KONDO Shingo

写真a

Affiliation

Faculty of Pharmacy, Department of Pharmacy Social Pharmacy (Shiba-Kyoritsu)

Position

Research Associate/Assistant Professor/Instructor

Contact Address

1-5-30 shibakoen, Minato-ku, Tokyo
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Career 【 Display / hide 】

  • 2017.04
    -
    2019.03

    Medical Hospital, Tokyo Medical and Dental University, Department of Pharmacy, pharmacist

  • 2019.04
    -
    2023.03

    慶應義塾大学薬学部, 化学療法学講座, 助教

  • 2023.04
    -
    Present

    慶應義塾大学薬学部, Social Pharmacy, 助教

  • 2023.04
    -
    Present

    慶應義塾大学薬学部附属薬局, 非常勤薬剤師

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Academic Background 【 Display / hide 】

  • 2013.04
    -
    2017.03

    Keio University

    Graduate School, Completed, Doctoral course

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Academic Degrees 【 Display / hide 】

  • Doctor（Pharmacy）, Keio University, Coursework, 2017.03

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Licenses and Qualifications 【 Display / hide 】

  • Pharmacist license, 2013.07

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Papers 【 Display / hide 】

  • Prescription Trends and Contributing Factors of Medications Causing Xerostomia in Elderly Patients

    Kondo Shingo, Sano Kunihiro, Hayashi Naoko, Fujishima Seitaro, Iwata Hiroki, Kobayashi Noriko, Yamaura Katsunori

    Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) (Japanese Society of Pharmaceutical Health Care and Sciences)  51 ( 6 ) 355 - 365 2025.06

    ISSN  1346342X

    　View Summary

    <p>Xerostomia is a syndrome characterized by subjective or objective findings of oral dryness. One quarter of the elderly population suffers from xerostomia owing to a decline in salivary secretion function with age and problems with oral closure. Additionally, many ethical drugs have xerostomia listed as an adverse drug reaction. Xerostomia reduces the self-cleansing action of the mouth and can cause problems in maintaining oral health. In this study, we created a list of drugs associated with xerostomia from these package inserts. Then, electronic medical record data from Keio University Hospital were analyzed to investigate prescribing trends among elderly patients and to identify patient characteristics associated with these drugs. Patients who received continuous prescriptions from April 2019 to March 2020 were included in this study based on age, prescribed drugs, and associated diseases. Among the 575 patients analyzed, 464 (80.7％) were prescribed at least one xerostomia-inducing medication. Compared with the early-stage elderly, a significantly higher proportion of late-stage elderly patients received these medications (<i>P</i> < 0.001) and had multiple prescriptions (<i>P</i> < 0.001). Logistic regression analysis examined the presence and multiple prescriptions of xerostomia-inducing drugs, showing significant associations with late-stage elderly patients and polypharmacy. The most common conditions among patients prescribed xerostomia-inducing drugs were endocrine, nutritional, metabolic, cardiovascular, and gastrointestinal diseases. Accordingly, vasodilators, peptic ulcer drugs, and hyperlipidemic drugs were frequently prescribed to these patients. The results suggest that the risk of xerostomia should be a point of consideration when prescribing multiple medicines to elderly patients.</p>

  • Practical training reduces aspiration-linked gaps in pressure ulcer education for pharmacy students

    Kondo Shingo, Mima Ririka, Okui Rira, Iwata Hiroki, Kawamoto Yoshiko, Kobayashi Noriko, Furuta Katsunori, Yamaura Katsunori

    Drug Discoveries & Therapeutics (International Research and Cooperation Association for Bio & Socio-Sciences Advancement)  advpub ( 0 ) 90 - 95 2025.04

    ISSN  1881-7831

    　View Summary

    <p>Expectations for pharmacists' contribution and involvement in pressure ulcer pharmacotherapy are growing. This study aimed to not only clarify the effects of incorporating practical training on the use of topical medications into clinical preparatory education but also examine the relationship between students' aspiration—or lack thereof—to pursue a career as a pharmacist. The percentage of positive responses to the questionnaire survey on knowledge, skills, and attitudes toward pressure ulcer treatment was significantly higher after the lecture than before and highest after the practical training. In addition, students who aspired to become pharmacists tended to provide a higher percentage of positive responses after the lecture. However, the gap between aspiring and non-aspiring pharmacists tended to narrow after practical training. These results suggest that incorporating practical training on pressure ulcer treatment into lectures improves students' knowledge, skills, and attitudes toward its treatment. Including practical training in pressure ulcer education may compensate for the difference in the educational effect of lectures between students who aspire to become pharmacists and those who do not, thereby improving the educational effect for the latter.</p>

  • Identification of Issues Related to Enteral Nutrients Using a Database of Near-miss Events from Community Pharmacies.

    Kondo S., Maese M., Iwata H., Kobayashi N., Yamaura K.

    The Keio journal of medicine (The Keio Journal of Medicine)  advpub ( 0 )  2025.03

    Accepted,  ISSN  0022-9717

    　View Summary

    <p>Undernutrition is a common risk after surgery or during periods when oral dietary intake is challenging. Enteral nutrients, frequently utilized in nutritional management, are drugs associated with multiple contraindications involving pathology and allergy, and they require careful attention in dispensing. However, the occurrence of nutrition-related incidents in community pharmacies remains unknown. This study aimed to identify issues regarding the safety of pharmacotherapy in patients requiring enteral nutrition using the database of Project to Collect and Analyze Pharmaceutical Near-Miss Event Information. We highlighted the critical information that pharmacists should focus on to prevent accidents and elucidated the details and prescription drugs of cases that matched the search for “Nutrition (all included)” in Japanese. There were 475 cases reported between January 2009 and September 2023. Of these, 347 cases (73%) were classified as “inquiry about prescription and provision of information to prescribing physician” (Category II) and 115 cases (24%) were classified as “drug dispensing” (Category I). In both cases, the top five drugs were enteral nutrients. Among the life-threatening Category II cases, 9 cases were for pathological contraindications including severe liver or renal dysfunction, 6 cases were for adverse reactions including diarrhea, and 5 cases were for allergies or patient constitutions. Notably, the incidence of adverse reactions was higher than in data for the latest annual reports. Therefore, pharmacists should be mindful while dealing with prescriptions involving possible contraindications in patients requiring enteral nutrition. Pharmacists should contribute to the provision of safe pharmacotherapy by remaining vigilant against dispensing errors.</p>

  • 腎機能の低下者に対して注意が必要なOTC医薬品の解析

    近藤 慎吾, 前瀬 鞠, 古堅 彩子, 岩田 紘樹, 小林 典子, 山浦 克典

    薬局薬学 (Pharmacy Society of Japan)  advpub ( 0 ) 126 - 135 2024.12

    Lead author, Accepted,  ISSN  18843077

    　View Summary

    <p>Obtaining laboratory data on renal function in community pharmacies is challenging, as pharmacists rarely perform pharmaceutical interventions based on the patient’s renal function during over-the-counter (OTC) medication sales. This study aimed to identify OTC medications requiring caution in patients with impaired renal function using the Pharmaceuticals and Medical Devices Agency (PMDA) database. Moreover, we compared renal function-related cautionary notes in the package inserts of prescription drugs having the same composition. The analysis focused on the package inserts of OTC medications sold exclusively by pharmacists. Among these, 64% (9/14 cases) of pharmaceuticals requiring guidance (<i>yo-shidou</i> medication) and 80% (107/134 cases) of Category 1 OTC medications had renal function-related warnings in the “precautions for use (what you should not do/who should seek consultation)” section. For OTC medications containing famotidine and nizatidine, the dosage and administration were set lower than those for prescription drugs. Although these drugs can be used for patients with impaired renal function on prescription, their use is restricted as OTC medications. We believe that enabling self-checks of renal function at community pharmacies could expand the range of indications for OTC medications and promote notified self-medication.</p>

  • Sex-related differences regarding headache triggered by low barometric pressure in Japan.

    Fujimoto T., Iwata H., Kobayashi N., Kondo S., Yamaura K.

    BMC research notes 17 ( 1 ) 203 2024.07

    　View Summary

    Purpose: The prevalence of migraine headache is higher in women. Low barometric pressure is a factor in headache triggering, but sex-related differences have not been identified. The purpose of this study was to examine sex-related differences in headache triggered by low barometric pressure. Methods: Study subjects aged 20–49 years were randomly selected from a research company’s (Macromill, Inc.) web panel. Those with chronic migraine or tension-type headache invited to complete a web-based self-administered questionnaire. Logistic regression analysis was performed with the objective variable as the Headache Impact Test-6 (HIT-6) high scores (56 or more) or headache triggered by low barometric pressure. Results: Participants were 332 women and 337 men in the headache population. HIT-6 high scores were associated with age at headache occurrence 20 years or younger (OR: odds ratio 1.85, 95% CI: confidence interval 1.15–2.99, p = 0.012) and headache triggered by low barometric pressure (OR 2.11, 95%CI 1.51–2.94, p < 0.001). Headache triggered by low barometric pressure was significantly associated with women (OR 2.92, 95%CI 2.12–4.02, p < 0.001). Conclusions: Headache triggered by low barometric pressure were related to sex-related differences. It was suggested that a sex-specific treatment approach for headache triggering is needed.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • ヒスチジン異化はメトトレキサート感受性の主要な決定因子である

    近藤 慎吾

    ファルマシア (公益社団法人日本薬学会)  55 ( 7 ) 702 2019.07

    Book review, literature introduction, etc., Single Work

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Presentations 【 Display / hide 】

  • 新型コロナウイルス感染症第7波自宅療養者における一般用医薬品の適正使用の実態と課題

    藤本卓磨, 岩田紘樹, 小林典子, 近藤慎吾, 中村友紀, 山浦克典

    2023.11
    , 

    Oral presentation (general)

  • 頭痛およびヘルスリテラシーの評価スコアを用いた頭痛患者の特性分析

    近藤 慎吾, 藤本 卓磨, 岩田 紘樹, 小林 典子, 中村 友紀, 山浦 克典

    2023.09
    , 

    Oral presentation (general)

  • ヒト結腸がん細胞株の上皮間葉転換に伴うグルタミナーゼ阻害剤高感受性とATF4の発現低下

    加藤 優, 近藤 慎吾, 杉本 芳一

    第27回日本がん分子標的治療学会学術集会 (佐賀市文化会館) , 

    2023.06
    , 

    Oral presentation (general), 日本がん分子標的治療学会

  • EMTを誘導したヒト大腸がんHCT116細胞に対するglutaminase阻害剤の効果

    奥村光遥, 加藤優, 近藤慎吾, 杉本芳一

    日本薬学会第142年会, 

    2023.03
    , 

    Poster presentation

  • BET阻害剤dBET6はSLUG導入EMT細胞のフェロトーシス感受性を増大させる

    加藤優, 深澤ゆかり, 近藤慎吾, 杉本芳一

    日本薬学会第142年会, 

    2023.03
    , 

    Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 口腔乾燥を誘導する薬剤の同定と薬剤師による臨床的介入の効果の検討

    2025.04
    -
    2028.03

    Grants-in-Aid for Scientific Research, 近藤 慎吾, Grant-in-Aid for Scientific Research (C), No Setting

    　View Summary

    口腔乾燥は医療用医薬品の添付文書中の「その他の副作用」に記載があるが、その危険度に関するデータは不足している。
    本研究ではエムスリー株式会社が保有する診療データベースを用いて、実際に口腔乾燥の訴えがある患者の服用薬を解析して、副作用症状を起こす可能性の高いハイリスク薬を同定することを目的とする。さらに、それらハイリスク薬に対する代替薬リストを作成する。口腔乾燥を感じる患者の処方に対して薬剤情報提供文書で医師に変更提案し、薬剤変更による口腔乾燥の改善効果を検証する。

  • がん分子標的薬に対する細胞周期の変化と薬剤耐性の克服

    2021.04
    -
    2022.03

    学事振興資金（個人研究）, No Setting, Principal investigator

  • がん分子標的薬に対する耐性機構の解明

    2020.04
    -
    2021.03

    学事振興資金（個人研究）, No Setting, Principal investigator

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Courses Taught 【 Display / hide 】

  • STUDY OF MAJOR FIELD: (SOCIAL PHARMACY)

    2025

  • SEMINAR: (SOCIAL PHARMACY)

    2025

  • RESEARCH FOR BACHELOR'S THESIS 1

    2025

  • PRIOR LEARNING FOR CLINICAL PRACTICE 5

    2025

  • PRE-CLINICAL TRAINING FOR HOSPITAL & COMMUNITY PHARMACY

    2025

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Courses Previously Taught 【 Display / hide 】

  • COMMUNITY PHARMACY

    Keio University

    2025.04
    -
    2026.03

  • CLINICAL PHARMACY AND PHARMACOTHERAPY

    Keio University

    2025.04
    -
    2026.03

  • STUDY OF MAJOR FIELD: (SOCIAL PHARMACY)

    Keio University

    2025.04
    -
    2026.03

  • PRACTICAL LEARNING ON SUPPORTING THE INTELLECTUALLY DISABLED PERSON'S ACTIVITIES

    Keio University

    2025.04
    -
    2026.03

  • ADVANCED MOLECULAR BIOLOGY OF DISEASE

    Keio University

    2025.04
    -
    2026.03

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Memberships in Academic Societies 【 Display / hide 】

  • 日本性差医学・医療学会, 

    2024.01
    -
    Present

  • 日本性差医学・医療学会, 

    2024.01
    -
    Present

  • 日本医療薬学会, 

    2023.08
    -
    Present

  • 日本医療薬学会, 

    2023.08
    -
    Present

  • 日本がん分子標的治療学会, 

    2019.04
    -
    Present

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