Goto, Nobuko



Research Centers and Institutes, Health Center (Hiyoshi)


Senior Assistant Professor (Non-tenured)/Assistant Professor (Non-tenured)

External Links

Profile 【 Display / hide

  • 肥満症の診療及び研究に興味を持って取り組んでいます。

Profile Summary 【 Display / hide

Other Affiliation 【 Display / hide

  • School of Medicine, 内科学(腎臓・内分泌・代謝), 兼担助教

Career 【 Display / hide

  • 2001.04

    Chiba University Hospital, Diabetes, Metabolism and Endocrinology, A trainee doctor

  • 2002.10

    Numazu City Hospital, Internal Medicine, A trainee doctor

  • 2003.10

    Numazu City Hospital, Department of Internal Medicine, A medical staff

  • 2004.10

    Yokohama Rosai Hospital, Internal medicine departments, Residency in Specialist

  • 2009.04

    Kyoto University Hospital, Divison of Endocrinology and Metabolism Department of Medicine and Clinical Science, Medical Staff

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Academic Background 【 Display / hide

  • 1994.04

    Chiba University, School of Medicine, 医学科

    University, Graduated

  • 2005.04

    Chiba University, Graduate School of Medicine

    Graduate School, Withdrawal before completion, Doctoral course

  • 2005.10

    The University of Tokyo, Graduate school of Pharmaceutical Science, Laboratory of Neurobiophysics

    Graduate School, Other, Other

  • 2007.04

    Kyoto University, Graduate School of Medicine, Division of Endocrinology and Metabolism, Department of Medicine and Clinical Science

    Graduate School, Other, Other

Academic Degrees 【 Display / hide

  • 医学, Kyoto University, Dissertation, 2011.09

    Impaired CNS leptin action is implicated in depression associated with obesity

Licenses and Qualifications 【 Display / hide

  • 日本内科学会認定医, 2005.09

  • 日本内分泌学会専門医, 2010.04

  • 日本糖尿病学会専門医, 2012.12

  • 日本肥満学会専門医, 2018.03

  • Occupational physician certified by the Japan Assosiation of Medical Practitioners, 2018.11

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Research Areas 【 Display / hide

  • Life Science / Metabolism and endocrinology

  • Life Science / Hygiene and public health (laboratory)

  • Life Science / Hygiene and public health (non-laboratory)

  • Life Science / Medical management and medical sociology

Research Keywords 【 Display / hide

  • メンタルヘルス

  • 肥満症


Books 【 Display / hide

  • Mental function and Obesity. Functional Brain Mapping and the Endeavor to Understand the Working Brain

    GOTO Nobuko Chirchiglia)., InTech, Croatia, 2013

    Scope: 16 Mental Function and Obesity 301

Papers 【 Display / hide

  • The impact of laparoscopic sleeve gastrectomy with duodenojejunal bypass on intestinal microbiota differs from that of laparoscopic sleeve gastrectomy in Japanese patients with obesity.

    Kikuchi R, Irie J, Yamada-Goto N, Kikkawa E, Seki Y, Kasama K, Itoh H.

    Clinical drug investigation (Clinical Drug Investigation)  38 ( 6 ) 545 - 552 2018.06

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  11732563

     View Summary

    © 2018, Springer International Publishing AG, part of Springer Nature. Background and Objectives: Bariatric surgery improves metabolic diseases and alters the intestinal microbiota in animals and humans, but different procedures reportedly have different impacts on the intestinal microbiota. We developed laparoscopic sleeve gastrectomy with duodenojejunal bypass (LSG-DJB) as an alternative to laparoscopic Roux-en-Y gastric bypass (LRYGB) in addition to laparoscopic sleeve gastrectomy (LSG) for Japanese patients with obesity. We investigated the precise change in the intestinal microbiota induced by these procedures in the present study. Methods: A prospective observational study of 44 Japanese patients with obesity was conducted [22 patients underwent LSG, 18 underwent LSG-DJB, and 4 underwent laparoscopic adjustable gastric banding (LAGB)]. The patients’ clinical parameters and intestinal microbiota were investigated before and for 6 months after surgery. The microbiota was analyzed by a 16S rDNA method. Results: LSG and LSG-DJB significantly improved the metabolic disorders in the patients with obesity. The proportion of the phylum Bacteroidetes and order Lactobacillales increased significantly in the LSG group, and that of the order Enterobacteriales increased significantly in the LSG-DJB group. Conclusions: LSG and LSG-DJB improved obesity and type 2 diabetes in Japanese patients with obesity, but the impact of LSG-DJB on the intestinal microbiota differed from that of LSG. This difference in the impact on the intestinal environment could explain the different efficacies of LSG and LSG-DJB in terms of their ability to resolve metabolic disorders in the clinical setting.

  • Neuronal cells derived from human induced pluripotent stem cells as a functional tool of melanocortin system. Neuropeptides.

    Yamada-Goto N, Ochi Y, Katsuura G, Yamashita Y, Ebihara K, Noguchi M, Fujikura J, Taura D, Sone M, Hosoda K, Gottschall PE, Nakao K.

    Neuropeptides 65   10 - 20 2017.10

    Research paper (scientific journal), Joint Work, Accepted

  • Brain-specific natriuretic peptide receptor-B deletion attenuates high-fat diet-induced visceral and hepatic lipid deposition in mice.

    Yamashita Y, Yamada-Goto N, Katsuura G, Ochi Y, Kanai Y, Miyazaki Y, Kuwahara K, Kanamoto N, Miura M, Yasoda A, Ohinata K, Inagaki N, Nakao K.

    Peptides 81   38 - 50 2016.06

    Research paper (scientific journal), Joint Work, Accepted

  • Intracerebroventricular administration of C-type natriuretic peptide suppresses food intake via activation of the melanocortin System in Mice.

    Yamada-Goto N, Katsuura G, Ebihara K, Inuzuka M, Ochi Y, Yamashita Y, Kusakabe T, Yasoda A, Satoh-Asahara N, Ariyasu H, Hosoda K, Nakao K.

    Diabetes 62   1500 - 1504 2013.05

    Research paper (scientific journal), Joint Work, Accepted

  • Impairment of fear-conditioning responses and changes of brain neurotrophic factors in diet-induced obese mice.

    Yamada-Goto N, Katsuura G, Ochi Y, Ebihara K, Kusakabe T, Hosoda K, Nakao K.

    Journal of Neuroendocrinolgy 24   1120 - 1125 2012.08

    Research paper (scientific journal), Joint Work, Accepted

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • 肥満の薬物療法. 肥満は病気である.


    成人病と生活習慣病 (東京医学社)  47 ( 11 )  2017.11

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work

  • III. 肥満・肥満症の調節、発症に関わる因子 新規摂食調節因子としてのC型ナトリウム利尿ペプチドの可能性. 最新肥満症学 -基礎・臨床研究の最前線-


    日本臨床 (日本臨床社)  72 ( 増刊4 ) 209 - 213 2014.05

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work

  • メタボリックシンドロームの高次脳機能障害へのアプローチ;肥満のkey分子であるレプチンの肥満に合併するうつ病態における意義


    日本神経精神薬理学雑誌 (日本神経精神薬理学会)  32 ( 5 ) 245 - 250 2012.11

    Research paper, summary (national, other academic conference), Joint Work

  • IV.病態 メタボリックシンドロームに起因もしくは関連する病態とその管理 うつ病. メタボリックシンドローム (第2版) –基礎・臨床の最新知見-.


    日本臨床 (日本臨床社)  69 ( 増刊号1 ) 421 - 425 2011.01

    Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

  • レプチンの抗うつ作用と肥満に合併する うつ病態における意義.


    肥満研究 (日本肥満学会)  16   188 - 191 2010.12

    Research paper, summary (national, other academic conference), Joint Work

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Presentations 【 Display / hide

Awards 【 Display / hide

  • 第19回臨床医科学フォーラム 三宅記念賞

    後藤(山田)伸子, 2011.09, 臨床医科学フォーラム, Impaired CNS leptin action is implicated in depression associated with obesity

  • 第8回メタボリックシンドロームカンファレンス若手研究奨励賞

    山田伸子, 2010.12, メタボリックシンドロームカンファレンス, 肥満とうつ病:海馬におけるレプチン作用

  • 第31回日本肥満学会若手研究奨励賞

    山田伸子, 2010.10, 日本肥満学会, レプチンの抗うつ作用と肥満に合併するうつ病態における意義

  • IASO Traveling Fellowship Award

    Nobuko Yamada, 2010.07, ICO2010, Depression in obesity: implication for pathophysiological role of endogenous leptin

    Country: Sweden

  • Academic Encouragement Award

    2010.04, Japan Society of Molecular Medicine, 肥満に合併するうつ病態におけるレプチンの意義

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Courses Taught 【 Display / hide








Memberships in Academic Societies 【 Display / hide

  • Japan Atherosclerosis Society, 

  • 日本糖尿病医療学学会, 

  • Japan Society for Occupational Health, 

  • The Japanese Association of School Health, 

  • Japan Association for Diabetes Education and Care, 


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