Reviews, Commentaries, etc. - Hase, Koji

腸内細菌による粘膜バリア制御機構

古平陽太郎, 込山星河, 長谷耕二

炎症と免疫 32 ( 3 ) 207 - 211 2024.04

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work, Last author, Corresponding author

マルチオミクスによるIBDにおけるディスバイオーシスの理解

高橋大輔, 長谷耕二

実験医学 41 ( 15 ) 204 - 210 2023.09

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work, Last author, Corresponding author

腸内細菌と次世代の健康

鈴木功一郎, 長谷耕二

Medical Science Digest 49 ( 8 ) 397 - 400 2023.08

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work, Last author, Corresponding author

腸内細菌による発達期における免疫インプリンティング

鈴木功一郎, 長谷耕二

腸内細菌学雑誌 37 ( 3 ) 149 - 155 2023.07

Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Last author, Corresponding author

空気中の異物を体内に取り込む呼吸器M細胞の発見

河合真悟, 木村俊介, 長谷耕二

呼吸器内科 40 ( 6 ) 590 - 595 2021.12

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

Psychiatric disorder and intestinal microibota

長谷 耕二

実験医学 39 ( 9 ) 1349 - 1355 2021.06

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Single Work

OsteoprotegrinによるM細胞の自己調節は粘膜免疫応答と上皮バリア機構のバランスを制御する

木村俊介, 長谷耕二.

臨床免疫・アレルギー科 75 ( 2 ) 194 - 200 2021.02

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

自己免疫疾患における粘膜免疫系の関与：M細胞の潜在的役割

大谷佑貴, 木村俊介, 長谷耕二

臨床免疫・アレルギー科 75 ( 1 ) 1 - 8 2021.01

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

Adverse effects of methylmercury on gut bacteria and accelerated accumulation of mercury in organs due to disruption of gut microbiota

Seki N., Akiyama M., Yamakawa H., Hase K., Kumagai Y., Kim Y.G.

Journal of Toxicological Sciences (Journal of Toxicological Sciences)  46 ( 2 ) 91 - 97 2021

ISSN  18803989

　View Summary

Methylmercury (MeHg), an environmental electrophile, binds covalently to the cysteine residues of proteins in organs, altering protein function and causing cytotoxicity. MeHg has also been shown to alter the composition of gut microbes. The gut microbiota is a complex community, the distur-bance of which has been linked to the development of certain diseases. However, the relationship between MeHg and gut bacteria remains poorly understood. In this study, we showed that MeHg binds covalently to gut bacterial proteins via cysteine residues. We examined the effects of MeHg on the growth of select-ed Lactobacillus species, namely, L. reuteri, L. gasseri, L. casei, and L. acidophilus, that are frequent-ly either positively or negatively correlated with human diseases. The results revealed that MeHg inhibits the growth of Lactobacillus to varying degrees depending on the species. Furthermore, the growth of L. reuteri, which was inhibited by MeHg exposure, was restored by Na2 S2 treatment. By comparing mice with and without gut microbiota colonization, we found that gut bacteria contribute to the production of reactive sulfur species such as hydrogen sulfide and hydrogen persulfide in the gut. We also discovered that the removal of gut bacteria accelerated accumulation of mercury in the cerebellum, liver, and lungs of mice subsequent to MeHg exposure. These results accordingly indicate that MeHg is captured and inacti-vated by the hydrogen sulfide and hydrogen persulfide produced by intestinal microbes, thereby providing evidence for the role played by gut microbiota in reducing MeHg toxicity.

• Access to Document (DOI)

絶食―再摂食は免疫系細胞の動態と粘膜免疫応答に影響を及ぼす.

永井基慈, 土肥多惠子, 長谷耕二.

消化器病サイエンス 4 ( 1 ) 50 - 54 2020.03

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

絶食-再摂食によるパイエル板リンパ球動態と粘膜免疫応答の制御.

永井基慈, 長谷耕二.

実験医学 38   457 - 460 2020.01

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

Sox8はM細胞取り込み能獲得を促進し,離乳期の抗原特異的IgA産生に必須である.

木村俊介, 長谷耕二.

臨床免疫・アレルギー科  73 ( 1 ) 89 - 95 2020.01

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

炎症性腸疾患とエピゲノム

大貫公義、長谷耕二

遺伝子医学 10 ( 1 ) 37 - 41 2020.01

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

Editorial: Immunological Consequences of Antigen Sampling at Mucosal Surfaces

Mabbott N., Hase K.

Frontiers in Immunology (Frontiers in Immunology)  10 2019.11

• Access to Document (DOI)

Regulation of the autoimmune and allergic responses by short-chain fatty acids

Masato Hirota, Chiaki Yarimizu, Takahiro Yamada, Daisuke Takahashi, Koji Hase

Luminacoid Res. 23   11 - 20 2019.06

Article, review, commentary, editorial, etc. (scientific journal), Joint Work

DNAメチル化機構による腸管Tregの機能制御.

長谷耕二

医学のあゆみ 268   1145 - 1150 2019.03

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Single Work

腸内エコロジーを支える生物間代謝経路

山田恭央, 長谷 耕二

実験医学 36 ( 18 ) 3964 - 3069 2018.11

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

腸内エコロジーの破綻と炎症性腸疾患

長谷 耕二

実験医学 36 ( 18 ) 3054 - 3058 2018.11

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Single Work

M cell-dependent antigen uptake on follicle-associated epithelium for mucosal immune surveillance.

Nakamura Y, Kimura S, HASE K.

Inflamm Regen. 38   15 2018.09

Article, review, commentary, editorial, etc. (scientific journal), Joint Work

粘膜免疫組織としての小腸

長谷 耕二

消化器病サイエンス 2 ( 3 )  2018.09

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Single Work

粘膜面におけるバリア機能と免疫恒常性の維持に果たすM細胞の役割

石原成美, 小林伸英, 長谷 耕二

アレルギー 67 ( 3 ) 171 - 187 2018.05

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

粘膜面における多彩な抗原取り込み機構とその意義

小林伸英, 長谷 耕二

臨床免疫・アレルギー科 69 ( 5 ) 482 - 488 2018.05

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

マイクロバイオータとアレルギー

長谷 耕二

日本小児アレルギー学会誌 32   1 - 8 2018.03

Article, review, commentary, editorial, etc. (scientific journal), Single Work

マイクロバイオームと制御性T細胞

HASE Koji

Clinical Neuroscience 35 ( 11 ) 1288 - 1289 2017.11

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

腸内細菌由来の代謝物によるバリア修飾

HASE Koji

実験医学 35   96 - 100 2017.04

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Single Work

腸内細菌と疾患

HASE Koji

糖尿病 9   8 - 16 2017.04

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

宿主-腸内細菌叢相互作用

OHNO Hiroshi, HASE Koji

最新医学 72 ( 2 ) 288 2017.02

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

腸内細菌による免疫制御

HASE Koji

モダンメディア 63 ( 2 ) 36 - 41 2017.02

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Single Work

マイクロバイオームとアレルギー

YUN-GI Kim, HASE Koji

小児内科 48 ( 1 ) 33 - 37 2017.01

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

腸内細菌とアレルギーとのかかわり

長谷 耕二

実験医学 34   2996 - 3001 2016.11

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Single Work

食品-腸内細菌-宿主クロストークによる腸管免疫制御

青木亮, 長谷 耕二

実験医学 34   2553 - 2560 2016.09

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

腸内細菌による免疫修飾作用

長谷 耕二

最新医学 71   1782 - 1785 2016.09

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Single Work

Fine-tuning of the mucosal barrier and metabolic systems using the diet-microbial metabolite axis.

Nagai M, Obata Y, Takahashi D, Hase K.

Int. Immunopharmacol. 37   79 - 86 2016.08

Article, review, commentary, editorial, etc. (scientific journal), Joint Work

短鎖脂肪酸による免疫・代謝制御

高橋大輔, 長谷 耕二

血管医学 17 2016.08

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

The diet-microbiota-metabolite axis regulates the host physiology.

Yamada T, Takahashi D, HASE Koji

J. Biochem. 160   1 - 10 2016.07

Article, review, commentary, editorial, etc. (scientific journal), Joint Work

Intestinal microbiota-derived short chain fatty acids regulate the immune system through epigenetic modifications

磯部順哉, 長谷 耕二

化学療法の領域 32 ( 2 ) 231 - 236 2016.02

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

自己免疫疾患・アレルギー疾患

長谷 耕二

医学のあゆみ 255   703 - 709 2015.11

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Single Work

腸管細菌と免疫系：新たな世界

HASE Kouji

血管医学 16 ( 3 ) 9 - 16 2015.10

Article, review, commentary, editorial, etc. (scientific journal), Single Work

腸内細菌と宿主免疫系の相互作用

中村篤央, 長谷 耕二

Pharma Medica 33 ( 10 ) 9 - 14 2015.10

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Single Work

T細胞と自然リンパ球の協調による感染防御機構

中村有孝, 長谷 耕二

実験医学 33   2771 - 2777 2015.10

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

ヒトの健康と疾患を制御する腸内微生物叢

HASE Kouji

ファルマシア 51 ( 8 ) 750 - 754 2015.08

Article, review, commentary, editorial, etc. (other), Single Work

Molecular machinery of Treg induction by intestinal microbiota

長谷 耕二, 尾畑佑樹, 古澤之裕

医学のあゆみ 253 ( 5 ) 387 - 391 2015.05

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Single Work

Regulation of host immunity and metabolism by intestinal microbiota

HASE Kouji

Foods & Food Ingredients Journal of Japan 220 ( 2 ) 132 - 138 2015.05

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Single Work

Commensal microbiota-derived signals regulate host immune system epigenetics. Inflammation and Regeneration

Takahashi D and Hase K.

Inflammation and Regeneration 35   129 - 136 2015.05

Article, review, commentary, editorial, etc. (scientific journal), Joint Work

Uhrf1による腸内細菌とT細胞制御

尾畑佑樹, 長谷 耕二

炎症と免疫 23   217 - 221 2015.04

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

Epigenetic regulator Uhrf1 secures homeostasis of regulatory T cells in the colon

HASE Kouji

臨床免疫・アレルギー科 63 ( 4 ) 323 - 327 2015.04

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

腸内細菌による炎症および糖・エネルギー代謝の制御

HASE Kouji

BioClinica 4 ( 1 ) 20 - 24 2015.03

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Single Work

Gut microbiota-dependent regulation of mucosal barrier funcitons

Yuuki Obata, HASE Kouji

実験医学 33 ( 4 ) 550 - 556 2015.03

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

Epigenetic modifications of the immune system in health and disease.

Obata Y, Furusawa Y, Hase K.

Immunol. Cell Biol. 93   226 - 232 2015.02

Article, review, commentary, editorial, etc. (scientific journal), Joint Work

腸内細菌由来代謝物による免疫エピゲノム制御

Yukihiro Furusawa, Yuuki, Obata, Koji Hase

細胞 47 ( 2 ) 53 - 56 2015.02

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

Mucosal Barriology: The molecular machinery and physiological significance of multiple epithelial barriers.

Obata Y and Hase K

Inflammation and Regeneration 35   3 - 13 2015.01

Article, review, commentary, editorial, etc. (scientific journal), Joint Work

Commensal microbiota regulates T cell fate decision in the gut

Furusawa Y, Obata Y, Hase K.

Semin. Immunopathol. 37   17 - 25 2015.01

Article, review, commentary, editorial, etc. (scientific journal), Joint Work

共生細菌によるエピゲノム修飾変化を介した免疫調節機構

長谷 耕二, 尾畑佑樹, 古澤之裕

感染・炎症・免疫 44 ( 3 ) 218 - 228 2014.10

Article, review, commentary, editorial, etc. (other), Joint Work

エピゲノム調節因子Uhrf1は大腸制御性T細胞の増殖および機能的成熟を保証する

長谷 耕二, 尾畑佑樹

分子消化器病 11 ( 3 ) 302 - 305 2014.09

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

粘膜面におけるバリア制御と慢性腸疾患

尾畑佑樹, 中村有考, 古澤之裕, 長谷 耕二

炎症と免疫 22 ( 4 ) 234 - 239 2014.06

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

腸内細菌由来の代謝物によるバリア修飾

HASE Koji

実験医学 35   95 - 100 2014.04

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)