Nishimura, Tomoyasu



Research Centers and Institutes, Health Center (Hiyoshi)


Assistant Professor/Senior Assistant Professor

External Links

Career 【 Display / hide

  • 2000.04

    慶應義塾大学病院, 内科, 研修医

  • 2002.05

    川崎市立川崎病院, 内科, 医員

  • 2003.06

    水戸赤十字病院, 内科, 医員

  • 2004.06

    慶應義塾大学医学部, 内科学(呼吸器), 助手

  • 2007.01

    慶應義塾大学医学部, 微生物学・免疫学, 研究員

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Academic Background 【 Display / hide

  • 2000.03

    Keio University, Faculty of Medicine, 医学科

    University, Graduated

Academic Degrees 【 Display / hide

  • 博士, Keio University, Dissertation, 2008.06

Licenses and Qualifications 【 Display / hide

  • 医師免許, 2000.04


Research Areas 【 Display / hide

  • Respiratory organ internal medicine

  • Infectious disease medicine

Research Keywords 【 Display / hide

  • Mycobacteriosis


Books 【 Display / hide

  • EBM呼吸器疾患の治療2016-2017

    Nishimura Tomoyasu, 中外医学社, 2016.01

    Scope: Interferon Gamma Release Assayの有用性は?

  • 新 呼吸器専門医テキスト

    Nishimura Tomoyasu, 南江堂, 2015.04

    Scope: 肺結核症

  • 内科研修マニュアル 改訂第2版

    Nishimura Tomoyasu, 南江堂, 2006.07

    Scope: 市中肺炎/院内肺炎

Papers 【 Display / hide

  • Evaluation of IS1245 LAMP in Mycobacterium avium and the influence of host-related genetic diversity on its application

    Akapelwa M.L., Kapalamula T.F., Ouchi-Aizu Y., Hang'ombe B.M., Nishiuchi Y., Gordon S.V., Solo E.S., Tamaru A., Nishimura T., Hasegawa N., Morimoto K., Fukushima Y., Suzuki Y., Nakajima C.

    Diagnostic Microbiology and Infectious Disease (Diagnostic Microbiology and Infectious Disease)  101 ( 4 )  2021.12

    ISSN  07328893

     View Summary

    Early detection and treatment are paramount for the timely control of Mycobacterium avium infections. Herein, we designed a LAMP assay targeting a widely used species-specific marker IS1245 for the rapid detection of M. avium and evaluated its applicability using human (n = 137) and pig (n = 91) M. avium isolates from Japan. The developed assay could detect as low as 1 genome copy of M. avium DNA within 30 minutes. All 91 (100%) M. avium isolates from pigs were detected positive while all other tested bacterial species were negative. Interestingly, among the 137 clinical M. avium isolates, 41 (30%) were undetectable with this LAMP assay as they lacked IS1245, the absence of which was revealed by PCR and whole-genome sequencing. These findings highlighted genotypic differences in M. avium strains from humans and pigs in Japan and how this diversity can influence the applicability of a detection tool across different geographic areas and hosts.

  • Potential biomarker enhancing the activity of tuberculosis, hsa-miR-346

    Uno S., Nishimura T., Nishio K., Kohsaka A., Tamizu E., Nakano Y., Kagyo J., Nakajima Y., Arai R., Hasegawa H., Arakawa K., Kashimura S., Ishii R., Miyazaki N., Uwamino Y., Hasegawa N.

    Tuberculosis (Tuberculosis)  129 2021.07

    ISSN  14729792

     View Summary

    Objectives: To determine the usefulness of hsa-miR-346, a potential biomarker enhancing the activity of non-tuberculous mycobacterial diseases, as a biomarker of tuberculosis activity. Methods: We investigated whether hsa-miR-346 is secreted by human macrophages infected with Mycobacterium tuberculosis (M. tuberculosis) in an in vitro study. In addition, a cross-sectional study was conducted first to evaluate whether serum hsa-miR-346 is elevated in patients with tuberculosis compared with that in healthy individuals. Second, we conducted a retrospective study to evaluate whether anti-tuberculosis treatment reduces serum hsa-miR-346 levels. Results: Log hsa-miR-346 levels were significantly elevated in the supernatant of human macrophages infected with M. tuberculosis in a dose-dependent manner. The mean serum log hsa-miR-346 levels were −15.48 (−15.76 to −15.21) in patients with tuberculosis and −16.12 (−16.29 to −15.95) in healthy volunteers, which significantly differed. In addition, hsa-miR-346 significantly decreased at 2 months from starting an anti-tuberculosis treatment. Conclusions: We consider hsa-miR-346 as a potential biomarker enhancing the tuberculosis activity.

  • Control of a Nosocomial Outbreak of COVID-19 in a University Hospital

    Harada S., Uno S., Ando T., Iida M., Takano Y., Ishibashi Y., Uwamino Y., Nishimura T., Takeda A., Uchida S., Hirata A., Sata M., Matsumoto M., Takeuchi A., Obara H., Yokoyama H., Fukunaga K., Amagai M., Kitagawa Y., Takebayashi T., Hasegawa N.

    Open Forum Infectious Diseases (Open Forum Infectious Diseases)  7 ( 12 ) 1 - 9 2020.12

     View Summary

    Background: Nosocomial spread of coronavirus disease 2019 (COVID-19) causes clusters of infection among high-risk individuals. Controlling this spread is critical to reducing COVID-19 morbidity and mortality. We describe an outbreak of COVID-19 in Keio University Hospital, Japan, and its control and propose effective control measures. Methods: When an outbreak was suspected, immediate isolation and thorough polymerase chain reaction (PCR) testing of patients and health care workers (HCWs) using an in-house system, together with extensive contact tracing and social distancing measures, were conducted. Nosocomial infections (NIs) were defined as having an onset or positive test after the fifth day of admission for patients and having high-risk contacts in our hospital for HCWs. We performed descriptive analyses for this outbreak. Results: Between March 24 and April 24, 2020, 27 of 562 tested patients were confirmed positive, of whom 5 (18.5%) were suspected as NIs. For HCWs, 52 of 697 tested positive, and 40 (76.9%) were considered NIs. Among transmissions, 95.5% were suspected of having occurred during the asymptomatic period. Large-scale isolation and testing at the first sign of outbreak terminated NIs. The number of secondary cases directly generated by a single primary case found before March 31 was 1.74, compared with 0 after April 1. Only 4 of 28 primary cases generated definite secondary infection; these were all asymptomatic. Conclusions: Viral shedding from asymptomatic cases played a major role in NIs. PCR screening of asymptomatic individuals helped clarify the pattern of spread. Immediate large-scale isolation, contact tracing, and social distancing measures were essential to containing outbreaks.

  • The distributions of hematologic and biochemical values in healthy high-school adolescents in Japan

    Azegami T., Nishimura T., Murai-Takeda A., Yamada-Goto N., Sato Y., Mori M.

    PLoS ONE (PLoS ONE)  15 ( 11 November )  2020.11

     View Summary

    Laboratory tests of adolescents are often interpreted by using reference intervals derived from adults, even though these populations differ in their physical and physiologic characteristics and disease susceptibility. Therefore, to examine the distribution of laboratory values specific for adolescents, we analyzed hematologic and biochemical measurements obtained from 12,023 healthy Japanese adolescents (ages 15 through 18 years; male, 9165; female, 2858) during 2009 through 2018. Distributions were shown as medians with 95% (2.5th and 97.5th percentiles) of values and were compared with those from previous studies that examined similar Asian populations. There were some differences between hematologic parameters, serum creatinine and uric acid concentration, and lipid levels of Japanese adults and adolescents. In comparison with other Asian populations, the distributions of serum uric acid and high-density–lipoprotein cholesterol in the present study were slightly higher than those in the other studies. Although further research is need, the distributions of hematologic and biochemical tests in adolescents may have the potential to facilitate the early identification and management of disease in this population.

  • Comorbidities associated with nontuberculous mycobacterial disease in Japanese adults: A claims-data analysis

    Uno S., Asakura T., Morimoto K., Yoshimura K., Uwamino Y., Nishimura T., Hoshino Y., Hasegawa N.

    BMC Pulmonary Medicine (BMC Pulmonary Medicine)  20 ( 1 )  2020.10

     View Summary

    © 2020 The Author(s). Background: Nontuberculous mycobacterial (NTM) lung disease is one of a growing number of chronic health problems that is difficult to cure in aging societies. While it is important to be vigilant about associated comorbidities in order to provide better patient care, data on the prevalence of comorbidities stratified by country or region are scarce. We aimed to elucidate the comorbidities associated with NTM disease based on Japanese health insurance claims data. Methods: Cross-sectional analyses were performed using the claims data for 2014 provided by the Japan Medical Data Center Co., Ltd. Patients aged 20-75 years with ≥3 claims associated with NTM disease were identified and matched to 10 sex-and-age-matched controls that had never made a claim for NTM disease. Thirty-one comorbidities previously suspected to be associated with NTM disease were selected, and the prevalence of these comorbidities compared between cases and controls. Result: Overall, 419 NTM patients (134 males and 285 females) and 4190 non-NTM controls were identified from the JMDC database. Aspergillosis, asthma, chronic heart failure, diffuse panbronchiolitis, gastroesophageal reflux, interstitial pneumonia, lung cancer, cancer other than breast, lung, ovary, or prostate cancer, and rheumatoid arthritis were associated with NTM disease in both males and females. Chronic obstructive pulmonary disease was associated with NTM in males while chronic kidney disease, osteoporosis, and Sjögren syndrome were associated with NTM in females. Conclusion: NTM disease was associated with multiple comorbidities that should be considered when providing medical care to individuals with NTM disease.

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Papers, etc., Registered in KOARA 【 Display / hide

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Presentations 【 Display / hide

  • 外国人留学生を対象とした結核感染調査


    第116回日本内科学会総会・講演会 (名古屋) , 2019.04, Poster (general)

  • 肺MAC症の新規検査法

    Nishimura Tomoyasu

    第101回日本細菌学会関東支部総会 (東京) , 2018.11, Symposium, Workshop, Panelist (nomination)

  • アスペルギルス沈降抗体陽性である肺Mycobacterium avium complex症患者の臨床的特徴

    鈴木翔二, 朝倉崇徳, 南宮湖, 岡森慧, 八木一馬, 鎌田浩史, 舩津洋平, 中野泰, 西村知泰, 石井誠, 海老原全, 別役智子, 長谷川直樹.

    第58回日本呼吸器学会学術講演会 (大阪) , 2018.04, Poster (general)

  • 大学生における先天性心疾患の管理状況

    牧野伸司, 和井内由充子, 武田彩乃, 畔上達彦, 広瀬寛, 西村知泰, 横山裕一, 河邊博史, 森正明.

    第115回日本内科学会年次学術講演会 (京都) , 2018.04, Poster (general)

  • 当大学医学部留学生に対するImmunization Recordの運用と考察

    武藤志保, 横山裕一, 弦巻美保, 齋藤圭美, 西村知泰, 森正明, 河邊博史.

    第55回全国大学保健管理研究集会 (宜野湾) , 2017.11, Poster (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 医療従事者における新型コロナウイルスの感染状況調査


    大和証券ヘルス財団, 西村知泰, Research grant, Principal Investigator

  • 慶應義塾における新型コロナウイルス感染症対策


    慶應義塾学事振興資金, Research grant, Principal Investigator

  • 肺MAC症の病態における菌細胞壁脂質の役割


    武田科学振興財団, 医学系研究助成, Research grant, Principal Investigator

  • 肺非結核性抗酸菌症患者のゲノム情報に基づいた病態解明


    文部科学省・日本学術振興会, 科学研究費補助金, Research grant, Co-investigator

  • 菌細胞壁脂質に着目した肺MAC症の病態解明


    文部科学省・日本学術振興会, 科学研究費補助金, Research grant, Principal Investigator

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Courses Taught 【 Display / hide









Courses Previously Taught 【 Display / hide

  • 感染症学

    Keio University, 2018, Full academic year, Other, Lecture, Lecturer outside of Keio

  • 現代社会と医学Ⅱ

    Keio University, 2018, Full academic year, Other, Lecture, Within own faculty


Social Activities 【 Display / hide

  • 平成27年度外務省巡回医師団

  • 平成26年度外務省巡回医師団


Memberships in Academic Societies 【 Display / hide

  • 日本臨床微生物学会

  • 日本環境感染学会

  • 日本免疫学会

  • 日本結核病学会

  • 日本内科学会


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Committee Experiences 【 Display / hide

  • 2016.04

    評議員, 日本感染症学会