KEIO RESEARCHERS INFORMATION SYSTEM

Career 【 Display / hide 】

Career 【 Display / hide 】

• 2008.04

  -

  2012.03

  RIKEN RCAI

• 2012.04

  -

  2015.03

  La Jolla Institute for Allergy & Immunology

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• Ph.D., Yokohama City University, Coursework, 2011.11

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Life Science / Cell biology (Intestinal epithelial cell)

• Life Science / Immunology (T lymphocyte)

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• Treg

• Mucosal Immunology

• IEC

• IEL

• Butyric acid

Research Themes 【 Display / hide 】

Research Themes 【 Display / hide 】

• Analysis of the Interaction between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs), 

  2015.04

  -

  Present

• Examination of the mechanism that communal bacteria derived SCFAs ameliorate rheumatoid arthritis., 

  2015.04

  -

  Present

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• M-cell-dependent commensal uptake confers encephalitogenic phenotypes on γδT17 cells in Peyer’s patches

  2. Komiyama S, Kodaira Y, Maeda R, Sugiura Y, Suzuki K, Saeki A, Kinashi Y, Oguchi H, Takano K, Onawa S, Matsui A, Sasaki E, Hattori-Muroi K, Kimura S, Fujimura Y, Ka Y, Ogura T, Hanaoka K, Ito M, Watarai H, Kaisho T, Udagawa N, Takahashi D, Hase K

   2026.01

  Research paper (scientific journal), Joint Work, Corresponding author, Accepted

  • Access to Document (DOI)

• Dietary soy shapes murine microbiota to consolidate the mucosal IgA response through T follicular helper cells.

  Hattori-Muroi K†, Maruta H†, Takahashi D†* (†equal contribution , *corresponding author), Kinashi Y, Hattori K, Kabumoto Y, Fujimura Y, Tsukamoto S, Suzuki K, Oguchi H, Ogihara Y, Kodaira Y, Hayashi E, Takano K, Komiyama S, Morita N, Naganawa-Asaoka H, Oya Y, Saito Y, Ohhashi W, Kimura S, Shinkura R, Matsuda T, Hase K.

  Immunity  2026

  Research paper (scientific journal), Lead author, Corresponding author, Accepted

• Identification and characterization of CXCL13 producers in bone tissue in response to fasting

  Takuma Okawa, Motoyoshi Nagai, Shinya Fujita, Koichiro Suzuki, Kazuaki Nakata, Reina Miyajima, Hiroaki Shiratori, Seiga Komiyama, Daisuke Takahashi, Yuki I. Kawamura, Taeko Dohi, Burkhard Ludewig, Keiyo Takubo, Koji Hase

  International Immunology  2026

  Research paper (scientific journal), Accepted

• AP-1B regulates interactions of epithelial cells and intraepithelial lymphocytes in the intestine

  Ryohtaroh Matsumoto, Kosuke Ogata, Daisuke Takahashi, Yusuke Kinashi, Takahiro Yamada, Ryo Morita, Keisuke Tanaka, Kouya Hattori, Mayumi Endo, Yumiko Fujimura, Nobuo Sasaki, Hiroshi Ohno, Yasushi Ishihama, Shunsuke Kimura, Koji Hase

  Cellular and Molecular Life Sciences (Springer Science and Business Media LLC)  81 ( 1 ) 425 2024.10

  Research paper (scientific journal), Joint Work, Accepted,  ISSN  1420-682X

  • Access to Document (DOI)

• T-cell immunosuppression in sepsis is augmented by sciatic denervation-induced skeletal muscle atrophy

  Osa S, Enoki Y, Takahashi D, Chuang VTG, Taguchi K, Matsumoto K.

   2024.08

  Research paper (scientific journal), Joint Work, Accepted

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• Soybean flour-derived factors enhance high-affinity IgA antibodies against commensal microbiota

  Takahashi, Daisuke

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2023

• Dietary factor-mediated enhancement of neutralizing antibody production against enterovirus in the intestinal tract

  Takahashi, Daisuke

  学事振興資金研究成果実績報告書 (慶應義塾大学)  2021

• Elucidation of follicular regulatory T cell differentiation mechanism using chemical biology

  Takahashi, Daisuke

  福澤諭吉記念慶應義塾学事振興基金事業報告集 (福澤基金運営委員会)  2021

• Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells

  Takahashi, Daisuke

  科学研究費補助金研究成果報告書 2020

• Study of IEC-IEL interaction in the development of gut epithelial immune system.

  Takahashi, Daisuke

  科学研究費補助金研究成果報告書 2016

Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• The Roles of Peyer's Patches and Microfold Cells in the Gut Immune System: Relevance to Autoimmune Diseases

  Nobuhide Kobayashi*, Daisuke Takahashi* (*equal contribution), Shunsuke Takano, Shunsuke Kimura and Koji Hase

  frontiers in Immunology (Frontiers Media S.A.)   2019.12

  Article, review, commentary, editorial, etc. (scientific journal)

  • Access to Document (DOI)

• 自己免疫疾患の発症を制御する短鎖脂肪酸

  長谷 耕二、髙橋 大輔

  腸内細菌-宿主のクロストークと食事要因 (建帛社)     191 - 200 2019.05

  Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

• 腸管免疫学研究のフロントライン

  松本 龍太郎, 髙橋 大輔, 長谷 耕二

  免疫・炎症病態×治療 Update (南山堂)     192 - 199 2019.05

  Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

• 腸内細菌と自己免疫疾患

  髙橋 大輔、長谷 耕二

  実験医学増刊 腸内細菌叢 健康と疾患を制御するエコシステム 137   91 - 96 2019.02

  Joint Work

• 短鎖脂肪酸による免疫・代謝制御

  髙橋 大輔長谷 耕二

  血管医学 17 2016.10

  Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

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Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• Microbial fermentation product butyrate Ameliorates Autoimmune Arthritis.

  Daisuke Takahashi, Trevor Lockett, Julie M Clarke, David L Topping, Koji Hase

  [Domestic presentation]  The 46th Annual Meeting of The Japanese Society for Immunology, 

  2017.12

  , 

  Oral presentation (general)

• 腸内細菌代謝物の酪酸によるIgA産生細胞誘導機構の解明

  髙橋 大輔長谷 耕二

  第46回日本腎臓学会西部学術大会, 

  2016.10

  , 

  Oral presentation (invited, special)

• The microbial metabolite butyrate attenuates autoimmune arthritis in mice.

  Takahashi DaisukeHase Koji

  フォーラム2016 衛生薬学・環境トキシコロジー, 

  2016.09

  , 

  Oral presentation (invited, special)

• Microbial fermentation product butyrate Ameliorates Autoimmune Arthritis.

  Takahashi Daisuke

  [International presentation]  International Congress of Immunology 2016 (ICI2016) (Australia Melbourne) , 

  2016.08

  , 

  Poster presentation

• 「腸内細菌由来の酪酸を介した免疫システムの制御」 第89回 日本細菌学会総会 2016.3.23

  Takahashi Daisuke

  [Domestic presentation]  第89回 日本細菌学会総会, 

  2016.03

  , 

  Oral presentation (invited, special)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• Induction of follicular helper T cells and IgA production and enhancement of anti-tumor immune response by intestinal bacteria

  2025.04

  -

  2028.03

  基盤研究(B), Principal investigator

• Elucidation of the effect of gdT cells recognizing intestinal bacteria as self in host-commensal symbiosis

  2025.04

  -

  2027.03

  学術変革領域研究(A), Principal investigator

• 腸内細菌を自己として認識するγδT17細胞による宿主-腸内細菌共生関係構築

  2023.04

  -

  2025.03

  2023年度 学術変革領域研究(A) (公募研究), Research grant, Principal investigator

• ケミカルバイオロジーを利用した濾胞制御性T細胞分化機序の解明

  2020.04

  -

  2025.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

• 腸内細菌が産生する酪酸による関節リウマチ抑制メカニズムの解明

  2017.04

  -

  2020.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Principal investigator

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Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• STUDY OF MAJOR FIELD: (BIOCHEMISTRY)

  2025

• SPECIAL PRACTICE IN TISSUE CULTURE AND GENE TECHNOLOGY

  2025

• SEMINAR: (BIOCHEMISTRY)

  2025

• RESEARCH FOR BACHELOR'S THESIS 1

  2025

• RESEARCH APPARATUS LABORATORY COURSE

  2025

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