Papers - OHE Tomoyuki

Pharmacokinetic and pharmacodynamic properties of the glucokinase activator MK-0941 in rodent models of type 2 diabetes and healthy dogs.

Eiki J, Nagata Y, Futamura M, Sasaki-Yamamoto K, Iino T, Nishimura T, Chiba M, Ohyama S, Yoshida-Yoshimioto R, Fujii K, Hosaka H, Goto-Shimazaki H, Kadotani A, Ohe T, Lin S, Langdon RB, Berger JP.

Mol Pharmacol 80   1156-1165 2011.12

Research paper (scientific journal), Joint Work, Accepted

Discovery and characterization of a novel potent, selective and orally active inhibitor for mammalian ELOVL6.

Shimamura K, Nagumo A, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Morita N, Ohe T, Takahashi T, Nagase T, Sato N, Tokita S.

Eur J Pharmacol 25   34-41 2010.03

Research paper (scientific journal), Joint Work, Accepted

A trapping method for semi-quantitative assessment of reactive metabolite formation using [35S]cysteine and [14C]cyanide.

Inoue K, Shibata Y, Takahashi H, Ohe T, Chiba M, Ishii Y.

Drug Metab Pharmacokinet 24   245-254 2009.10

Research paper (scientific journal), Joint Work, Accepted

Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist.

Haga Y, Sakamoto T, Shibata T, Nonoshita K, Ishikawa M, Suga T, Takahashi H, Takahashi T, Takahashi H, Ando M, Murai T, Gomori A, Oda Z, Kitazawa H, Mitobe Y, Kanesaka M, Ohe T, Iwaasa H, Ishii Y, Ishihara A, Kanatani A, Fukami T.

Bioorg Med Chem 17   6971-6982 2009.09

Research paper (scientific journal), Joint Work, Accepted

Identification of positron emission tomography ligands for NPY Y5 receptors in the brain.

Takahashi H, Haga Y, Shibata T, Nonoshita K, Sakamoto T, Moriya M, Ohe T, Chiba M, Mitobe Y, Kitazawa H, Iwaasa H, Ishihara A, Ishii Y, Kanatani A, Fukami T.

Bioorg Med Chem Lett 19   5436-5439 2009.09

Research paper (scientific journal), Joint Work, Accepted

Aromatic substitution reaction of 2-chloropyridines catalyzed by microsomal glutathione S-transferase 1.

Inoue K, Ohe T, Mori K, Sagara T, Ishii Y, Chiba M.

Drug Metab Dispos 37   1797-1800 2009.09

Research paper (scientific journal), Joint Work, Accepted

Discovery of pyridone-containing imidazolines as potent and selective inhibitors of neuropeptide Y Y5 receptor.

Ando M, Sato N, Nagase T, Nagai K, Ishikawa S, Takahashi H, Ohtake N, Ito J, Hirayama M, Mitobe Y, Iwaasa H, Gomori A, Matsushita H, Tadano K, Fujino N, Tanaka S, Ohe T, Ishihara A, Kanatani A, Fukami T.

Bioorg Med Chem 17   6106-6122 2009.08

Research paper (scientific journal), Joint Work, Accepted

Aryl urea derivatives of spiropiperidines as NPY Y5 receptor antagonists.

Takahashi T, Haga Y, Sakamoto T, Moriya M, Okamoto O, Nonoshita K, Shibata T, Suga T, Takahashi H, Hirohashi T, Sakuraba A, Gomori A, Iwaasa H, Ohe T, Ishihara A, Ishii Y, Kanatani A, Fukami T.

Bioorg Med Chem Lett 19   3511-3516 2009.07

Research paper (scientific journal), Joint Work, Accepted

5,5-Dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione, a potent inhibitor for mammalian elongase of long-chain fatty acids family 6:

Shimamura K, Kitazawa H, Miyamoto Y, Kanesaka M, Nagumo A, Yoshimoto R, Aragane K, Morita N, Ohe T, Takahashi T, Nagase T, Sato N, Tokita S.

J Pharmacol Exp Ther 330   249-256 2009.07

Research paper (scientific journal), Joint Work, Accepted

Discovery of tetrasubstituted imidazolines as potent and selective neuropeptide Y Y5 receptor antagonists: reduced human ether-a-go-go related gene potassium channel binding affinity and potent antiobesity effect.

Sato N, Ando M, Ishikawa S, Jitsuoka M, Nagai K, Takahashi H, Sakuraba A, Tsuge H, Kitazawa H, Iwaasa H, Mashiko S, Gomori A, Moriya R, Fujino N, Ohe T, Ishihara A, Kanatani A, Fukami T.

J Med Chem 52   3385-3392 2009.05

Research paper (scientific journal), Joint Work, Accepted

Design, syntheses, and structure-activity relationships of novel NPY Y5 receptor antagonists: 2-{3-Oxospiro[isobenzofuran-1(3H),4'-piperidin]-1'-yl}benzimidazole derivatives.

Ogino Y, Ohtake N, Nagae Y, Matsuda K, Moriya M, Suga T, Ishikawa M, Kanesaka M, Mitobe Y, Ito J, Kanno T, Ishihara A, Iwaasa H, Ohe T, Kanatani A, Fukami T.

Bioorg Med Chem Lett 18   5010-5014 2008.09

Research paper (scientific journal), Joint Work, Accepted

Syntheses and structure-activity relationships of novel, potent, and selective trans-2-[3-oxospiro[isobenzofuran-1(3H),1'-cyclohexan]-4'-yl]benzimidazole NPY Y5 receptor antagonists.

Ogino Y, Ohtake N, Nagae Y, Matsuda K, Ishikawa M, Moriya M, Kanesaka M, Mitobe Y, Ito J, Kanno T, Ishihara A, Iwaasa H, Ohe T, Kanatani A, Fukami T.

Bioorg Med Chem Lett 18   4997-5001 2008.09

Research paper (scientific journal), Joint Work, Accepted

(9S)-9-(2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one, a selective and orally active neuropeptide Y Y5 receptor antagonist.

Sato N, Jitsuoka M, Shibata T, Hirohashi T, Nonoshita K, Moriya M, Haga Y, Sakuraba A, Ando M, Ohe T, Iwaasa H, Gomori A, Ishihara A, Kanatani A, Fukami T.

J Med Chem 51   4765-4770 2008.08

Research paper (scientific journal), Joint Work, Accepted

A neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice.

Ishihara A, Kanatani A, Mashiko S, Tanaka T, Hidaka M, Gomori A, Iwaasa H, Murai N, Egashira S, Murai T, Mitobe Y, Matsushita H, Okamoto O, Sato N, Jitsuoka M, Fukuroda T, Ohe T, Guan X, MacNeil DJ, Van der Ploeg LH, Nishikibe M, Ishii Y, Ihara M, Fukami T.

Proc Natl Acad Sci U S A 103   7154-7158 2006.05

Research paper (scientific journal), Joint Work, Accepted

Effect of P-glycoprotein-mediated efflux on cerebrospinal fluid/plasma concentration ratio.

Ohe T, Sato M, Tanaka S, Fujino N, Hata M, Shibata Y, Kanatani A, Fukami T, Yamazaki M, Chiba M, Ishii Y.

Drug Metab Dispos 31   1251-1254 2003.10

Research paper (scientific journal), Joint Work, Accepted

Evaluation of drug interactions with P-glycoprotein in drug discovery: in vitro assessment of the potential for drug-drug interactions with P-glycoprotein.

Hochman JH, Yamazaki M, Ohe T, Lin JH.

Curr Drug Metab (Bentham Science Publishers )  3   257 - 273 2002.06

Research paper (scientific journal), Joint Work

In Vitro Identification Studies for P-Glycoprotein-Mediated Transport: Species Difference and Predictability of In Vivo Results.

M. Yamazaki, W. E. Neway, T. Ohe, I.-W. Chen, J. F. Rowe, J. H. Hochman, M. Chiba and J. H. Li

J. Pharmacol. Exp. Ther. 296   723 - 735 2001

Research paper (scientific journal), Joint Work, Accepted

A Typical Y1 Receptor Regulates Feeding Behaviors: Effects of a Potent and Selective Y1 Antagonist, J-115814

A. Kanatani, M. Hata, S. Mashiko, A. Ishihara, O. Okamoto, Y. Haga, T. Ohe, T. Kanno, N. Murai, Y. Ishii, T. Fukuroda, T. Fukami and M. Ihara

Mol. Pharmacol. 59   501 - 505 2001

Research paper (scientific journal), Joint Work, Accepted

Novel metabolic pathway of estrone and 17b-estradiol catalyzed by cytochrome P450.

Ohe T, Hirobe M, Mashino T.

Drug Metab Dispos 28   110-112 2000.01

Research paper (scientific journal), Joint Work, Accepted

Substituent Elimination from para-Substituted Phenols by Cytochrome P450: ipso-Substitution by the Oxygen Atom of the Active Species

T. Ohe, T. Mashino and M. Hirobe

Drug Metab Dispos 25   116 - 122 1997

Research paper (scientific journal), Joint Work, Accepted