, 岩田紘樹, 小林典子, 近藤慎吾, 中村友紀, 山浦克典

    2023.11
    , 

    Oral presentation (general)

  • 頭痛およびヘルスリテラシーの評価スコアを用いた頭痛患者の特性分析

    近藤 慎吾, 藤本 卓磨, 岩田 紘樹, 小林 典子, 中村 友紀, 山浦 克典

    2023.09
    , 

    Oral presentation (general)

  • ヒト結腸がん細胞株の上皮間葉転換に伴うグルタミナーゼ阻害剤高感受性とATF4の発現低下

    加藤 優, 近藤 慎吾, 杉本 芳一

    第27回日本がん分子標的治療学会学術集会 (佐賀市文化会館) , 

    2023.06
    , 

    Oral presentation (general), 日本がん分子標的治療学会

  • EMTを誘導したヒト大腸がんHCT116細胞に対するglutaminase阻害剤の効果

    奥村光遥, 加藤優, 近藤慎吾, 杉本芳一

    日本薬学会第142年会, 

    2023.03
    , 

    Poster presentation

  • BET阻害剤dBET6はSLUG導入EMT細胞のフェロトーシス感受性を増大させる

    加藤優, 深澤ゆかり, 近藤慎吾, 杉本芳一

    日本薬学会第142年会, 

    2023.03
    , 

    Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 口腔乾燥を誘導する薬剤の同定と薬剤師による臨床的介入の効果の検討

    2025.04
    -
    2028.03

    Grants-in-Aid for Scientific Research, 近藤 慎吾, Grant-in-Aid for Scientific Research (C), No Setting

    　View Summary

    口腔乾燥は医療用医薬品の添付文書中の「その他の副作用」に記載があるが、その危険度に関するデータは不足している。
    本研究ではエムスリー株式会社が保有する診療データベースを用いて、実際に口腔乾燥の訴えがある患者の服用薬を解析して、副作用症状を起こす可能性の高いハイリスク薬を同定することを目的とする。さらに、それらハイリスク薬に対する代替薬リストを作成する。口腔乾燥を感じる患者の処方に対して薬剤情報提供文書で医師に変更提案し、薬剤変更による口腔乾燥の改善効果を検証する。

  • がん分子標的薬に対する細胞周期の変化と薬剤耐性の克服

    2021.04
    -
    2022.03

    学事振興資金（個人研究）, No Setting, Principal investigator

  • がん分子標的薬に対する耐性機構の解明

    2020.04
    -
    2021.03

    学事振興資金（個人研究）, No Setting, Principal investigator

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Courses Taught 【 Display / hide 】

  • STUDY OF MAJOR FIELD: (SOCIAL PHARMACY)

    2025

  • SEMINAR: (SOCIAL PHARMACY)

    2025

  • RESEARCH FOR BACHELOR'S THESIS 1

    2025

  • PRIOR LEARNING FOR CLINICAL PRACTICE 5

    2025

  • PRE-CLINICAL TRAINING FOR HOSPITAL & COMMUNITY PHARMACY

    2025

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Courses Previously Taught 【 Display / hide 】

  • COMMUNITY PHARMACY

    Keio University

    2025.04
    -
    2026.03

  • CLINICAL PHARMACY AND PHARMACOTHERAPY

    Keio University

    2025.04
    -
    2026.03

  • STUDY OF MAJOR FIELD: (SOCIAL PHARMACY)

    Keio University

    2025.04
    -
    2026.03

  • PRACTICAL LEARNING ON SUPPORTING THE INTELLECTUALLY DISABLED PERSON'S ACTIVITIES

    Keio University

    2025.04
    -
    2026.03

  • ADVANCED MOLECULAR BIOLOGY OF DISEASE

    Keio University

    2025.04
    -
    2026.03

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Memberships in Academic Societies 【 Display / hide 】

  • 日本性差医学・医療学会, 

    2024.01
    -
    Present

  • 日本性差医学・医療学会, 

    2024.01
    -
    Present

  • 日本医療薬学会, 

    2023.08
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    Present

  • 日本医療薬学会, 

    2023.08
    -
    Present

  • 日本がん分子標的治療学会, 

    2019.04
    -
    Present

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