Presentations -

How can we predict absorption in human? impact of drug transporters on intestinal absorption.

○T, Ohe, H, Sato.

[Domestic presentation]  Banyu Drug Metabolism and Pharmacokinetics Forum (Tsukuba) , 

2007.06

RNA Interference of Na+/taurocholate Co-transporting Polypeptide in Primary Cultured Rat Hepatocytes.

K, Wakayama, A, Nakajima, N, Morita, K, Imagaki, Y, Tamai, T, Ohe, M, Chiba, Y, Ishii.

[International presentation]  14th North American ISSX Meeting (Puerto Rico) , 

2006.10

RNA Interference of Na+/taurocholate Co-transporting Polypeptide in Primary Cultured Rat Hepatocytes.

K, Wakayama, A, Nakajima, N, Morita, K, Imagaki, Y, Tamai, T, Ohe, M, Chiba, Y, Ishii.

[Domestic presentation]  8th Seizai Forum (Kyoto) , 

2006.09

Involvement of P-Glycoprotein in the Intestinal Secretion.

○T, Ohe, N, Fujino, M, Sato, S, Tanaka, N, Morita, N, Takenaga, M, Chiba, Y, Ishii.

[International presentation]  13th North American ISSX Meeting/20th JSSX Meeting (Hawaii) , 

2005.10

Effect of P-Glycoprotein on CSF/Plasma Concentration Ratio.

○T, Ohe, M, Sato, S, Tanaka, N, Fujino, M, Hata, Y, Shibata, Y, Sawazaki, A, Kanatani, T, Fukami, M, Yamazaki, M, Chiba, Y, Ishii.

[Domestic presentation]  5th Seizai Forum (Tokyo) , 

2003.09

Effect of P-Glycoprotein on CSF/Plasma Concentration Ratio.

○T, Ohe, M, Sato, S, Tanaka, N, Fujino, M, Hata, Y, Shibata, Y, Sawazaki, A, Kanatani, T, Fukami, M, Yamazaki, M, Chiba, Y, Ishii.

[International presentation]  AAPS Annual Meeting (Toronto) , 

2002.11

Effect of P-Glycoprotein on CSF/Plasma Concentration Ratio.

○T, Ohe, M, Yamazaki, M, Sato, N, Fujino, M, Hata, Y, Shibata, Y, Sawazaki, T, Fukami, M, Chiba, Y, Ishii.

[International presentation]  6th International ISSX Meeting (Munich) , 

2001.10

Strategy for In Vitro Identification of Substrates/Inhibitors of P-Glycoprotein: A Case Study for a Carbapenem Antibiotic, MK-0826, with Poor Membrane Permeability.

○T, Ohe, M, Yamazaki, W, E, Neway, J, H, Hochman, Y, Ishii, M, Chiba, J, H, Lin.

[International presentation]  Pharmaceutical Sciences Millennial World Congress (San Francisco) , 

2000.04

Validation of In Vitro P-Glycoprotein Transport Substrate Identification Studies: Species Difference and Predictability of In Vitro Results.

M, Yamazaki, T, Ohe, W, E, Neway, I,-W, Chen, J, Rowe, Y, Ishii, J, H, Hochman, M, Chiba, J, H, Lin.

[International presentation]  Pharmaceutical Sciences Millennial World Congress (San Francisco) , 

2000.04

Difference in the Susceptibility as a Substrate of P-Glycoprotein Mediated Transport between Two Benzodiazepine derivatives, L-365260 and Diazepam

T. Ohe, M. Yamazaki, I.-W. Chen, J. Rowe, W. E. Neway, Y. Ishii, M. Chiba and J. H. Lin

[International presentation]  9th North American ISSX Meeting (Nashville, Tennessee) , 

1999.10

, 

Poster presentation

新規抗血小板薬NSP-513のヒト, ラットおよびイヌにおけるin vitro代謝 酸化開裂型代謝物の同定とヒトの代謝におけるCYP3A4の関与

石原 亜矢, 石井 康行, 柴田 芳宏, 大江 知之, 安盛 俊雄, 亀井 敏夫

[Domestic presentation]  第19回 日本臨床薬理学会, 

1998.11

, 

Oral presentation (general)

Novel Metabolic Reaction of Cytochrome P450 (TCDD Formation from Chlorophenols),

T. Mashino, M. Mochizuki, K. Watanabe, T. Ohe, T. Nagano and M. Hirobe

[Domestic presentation]  17th Symposium on Medicinal Chemistry and 6th Annual Meeting of Division Medicinal Chemistry, 

1997.11

, 

Poster presentation

シトクロムP450による新規代謝反応：クロロフェノールからのTCDD生成反応

渡辺健悟、長野哲雄、廣部雅昭、増野匡彦、大江知之

[Domestic presentation]  日本薬学会第117年会 (東京) , 

1997.03

, 

Oral presentation (general)

シトクロムP450による置換フェノール類のイプソ付加型新規代謝反応

大江知之、長野哲雄、廣部雅昭、増野匡彦

[Domestic presentation]  日本薬学会第117年会 (東京) , 

1997.03

シトクロムP450によるフェノール類のipso付加型新規代謝反応

大江知之、増野匡彦、廣部雅昭、長野哲雄

[Domestic presentation]  第16回メディシナルケミストリーシンポジウム/第5回医薬化学部会年会 (富山) , 

1996.11

, 

Poster presentation

シトクロムP450による新規代謝様式：パラ置換フェノール類における置換基脱離反応（イプソ置換反応）及び脱離機構の検討

大江知之、増野匡彦、廣部雅昭

[Domestic presentation]  日本薬学会第116年会 (金沢) , 

1996.03

, 

Oral presentation (general)

Novel Metabolic Pathway of para-Substituted Phenols by Cytochrome P450: ipso-Substitution by the Oxygen Atom of the Active Species in Chemical Cytochrome P450 Model and Cytochrome P450

Tomoyuki Ohe, Tadahiko Mashino, Masaaki Hirobe

[International presentation]  1995 International Chemical Congress of the Pacific Basin Societies (PACIFICHEM95) (Honolulu) , 

1995.12

, 

Poster presentation

Novel Metabolic Pathway of para-Substituted Phenols by Cytochrome P450: ipso-Substitution by the Oxygen Atom of the Active Species in Chemical Cytochrome P450 Model and Cytochrome P450

Tomoyuki Ohe, Tadahiko Mashino, Masaaki Hirobe

[International presentation]  AFMC International Medicinal Chemistry Symposium (AIMECS95) (Tokyo) , 

1995.09

, 

Oral presentation (general)

シトクロムP450による新規代謝様式：パラ置換フェノール類の置換基脱離反応

大江知之、増野匡彦、廣部雅昭

[Domestic presentation]  日本薬学会第115年会 (仙台) , 

1995.03

, 

Oral presentation (general)

シトクロムP450化学モデル及びシトクロムP450によるarylether類のipso置換を伴う芳香環-酸素結合の開裂反応

大江知之、増野匡彦、廣部雅昭

[Domestic presentation]  第9回生体関連化学シンポジウム (東京) , 

1994.05

, 

Oral presentation (general)