Kazoe, Yutaka

写真a

Affiliation

Faculty of Science and Technology, Department of System Design Engineering (Yagami)

Position

Professor

E-mail Address

E-mail address

Related Websites

External Links
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Career 【 Display / hide 】

  • 2006.04
    -
    2008.03

    The 21st Century COE, Research Assistant

  • 2008.04
    -
    2008.09

    The Japan Society for the Promotion of Science, Research Fellow (DC2)

  • 2008.10
    -
    2010.03

    The Japan Society for the Promotion of Science, Research Fellow (PD)

  • 2009.03
    -
    2010.03

    Georgia Institute of Technology, George W. Woodruff School of Mechanical Engineering, Research Scholar

  • 2010.04

    Georgia Institute of Technology, George W. Woodruff School of Mechanical Engineering, Postdoctoral Researcher

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Academic Background 【 Display / hide 】

  • 2000.04
    -
    2004.03

    Keio University, Faculty of Science and Technology, Department of System Design Engineering

    University, Graduated, Other

  • 2004.04
    -
    2006.03

    Keio University, Graduate School of Science and Technology, School of Integrated Design Engineering

    Graduate School, Completed, Master's course

  • 2006.04
    -
    2008.09

    Keio University, Graduate School of Science and Technology, School of Integrated Design Engineering

    Graduate School, Completed, Doctoral course

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Academic Degrees 【 Display / hide 】

  • Ph. D., Keio University, Coursework, 2008.09

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Research Areas 【 Display / hide 】

  • Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Fluid engineering (Microfluidics, Nanofluidics, Fluid science)

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Books 【 Display / hide 】

  • Nanofluidic technologies for drug screening and drug delivery, in “Nano- and Microfabrication Techniques in Drug Delivery” Ed. Dimitrios Lamprou

    Yutaka Kazoe, Kenji Sueyoshi, Sasikarn Seetasang, Yan Xu, Springer Cham, 2023.05,  Page： 54

    Scope: 14.2. Fabrication Technologies, 14.3. Ultrasmall Fluid Manipulation Methods, 14.5. Detection in Nanofluidic Devices, 14.7. Applications, 14.8. Summary and Perspectives

  • マイクロ・ナノ熱工学の進展, 第4章 マイクロチャネル（１）流れの特性

    嘉副裕, エヌ・ティー・エス, 2021.05,  Page： 10

    Scope: 第4章 マイクロチャネル（１）流れの特性 , Accepted

  • Extended-nano scale fluidics and applications to bioanalysis, in "Intelligent Nanosystems for Energy, Information and Biological Technologies"

    Hisashi Shimizu, Kazuma Mawatari, Yutaka Kazoe, Yuriy Pihosh, Takehiko Kitamori, Springer, 2016.09,  Page： 20

    Scope: Extended-Nano Scale Fluidics and Applications to Bioanalysis

  • Micro and extended-nano fluidics and optics for chemical and bioanalytical technology, in “Progress in Nanophotonics 2” Ed. Motoichi Ohtsu

    Kazuma Mawatari, Yuriy Pihosh, Hisashi Shimizu, Yutaka Kazoe, Takehiko Kitamori, Springer-Verlag Berlin Heidelberg, 2013.03,  Page： 44

    Scope: Section 5.3. Extended-Nano Fluidics and Optics

  • Extended-nano fluidic systems for chemistry and biotechnology

    Kazuma Mawatari, Takehiko Tsukahara, Yo Tanaka, Yutaka Kazoe, Philip Dextras, Takehiko Kitamori, Imperial College Press, 2012.07,  Page： 188

    Scope: Chapter 4. Fundamental Technology: Fluidic Control Methods, Chapter 5. Fundamental Technology: Detection Methods

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Papers 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • ガラスの微小変形によるナノ流路開閉バルブの開発と超微量分析への応用

    嘉副裕，佐野大樹，北森武彦

    Japan Energy & Technology Intelligence 70 ( 12 ) 84 - 88 2022.12

    Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work, Lead author, Corresponding author

  • Advances in Nanofluidics

    Yutaka Kazoe, Yan Xu

    Micromachines 12 ( 4 ) 427 (3 pages) 2021.04

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Lead author, Corresponding author,  ISSN  2072-666X

  • 粒子追跡法によるナノ空間流速分布計測に向けたナノ粒子挙動の統計力学的解析

    田中美典，花崎逸雄，嘉副裕

    流れ  ( 2020年12月 ) 5 (online) 2020.12

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Last author, Corresponding author

  • ナノ混相流体工学によるフェムトリットル化学プロセシング

    嘉副裕

    Agricultural biotechnology 4 ( 10 ) 57 - 60 2020.09

    Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Single Work, Lead author, Corresponding author

  • Hierarchical structure of fluidic channels and their application to bio-devices

    Takehiko Kitamori, Kazuma Mawatari, Yutaka Kazoe

    Oyo Buturi 84 ( 10 ) 882 - 888 2015.10

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work

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Presentations 【 Display / hide 】

  • Development of a sampling method for single nanoparticles utilizing hierarchical nanofluidic channels

    Rina Kakiuchi, Yutaka Kazoe

    The 16th IEEE International Conference on Nano/Molecular Medicine & Engineering (Okinawa, Japan) , 

    2023.12
    , 

    Oral presentation (general)

  • Measurement of particle behavior in micro/nano channels using defocusing nano-PIV

    Yo Saeki, Yutaka Kazoe

    The 76th Annual Meeting of the Division of Fluid Dynamics (Washington, D.C., USA) , 

    2023.11
    , 

    Oral presentation (general)

  • Effect of electrode’s shape and application voltage on thrust generated by corona discharge

    Hiroaki Katagiri, Shigeki Yashita, Tomoya Kitamura, Yuki Inada, Yutaka Kazoe, Takahiro Nozaki

    The 49th Annual Conference of the IEEE Industrial Electronics Society (IECON 2023) (Singapore) , 

    2023.10
    , 

    Oral presentation (general)

  • Attitude control method based on differential mode voltage considering start voltage of corona discharge

    Shigeki Yashita, Hiroaki Katagiri, Tomoya Kitamura, Yuki Inada, Yutaka Kazoe, Takahiro Nozaki

    The 49th Annual Conference of the IEEE Industrial Electronics Society (IECON 2023) (Singapore) , 

    2023.10
    , 

    Oral presentation (general)

  • Angle control of using corona discharge considering voltage range limitations

    Shigeki Yashita, Hiroaki Katagiri, Tomoya Kitamura, Yuki Inada, Yutaka Kazoe, Takahiro Nozaki

    The 32nd International Symposium on Industrial Electronics (ISIE) (Helsinki-Espoo, Finland) , 

    2023.06
    , 

    Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 化学反応誘起スラリー援用研削におけるCeO2粒子付着の安定化と形状制御

    2023.04
    -
    2026.03

    Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), No Setting

    　View Summary

    8K対応光学機器の普及に向けて，大口径非球面光学レンズの高能率生産が要求されている．これに応えるため，酸化セリウム（CeO2）スラリーを用いて効率よく延性モード研削を行う，化学反応誘起スラリー援用研削法（RISA研削）の研究を進めてきた．CeO2粒子が砥石表面に付着すると，延性モード研削能力が桁違いに高まる一方で，付着は不安定で，滞留時間の違いによる形状の崩れも生じる．そこで，本研究では，CeO2粒子付着メカニズムを明らかにし，プロセス制御するために感覚機能を備えた超精密加工システムを開発する．これにより，RISA研削の安定化に加え形状制御を実現する．

  • Development of super-resolution three-dimensional non-fluorescent single particle tracking method for nanospaces utilizing light scattering

    2022.04
    -
    2026.03

    Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), No Setting

    　View Summary

    10-100 nmのナノ空間の流体科学・工学の進展に伴い、表面支配の極小空間における溶質分子輸送現象の解明が重要となっている。本研究では、独自の技術と方法論に基づき光散乱を用いたナノ空間非蛍光ナノ粒子の超解像度追跡法を創成することを目的とする。サイズと表面粗さを1 nm以下の精度で制御したガラス製ナノ流路を作製して、バックグラウンド光を極限まで低減して光学的に整えた条件下で、ナノ粒子の散乱光と流路壁面からの反射光との干渉により形成される粒子像を高速・高感度に検出し、位相差に伴う粒子像変化からナノ空間を流れる非蛍光ナノ粒子の位置をx, y, zの3方向で10 nm分解能で測定する。

  • Development of a method for single-molecule chemical processing utilizing ultra-small droplets in nanospace and application to cytokine analysis

    2021.07
    -
    2025.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Pioneering), Principal investigator

    　View Summary

    ナノ空間の流体工学の進展により、化学分析の可算個分子レベルへの超微量化が実現しつつある。しかし、試料分子数が限定されても、空間の微小化の単なる延長では流体工学の極限である分子1個の輸送・化学処理とこれにより初めて実現する1分子分析には到達できない。本研究では、独自技術によりナノ流路で極小液滴を生成して、統計力学の原理により液滴中に試料分子1個を閉じ込め個数の単位で配列・輸送、更に液滴の合一により1分子を衝突・反応させる方法論とこれを用いた分析法を創成し、病変部の表皮角化細胞、涙液、汗などに含まれるサイトカイン分析に応用することを目的とする。

  • Development of a fabrication method for cellular membrane-integrated nanofluidic device utilizing nanochannel parallel two-phase flows

    2019.06
    -
    2021.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Kazoe Yutaka, Grant-in-Aid for Challenging Research (Exploratory) , Principal investigator

    　View Summary

    Nanofluidics utilizing 100 nm spaces has developed and realized analytical methods with ultra-high performances. On the other hand, cells and organelles with sizes similar to micro/nanospaces have various functions, which can not be realized by conventional chemical methods, and cellular membranes have specific roles such as ultra-high selective molecular transport and active transport opposite to the concentration gradient. Therefore, to create new functional devices by incorporating cellular membrane in nanochannels, this study developed a method to form lipid bilayer in nanochannel utilizing our multiphase fluid control technology. Utilizing a nanochannel with partial hydrophobic modification, stable manipulation of parallel two-phase flow was achieved. Based on this fluid operation, we succeeded in formation of lipid bilayer at an interface between two parallel channels with a 4000 nm depth for the first time.

  • Development of a 3D3C super-resolution measurement method for flow velocity distribution in nanospace utilizing defocusing particle image with light interference

    2019.04
    -
    2022.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Kazoe Yutaka, Grant-in-Aid for Scientific Research (B), Principal investigator

    　View Summary

    The field of fluid engineering has expanded to nanospaces smaller than the light wavelengths. When the space size becomes smaller than 1000 nm, various specific phenomena such as changes of liquid properties appear. Therefore, super-resolution measurements of flow velocity distribution with 10 nm spatial resolution become important for understanding of transport phenomena in nanospaces. In this study, by utilizing spherical aberration, which is a problem in the imaging, we developed defocusing nano-particle image velocimetry (PIV) to determine the position of nanoparticles with 10 nm spatial resolution based on particle images in the defocused region. Characteristics of defocused nanoparticle images with spherical aberration was revealed and a measurement system was constructed. We realized measurements of velocity distribution of nanoparticles migrating with pressure-driven flow in nanospace. This work will greatly contribute to advancements of various fields such as nanofluidics.

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Awards 【 Display / hide 】

  • 優秀講演論文表彰

    杉田昌平, 小山瑞歩, 嘉副裕, 2023.11, 第14回マイクロ・ナノ工学シンポジウム, ガラスの弾性変形を用いたナノ流路開閉バルブの集積化に向けた水圧駆動アクチュエータの開発

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 優秀研究賞

    森川響二朗, Po-yin Chen, Hai Linh Tran, 嘉副裕, Chihchen Chen, 北森武彦, 2023.05, 化学とマイクロ・ナノシステム学会第47回研究会, ドライエッチングによる平滑なガラス製マイクロ流路の高選択比加工法

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 優秀研究賞

    嘉副裕, 高木雄斗, 森川響二朗, 北森武彦, 2021.05, 化学とマイクロ・ナノシステム学会第43回研究会, ナノ流体工学によるフェムトリットル液滴MSインターフェース

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • Poster Award

    Yuto Takagi, Yutaka Kazoe, Takehiko Kitamori, 2019.12, 49th International Symposium on High Performance Liquid Phase Separations and Related Techniques, Femtoliter sample droplet shooting by micro/nano fluidics for digitalized mass spectrometry

    Type of Award： Award from international society, conference, symposium, etc.

  • 優秀発表賞

    松浦柊, 嘉副裕, 北森武彦, 2019.11, 化学とマイクロ・ナノシステム学会第40回研究会, ナノ平行二相流を用いたフェムトリットルタンパク質精製

    Type of Award： Award from Japanese society, conference, symposium, etc.

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Courses Taught 【 Display / hide 】

  • SEMINAR IN SYSTEM DESIGN ENGINEERING

    2025

  • SCIENCE OF ENVIRONMENTAL SYSTEMS

    2025

  • MEASUREMENTS AND EXPERIMENTAL ANALYSIS IN FLOW SYSTEMS

    2025

  • LABORATORIES IN SCIENCE AND TECHNOLOGY

    2025

  • INTRODUCTION TO SYSTEM DESIGN ENGINEERING

    2025

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Courses Previously Taught 【 Display / hide 】

  • OFF-CAMPUS WORK-STUDY PROGRAM

    Keio University

    2023.10
    -
    Present
    , 

    Autumn Semester, Undergraduate (specialized), Laboratory work/practical work/exercise, Within own ｆaculty

  • ADVANCED SYSTEM DESIGN ENGINEERING

    Keio University

    2023.04
    -
    2023.08
    , 

    Spring Semester, Postgraduate, Lecture, Within own ｆaculty

  • ADVANCED SYSTEM DESIGN ENGINEERING

    Keio University

    2021.04
    -
    2021.08
    , 

    Spring Semester, Postgraduate, Lecture, Within own ｆaculty

  • APPLIED OPTICAL SYSTEM ENGINEERING

    Keio University

    2020.10
    -
    Present
    , 

    Autumn Semester, Postgraduate, Lecture, Within own ｆaculty

  • MEASUREMENTS AND EXPERIMENTAL ANALYSIS IN FLOW SYSTEMS

    Keio University

    2020.10
    -
    Present
    , 

    Autumn Semester, Undergraduate (specialized), Lecture, Within own ｆaculty

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Memberships in Academic Societies 【 Display / hide 】

  • The Society of Nanoscience and Technology, 

    2013.04
    -
    2023.03

  • The Japan Society for Analytical Chemistry, 

    2012.06
    -
    Present

  • Society for Chemistry and Micro-Nano Systems, 

    2011.09
    -
    Present

  • The Japan Society of Mechanical Engineers, 

    2004.11
    -
    Present
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Committee Experiences 【 Display / hide 】

  • 2024.03
    -
    Present

    理事, 日本カンナビノイド学会

  • 2023.03
    -
    Present

    マイクロ流体OSオーガナイザー, 日本流体力学会年会

  • 2022.07
    -
    2023.06

    特別研究員等審査会審査員, 日本学術振興会

  • 2022.06
    -
    2022.09

    シンポジウム実行委員長, 4大学ナノ・マイクロファブリケーションコンソーシアム

  • 2021.05
    -
    2022.10

    実行委員, 日本機械学会熱工学コンファレンス2022

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