Presentations -

Discovery and optimization of imidazoline derivatives, a potent, orally active neuropeptide Y Y5 receptor antagonist.

M, Ando, N, Sato, S, Ishikawa, M, Jitsuoka, K, Nagai, T, Nagase, H, Takahashi, A, Sakuraba, H, Tsuge, M, Hirayama, J, Ito, H, Iwaasa, H, Natsushita, A, Gomori, S, Mashiko, A, Ishihara, N, Fujino, S, Tanaka, T, Ohe, K, Tadano, T, Fukuroda, Y, Ishii, A, Kanatani, T, Fukami.

[International presentation]  234th ACS National Meeting (Boston) , 

2007.08

How can we predict absorption in human? impact of drug transporters on intestinal absorption.

○T, Ohe, H, Sato.

[Domestic presentation]  Banyu Drug Metabolism and Pharmacokinetics Forum (Tsukuba) , 

2007.06

RNA Interference of Na+/taurocholate Co-transporting Polypeptide in Primary Cultured Rat Hepatocytes.

K, Wakayama, A, Nakajima, N, Morita, K, Imagaki, Y, Tamai, T, Ohe, M, Chiba, Y, Ishii.

[International presentation]  14th North American ISSX Meeting (Puerto Rico) , 

2006.10

RNA Interference of Na+/taurocholate Co-transporting Polypeptide in Primary Cultured Rat Hepatocytes.

K, Wakayama, A, Nakajima, N, Morita, K, Imagaki, Y, Tamai, T, Ohe, M, Chiba, Y, Ishii.

[Domestic presentation]  8th Seizai Forum (Kyoto) , 

2006.09

Involvement of P-Glycoprotein in the Intestinal Secretion.

○T, Ohe, N, Fujino, M, Sato, S, Tanaka, N, Morita, N, Takenaga, M, Chiba, Y, Ishii.

[International presentation]  13th North American ISSX Meeting/20th JSSX Meeting (Hawaii) , 

2005.10

Effect of P-Glycoprotein on CSF/Plasma Concentration Ratio.

○T, Ohe, M, Sato, S, Tanaka, N, Fujino, M, Hata, Y, Shibata, Y, Sawazaki, A, Kanatani, T, Fukami, M, Yamazaki, M, Chiba, Y, Ishii.

[Domestic presentation]  5th Seizai Forum (Tokyo) , 

2003.09

Effect of P-Glycoprotein on CSF/Plasma Concentration Ratio.

○T, Ohe, M, Sato, S, Tanaka, N, Fujino, M, Hata, Y, Shibata, Y, Sawazaki, A, Kanatani, T, Fukami, M, Yamazaki, M, Chiba, Y, Ishii.

[International presentation]  AAPS Annual Meeting (Toronto) , 

2002.11

Effect of P-Glycoprotein on CSF/Plasma Concentration Ratio.

○T, Ohe, M, Yamazaki, M, Sato, N, Fujino, M, Hata, Y, Shibata, Y, Sawazaki, T, Fukami, M, Chiba, Y, Ishii.

[International presentation]  6th International ISSX Meeting (Munich) , 

2001.10

Strategy for In Vitro Identification of Substrates/Inhibitors of P-Glycoprotein: A Case Study for a Carbapenem Antibiotic, MK-0826, with Poor Membrane Permeability.

○T, Ohe, M, Yamazaki, W, E, Neway, J, H, Hochman, Y, Ishii, M, Chiba, J, H, Lin.

[International presentation]  Pharmaceutical Sciences Millennial World Congress (San Francisco) , 

2000.04

Validation of In Vitro P-Glycoprotein Transport Substrate Identification Studies: Species Difference and Predictability of In Vitro Results.

M, Yamazaki, T, Ohe, W, E, Neway, I,-W, Chen, J, Rowe, Y, Ishii, J, H, Hochman, M, Chiba, J, H, Lin.

[International presentation]  Pharmaceutical Sciences Millennial World Congress (San Francisco) , 

2000.04

Difference in the Susceptibility as a Substrate of P-Glycoprotein Mediated Transport between Two Benzodiazepine derivatives, L-365260 and Diazepam

T. Ohe, M. Yamazaki, I.-W. Chen, J. Rowe, W. E. Neway, Y. Ishii, M. Chiba and J. H. Lin

[International presentation]  9th North American ISSX Meeting (Nashville, Tennessee) , 

1999.10

, 

Poster presentation

新規抗血小板薬NSP-513のヒト, ラットおよびイヌにおけるin vitro代謝 酸化開裂型代謝物の同定とヒトの代謝におけるCYP3A4の関与

石原 亜矢, 石井 康行, 柴田 芳宏, 大江 知之, 安盛 俊雄, 亀井 敏夫

[Domestic presentation]  第19回 日本臨床薬理学会, 

1998.11

, 

Oral presentation (general)

Novel Metabolic Reaction of Cytochrome P450 (TCDD Formation from Chlorophenols),

T. Mashino, M. Mochizuki, K. Watanabe, T. Ohe, T. Nagano and M. Hirobe

[Domestic presentation]  17th Symposium on Medicinal Chemistry and 6th Annual Meeting of Division Medicinal Chemistry, 

1997.11

, 

Poster presentation

シトクロムP450による新規代謝反応：クロロフェノールからのTCDD生成反応

渡辺健悟、長野哲雄、廣部雅昭、増野匡彦、大江知之

[Domestic presentation]  日本薬学会第117年会 (東京) , 

1997.03

, 

Oral presentation (general)

シトクロムP450による置換フェノール類のイプソ付加型新規代謝反応

大江知之、長野哲雄、廣部雅昭、増野匡彦

[Domestic presentation]  日本薬学会第117年会 (東京) , 

1997.03

シトクロムP450によるフェノール類のipso付加型新規代謝反応

大江知之、増野匡彦、廣部雅昭、長野哲雄

[Domestic presentation]  第16回メディシナルケミストリーシンポジウム/第5回医薬化学部会年会 (富山) , 

1996.11

, 

Poster presentation

シトクロムP450による新規代謝様式：パラ置換フェノール類における置換基脱離反応（イプソ置換反応）及び脱離機構の検討

大江知之、増野匡彦、廣部雅昭

[Domestic presentation]  日本薬学会第116年会 (金沢) , 

1996.03

, 

Oral presentation (general)

Novel Metabolic Pathway of para-Substituted Phenols by Cytochrome P450: ipso-Substitution by the Oxygen Atom of the Active Species in Chemical Cytochrome P450 Model and Cytochrome P450

Tomoyuki Ohe, Tadahiko Mashino, Masaaki Hirobe

[International presentation]  1995 International Chemical Congress of the Pacific Basin Societies (PACIFICHEM95) (Honolulu) , 

1995.12

, 

Poster presentation

Novel Metabolic Pathway of para-Substituted Phenols by Cytochrome P450: ipso-Substitution by the Oxygen Atom of the Active Species in Chemical Cytochrome P450 Model and Cytochrome P450

Tomoyuki Ohe, Tadahiko Mashino, Masaaki Hirobe

[International presentation]  AFMC International Medicinal Chemistry Symposium (AIMECS95) (Tokyo) , 

1995.09

, 

Oral presentation (general)

シトクロムP450による新規代謝様式：パラ置換フェノール類の置換基脱離反応

大江知之、増野匡彦、廣部雅昭

[Domestic presentation]  日本薬学会第115年会 (仙台) , 

1995.03

, 

Oral presentation (general)