KEIO RESEARCHERS INFORMATION SYSTEM

Career 【 Display / hide 】

Career 【 Display / hide 】

• 2017.04

  -

  2019.03

  Medical Hospital, Tokyo Medical and Dental University, Department of Pharmacy, pharmacist

• 2019.04

  -

  2023.03

  慶應義塾大学薬学部, 化学療法学講座, 助教

• 2023.04

  -

  Present

  慶應義塾大学薬学部, Social Pharmacy, 助教

• 2023.04

  -

  Present

  慶應義塾大学薬学部附属薬局, 非常勤薬剤師

Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 2013.04

  -

  2017.03

  Keio University

  Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• Doctor（Pharmacy）, Keio University, Coursework, 2017.03

Licenses and Qualifications 【 Display / hide 】

Licenses and Qualifications 【 Display / hide 】

• Pharmacist license, 2013.07

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Analysis of drug-induced adverse reactions affecting appetite and taste using the Japanese Adverse Drug Event Report Database

  Maese M, Kondo S, Sakatsume Y, Takagi M, Yokoyama Y, Iwata H, Kobayashi N, Yamaura K

  BMC Research Notes  2026

  Research paper (scientific journal), Accepted

• A blended learning program sustains pharmacists' oral health support competency for 15 months: A longitudinal study

  Hayashi N, Goto T, Shiga Y, Okazaki M, Sano A, Maida N, Iwata H, Matsui H, Kondo S, Kobayashi N, Yamaura K

  Drug discoveries & therapeutics (International Research and Cooperation Association for Bio & Socio-Sciences Advancement)  advpub ( 0 )  2026

  Research paper (scientific journal), Accepted,  ISSN  1881-7831

  　View Summary

  <p>The importance of oral health has gained increasing recognition in the recent years owing to its association with numerous systemic diseases such as diabetes and cardiovascular disease. Dental checkups are crucial for maintaining and promoting oral health; however, in Japan, a relatively low uptake of dental checkups remains a challenge. Community pharmacists are expected to play a vital role in supporting the health and well-being of local residents; however, they have been observed to be reluctant to provide support in the oral health domain. This study aimed to develop and evaluate a blended learning training program on oral health support aimed at educating pharmacists working in health support pharmacies. The training, which involved online learning and on-site training, covered topics such as the importance of oral health, methods of oral health assessment, and the mechanisms of eating and swallowing. The participants, including a total of 39 pharmacists from across the country, completed surveys before and after the training, as well as at 9 months and 15 months posttraining. The results demonstrated a significant improvement in the pharmacists' knowledge, explanatory abilities, and confidence in providing oral health support, and these effects were observed to persist for up to 15 months after the training had ended. In addition, the variety of oral health-related products in pharmacies increased. This blended learning program demonstrates the potential to redefine the role of pharmacists in promoting oral health and contribute to the improvement of oral health among local residents.</p>

  • Access to Document (DOI)
  • CiNii Research

• 心不全患者のトリプルワーミー回避に関する 歯薬連携の新規モデル構築の契機となった1 例

  前瀬 鞠, 近藤慎吾, 林直子, 岩田紘樹, 小林典子, 岡本侑子, 榎木裕紀, 漆畑俊哉, 山浦克典

  薬局薬学  2026

  Research paper (scientific journal), Joint Work, Accepted

• Loneliness and analgesic overuse among low-dose estrogen-progestin users in Japan

  Fujimoto T., Iwata H., Kobayashi N., Kondo S., Yamaura K.

  BMC Women S Health 25 ( 1 ) 422 2025.12

  Research paper (scientific journal), Accepted

  　View Summary

  Purpose: Loneliness is related to menstrual disorders and medication use. Loneliness and pain are related and may be associated with analgesic use. The aim of this study was to investigate the prevalence of concomitant analgesic use and overuse, and to clarify factors associated with loneliness and analgesic overuse among women who are low-dose estrogen-progestin (LEP) users. Methods: Women in their 20s and 30s were randomly selected from a research company’s web panel (Macromill, Inc.) and LEP users were screened. The survey included analgesic concomitant use days per month and the Three-Item Loneliness Scale (TIL). Logistic regression analysis was performed with high TIL score (≥ 6) and analgesic use ≥ 10 days per month as the objective variables. Results: A total of 516 valid responses from LEP users were analyzed. Among them, 64.1% reported concomitant analgesic use on ≥ 1 day per month, 11.2% on ≥ 10 days per month, and 45.7% had high TIL score. High TIL score was significantly associated with concomitant analgesic use on ≥ 1 day per month (odds ratio [OR] 1.76, 95% confidence interval [95%CI] 1.18–2.63, p = 0.006). Concomitant analgesic use on ≥ 10 days per month was significantly associated with endometriosis (OR 5.25, 95%CI 2.15–12.81, p < 0.001) and concomitant analgesic use for low back pain (OR 4.67, 95%CI 1.65–13.18, p = 0.04). Conclusions: To our knowledge, this is the first detailed study to investigate concomitant analgesic use and overuse among LEP users. Loneliness was found to be prevalent in this population and was associated with concomitant analgesic use, potentially reflecting underlying patterns of frequent or habitual analgesic intake. Furthermore, concomitant analgesic overuse was linked to conditions such as endometriosis and low back pain, underscoring the importance of medication monitoring that takes into account both loneliness and the self-recording of menstrual symptoms. Greater attention by healthcare professionals to the psychosocial context of concomitant analgesic overuse and loneliness may facilitate more meaningful patient dialogue and contribute to improved quality of life.

  • Access to Document (DOI)

• Use of Dysphagia-Inducing Drugs and Risk of Aspiration Pneumonia: A Cross-Sectional Analysis Using a Japanese Claims Database.

  Hayashi N., Yoshida M., Maida N., Kondo S., Ogawa M., Iwata H., Kobayashi N., Yamaura K.

  Drugs - real world outcomes 12 ( 4 ) 607 - 614 2025.09

  Research paper (scientific journal), Accepted,  ISSN  2199-1154

  　View Summary

  Background and Objectives: Oropharyngeal dysphagia (OD), a dysfunction in swallowing food or drink, can result from various diseases and adverse drug reactions. OD is a risk factor for aspiration pneumonia (AP). However, the specific drugs causing OD and their incidence rates are not fully understood. This study aimed to identify drugs associated with OD, their incidence rates, and AP risk factors in patients taking these drugs on the basis of the information provided in package inserts. Methods: This study identified candidate dysphagia-inducing drugs (CDIDs) from Japanese package inserts that listed OD as an adverse reaction. The age, sex, medications, and comorbidities of patients taking CDIDs were analyzed using the JammNet insurance database, purchased from JammNet Co., Ltd. (Tokyo, Japan). Results: Overall, 54 ingredients were identified as CDIDs. Out of 24,276 patients taking CDIDs, 146 (0.6%) were diagnosed with OD and 76 (0.3%) with AP. Among those with AP, 23 patients (30%) also had OD. OD or AP occurred in patients taking 28 (52%) of the 54 target ingredients. In addition, 13 ingredients had an adverse reaction incidence of 1% or greater for either condition. The top five CDIDs with the highest incidence rates for each diagnosis were clobazam, baclofen, zonisamide, tiapride hydrochloride, and topiramate. Incidence rates of OD and AP were significantly higher with multiple CDIDs than with a single drug (p < 0.05). Logistic regression analysis showed that AP occurrence was significantly associated with males, late-stage elderly individuals, a diagnosis of OD, and constipation. Conclusions: The results of this study suggest that careful attention should be given to the risk of AP when prescribing CDIDs, particularly for elderly male patients.

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• Overcoming drug resistance and cell cycle alteration to cancer molecular target drugs

  Kondo, Shingo

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2021

• Clarification of the mechanism of resistance to cancer molecular target drugs

  Kondo, Shingo

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2020

• ABCB5/Abcb5発現細胞の薬剤耐性機構に関する研究(審査報告)

  Kondo, Shingo

  (慶應義塾大学大学院薬学研究科)  2016

Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• ヒスチジン異化はメトトレキサート感受性の主要な決定因子である

  近藤 慎吾

  ファルマシア (公益社団法人日本薬学会)  55 ( 7 ) 702 2019.07

  Book review, literature introduction, etc., Single Work

Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• 新型コロナウイルス感染症第7波自宅療養者における一般用医薬品の適正使用の実態と課題

  藤本卓磨, 岩田紘樹, 小林典子, 近藤慎吾, 中村友紀, 山浦克典

  [Domestic presentation] 

  2023.11

  , 

  Oral presentation (general)

• 頭痛およびヘルスリテラシーの評価スコアを用いた頭痛患者の特性分析

  近藤 慎吾, 藤本 卓磨, 岩田 紘樹, 小林 典子, 中村 友紀, 山浦 克典

  [Domestic presentation] 

  2023.09

  , 

  Oral presentation (general)

• ヒト結腸がん細胞株の上皮間葉転換に伴うグルタミナーゼ阻害剤高感受性とATF4の発現低下

  加藤 優, 近藤 慎吾, 杉本 芳一

  [Domestic presentation]  第27回日本がん分子標的治療学会学術集会 (佐賀市文化会館) , 

  2023.06

  , 

  Oral presentation (general), 日本がん分子標的治療学会

• EMTを誘導したヒト大腸がんHCT116細胞に対するglutaminase阻害剤の効果

  奥村光遥, 加藤優, 近藤慎吾, 杉本芳一

  [Domestic presentation]  日本薬学会第142年会, 

  2023.03

  , 

  Poster presentation

• BET阻害剤dBET6はSLUG導入EMT細胞のフェロトーシス感受性を増大させる

  加藤優, 深澤ゆかり, 近藤慎吾, 杉本芳一

  [Domestic presentation]  日本薬学会第142年会, 

  2023.03

  , 

  Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• 口腔乾燥を誘導する薬剤の同定と薬剤師による臨床的介入の効果の検討

  2025.04

  -

  2028.03

  Grants-in-Aid for Scientific Research, 近藤 慎吾, Grant-in-Aid for Scientific Research (C), No Setting

  　View Summary

  口腔乾燥は医療用医薬品の添付文書中の「その他の副作用」に記載があるが、その危険度に関するデータは不足している。
  本研究ではエムスリー株式会社が保有する診療データベースを用いて、実際に口腔乾燥の訴えがある患者の服用薬を解析して、副作用症状を起こす可能性の高いハイリスク薬を同定することを目的とする。さらに、それらハイリスク薬に対する代替薬リストを作成する。口腔乾燥を感じる患者の処方に対して薬剤情報提供文書で医師に変更提案し、薬剤変更による口腔乾燥の改善効果を検証する。

• がん分子標的薬に対する細胞周期の変化と薬剤耐性の克服

  2021.04

  -

  2022.03

  学事振興資金（個人研究）, No Setting, Principal investigator

• がん分子標的薬に対する耐性機構の解明

  2020.04

  -

  2021.03

  学事振興資金（個人研究）, No Setting, Principal investigator

Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• RESEARCH FOR BACHELOR'S THESIS 1

  2025

• PRIOR LEARNING FOR CLINICAL PRACTICE 5

  2025

• PRE-CLINICAL TRAINING FOR HOSPITAL & COMMUNITY PHARMACY

  2025

• PRACTICAL LEARNING ON SUPPORTING THE INTELLECTUALLY DISABLED PERSON'S ACTIVITIES

  2025

• PRACTICAL LEARNING ON SUPPORTING THE HEALTH PROMOTION OF COMMUNITY

  2025

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Courses Previously Taught 【 Display / hide 】

Courses Previously Taught 【 Display / hide 】

• COMMUNITY PHARMACY

  Keio University

  2025.04

  -

  2026.03

• CLINICAL PHARMACY AND PHARMACOTHERAPY

  Keio University

  2025.04

  -

  2026.03

• STUDY OF MAJOR FIELD: (SOCIAL PHARMACY)

  Keio University

  2025.04

  -

  2026.03

• PRACTICAL LEARNING ON SUPPORTING THE INTELLECTUALLY DISABLED PERSON'S ACTIVITIES

  Keio University

  2025.04

  -

  2026.03

• ADVANCED MOLECULAR BIOLOGY OF DISEASE

  Keio University

  2025.04

  -

  2026.03

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Memberships in Academic Societies 【 Display / hide 】

Memberships in Academic Societies 【 Display / hide 】

• 日本性差医学・医療学会, 

  2024.01

  -

  Present

• 日本医療薬学会, 

  2023.08

  -

  Present

• 日本がん分子標的治療学会, 

  2019.04

  -

  Present

• 日本癌学会, 

  2012.04

  -

  Present

• 日本薬学会, 

  2011.04

  -

  Present