西村 知泰 (ニシムラ トモヤス)

Nishimura, Tomoyasu

写真a

所属(所属キャンパス)

研究所・センター等 保健管理センター (日吉)

職名

専任講師

外部リンク

経歴 【 表示 / 非表示

  • 2000年04月
    -
    2002年04月

    慶應義塾大学病院, 内科, 研修医

  • 2002年05月
    -
    2003年05月

    川崎市立川崎病院, 内科, 医員

  • 2003年06月
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    2004年05月

    水戸赤十字病院, 内科, 医員

  • 2004年06月
    -
    2010年01月

    慶應義塾大学医学部, 内科学(呼吸器), 助手

  • 2007年01月
    -
    2010年01月

    慶應義塾大学医学部, 微生物学・免疫学, 研究員

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学歴 【 表示 / 非表示

  • 2000年03月

    慶應義塾, 医学部, 医学科

    大学, 卒業

学位 【 表示 / 非表示

  • 博士, 慶應義塾, 論文, 2008年06月

免許・資格 【 表示 / 非表示

  • 医師免許, 2000年04月

 

研究分野 【 表示 / 非表示

  • 呼吸器内科学

  • 感染症内科学

研究キーワード 【 表示 / 非表示

  • 抗酸菌症

 

著書 【 表示 / 非表示

  • EBM呼吸器疾患の治療2016-2017

    西村 知泰, 中外医学社, 2016年01月

    担当範囲: Interferon Gamma Release Assayの有用性は?

  • 新 呼吸器専門医テキスト

    西村 知泰, 南江堂, 2015年04月

    担当範囲: 肺結核症

  • 内科研修マニュアル 改訂第2版

    西村 知泰, 南江堂, 2006年07月

    担当範囲: 市中肺炎/院内肺炎

論文 【 表示 / 非表示

  • Effect of refrigeration of blood samples in lithium-heparin tubes on QuantiFERON TB Gold Plus test result

    Uwamino Y., Sakai A., Nishimura T., Noguchi M., Uno S., Fujiwara H., Mori M., Wakui M., Murata M., Hasegawa N.

    Journal of Infection and Chemotherapy (Journal of Infection and Chemotherapy)  26 ( 3 ) 312 - 314 2020年03月

    ISSN  1341321X

     概要を見る

    © 2019 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases The QuantiFERON TB Gold Plus (QFT-Plus) test is a newly approved interferon-gamma releasing assay test for detecting latent tuberculosis. Although blood samples for QFT test can be refrigerated for 48 h in lithium-heparin tubes according to package inserts, no published data are available on the effects of sample refrigeration on the test results. We conducted a clinical study that aimed to elucidate whether sample refrigeration for 48 h affects QFT-Plus test results. We collected 2 blood samples each from 40 participants for QFT-Plus; one sample was refrigerated before incubation for QFT-Plus assay, while the other sample was incubated soon after collection and treated as control. After comparing QFT-Plus test results of refrigerated samples and control samples, the concordance rate and kappa coefficient between them were 95% and 0.90, respectively. Thus, blood samples for QFT-Plus test can be refrigerated for 48 h in lithium-heparin tubes without influencing the test results.

  • Showering is associated with Mycobacterium avium complex lung disease: An observational study in Japanese women

    Uwamino Y., Nishimura T., Sato Y., Tamizu E., Uno S., Mori M., Fujiwara H., Kawabe H., Murata M., Hasegawa N.

    Journal of Infection and Chemotherapy (Journal of Infection and Chemotherapy)  26 ( 3 ) 211 - 214 2020年03月

    ISSN  1341321X

     概要を見る

    © 2019 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases Mycobacterium avium complex refers to a group of environmental bacteria which inhabit water and soil. Although Mycobacterium avium complex is capable of causing refractory lung infections, the risk factors for Mycobacterium avium complex lung disease are still unclear. This study aimed to determine the associations between Mycobacterium avium complex lung disease and soil or water exposure. Using questionnaires along with clinical data, we compared soil exposure, along with bathtub bathing and showering habits between 172 women with Mycobacterium avium complex lung disease and 339 women without Mycobacterium avium complex infection as controls. Showering was found to be independently associated with the presence of Mycobacterium avium complex lung disease (adjusted odds ratio 5.72, 95%, confidence interval 1.99 to 16.46). Although the mean age of the groups was different, an age-matched sub-analysis yielded similar results. These results indicate that showering may be a risk factor for Mycobacterium avium complex lung disease.

  • Infiltration of tumor-associated macrophages is involved in tumor programmed death-ligand 1 expression in early lung adenocarcinoma

    Shima T., Shimoda M., Shigenobu T., Ohtsuka T., Nishimura T., Emoto K., Hayashi Y., Iwasaki T., Abe T., Asamura H., Kanai Y.

    Cancer Science (Cancer Science)  111 ( 2 ) 727 - 738 2020年02月

    ISSN  13479032

     概要を見る

    © 2019 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. Programmed death-ligand 1 (PD-L1) is an immune modulator that promotes immunosuppression by binding to programmed death-1 of T-lymphocytes. Although tumor cell PD-L1 expression has been shown to be associated with the clinical response to anti–PD-L1 antibodies, its concise regulatory mechanisms remain elusive. In this study, we evaluated the associations of tumor PD-L1 expression and immune cell infiltrating patterns in 146 cases of early lung adenocarcinoma (AC) to investigate the possible extrinsic regulation of tumor PD-L1 by immune cells. Using immunohistochemistry, cell surface PD-L1 expression in tumor cells was observed in 18.5% of stage 0-IA lung AC patients. Tumor PD-L1 positivity was significantly associated with stromal invasion, which was accompanied by increased tumor-associated macrophages (TAM), CD8+ cytotoxic T cells and FoxP3+ regulatory T cells. Among these immune cells, TAM and CD8+ T cells significantly accumulated in PD-L1-positive carcinoma cell areas, which showed a tumor cell nest-infiltrating pattern. Although CD8+ T cells are known to induce tumor PD-L1 expression via interferon-ɣ production, the increased TAM within tumors were also associated with tumor cell PD-L1 positivity, independently of CD8+ T cell infiltration. Our in vitro experiments revealed that PD-L1 expression in lung cancer cell lines was significantly upregulated by co–culture with M2-differentiated macrophages; expression of PD-L1 was reduced to baseline levels following treatment with a transforming growth factor-β inhibitor. These results demonstrated that tumor-infiltrating TAM are extrinsic regulators of tumor PD-L1 expression, indicating that combination therapy targeting both tumor PD-L1 and stromal TAM might be a possible strategy for effective treatment of lung cancer.

  • The annual risk of tuberculosis infection in newly hired researchers and healthcare workers using interferon-gamma release assay in Japan

    Nishimura T., Ota M., Mori M., Takano Y., Fujiwara H., Uwamino Y., Uno S., Hasegawa N.

    Journal of Infection and Chemotherapy (Journal of Infection and Chemotherapy)  2020年

    ISSN  1341321X

     概要を見る

    © 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases The tuberculosis (TB) notification rate in Japan is gradually decreasing but has not yet achieved “pre-elimination,” defined by the World Health Organization. To effectively tackle, control, and eliminate TB, estimating and monitoring the annual risk of TB infection (ARI) using tuberculin skin testing (TST) to understand the dynamics of TB epidemiology are significantly important. However, studies estimating ARIs using TST are few considering that Bacillus Calmette-Guérin vaccination coverage is high in Japan. This was a single-center, cross-sectional study conducted between January 2011 and December 2018 in Tokyo area where interferon-gamma release assays (IGRAs) were performed in newly hired researchers of Keio University School of Medicine and healthcare workers of Keio University Hospital to determine TB infection. We estimated the prevalence of TB infection and ARI based on their IGRA results. Among the 3908 subjects, 83 (2.124%) had positive IGRA results. Multiple logistic regression analysis revealed that age was a significant risk factor for positive IGRA result (adjusted odds ratio, 1.046). The ARIs were 0.049%–0.156% between 1986 and 2004, midyears of TB infection, but have not significantly decreased over approximately two decades. To decrease the risk of TB infection, advanced strategies to control and eliminate TB in Tokyo area are significantly required.

  • Serum Krebs von den Lungen-6 level in the disease progression and treatment of Mycobacterium avium complex lung disease

    Asakura T., Kimizuka Y., Nishimura T., Suzuki S., Namkoong H., Masugi Y., Sato Y., Ishii M., Hasegawa N.

    Respirology (Respirology)  2020年

    ISSN  13237799

     概要を見る

    © 2020 Asian Pacific Society of Respirology Background and objective: The lack of useful biomarkers reflecting the disease state limits the management of Mycobacterium avium complex lung disease (MAC-LD). We clarified the associations between serum KL-6 level, disease progression and treatment response. Methods: Resected lung tissues from MAC-LD patients were immunostained for KL-6. We compared serum KL-6 levels between MAC-LD and healthy control or bronchiectasis patients without nontuberculous mycobacterial lung disease (NTM-LD). Serum KL-6 level was assessed in a prospective observational study at Keio University Hospital between May 2012 and May 2016. We investigated associations between serum KL-6 level and disease progression and treatment response in patients untreated for MAC-LD on registration (n = 187). Results: The KL-6+ alveolar type 2 cell population in the lung and serum KL-6 level were significantly higher in MAC-LD patients than in controls. Serum KL-6 level in bronchiectasis patients without NTM-LD showed no significant increase. Of the 187 patients who did not receive treatment on registration, 53 experienced disease progression requiring treatment. Multivariable Cox analysis revealed that the serum KL-6 level (aHR: 1.18, P = 0.005), positive acid-fast bacilli smear (aHR: 2.64, P = 0.001) and cavitary lesions (aHR: 3.01, P < 0.001) were significantly associated with disease progression. The change in serum KL-6 (ΔKL-6) was significantly higher in the disease progression group; it decreased post-treatment, reflecting the negative sputum culture conversion. Conclusion: Serum KL-6 level is associated with disease progression and treatment response. Longitudinal assessment combined with AFB smear status and presence of cavitary lesions may aid MAC-LD management.

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KOARA(リポジトリ)収録論文等 【 表示 / 非表示

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研究発表 【 表示 / 非表示

  • 外国人留学生を対象とした結核感染調査

    西村知泰,森正明,牧野伸司,広瀬寛,和井内由充子,横山裕一,武田彩乃,畔上達彦,後藤伸子,河邊博史

    第116回日本内科学会総会・講演会 (名古屋) , 2019年04月, ポスター(一般)

  • 肺MAC症の新規検査法

    西村 知泰

    第101回日本細菌学会関東支部総会 (東京) , 2018年11月, シンポジウム・ワークショップ パネル(指名)

  • アスペルギルス沈降抗体陽性である肺Mycobacterium avium complex症患者の臨床的特徴

    鈴木翔二, 朝倉崇徳, 南宮湖, 岡森慧, 八木一馬, 鎌田浩史, 舩津洋平, 中野泰, 西村知泰, 石井誠, 海老原全, 別役智子, 長谷川直樹.

    第58回日本呼吸器学会学術講演会 (大阪) , 2018年04月, ポスター(一般)

  • 大学生における先天性心疾患の管理状況

    牧野伸司, 和井内由充子, 武田彩乃, 畔上達彦, 広瀬寛, 西村知泰, 横山裕一, 河邊博史, 森正明.

    第115回日本内科学会年次学術講演会 (京都) , 2018年04月, ポスター(一般)

  • 当大学医学部留学生に対するImmunization Recordの運用と考察

    武藤志保, 横山裕一, 弦巻美保, 齋藤圭美, 西村知泰, 森正明, 河邊博史.

    第55回全国大学保健管理研究集会 (宜野湾) , 2017年11月, ポスター(一般)

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競争的資金等の研究課題 【 表示 / 非表示

  • 慶應義塾における新型コロナウイルス感染症対策

    2020年08月
    -
    2021年03月

    慶應義塾学事振興資金, 補助金,  代表

  • 肺MAC症の病態における菌細胞壁脂質の役割

    2019年06月
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    2022年05月

    武田科学振興財団, 医学系研究助成, 補助金,  代表

  • 肺非結核性抗酸菌症患者のゲノム情報に基づいた病態解明

    2019年04月
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    2022年03月

    文部科学省・日本学術振興会, 科学研究費補助金, 補助金,  分担

  • 菌細胞壁脂質に着目した肺MAC症の病態解明

    2019年04月
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    2022年03月

    文部科学省・日本学術振興会, 科学研究費補助金, 補助金,  代表

  • がん微小環境形成・腫瘍進展に関わるHYBID-ヒアルロン酸代謝機構の病理学的解析

    2019年04月
    -
    2022年03月

    文部科学省・日本学術振興会, 科学研究費補助金, 補助金,  分担

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担当授業科目 【 表示 / 非表示

  • 感染症学

    2020年度

  • 現代社会と医学Ⅱ

    2019年度

  • 感染症学

    2019年度

担当経験のある授業科目 【 表示 / 非表示

  • 感染症学

    慶應義塾, 2018年度, 通年, その他, 講義, 兼担

  • 現代社会と医学Ⅱ

    慶應義塾, 2018年度, 通年, その他, 講義, 専任

 

社会活動 【 表示 / 非表示

  • 平成27年度外務省巡回医師団

    2016年02月
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    2016年03月
  • 平成26年度外務省巡回医師団

    2015年01月
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    2015年02月

所属学協会 【 表示 / 非表示

  • 日本免疫学会

     
  • 日本内科学会

     
  • 日本呼吸器学会

     
  • 日本呼吸器内視鏡学会

     
  • 日本感染症学会

     

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委員歴 【 表示 / 非表示

  • 2016年04月
    -
    継続中

    評議員, 日本感染症学会