Reviews, Commentaries, etc. - Hase, Koji

腸内細菌による粘膜バリア制御機構

古平陽太郎, 込山星河, 長谷耕二

炎症と免疫 32 ( 3 ) 207 - 211 2024.04

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work, Last author, Corresponding author

マルチオミクスによるIBDにおけるディスバイオーシスの理解

高橋大輔, 長谷耕二

実験医学 41 ( 15 ) 204 - 210 2023.09

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work, Last author, Corresponding author

腸内細菌と次世代の健康

鈴木功一郎, 長谷耕二

Medical Science Digest 49 ( 8 ) 397 - 400 2023.08

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work, Last author, Corresponding author

腸内細菌による発達期における免疫インプリンティング

鈴木功一郎, 長谷耕二

腸内細菌学雑誌 37 ( 3 ) 149 - 155 2023.07

Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Last author, Corresponding author

空気中の異物を体内に取り込む呼吸器M細胞の発見

河合真悟, 木村俊介, 長谷耕二

呼吸器内科 40 ( 6 ) 590 - 595 2021.12

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

Psychiatric disorder and intestinal microibota

長谷 耕二

実験医学 39 ( 9 ) 1349 - 1355 2021.06

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Single Work

OsteoprotegrinによるM細胞の自己調節は粘膜免疫応答と上皮バリア機構のバランスを制御する

木村俊介, 長谷耕二.

臨床免疫・アレルギー科 75 ( 2 ) 194 - 200 2021.02

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

自己免疫疾患における粘膜免疫系の関与：M細胞の潜在的役割

大谷佑貴, 木村俊介, 長谷耕二

臨床免疫・アレルギー科 75 ( 1 ) 1 - 8 2021.01

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

Adverse effects of methylmercury on gut bacteria and accelerated accumulation of mercury in organs due to disruption of gut microbiota

Seki N., Akiyama M., Yamakawa H., Hase K., Kumagai Y., Kim Y.G.

Journal of Toxicological Sciences (Journal of Toxicological Sciences)  46 ( 2 ) 91 - 97 2021

ISSN  18803989

　View Summary

Methylmercury (MeHg), an environmental electrophile, binds covalently to the cysteine residues of proteins in organs, altering protein function and causing cytotoxicity. MeHg has also been shown to alter the composition of gut microbes. The gut microbiota is a complex community, the distur-bance of which has been linked to the development of certain diseases. However, the relationship between MeHg and gut bacteria remains poorly understood. In this study, we showed that MeHg binds covalently to gut bacterial proteins via cysteine residues. We examined the effects of MeHg on the growth of select-ed Lactobacillus species, namely, L. reuteri, L. gasseri, L. casei, and L. acidophilus, that are frequent-ly either positively or negatively correlated with human diseases. The results revealed that MeHg inhibits the growth of Lactobacillus to varying degrees depending on the species. Furthermore, the growth of L. reuteri, which was inhibited by MeHg exposure, was restored by Na2 S2 treatment. By comparing mice with and without gut microbiota colonization, we found that gut bacteria contribute to the production of reactive sulfur species such as hydrogen sulfide and hydrogen persulfide in the gut. We also discovered that the removal of gut bacteria accelerated accumulation of mercury in the cerebellum, liver, and lungs of mice subsequent to MeHg exposure. These results accordingly indicate that MeHg is captured and inacti-vated by the hydrogen sulfide and hydrogen persulfide produced by intestinal microbes, thereby providing evidence for the role played by gut microbiota in reducing MeHg toxicity.

• Access to Document (DOI)

絶食―再摂食は免疫系細胞の動態と粘膜免疫応答に影響を及ぼす.

永井基慈, 土肥多惠子, 長谷耕二.

消化器病サイエンス 4 ( 1 ) 50 - 54 2020.03

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

絶食-再摂食によるパイエル板リンパ球動態と粘膜免疫応答の制御.

永井基慈, 長谷耕二.

実験医学 38   457 - 460 2020.01

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

Sox8はM細胞取り込み能獲得を促進し,離乳期の抗原特異的IgA産生に必須である.

木村俊介, 長谷耕二.

臨床免疫・アレルギー科  73 ( 1 ) 89 - 95 2020.01

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

炎症性腸疾患とエピゲノム

大貫公義、長谷耕二

遺伝子医学 10 ( 1 ) 37 - 41 2020.01

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

Editorial: Immunological Consequences of Antigen Sampling at Mucosal Surfaces

Mabbott N., Hase K.

Frontiers in Immunology (Frontiers in Immunology)  10 2019.11

• Access to Document (DOI)

Regulation of the autoimmune and allergic responses by short-chain fatty acids

Masato Hirota, Chiaki Yarimizu, Takahiro Yamada, Daisuke Takahashi, Koji Hase

Luminacoid Res. 23   11 - 20 2019.06

Article, review, commentary, editorial, etc. (scientific journal), Joint Work

DNAメチル化機構による腸管Tregの機能制御.

長谷耕二

医学のあゆみ 268   1145 - 1150 2019.03

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Single Work

腸内エコロジーを支える生物間代謝経路

山田恭央, 長谷 耕二

実験医学 36 ( 18 ) 3964 - 3069 2018.11

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

腸内エコロジーの破綻と炎症性腸疾患

長谷 耕二

実験医学 36 ( 18 ) 3054 - 3058 2018.11

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Single Work

M cell-dependent antigen uptake on follicle-associated epithelium for mucosal immune surveillance.

Nakamura Y, Kimura S, HASE K.

Inflamm Regen. 38   15 2018.09

Article, review, commentary, editorial, etc. (scientific journal), Joint Work

粘膜免疫組織としての小腸

長谷 耕二

消化器病サイエンス 2 ( 3 )  2018.09

Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Single Work