KEIO RESEARCHERS INFORMATION SYSTEM

Career 【 Display / hide 】

Career 【 Display / hide 】

• 2008.04

  -

  2012.03

  RIKEN RCAI

• 2012.04

  -

  2015.03

  La Jolla Institute for Allergy & Immunology

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• Ph.D., Yokohama City University, Coursework, 2011.11

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Life Science / Cell biology (Intestinal epithelial cell)

• Life Science / Immunology (T lymphocyte)

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• Treg

• Mucosal Immunology

• IEC

• IEL

• Butyric acid

Research Themes 【 Display / hide 】

Research Themes 【 Display / hide 】

• Analysis of the Interaction between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs), 

  2015.04

  -

  Present

• Examination of the mechanism that communal bacteria derived SCFAs ameliorate rheumatoid arthritis., 

  2015.04

  -

  Present

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Safe and efficient oral allergy immunotherapy using one-pot-prepared mannan-coated allergen nanoparticles

  Biomaterials  2023.12

  Research paper (scientific journal), Joint Work, Accepted

  • Access to Document (DOI)

• α-Glucosidase inhibitors boost gut immunity by inducing IgA responses in Peyer’s patches

  Front Immunol.   2023.11

  Research paper (scientific journal), Joint Work, Corresponding author, Accepted

  • Access to Document (DOI)

• Gut microbiota-derived lipid metabolites facilitate regulatory T cell differentiation

  Sci Rep.  2023.06

  Research paper (scientific journal), Joint Work, Accepted

• Medium-chain fatty acids suppress lipotoxicity-induced hepatic fibrosis via the immunomodulating receptor GPR84

  Ryuji Ohue-Kitano, Hazuki Nonaka, Akari Nishida, Yuki Masujima, Daisuke Takahashi, Takako Ikeda, Akiharu Uwamizu, Miyako Tanaka, Motoyuki Kohjima, Miki Igarashi, Hironori Katoh, Tomohiro Tanaka, Asuka Inoue, Takayoshi Suganami, Koji Hase, Yoshihiro Ogawa, Junken Aoki, Ikuo Kimura

  JCI insight    e165469 2022.12

  Research paper (scientific journal), Joint Work, Accepted

• A Novel HDAC1-Selective Inhibitor Attenuates Autoimmune Arthritis by Inhibiting Inflammatory Cytokine Production

  Wei Zhe, Naomi Hoshina, Yukihiro Itoh, Toshifumi Tojo, Takayoshi Suzuki, Koji Hase, Daisuke Takahashi

  Biological and Pharmaceutical Bulletin 9 （ 1 ） 1364 - 1372 2022.09

  Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• Dietary factor-mediated enhancement of neutralizing antibody production against enterovirus in the intestinal tract

  Takahashi, Daisuke

  学事振興資金研究成果実績報告書 （慶應義塾大学)  2021

• Elucidation of follicular regulatory T cell differentiation mechanism using chemical biology

  Takahashi, Daisuke

  福澤諭吉記念慶應義塾学事振興基金事業報告集 （福澤基金運営委員会)  2021

• Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells

  Takahashi, Daisuke

  科学研究費補助金研究成果報告書 2020

• Study of IEC-IEL interaction in the development of gut epithelial immune system.

  Takahashi, Daisuke

  科学研究費補助金研究成果報告書 2016

Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• The Roles of Peyer's Patches and Microfold Cells in the Gut Immune System: Relevance to Autoimmune Diseases

  Nobuhide Kobayashi*, Daisuke Takahashi* (*equal contribution), Shunsuke Takano, Shunsuke Kimura and Koji Hase

  frontiers in Immunology (Frontiers Media S.A.)   2019.12

  Article, review, commentary, editorial, etc. (scientific journal)

  • Access to Document (DOI)

• 自己免疫疾患の発症を制御する短鎖脂肪酸

  長谷 耕二、髙橋 大輔

  腸内細菌-宿主のクロストークと食事要因 (建帛社)     191 - 200 2019.05

  Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

• 腸管免疫学研究のフロントライン

  松本 龍太郎, 髙橋 大輔, 長谷 耕二

  免疫・炎症病態×治療 Update (南山堂)     192 - 199 2019.05

  Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

• 腸内細菌と自己免疫疾患

  髙橋 大輔、長谷 耕二

  実験医学増刊 腸内細菌叢 健康と疾患を制御するエコシステム 137   91 - 96 2019.02

  Joint Work

• 短鎖脂肪酸による免疫・代謝制御

  髙橋 大輔長谷 耕二

  血管医学 17 2016.10

  Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media), Joint Work

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Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• Microbial fermentation product butyrate Ameliorates Autoimmune Arthritis.

  Daisuke Takahashi, Trevor Lockett, Julie M Clarke, David L Topping, Koji Hase

  The 46th Annual Meeting of The Japanese Society for Immunology, 

  2017.12

  , 

  Oral presentation (general)

• 腸内細菌代謝物の酪酸によるIgA産生細胞誘導機構の解明

  髙橋 大輔長谷 耕二

  第46回日本腎臓学会西部学術大会, 

  2016.10

  , 

  Oral presentation (invited, special)

• The microbial metabolite butyrate attenuates autoimmune arthritis in mice.

  Takahashi DaisukeHase Koji

  フォーラム2016 衛生薬学・環境トキシコロジー, 

  2016.09

  , 

  Oral presentation (invited, special)

• Microbial fermentation product butyrate Ameliorates Autoimmune Arthritis.

  Takahashi Daisuke

  International Congress of Immunology 2016 (ICI2016) (Australia Melbourne) , 

  2016.08

  , 

  Poster presentation

• 「腸内細菌由来の酪酸を介した免疫システムの制御」 第89回 日本細菌学会総会 2016.3.23

  Takahashi Daisuke

  第89回 日本細菌学会総会, 

  2016.03

  , 

  Oral presentation (invited, special)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• 腸内細菌を自己として認識するγδT17細胞による宿主-腸内細菌共生関係構築

  2023.04

  -

  2025.03

  2023年度 学術変革領域研究(A) (公募研究), Research grant, Principal investigator

• ケミカルバイオロジーを利用した濾胞制御性T細胞分化機序の解明

  2020.04

  -

  2025.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

• 腸内細菌が産生する酪酸による関節リウマチ抑制メカニズムの解明

  2017.04

  -

  2020.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Principal investigator

• 腸上皮と上皮間リンパ球の相互作用に基づく粘膜上皮層免疫システムの成立機構の解析

  2015.11

  -

  2017.03

  Grant-in-Aid for Scientific Research, Principal investigator

Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• ENGLISH EXERCISES FOR PHARMACEUTICAL SCIENCES

  2024

• EARLY EXPOSURE TO INDUSTRY

  2024

• DATA SCIENCE AND BIOINFORMATICS

  2024

• BIOCHEMISTRY AND IMMUNOLOGY LABORATORY COURSE

  2024

• BIOCHEMISTRY

  2024

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