Azegami, Tatsuhiko

写真a

Affiliation

Research Centers and Institutes, Health Center (Hiyoshi)

Position

Assistant Professor (Non-tenured)/Research Associate (Non-tenured)/Instructor (Non-tenured)

External Links

Other Affiliation 【 Display / hide

  • School of Medicine, 腎臓・内分泌・代謝内科

Career 【 Display / hide

  • 2010.04
    -
    2012.03

    慶應義塾大学大学院, 医学研究科, 研究奨励助教

  • 2012.04
    -
    2013.03

    慶應義塾大学 医学部, MSD抗加齢内分泌学寄付講座, 特任助教

  • 2013.04
    -
    2017.03

    慶應義塾大学 医学部, 内科学(腎臓内分泌代謝), 助教

  • 2017.04
    -
    2019.03

    東京大学医科学研究所, 感染・免疫部門 炎症免疫学分野, 客員研究員

  • 2017.04
    -
    Present

    慶応義塾大学, 保健管理センター, 助教

Academic Background 【 Display / hide

  • 2001.04
    -
    2007.03

    慶応義塾大学, 医学部

    University, Graduated

  • 2009.04
    -
    2012.03

    慶応義塾大学, 医学研究科, 内科学

    Graduate School, Graduated, Doctoral course

Academic Degrees 【 Display / hide

  • 医学博士, 慶應義塾大学大学院, Coursework, 2012.03

Licenses and Qualifications 【 Display / hide

  • 日本内科学会 認定医, 2010

  • 日本内科学会 総合内科専門医, 2013

  • 日本透析医学会 専門医, 2013

  • 日本腎臓学会 腎臓専門医, 2013

  • 日本高血圧学会 高血圧専門医, 2014

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Research Areas 【 Display / hide

  • Immunology

  • Kidney internal medicine

Research Keywords 【 Display / hide

  • ワクチン

  • 生活習慣病

  • 粘膜免疫

  • 腎病理

  • 高血圧

 

Books 【 Display / hide

  • Mucosal Vaccines: Innovation for Preventing Infectious Diseases, 2nd edition.

    Elsevier, 2020

    Scope: Plant-Based Mucosal Vaccine Delivery System,  Contact page: 357-370

  • Therapeutic Vaccines as Novel Immunotherapy

    Springer, 2019

    Scope: Immunotherapy for Obeisty,  Contact page: 33-44

  • 腎生検病理アトラス改訂版(尿細管・間質・血管病変の分類)

    AZEGAMI Tatsuhiko, 2017.08

  • 次世代アジュバント開発のためのメカニズム解析と安全性評価(鼻粘膜投与へのワクチン,アジュバントのターゲッティング)

    幸義和、畔上達彦、清野宏, シーエムシー出版, 2017.03

  • Molecular Vaccines (Vaccines for Hypertension and Atherosclerosis)

    Sasamura Hiroyuki, Azegami Tatsuhiko, Itoh Hiroshi, Springer, 2014

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Papers 【 Display / hide

  • Association of childhood anthropometric measurements and laboratory parameters with high blood pressure in young adults

    Azegami T., Uchida K., Arima F., Sato Y., Awazu M., Inokuchi M., Murai-Takeda A., Itoh H., Tokumura M., Mori M.

    Hypertension Research (Hypertension Research)   2021

    ISSN  09169636

     View Summary

    © 2021, The Author(s), under exclusive licence to The Japanese Society of Hypertension. Early intervention to manage high blood pressure (BP) in young adulthood is a promising approach for the prevention of future cardiovascular diseases. We aimed to examine the ability of childhood health information to predict the incidence of young adults with high BP. This cohort study included baseline clinical data of Japanese individuals aged 12–13 years. A total of 1129 participants were followed up for an average of 8.6 years. We examined the association of childhood variables consisting of body weight, body mass index, systolic BP, white blood cell count, red blood cell count, hemoglobin, hematocrit, platelet count, uric acid, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol with the development of high BP defined as ≥120/80 mmHg at 18–22 years old. At follow-up, the prevalence of high BP was 42.2% in men and 7.7% in women. Young men with high BP had childhood baseline characteristics that included higher body weight, body mass index, systolic BP, red blood cell count, hemoglobin, hematocrit, and uric acid than normotensive men. Young women with high BP had higher body weight, systolic BP, and uric acid at baseline. Multivariable logistic regression analysis revealed that a model including body weight, systolic BP, hematocrit, and uric acid had the highest predictive power (AUC 0.65 [95% CI, 0.62–0.69]) for men, and a model including body weight, systolic BP, and uric acid had the highest predictive power (AUC 0.70 [95% CI, 0.58–0.81]) for women. Comprehensive childhood health information contributes to the prediction of high BP in young adults.

  • Association of glomerular DNA damage and DNA methylation with one-year eGFR decline in IgA nephropathy

    Hayashi K., Hishikawa A., Hashiguchi A., Azegami T., Yoshimoto N., Nakamichi R., Tokuyama H., Itoh H.

    Scientific Reports (Scientific Reports)  10 ( 1 )  2020.12

     View Summary

    © 2020, The Author(s). Accumulation of DNA double-strand breaks (DSBs) is linked to aging and age-related diseases. We recently reported the possible association of DNA DSBs with altered DNA methylation in murine models of kidney disease. However, DSBs and DNA methylation in human kidneys was not adequately investigated. This study was a cross-sectional observational study to evaluate the glomerular DNA DSB marker γH2AX and phosphorylated Ataxia Telangiectasia Mutated (pATM), and the DNA methylation marker 5-methyl cytosine (5mC) by immunostaining, and investigated the association with pathological features and clinical parameters in 29 patients with IgA nephropathy. To evaluate podocyte DSBs, quantitative long-distance PCR of the nephrin gene using laser-microdissected glomerular samples and immunofluorescent double-staining with WT1 and γH2AX were performed. Glomerular γH2AX level was associated with glomerular DNA methylation level in IgA nephropathy. Podocytopathic features were associated with increased number of WT1(+)γH2AX(+) cells and reduced amount of PCR product of the nephrin gene, which indicate podocyte DNA DSBs. Glomerular γH2AX and 5mC levels were significantly associated with the slope of eGFR decline over one year in IgA nephropathy patients using multiple regression analysis adjusted for age, baseline eGFR, amount of proteinuria at biopsy and immunosuppressive therapy after biopsy. Glomerular γH2AX level was associated with DNA methylation level, both of which may be a good predictor of renal outcome in IgA nephropathy.

  • The distributions of hematologic and biochemical values in healthy high-school adolescents in Japan

    Azegami T., Nishimura T., Murai-Takeda A., Yamada-Goto N., Sato Y., Mori M.

    PLoS ONE (PLoS ONE)  15 ( 11 November )  2020.11

     View Summary

    © 2020 Azegami et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Laboratory tests of adolescents are often interpreted by using reference intervals derived from adults, even though these populations differ in their physical and physiologic characteristics and disease susceptibility. Therefore, to examine the distribution of laboratory values specific for adolescents, we analyzed hematologic and biochemical measurements obtained from 12,023 healthy Japanese adolescents (ages 15 through 18 years; male, 9165; female, 2858) during 2009 through 2018. Distributions were shown as medians with 95% (2.5th and 97.5th percentiles) of values and were compared with those from previous studies that examined similar Asian populations. There were some differences between hematologic parameters, serum creatinine and uric acid concentration, and lipid levels of Japanese adults and adolescents. In comparison with other Asian populations, the distributions of serum uric acid and high-density–lipoprotein cholesterol in the present study were slightly higher than those in the other studies. Although further research is need, the distributions of hematologic and biochemical tests in adolescents may have the potential to facilitate the early identification and management of disease in this population.

  • Immunotherapy for obesity

    Azegami T., Itoh H.

    Therapeutic Vaccines as Novel Immunotherapy: Biological and Clinical Concepts (Therapeutic Vaccines as Novel Immunotherapy: Biological and Clinical Concepts)     33 - 44 2020.01

    ISSN  9789813296275

     View Summary

    © Springer Nature Singapore Pte Ltd. 2019. Obesity prevalence continues to increase in both adults and children worldwide and greatly contributes to increased morbidity and mortality. Although there are some anti-obesity drugs globally available for clinical use, their inadequate effectiveness coupled with safety concerns sometimes discourage the widespread use of anti-obesity medication. Because of its prolonged therapeutic effect and low frequency of administration, a therapeutic vaccine may be an attractive strategy for the prevention and treatment of obesity. Over the last two decades, several attempts have been made to develop vaccines for the control of obesity. Animal studies have shown that vaccines targeting ghrelin, glucose-dependent insulinotropic polypeptide, adipocytes, somatostatin, and adenovirus 36 successfully led to a reduction in weight gain without serious adverse effects. This chapter provides an overview of recent progress toward a therapeutic vaccine against obesity.

  • Low birth weight is associated with decline in renal function in Japanese male and female adolescents

    Murai-Takeda A., Kanda T., Azegami T., Hirose H., Inokuchi M., Tokuyama H., Wakino S., Tokumura M., Kawabe H., Mori M., Itoh H.

    Clinical and Experimental Nephrology (Clinical and Experimental Nephrology)  23 ( 12 ) 1364 - 1372 2019.12

    ISSN  13421751

     View Summary

    © 2019, Japanese Society of Nephrology. Background: Low birth weight (LBW) is a risk factor for chronic kidney disease (CKD) in later life and is becoming increasingly common in developed countries, including Japan. Furthermore, a serial decrease in birth weight has been associated with an increasing prevalence of CKD stage 2 in male Japanese adolescents. Sex-specific differences affect CKD susceptibility, and the association between birth weight and CKD in women, has not been elucidated. In this study, we investigated the sex-specific effect of LBW on renal function. Methods: Annual cross-sectional data of 2417 Japanese adolescents (males 1736; females 681), aged 15–16 years, were evaluated over 8 years (2007–2014). Results: Over the study period, mean birth weights decreased significantly in males (p < 0.01) and females (p < 0.05). Furthermore, both sexes showed significant decrease in estimated glomerular filtration rates corresponding to the birth weight reduction. The prevalence of CKD stage 2 also increased in males (from 26.0 to 32.4%, p < 0.01) and females (from 6.3 to 18.5%, p < 0.05). The incidence of CKD stage 2 was significantly related to history of LBW (males: odds ratio 1.73; 95% confidence interval 1.06–2.80; p < 0.05; females: odds ratio 3.29; 95% confidence interval 1.25–8.02; p < 0.05). Conclusions: Our data revealed that renal function and birth weight have decreased over time, in healthy Japanese adolescents. In view of the recent declining trend demonstrated by birth weight in Japan, we speculate that the prevalence of CKD might increase in the future.

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Papers, etc., Registered in KOARA 【 Display / hide

Research Projects of Competitive Funds, etc. 【 Display / hide

  • 糖尿病性腎症に対する新規治療戦略の開発

    2018.04
    -
    2021.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 畔上 達彦, Grant-in-Aid for Early-Career Scientists , Principal Investigator

Awards 【 Display / hide

  • Asian-Pacific Society of Hypertension Young Investigator Fellowships

    2018.10

    Type of Award: Awards of International Conference, Council and Symposium

  • 第8回臨床医学研究塾 奨励賞

    2017.10, 第8回臨床医学研究塾

  • Premium Hypertension Conference 優秀演題賞

    2015.08, Premium Hypertension Conference

  • Asian-Pacific Society of Hypertension Young Investigator Fellowships

    2012.10, International Society of Hypertension

  • 東京高血圧研究会 優秀演題奨励賞

    2011.09, 東京高血圧研究会

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Courses Taught 【 Display / hide

  • MEDICINE IN MODERN SOCIETY 1

    2021

  • MEDICINE IN MODERN SOCIETY 2

    2020

  • MEDICINE IN MODERN SOCIETY 2

    2019

 

Memberships in Academic Societies 【 Display / hide

  • 日本内科学会

     
  • 日本腎臓学会

     
  • 日本高血圧学会

     
  • 日本透析医学会

     
  • 日本腎病理協会

     

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