Takahashi, Daisuke

写真a

Affiliation

Faculty of Pharmacy, Department of Pharmaceutical Sciences 生化学講座 (Shiba-Kyoritsu)

Position

Assistant Professor/Senior Assistant Professor

External Links

Career 【 Display / hide

  • 2008.04
    -
    2012.03

    RIKEN RCAI

  • 2012.04
    -
    2015.03

    La Jolla Institute for Allergy & Immunology

Academic Degrees 【 Display / hide

  • Ph.D., Yokohama City University, Coursework, 2011.11

 

Research Areas 【 Display / hide

  • Immunology

Research Keywords 【 Display / hide

  • Treg

  • Mucosal Immunology

  • IEC

  • IEL

  • Butyric acid

Research Themes 【 Display / hide

  • Analysis of the Interaction between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs), 

    2015.04
    -
    Present

  • Examination of the mechanism that communal bacteria derived SCFAs ameliorate rheumatoid arthritis., 

    2015.04
    -
    Present

 

Papers 【 Display / hide

  • Polyamines polarized Th2/Th9 cell-fate decision by regulating GATA3 expression

    Atsuo Nakamura, Daisuke Takahashi, Yutaka Nakamura, Takahiro Yamada, Mitsuharu Matsumoto, Koji Hase,

    Arch Biochem Biophys  693   108587 2020.10

    Research paper (scientific journal), Joint Work, Accepted

  • Epithelial HVEM promotes basement membrane synthesis and intraepithelial T cell survival and migration

    Daisuke Takahashi, Qingyang Wang, Goo-Young Seo, Jr-wen Shui, Zbigniew Mikulski, Paola Marcovecchio, Masumi Takahashi, Charles D. Surh, Hilde Cheroutre, Mitchell Kronenberg

    bioRxiv  2020.10

    Research paper (scientific journal), Joint Work

  • Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells

     2020.08

    Research paper (scientific journal), Joint Work, Accepted

  • Microfold cell-dependent antigen transport alleviates infectious colitis by inducing antigen-specific cellular immunity.

    Nakamura Y, Mimuro H, Kunisawa J, Furusawa Y, Takahashi D, Fujimura Y, Kaisho T, Kiyono H, Hase K

    Mucosal immunology 13 ( 4 ) 679 - 690 2020.07

    Research paper (scientific journal), Accepted,  ISSN  1933-0219

  • Commensal-bacteria-derived butyrate promotes the T-cell-independent IgA response in the colon

    Junya Isobe, Shintarou Maeda, Yuuki Obata, Keito Iizuka, Yutaka Nakamura, Yumiko Fujimura, Tatsuki Kimizuka, Kouya Hattori, Yun-Gi Kim, Tatsuya Morita, Ikuo Kimura, Stefan Offermanns, Takahiro Adachi, Atsuhito Nakao, Hiroshi Kiyono, Daisuke Takahashi (*equal correspondance), Koji Hase*;

    International Immunology (Oxford University Press)  32 ( 4 ) 243 - 258 2019.12

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  0953-8178

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • The Roles of Peyer's Patches and Microfold Cells in the Gut Immune System: Relevance to Autoimmune Diseases

    Nobuhide Kobayashi*, Daisuke Takahashi* (*equal contribution), Shunsuke Takano, Shunsuke Kimura and Koji Hase

    frontiers in Immunology (Frontiers Media S.A.)   2019.12

    Introduction and explanation (scientific journal)

  • 自己免疫疾患の発症を制御する短鎖脂肪酸

    長谷 耕二、髙橋 大輔

    腸内細菌-宿主のクロストークと食事要因 (建帛社)     191 - 200 2019.05

    Introduction and explanation (commerce magazine), Joint Work

  • 腸管免疫学研究のフロントライン

    松本 龍太郎, 髙橋 大輔, 長谷 耕二

    免疫・炎症病態×治療 Update (南山堂)     192 - 199 2019.05

    Introduction and explanation (commerce magazine)

  • 腸内細菌と自己免疫疾患

    髙橋 大輔、長谷 耕二

    実験医学増刊 腸内細菌叢 健康と疾患を制御するエコシステム 137   91 - 96 2019.02

    Joint Work

  • 短鎖脂肪酸による免疫・代謝制御

    髙橋 大輔長谷 耕二

    血管医学 17 2016.10

    Introduction and explanation (commerce magazine), Joint Work

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Presentations 【 Display / hide

  • Microbial fermentation product butyrate Ameliorates Autoimmune Arthritis.

    Daisuke Takahashi, Trevor Lockett, Julie M Clarke, David L Topping, Koji Hase

    The 46th Annual Meeting of The Japanese Society for Immunology, 2017.12, Oral Presentation(general)

  • 腸内細菌代謝物の酪酸によるIgA産生細胞誘導機構の解明

    髙橋 大輔長谷 耕二

    第46回日本腎臓学会西部学術大会, 2016.10, Oral Presentation(guest/special)

  • The microbial metabolite butyrate attenuates autoimmune arthritis in mice.

    Takahashi DaisukeHase Koji

    フォーラム2016 衛生薬学・環境トキシコロジー, 2016.09, Oral Presentation(guest/special)

  • Microbial fermentation product butyrate Ameliorates Autoimmune Arthritis.

    Takahashi Daisuke

    International Congress of Immunology 2016 (ICI2016) (Australia Melbourne) , 2016.08, Poster (general)

  • 「腸内細菌由来の酪酸を介した免疫システムの制御」 第89回 日本細菌学会総会 2016.3.23

    Takahashi Daisuke

    第89回 日本細菌学会総会, 2016.03, Oral Presentation(guest/special)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • ケミカルバイオロジーを利用した濾胞制御性T細胞分化機序の解明

    2020.04
    -
    2025.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 高橋 大輔, Grant-in-Aid for Scientific Research (C), Principal Investigator

  • 腸内細菌が産生する酪酸による関節リウマチ抑制メカニズムの解明

    2017.04
    -
    2020.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 高橋 大輔, Grant-in-Aid for Young Scientists (B), Principal Investigator

  • 腸内細菌由来の代謝物である酪酸による関節リウマチの炎症抑制メカニズムの解明

    2015.12
    -
    2016.11

    公益財団法人鈴木謙三記念医科学応用研究財団, 平成27年度調査研究助成金

  • 腸上皮と上皮間リンパ球の相互作用に基づく粘膜上皮層免疫システムの成立機構の解析

    2015.11
    -
    2017.03

    Grant-in-Aid for Scientific Research, Principal Investigator

  • 腸内細菌由来の酪酸による関節リウマチの炎症抑制メカニズムの解明

    2015.11
    -
    2016.10

    公益財団法人持田記念医学薬学振興財団, 平成27年度持田記念研究助成金申請書, Principal Investigator

 

Courses Taught 【 Display / hide

  • STUDY OF MAJOR FIELD: (BIOCHEMISTRY)

    2021

  • SPECIAL PRACTICE IN TISSUE CULTURE AND GENE TECHNOLOGY

    2021

  • SEMINAR: (BIOCHEMISTRY)

    2021

  • RESEARCH FOR BACHELOR'S THESIS 1

    2021

  • RESEARCH APPARATUS LABORATORY COURSE

    2021

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