西村 知泰 (ニシムラ トモヤス)

Nishimura, Tomoyasu

写真a

所属(所属キャンパス)

研究所・センター等 保健管理センター (日吉)

職名

教授

外部リンク

経歴 【 表示 / 非表示

  • 2000年05月
    -
    2002年04月

    慶應義塾大学医学部, 内科学, 研修医

  • 2002年05月
    -
    2004年05月

    慶應義塾大学医学部, 内科学, 専修医

  • 2004年06月
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    2010年01月

    慶應義塾大学医学部, 内科学(呼吸器), 助手

  • 2007年01月
    -
    2010年01月

    慶應義塾大学医学部, 微生物学・免疫学, 研究員

  • 2008年07月
    -
    2010年01月

    佐野厚生総合病院, 内科, 医員

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学歴 【 表示 / 非表示

  • 2000年03月

    慶應義塾大学, 医学部, 医学科

    大学, 卒業

学位 【 表示 / 非表示

  • 博士, 慶應義塾大学, 論文, 2008年06月

免許・資格 【 表示 / 非表示

  • 医師免許, 2000年04月

 

研究分野 【 表示 / 非表示

  • ライフサイエンス / 呼吸器内科学

  • ライフサイエンス / 感染症内科学

研究キーワード 【 表示 / 非表示

  • 抗酸菌症

 

著書 【 表示 / 非表示

  • EBM呼吸器疾患の治療2016-2017

    西村 知泰, 中外医学社, 2016年01月

    担当範囲: Interferon Gamma Release Assayの有用性は?

  • 新 呼吸器専門医テキスト

    西村 知泰, 南江堂, 2015年04月

    担当範囲: 肺結核症

  • 内科研修マニュアル 改訂第2版

    西村 知泰, 南江堂, 2006年07月

    担当範囲: 市中肺炎/院内肺炎

論文 【 表示 / 非表示

  • Sectm1a Depletion Promotes Neutrophil Recruitment during Pneumococcal Pneumonia

    Tanaka H., Kamata H., Ishii M., Asakura T., Namkoong H., Nakagawara K., Morita A., Kusumoto T., Azekawa S., Kaji M., Nagao G., Fukunaga N., Nishimura T., Asakura K., Hasegawa N., Fukunaga K.

    American Journal of Respiratory Cell and Molecular Biology 73 ( 1 ) 60 - 72 2025年07月

    ISSN  10441549

     概要を見る

    Airway epithelial cells (AECs) play an essential role in the immune response during bacterial pneumonia. Secreted and transmembrane 1a (Sectm1a) is specifically expressed in AECs during early Streptococcus pneumoniae (SP) infection. However, its function remains largely unexplored. Here, we aimed to clarify the function of Sectm1a during serotype 3 pneumococcal pneumonia primarily using an in vivo mouse model. Our findings showed that Type I IFNs directly induced Sectm1a expression in AECs. Sectm1a depletion in an in vivo mouse model improved survival rate and enhanced the clearance of intrapulmonary bacterial burden at an early stage of SP infection. Correspondingly, Sectm1a depletion increased the count of intrapulmonary γδT cells, promoted IL-17A production by these cells, and enhanced intrapulmonary neutrophil responses against SP. Notably, IL-17A production in isolated lung γδT cells was directly suppressed by Sectm1a ex vivo. Furthermore, Sectm1a depletion altered the migration and activation markers of γδT cellsin vivo, indicating that the AEC-derived Sectm1a is associated with the phenotypes of γδT cells. These findings suggest that Type I IFNs may play an important role through AEC-derived Sectm1a in this model, and Sectm1a signaling modulates excessive neutrophil inflammation and influences bacterial clearance by directly altering γδT cell functions during pneumococcal pneumonia. In summary, this study demonstrates that the Type I IFN–Sectm1a pathway could be a potential target to modify the acute response to bacterial pneumonia.

  • Breakthrough Infection After a Primary Series of COVID-19 Vaccination Induces Stronger Humoral Immunity and Equivalent Cellular Immunity to the Spike Protein Compared with Booster Shots

    Uwamino Y., Yokoyama T., Sato Y., Tanaka S., Kamoshita Y., Shibata A., Kurafuji T., Tanabe A., Arai T., Ohno A., Namkoong H., Nishimura T., Wakui M., Murata M., Hasegawa N., Matsushita H.

    Vaccines 13 ( 7 )  2025年07月

     概要を見る

    Background: The long-term immune implications of administering more than four doses of COVID-19 vaccine and the impact of breakthrough infections are not fully understood. Research Design and Methods: We conducted a follow-up cohort study on Japanese healthcare workers who received more than three doses of the BNT162b2 vaccine. We assessed both the anti-SARS-CoV-2 antibody titer and cellular immunity in 429 participants and investigated the numbers, types, and brands of COVID-19 vaccines administered, as well as the episodes of COVID-19 infections after the third dose. Results: Individuals who received three total doses of vaccines with BTI episodes demonstrated higher antibody titers than those who received four total doses of vaccines with no BTIs. The cellular immune responses between these two groups were comparable. Conclusions: These findings suggest that BTIs occurring after the primary series of COVID-19 vaccinations (first to third dose) induced humoral immunity to the spike protein that is greater than that induced by booster doses (fourth or fifth dose) and elicit cellular immunity to the spike protein comparable to that of booster doses.

  • Combined dual β-lactams and diazabicyclooctane β-lactamase inhibitor is highly effective against Mycobacterium abscessus species in vitro

    Misawa K., Nishimura T., Yoshikawa M., Shimamura R., Kashimura S., Enoki Y., Taguchi K., Matsumoto K., Hasegawa N.

    Journal of Global Antimicrobial Resistance 42   142 - 150 2025年05月

    ISSN  22137165

     概要を見る

    Objective: Mycobacterium abscessus pulmonary disease is a refractory infectious disease. Developing an effective treatment is urgent as the number of patients infected with M. abscessus species (MABS) is increasing worldwide. We previously reported that nacubactam, a diazabicyclooctane (DBO) β-lactamase inhibitor, could inhibit MABS β-lactamase. Few reports have indicated that dual β-lactams are effective with a DBO β-lactamase inhibitor against MABS. The objective of this study was to determine which dual β-lactams have high antibacterial activity against MABS in the presence and absence of nacubactam. Methods: Antimicrobial susceptibility tests were conducted through a checkerboard assay of 27 β-lactams using the broth microdilution method for three subspecies-type strains and 20 clinical isolates of MABS. The number of intracellular and extracellular bacteria was measured using human macrophages infected with M. abscessus treated with effective combinations confirmed in susceptibility tests. Results: In antimicrobial susceptibility tests, 91 combinations of dual β-lactams with nacubactam exhibited synergistic effects on M. abscessus JCM13569. Among them, the combination of cefazolin, cefotiam, cefoxitin, or cefuroxime with imipenem and nacubactam exhibited highly synergistic effects, resulting in low MICs against MABS clinical isolates. Without nacubactam, the combination of imipenem and cefoxitin showed the lowest MIC. In experiments using human macrophages infected with M. abscessus, these dual β-lactam combinations reduced the number of intracellular and extracellular bacteria compared with those of single β-lactams. Conclusions: The combination of cefazolin, cefotiam, cefoxitin, or cefuroxime with imipenem and nacubactam was highly effective against MABS. Without nacubactam, the combination of cefoxitin and imipenem was effective.

  • Germline variants and mosaic chromosomal alterations affect COVID-19 vaccine immunogenicity

    Sonehara K., Uwamino Y., Saiki R., Takeshita M., Namba S., Uno S., Nakanishi T., Nishimura T., Naito T., Sato G., Kanai M., Liu A., Uchida S., Kurafuji T., Tanabe A., Arai T., Ohno A., Shibata A., Tanaka S., Wakui M., Kashimura S., Tomi C., Hara A., Yoshikawa S., Gotanda K., Misawa K., Tanaka H., Azekawa S., Wang Q.S., Edahiro R., Shirai Y., Yamamoto K., Nagao G., Suzuki T., Kiyoshi M., Ishii-Watabe A., Higashiue S., Kobayashi S., Yamaguchi H., Okazaki Y., Matsumoto N., Masumoto A., Koga H., Kanai A., Oda Y., Suzuki Y., Matsuda K., Kitagawa Y., Koike R., Kimura A., Kumanogoh A., Yoshimura A., Imoto S., Miyano S., Kanai T., Fukunaga K., Hasegawa N., Murata M., Matsushita H., Ogawa S., Okada Y., Namkoong H.

    Cell Genomics 5 ( 3 )  2025年03月

     概要を見る

    Vaccine immunogenicity is influenced by the vaccinee's genetic background. Here, we perform a genome-wide association study of vaccine-induced SARS-CoV-2-specific immunoglobulin G (IgG) antibody titers and T cell immune responses in 1,559 mRNA-1273 and 537 BNT162b2 vaccinees of Japanese ancestry. SARS-CoV-2-specific antibody titers are associated with the immunoglobulin heavy chain (IGH) and major histocompatibility complex (MHC) locus, and T cell responses are associated with MHC. The lead variants at IGH contain a population-specific missense variant (rs1043109-C; p.Leu192Val) in the immunoglobulin heavy constant gamma 1 gene (IGHG1), with a strong decreasing effect (β = −0.54). Antibody-titer-associated variants modulate circulating immune regulatory proteins (e.g., LILRB4 and FCRL6). Age-related hematopoietic expanded mosaic chromosomal alterations (mCAs) affecting MHC and IGH also impair antibody production. MHC-/IGH-affecting mCAs confer infectious and immune disease risk, including sepsis and Graves’ disease. Impacts of expanded mosaic loss of chromosomes X/Y on these phenotypes were examined. Altogether, both germline and somatic mutations contribute to adaptive immunity functions.

  • Factors affecting motivation for receiving a booster dose of the COVID-19 vaccine among Japanese university students and staff: a cross-sectional questionnaire survey

    Uchida S., Uno S., Kondo M., Uwamino Y., Namkoong H., Nishimura T., Misawa K., Kashimura S., Yamato K., Ishizaka T., Nagashima K., Kitagawa Y., Hasegawa N.

    Scientific Reports 14 ( 1 )  2024年12月

     概要を見る

    Understanding the factors that influence people’s decisions regarding vaccination is essential to promote vaccination. We aimed to clarify the motivations for receiving booster vaccines. We conducted a paper-based questionnaire distributed during January–February 2022 involving students and faculty staff who received the first COVID-19 vaccination at the mass vaccination program during June–September 2021 at Keio University. A total of 1725 participants were enrolled, and all completed the survey. Among these, 64.9% reported a significant adverse event (AEs) affecting daily life after the second vaccine. “Fear of severe COVID-19 illness” (72.6%) was the most common reason for getting vaccinated, followed by “concern of infecting others” (68.4%) and “fear of COVID-19 infection itself” (68.3%). Television emerged as the most influential source of information (80%), followed by university information (50.2%) and social networking sites (42.8%). Multivariate analysis revealed “fear of severe COVID-19 illness”, “fear of COVID-19 infection itself”, and “trust in the efficacy and safety of the vaccines in general” were significantly correlated with willingness to receive paid vaccinations. The severity of AEs and source of information were not related to participants’ willingness to receive booster vaccinations. Participants with positive reasons for vaccination were more likely to accept a third dose.

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研究発表 【 表示 / 非表示

  • 外国人留学生を対象とした結核感染調査

    西村知泰,森正明,牧野伸司,広瀬寛,和井内由充子,横山裕一,武田彩乃,畔上達彦,後藤伸子,河邊博史

    第116回日本内科学会総会・講演会 (名古屋) , 

    2019年04月

    ポスター発表

  • 肺MAC症の新規検査法

    西村 知泰

    第101回日本細菌学会関東支部総会 (東京) , 

    2018年11月

    シンポジウム・ワークショップ パネル(指名)

  • アスペルギルス沈降抗体陽性である肺Mycobacterium avium complex症患者の臨床的特徴

    鈴木翔二, 朝倉崇徳, 南宮湖, 岡森慧, 八木一馬, 鎌田浩史, 舩津洋平, 中野泰, 西村知泰, 石井誠, 海老原全, 別役智子, 長谷川直樹.

    第58回日本呼吸器学会学術講演会 (大阪) , 

    2018年04月

    ポスター発表

  • 大学生における先天性心疾患の管理状況

    牧野伸司, 和井内由充子, 武田彩乃, 畔上達彦, 広瀬寛, 西村知泰, 横山裕一, 河邊博史, 森正明.

    第115回日本内科学会年次学術講演会 (京都) , 

    2018年04月

    ポスター発表

  • 当大学医学部留学生に対するImmunization Recordの運用と考察

    武藤志保, 横山裕一, 弦巻美保, 齋藤圭美, 西村知泰, 森正明, 河邊博史.

    第55回全国大学保健管理研究集会 (宜野湾) , 

    2017年11月

    ポスター発表

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競争的研究費の研究課題 【 表示 / 非表示

  • 慶應義塾の健康関連データベースを用いた、健康問題発生における危険因子の探索

    2025年04月
    -
    2026年03月

    福澤基金研究補助, 補助金,  研究代表者

  • 難治性肺非結核性抗酸菌症の新規薬物治療法開発

    2025年01月
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    2026年12月

    公益財団法人 シオノギ感染症研究振興財団, 創薬研究助成金, 補助金,  研究代表者

  • 新規肺MABC症治療薬の開発と革新的非臨床PK/PD評価法の構築

    2024年04月
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    2028年03月

    文部科学省・日本学術振興会, 科学研究費補助金, 補助金,  研究分担者

  • 難治性肺非結核性抗酸菌症の新規薬物治療法開発

    2024年01月
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    2024年12月

    公益財団法人 シオノギ感染症研究振興財団, 萌芽的研究助成金, 補助金,  研究代表者

  • 肺MAC症の新規治療法開発に向けた菌細胞壁脂質の解析

    2023年04月
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    2026年03月

    文部科学省・日本学術振興会, 科学研究費補助金, 補助金,  研究代表者

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担当授業科目 【 表示 / 非表示

  • 現代社会と医学Ⅱ

    2025年度

  • 現代社会と医学Ⅰ

    2025年度

  • 感染症学

    2025年度

  • 現代社会と医学Ⅰ

    2024年度

  • 感染症学

    2024年度

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担当経験のある授業科目 【 表示 / 非表示

  • 感染症学

    慶應義塾

    2018年04月
    -
    2019年03月

    通年, その他, 講義, 兼担

  • 現代社会と医学Ⅱ

    慶應義塾

    2018年04月
    -
    2019年03月

    通年, その他, 講義, 専任

 

社会活動 【 表示 / 非表示

  • 平成27年度外務省巡回医師団

    2016年02月
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    2016年03月
  • 平成26年度外務省巡回医師団

    2015年01月
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    2015年02月

所属学協会 【 表示 / 非表示

  • 日本免疫学会

     
  • 日本内科学会

     
  • 日本呼吸器学会

     
  • 日本呼吸器内視鏡学会

     
  • 日本感染症学会

     

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委員歴 【 表示 / 非表示

  • 2016年04月
    -
    継続中

    評議員, 日本感染症学会