Papers - OHE Tomoyuki
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Hit-to-Lead in Academia: Discovery of a Protein-Protein Interaction Inhibitor of Keap1-Nrf2
Daisuke Yasuda, Rika Obata, Kyoko Takahashi, Tomoyuki Ohe, Tadahiko Mashino
YAKUGAKU ZASSHI 138 ( 8 ) 1059 - 1065 2018.08
Research paper (scientific journal), Joint Work, Accepted
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Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor
Yasuda, D., Yuasa, A., Obata, R., Nakajima M., Takahashi, K., Ohe, T., Ichimura, Y., Komatsu, M., Yamamoto, M., Imamura, R., Kojima, H., Okabe, T., Nagano, T., and Mashino, T.
Bioorg Med Chem Lett 27 ( 22 ) 5006 - 5009 2017.11
Research paper (scientific journal), Joint Work, Accepted
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alpha-Tocopherol attenuates the anti-tumor activity of crizotinib against cells transformed by NPM-ALK
Uchihara Y, Ueda F, Tago K, Nakazawa Y, Ohe T, Mashino T, Yokota S, Kasahara T, Tamura H, and Funakoshi-Tago M
PLOS ONE 12 ( 8 ) e0183003 2017.08
Research paper (scientific journal), Joint Work, Accepted
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ヒトや野生生物における医薬品、環境化学物質の安全性評価の精度向上にむけて -代謝的活性化、種差、エピジェネティクスの観点から 肝毒性を示す医薬品の代謝活性化機構の解析とそれに基づいた創薬戦略
Ohe T., Takahashi K., Nakamura S., Mashino T.
YAKUGAKU ZASSHI 137 ( 3 ) 249 - 255 2017.03
Research paper (scientific journal), Joint Work, Accepted
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Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity
Yasuda, D., Nakajima, M., Yuasa, A., Obata, R., Takahashi, K., Ohe, T., Ichimura, Y., Komatsu, M., Yamamoto, M., Imamura, R., Kojima, H., Okabe, T., Nagano, T., and Mashino, T.
Bioorg Med Chem Lett 26 ( 24 ) 5956 - 5959 2016.12
Research paper (scientific journal), Joint Work, Accepted
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Preparation and antioxidant/pro-oxidant activities of 3-monosubstituted 5-hydroxyoxindole derivatives
Yasuda, D., Takahashi, K., Ohe, T., Nakamura, S., and Mashino, T.
J Clin Biochem Nutr 59 ( 3 ) 165 - 173 2016.11
Research paper (scientific journal), Joint Work, Accepted
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Potential suppressive effects of two C60-fullerene derivatives on acquired immunity
Toshiro Hirai, Yasuo Yoshioka, Asako Udaka, Eiichiro Uemura, Tomoyuki Ohe, Hisae Aoshima, Jian-Qing Gao, Ken Kokubo, Takumi Oshima, Kazuya Nagano, Kazuma Higashisaka, Tadahiko Mashino, Yasuo Tsutsumi
Nanoscale Research Letters 11 449 2016.10
Research paper (scientific journal), Joint Work, Accepted
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Novel fullerene derivatives as dual inhibitors of Hepatitis C virus NS5B polymerase and NS3/4A protease
Hiroki Kataoka, Tomoyuki Ohe, Kyoko Takahashi, Shigeo Nakamura, Tadahiko Mashino
Bioorg Med Chem Lett 26 4565 - 4567 2016.10
Research paper (scientific journal), Joint Work, Accepted
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p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
Saito T, Ichimura Y, Taguchi K, Suzuki T, Mizushima T, Takagi K, Hirose Y, Nagahashi M, Iso T, Fukutomi T, Ohishi M, Endo K, Uemura T, Nishito Y, Okuda S, Obata M, Kouno T, Imamura R, Tada Y, Obata R, Yasuda D, Takahashi K, Fujimura T, Pi J, Lee MS, Ueno T, Ohe T, Mashino T, Wakai T, Kojima H, Okabe T, Nagano T, Motohashi H, Waguri S, Soga T, Yamamoto M, Tanaka K, Komatsu M
Nature Communications 7 ( 12030 ) 1 - 16 2016.06
Research paper (scientific journal), Joint Work, Accepted
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A proline-type fullerene derivative inhibits adipogenesis by preventing PPARgamma activation
Megumi Funakoshi-Tagoa, Takahiro Hattori, Fumihito Ueda, Kenji Tago, Tomoyuki Ohe, Tadahiko Mashino, Hiroomi Tamura
Biochemistry and Biophysics Reports 20 ( 1 ) 258 - 263 2016.01
Research paper (scientific journal), Joint Work, Accepted
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Novel Bioactivation Pathway of Benzbromarone Mediated by Cytochrome P450
Yumina Kitagawara, Tomoyuki Ohe, Kumiko Tachibana, Kyoko Takahashi, Shigeo Nakamura, and Tadahiko Mashino
Drug Metab Dispos 43 1303 - 1306 2015.09
Research paper (scientific journal), Joint Work, Accepted
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The human immunodeficiency virus-reverse transcriptase inhibition activity of novel pyridine/pyridinium-type fullerene derivatives
Takumi Yasuno, Tomoyuki Ohe, Kyoko Takahashi, Shigeo Nakamura, Tadahiko Mashino
Bioorg Med Chem Lett 25 ( 16 ) 3226 - 3229 2015.08
Research paper (scientific journal), Joint Work, Accepted
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Blood-Brain Barrier Pharmacoproteomics-based Reconstruction of the In-Vivo Brain Distribution of P-glycoprotein Substrates in Cynomolgus Monkeys.
Uchida Y, Wakayama K, Ohtsuki S, Chiba M, Ohe T, Ishii Y, Terasaki T.
J Pharmacol Exp Ther 350 578-588 2014.09
Research paper (scientific journal), Joint Work, Accepted
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Pyrrolidinium fullerene induces apoptosis by activation of procaspase-9 via suppression of Akt in primary effusion lymphoma.
Watanabe T, Nakamura S, Ono T, Ui S, Yagi S, Kagawa H, Watanabe H, Ohe T, Mashino T, Fujimuro M.
Biochem Biophys Res Commun 451 93-100 2014.08
Research paper (scientific journal), Joint Work, Accepted
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Effect of chemical modification on the ability of pyrrolidinium fullerene to induce apoptosis of cells transformed by JAK2 V617F mutant.
Funakoshi-Tago M, Tsukada M, Watanabe T, Mameda Y, Tago K, Ohe T, Nakamura S, Mashino T, Kasahara T.
Int Immunopharmacol 20 258-263 2014.03
Research paper (scientific journal), Joint Work, Accepted
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Antioxidant activities of 5-hydroxyoxindole and its 3-hydroxy-3-phenacyl derivatives: The suppression of lipid peroxidation and intracellular oxidative stress.
Yasuda D, Takahashi K, Ohe T, Nakamura S, Mashino T.
Bioorg Med Chem 21 7709-7714 2013.12
Research paper (scientific journal), Joint Work, Accepted
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Synthesis, radical scavenging activity and structurer-activity relationship of uric acid analogs.
Yasuda D, Takahashi K, Kakinoki T, Tanaka Y, Ohe T, Nakamura S, Mashino T.
MedChemComm 4 527-529 2013.01
Research paper (scientific journal), Joint Work, Accepted
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A novel method for the determination of the site of glucuronidation by ion mobility spectrometry-mass spectrometry.
Shimizu A, Ohe T, Chiba M.
Drug Metab Dispos 40 1456-1459 2012.05
Research paper (scientific journal), Joint Work, Accepted
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Pharmacokinetic and pharmacodynamic properties of the glucokinase activator MK-0941 in rodent models of type 2 diabetes and healthy dogs.
Eiki J, Nagata Y, Futamura M, Sasaki-Yamamoto K, Iino T, Nishimura T, Chiba M, Ohyama S, Yoshida-Yoshimioto R, Fujii K, Hosaka H, Goto-Shimazaki H, Kadotani A, Ohe T, Lin S, Langdon RB, Berger JP.
Mol Pharmacol 80 1156-1165 2011.12
Research paper (scientific journal), Joint Work, Accepted
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Discovery and characterization of a novel potent, selective and orally active inhibitor for mammalian ELOVL6.
Shimamura K, Nagumo A, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Morita N, Ohe T, Takahashi T, Nagase T, Sato N, Tokita S.
Eur J Pharmacol 25 34-41 2010.03
Research paper (scientific journal), Joint Work, Accepted