畔上 達彦 (アゼガミ タツヒコ)

Azegami, Tatsuhiko

写真a

所属(所属キャンパス)

研究所・センター等 保健管理センター (日吉)

職名

助教(有期)

その他の所属・職名 【 表示 / 非表示

  • 医学部, 腎臓・内分泌・代謝内科

経歴 【 表示 / 非表示

  • 2010年04月
    -
    2012年03月

    慶應義塾大学大学院, 医学研究科, 研究奨励助教

  • 2012年04月
    -
    2013年03月

    慶應義塾大学 医学部, MSD抗加齢内分泌学寄付講座, 特任助教

  • 2013年04月
    -
    2017年03月

    慶應義塾大学 医学部, 内科学(腎臓内分泌代謝), 助教

  • 2017年04月
    -
    継続中

    東京大学医科学研究所, 感染・免疫部門 炎症免疫学分野, 客員研究員

  • 2017年04月
    -
    継続中

    慶応義塾大学, 保健管理センター, 助教

学歴 【 表示 / 非表示

  • 2001年04月
    -
    2007年03月

    慶応義塾大学, 医学部

    大学, 卒業

  • 2009年04月
    -
    2012年03月

    慶応義塾大学, 医学研究科, 内科学

    大学院, 卒業, 博士

学位 【 表示 / 非表示

  • 医学博士, 慶應義塾大学大学院, 課程, 2012年03月

免許・資格 【 表示 / 非表示

  • 日本内科学会 認定医, 2010年

  • 日本内科学会 総合内科専門医, 2013年

  • 日本透析医学会 専門医, 2013年

  • 日本腎臓学会 腎臓専門医, 2013年

  • 日本高血圧学会 高血圧専門医, 2014年

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研究分野 【 表示 / 非表示

  • 免疫学

  • 腎臓内科学

研究キーワード 【 表示 / 非表示

  • ワクチン

  • 生活習慣病

  • 粘膜免疫

  • 腎病理

  • 高血圧

 

著書 【 表示 / 非表示

  • 腎生検病理アトラス改訂版(尿細管・間質・血管病変の分類)

    畔上達彦、山口裕, 2017年08月

  • 次世代アジュバント開発のためのメカニズム解析と安全性評価(鼻粘膜投与へのワクチン,アジュバントのターゲッティング)

    幸義和、畔上達彦、清野宏, シーエムシー出版, 2017年03月

  • Molecular Vaccines (Vaccines for Hypertension and Atherosclerosis)

    Sasamura Hiroyuki, Azegami Tatsuhiko, Itoh Hiroshi, Springer, 2014年

  • 応用が拡がるDDS~人体環境から農業・家電まで~(経口ワクチン)

    畔上達彦、幸義和、清野宏, エヌ・ティー・エス, 2013年07月

論文 【 表示 / 非表示

  • Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes

    Hishikawa A., Hayashi K., Abe T., Kaneko M., Yokoi H., Azegami T., Nakamura M., Yoshimoto N., Kanda T., Sakamaki Y., Itoh H.

    Cell Reports (Cell Reports)  26 ( 5 ) 1318 - 1332.e4 2019年01月

     概要を見る

    © 2019 The Author(s) Hishikawa et al. reveal that KAT5-mediated DNA repair is essential for podocyte maintenance and is related to changes in DNA methylation status. Decreased podocyte KAT5 expression may contribute to the pathophysiology of diabetic nephropathy, suggesting a therapeutic target.

  • Features of and preventive measures against hypertension in the young

    Kawabe H., Azegami T., Takeda A., Kanda T., Saito I., Saruta T., Hirose H.

    Hypertension Research (Hypertension Research)  2019年

    ISSN  09169636

     概要を見る

    © 2019, The Author(s). The Japanese hypertension guidelines report that essential hypertension is detected in 1–3% of upper elementary and high school students during blood pressure (BP) screenings. Hypertension in these age groups is an emerging public health concern mainly attributed to the rising rate of pediatric obesity. Considering the existence of BP tracking phenomenon, early preventive education and instruction are necessary, especially for male students with moderately elevated BP showing a tendency toward obesity, despite the low prevalence of hypertension in high school students. Students with a positive family history of hypertension and those born with low birth weight need the same measures. Lifestyle habits, such as increased alcohol intake, dramatically change once students begin university; thus, early education and instruction regarding the factors influencing BP are necessary. In particular, for male students with higher BP during high school, caution regarding increased body weight is required irrespective of their level of obesity. Young adults aged <40 years should be educated about the association between body weight and hypertension. Particular caution surrounding lifestyle habits, including drinking and smoking, is warranted in male hypertensive subjects because hypertension at a young age is strongly associated with obesity. BP monitoring and the management of obesity should be considered efficient approaches to the detection and treatment of hypertension. For the lifetime prevention of hypertension, it is essential to be aware of one’s health status and learn about healthy lifestyles beginning in childhood. BP measurement may be an appropriate means to achieve this goal.

  • Intranasal vaccination against angiotensin II type 1 receptor and pneumococcal surface protein A attenuates hypertension and pneumococcal infection in rodents

    畔上 達彦

    Journal of Hypertension (Journal of Hypertension)  36 ( 2 ) 387 - 394 2017年

    研究論文(学術雑誌), 査読有り,  ISSN  02636352

     概要を見る

    © 2018 Wolters Kluwer Health, Inc. All rights reserved. Objectives: To combat global increases in the prevalence of lifestyle-related diseases and concomitant infectious diseases, we aimed to develop an innovative intranasal vaccine that simultaneously targets both hypertension and pneumonia, is not given by invasive injection, and offers prolonged therapeutic effect and reduced frequency of administration. Methods: Angiotensin II type 1 receptor-pneumococcal surface protein A (AT1R-PspA) vaccine, consisting of a cationic nanometer-sized hydrogel incorporating AT1R partial peptide conjugated with PspA and cyclic diguanylate monophosphate adjuvant, was created and given intranasally to spontaneously hypertensive rats (SHRs). Antigen-specific antibodies and blood pressure were examined to evaluate immune responses and the antihypertensive effect of the vaccine. To examine the protective effect of antibodies induced by vaccination on pneumococcal infection, sera obtained from immunized SHRs were incubated with a lethal dose of Streptococcus pneumoniae and then administered to mice. Results: Five doses of AT1R-PspA nasal-vaccine-induced AT1R-specific serum IgG antibody production and attenuated the development of hypertension in SHRs in the long term. Both in-vitro and in-vivo studies revealed that responses to angiotensin II were suppressed in vaccinated rats. Mice passively immunized with sera obtained from AT1R-PspA-vaccinated SHRs were protected from lethal pneumococcal infection. Conclusion: Intranasal immunization with AT1R-PspA vaccine has the potential to simultaneously attenuate the development of hypertension and protect from lethal pneumococcal infection.

  • Nanogel-based nasal ghrelin vaccine prevents obesity.

    畔上 達彦

    Mucosal Immunology 10 ( 5 ) 1351 - 1360 2017年

    研究論文(学術雑誌), 査読有り

  • Nanogel-based nasal vaccines for infectious and lifestyle-related diseases

    畔上 達彦

    Molecular Immunology (Molecular Immunology)  98   19 - 24 2017年

    研究論文(学術雑誌), 査読有り,  ISSN  01615890

     概要を見る

    © 2017 Because the mucosa is the major entry route for most pathogens, the development of mucosal vaccines is a rational approach for protecting against these undesired agents. Mucosal administration of vaccine antigen is useful for non-infectious chronic diseases as well, because of its advantages over injection routes, including comparable efficacy in the induction of systemic immune responses, less pain, and no risk of adverse events at the injection site. However, because it is difficult to effectively induce and regulate antigen-specific mucosal and systemic immune responses when antigen alone is mucosally administered, an appropriate form of mucosal delivery vehicle must be used. Antigen delivery systems involving nanogels, which act as artificial chaperones and mucosal adhesives, are a promising approach to overcoming this problem. Here, we introduce current perspectives regarding the development of nanogel-based nasal vaccines for both infectious and lifestyle-related diseases.

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KOARA(リポジトリ)収録論文等 【 表示 / 非表示

競争的資金等の研究課題 【 表示 / 非表示

  • 糖尿病性腎症に対する新規治療戦略の開発

    2018年04月
    -
    2021年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 畔上 達彦, 若手研究, 補助金,  代表

受賞 【 表示 / 非表示

  • 第8回臨床医学研究塾 奨励賞

    2017年10月, 第8回臨床医学研究塾

  • Premium Hypertension Conference 優秀演題賞

    2015年08月, Premium Hypertension Conference

  • Asian-Pacific Society of Hypertension Young Investigator Fellowships

    2012年10月, International Society of Hypertension

  • 東京高血圧研究会 優秀演題奨励賞

    2011年09月, 東京高血圧研究会

  • Asian-Pacific Society of Hypertension Young Investigator Fellowships

    2010年09月, International Society of Hypertension

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担当授業科目 【 表示 / 非表示

  • 現代社会と医学Ⅱ

    2019年度