GOTO Nobuko



Research Centers and Institutes, Health Center (Hiyoshi)


Senior Assistant Professor (Non-tenured)/Assistant Professor (Non-tenured)

External Links

Profile 【 Display / hide

  • 肥満症の診療及び研究に興味を持って取り組んでいます。

Profile Summary 【 Display / hide

Other Affiliation 【 Display / hide

  • School of Medicine, 内科学(腎臓・内分泌・代謝), 兼担助教

Career 【 Display / hide

  • 2001.04

    Chiba University Hospital, Diabetes, Metabolism and Endocrinology, A trainee doctor

  • 2002.10

    Numazu City Hospital, Internal Medicine, A trainee doctor

  • 2003.10

    Numazu City Hospital, Department of Internal Medicine, A medical staff

  • 2004.10

    Yokohama Rosai Hospital, Internal medicine departments, Residency in Specialist

  • 2009.04

    Kyoto University Hospital, Divison of Endocrinology and Metabolism Department of Medicine and Clinical Science, Medical Staff

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Academic Background 【 Display / hide

  • 1994.04

    Chiba University, School of Medicine, 医学科

    University, Graduated

  • 2005.04

    Chiba University, Graduate School of Medicine

    Graduate School, Withdrawal before completion, Doctoral course

  • 2005.10

    The University of Tokyo, Graduate school of Pharmaceutical Science, Laboratory of Neurobiophysics

    Graduate School, Other, Other

  • 2007.04

    Kyoto University, Graduate School of Medicine, Division of Endocrinology and Metabolism, Department of Medicine and Clinical Science

    Graduate School, Other, Other

Academic Degrees 【 Display / hide

  • 医学, Kyoto University, Dissertation, 2011.09

    Impaired CNS leptin action is implicated in depression associated with obesity

Licenses and Qualifications 【 Display / hide

  • 日本内科学会認定医, 2005.09

  • 日本内分泌学会専門医, 2010.04

  • 日本糖尿病学会専門医, 2012.12

  • 日本肥満学会専門医, 2018.03

  • Occupational physician certified by the Japan Assosiation of Medical Practitioners, 2018.11

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Research Areas 【 Display / hide

  • Life Science / Metabolism and endocrinology

  • Life Science / Hygiene and public health (laboratory)

  • Life Science / Hygiene and public health (non-laboratory)

  • Life Science / Medical management and medical sociology

Research Keywords 【 Display / hide

  • メンタルヘルス

  • 肥満症


Books 【 Display / hide

  • Mental function and Obesity. Functional Brain Mapping and the Endeavor to Understand the Working Brain

    GOTO Nobuko Chirchiglia)., InTech, Croatia, 2013

    Scope: 16 Mental Function and Obesity 301

Papers 【 Display / hide

  • Brain fractalkine-CX3CR1 signalling is anti-obesity system as anorexigenic and anti-inflammatory actions in diet-induced obese mice

    Kawamura N., Katsuura G., Yamada-Goto N., Nakama R., Kambe Y., Miyata A., Furuyashiki T., Narumiya S., Ogawa Y., Inui A.

    Scientific Reports (Scientific Reports)  12 ( 1 )  2022.12

     View Summary

    Fractalkine is one of the CX3C chemokine family, and it is widely expressed in the brain including the hypothalamus. In the brain, fractalkine is expressed in neurons and binds to a CX3C chemokine receptor 1 (CX3CR1) in microglia. The hypothalamus regulates energy homeostasis of which dysregulation is associated with obesity. Therefore, we examined whether fractalkine-CX3CR1 signalling involved in regulating food intake and hypothalamic inflammation associated with obesity pathogenesis. In the present study, fractalkine significantly reduced food intake induced by several experimental stimuli and significantly increased brain-derived neurotrophic factor (BDNF) mRNA expression in the hypothalamus. Moreover, tyrosine receptor kinase B (TrkB) antagonist impaired fractalkine-induced anorexigenic actions. In addition, compared with wild-type mice, CX3CR1-deficient mice showed a significant increase in food intake and a significant decrease in BDNF mRNA expression in the hypothalamus. Mice fed a high-fat diet (HFD) for 16 weeks showed hypothalamic inflammation and reduced fractalkine mRNA expression in the hypothalamus. Intracerebroventricular administration of fractalkine significantly suppressed HFD-induced hypothalamic inflammation in mice. HFD intake for 4 weeks caused hypothalamic inflammation in CX3CR1-deficient mice, but not in wild-type mice. These findings suggest that fractalkine-CX3CR1 signalling induces anorexigenic actions via activation of the BDNF-TrkB pathway and suppresses HFD-induced hypothalamic inflammation in mice.

  • Activation of α7 nicotinic receptors suppresses sucrose addiction in mice

    Kawamura N., Novianti E., Yamada-Goto N., Nakama R., Asakawa A., Katsuura G., Inui A.

    Progress in Neuro-Psychopharmacology and Biological Psychiatry (Progress in Neuro-Psychopharmacology and Biological Psychiatry)  113 2022.03

    ISSN  02785846

     View Summary

    The mesolimbic dopamine system is important for the rewarding and motivational aspects of consuming rewarding and palatable food. Nicotinic receptors are present in the mesolimbic dopamine system and enhance the reinforcement of drugs of abuse. In this study, we examined the involvement of nicotine receptor subtypes in sucrose addiction in a sucrose preference paradigm. Sucrose preference and intake in mice increased in proportion to stepwise increases in sucrose concentrations. Moreover, sucrose preference and intake following sucrose withdrawal in mice were increased in comparison with the first set of trials. In the present study, α7, but not α4 and β2, nicotinic receptor subunit mRNA was decreased in the nucleus accumbens, but not in the hypothalamus, after sucrose withdrawal and subsequent sucrose intake. Administration of an agonist for α7, but not α4 and β2, nicotinic receptors suppressed the enhancement of sucrose preference and intake following sucrose withdrawal. These findings indicate that α7 nicotinic receptor activation suppresses sucrose addiction in a sucrose preference test in mice.

  • Birth weight and risk factors for atherosclerosis-retrospective cohort study in Japanese workers.

    Azegami T, Takeda A, Yokoyama H, Wainai Y, Hirose H, Makino S, Nishimura T, Goto N, Itoh H, Mori M.

    J Hypertens 39   e170 - e171 2021.04

    Joint Work, Accepted

  • Impaired brain fractalkine-CX3CR1 signaling is implicated in cognitive dysfunction in diet-induced obese mice

    Kawamura N., Katsuura G., Yamada-Goto N., Novianti E., Inui A., Asakawa A.

    BMJ Open Diabetes Research and Care (BMJ Open Diabetes Research and Care)  9 ( 1 )  2021.02

     View Summary

    Introduction A diet high in saturated fat is well known to affect neuronal function and contribute to cognitive decline in experimental animals and humans. Fractalkine released from neurons acts on its receptor, CX3C chemokine receptor 1 (CX3CR1), in the microglia to regulate several brain functions. The present study addressed whether fractalkine-CX3CR1 signaling in the brain, especially the hippocampus, contributes to the cognitive deficits observed in diet-induced obese (DIO) mice. Research design and methods Mice were given 60% high-fat diet for 16 weeks. The expression of fractalkine and CX3CR1 in the hippocampus, amygdala and prefrontal cortex of DIO mice was analyzed. Cognitive ability in the Y-maze test and hippocampal glutamate receptors and synaptic markers were observed in DIO and CX3CR1 antagonist-treated mice. Regulation of fractalkine and CX3CR1 expression in the hippocampus was examined following administration of a selective insulin-like growth factor-1 (IGF-1) receptor inhibitor and a tyrosine receptor kinase B (TrkB) antagonist in normal mice. Results DIO mice exhibited significant cognitive deficits in the Y-maze test and decrease in fractalkine and CX3CR1 in the hippocampus and amygdala compared with mice fed a control diet (CD mice). Administration of the CX3CR1 antagonist 18a in normal mice induced significant cognitive deficits in the Y-maze test. DIO mice and CX3CR1 antagonist-treated mice exhibited significant decreases in protein levels of NMDA (N-methyl-D-aspartate) receptor subunit (NR2A), AMPA (α-amino-5-methyl-3-hydroxy-4-isoxazole propionate) receptor subunit (GluR1) and postsynaptic density protein 95 in the hippocampus compared with their respective controls. Furthermore, plasma IGF-1 and hippocampal brain-derived neurotrophic factor were significantly decreased in DIO mice compared with CD mice. Administration of a selective IGF-1 receptor inhibitor and a TrkB antagonist in normal mice significantly decreased fractalkine and CX3CR1 in the hippocampus. Conclusions These findings indicate that the cognitive decline observed in DIO mice is due, in part, to reduced fractalkine-CX3CR1 signaling in the corticolimbic system.

  • Sars-cov-2 infection among medical institution faculty and healthcare workers in tokyo, japan

    Nishimura T., Uwamino Y., Uno S., Kashimura S., Shiraki T., Kurafuji T., Morita M., Noguchi M., Azegami T., Yamada-Goto N., Murai-Takeda A., Yokoyama H., Kuwabara K., Kato S., Matsumoto M., Hirata A., Iida M., Harada S., Ishizaka T., Misawa K., Murata M., Saya H., Amagai M., Kitagawa Y., Takeuchi T., Mori M., Takebayashi T., Hasegawa N.

    Internal Medicine (Internal Medicine)  60 ( 16 ) 2569 - 2575 2021

    ISSN  09182918

     View Summary

    Objective To consider effective measures against severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) infection in medical institutions, this study estimated the SARS-CoV-2 infection rate among healthcare workers (HCWs) in Tokyo, Japan, and determined the specific findings for mild coronavirus disease 2019 (COVID-19) cases. Methods This study analyzed the results of serologic tests to detect immunoglobulin G antibodies against SARS-CoV-2 and evaluated the demographic and clinical characteristics of the faculty and HCWs at a Tokyo medical institution in August 2020. The demographic and clinical characteristics of participants with antibody-positive results were compared to those of participants with antibody-negative results. Materials This study recruited 2,341 faculty and HCWs at a Tokyo medical institution, 21 of whom had a COVID-19 history. Results Of the 2,320 participants without a COVID-19 history, 20 (0.862%) had positive serologic test results. A fever and dysgeusia or dysosmia occurred with greater frequency among the participants with positive test results than in those with negative results [odds ratio (OR), 5.475; 95% confidence interval (CI), 1.960-15.293 and OR, 24.158; 95% CI, 2.693-216.720, respectively]. No significant difference was observed in the positivity rate between HCWs providing medical care for COVID-19 patients using adequate protection and other HCWs (OR, 2.514; 95% CI, 0.959-6.588). Conclusion To reduce the risk of COVID-19 spread in medical institutions, faculty and HCWs should follow standard and necessary transmission-based precautions, and those with a fever and dysgeusia or dysosmia should excuse themselves from work as soon as possible.

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • The target of the specific health checkupsand the specific health guidance


    慶應保健研究 (慶應義塾大学保健管理センター)  38 ( 1 ) 21 - 28 2020.04

    Article, review, commentary, editorial, etc. (bulletin of university, research institution), Joint Work, Lead author, Corresponding author

  • The impact of sleep on glucose metabolism

    後藤 伸子

    慶應保健研究 (慶應義塾大学保健管理センター)  37 ( 1 ) 23 - 28 2019.04

    Article, review, commentary, editorial, etc. (bulletin of university, research institution), Lead author, Last author, Corresponding author

  • 肥満の薬物療法. 肥満は病気である.


    成人病と生活習慣病 (東京医学社)  47 ( 11 )  2017.11

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work

  • III. 肥満・肥満症の調節、発症に関わる因子 新規摂食調節因子としてのC型ナトリウム利尿ペプチドの可能性. 最新肥満症学 -基礎・臨床研究の最前線-


    日本臨床 (日本臨床社)  72 ( 増刊4 ) 209 - 213 2014.05

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work

  • メタボリックシンドロームの高次脳機能障害へのアプローチ;肥満のkey分子であるレプチンの肥満に合併するうつ病態における意義


    日本神経精神薬理学雑誌 (日本神経精神薬理学会)  32 ( 5 ) 245 - 250 2012.11

    Research paper, summary (national, other academic conference), Joint Work

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Presentations 【 Display / hide

Awards 【 Display / hide

  • 第19回臨床医科学フォーラム 三宅記念賞

    後藤(山田)伸子, 2011.09, 臨床医科学フォーラム, Impaired CNS leptin action is implicated in depression associated with obesity

  • 第8回メタボリックシンドロームカンファレンス若手研究奨励賞

    山田伸子, 2010.12, メタボリックシンドロームカンファレンス, 肥満とうつ病:海馬におけるレプチン作用

  • 第31回日本肥満学会若手研究奨励賞

    山田伸子, 2010.10, 日本肥満学会, レプチンの抗うつ作用と肥満に合併するうつ病態における意義

  • IASO Traveling Fellowship Award

    Nobuko Yamada, 2010.07, ICO2010, Depression in obesity: implication for pathophysiological role of endogenous leptin

    Country: Sweden

  • Academic Encouragement Award

    2010.04, Japan Society of Molecular Medicine, 肥満に合併するうつ病態におけるレプチンの意義

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Courses Taught 【 Display / hide










Memberships in Academic Societies 【 Display / hide

  • Japan Atherosclerosis Society, 

  • 日本糖尿病医療学学会, 

  • Japan Society for Occupational Health, 

  • The Japanese Association of School Health, 

  • Japan Association for Diabetes Education and Care, 


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