Presentations -
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HCV-RNA ポリメラーゼ及び HIV 逆転写酵素阻害活性を有する新規フラーレン誘導体の合成.
○篠原舞, 高橋恭子, 大江知之, 中村成夫, 下遠野久美子, 増野匡彦.
日本薬学会第132年会 (札幌) ,
2012.03 -
3位置換Oxindole誘導体のXanthine Oxidase阻害活性と構造活性相関.
○安田大輔, 高橋恭子, 大江知之, 中村成夫, 増野匡彦.
日本薬学会第132年会 (札幌) ,
2012.03 -
フルバスタチン構造を基にした新規抗酸化化合物の創製.
○関陽平, 高橋恭子, 中村成夫, 大江知之, 増野匡彦.
日本薬学会第132年会 (札幌) ,
2012.03 -
医薬品開発における反応性代謝物の評価
大江知之
持田製薬株式会社講演会,
2012.03,Public lecture, seminar, tutorial, course, or other speech
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フラーレン誘導体添加による抗酸化剤プロオキシダント効果の抑制.
宮川知美, ○高橋恭子, 大江知之, 中村成夫, 増野匡彦.
第26回日本酸化ストレス学会関東支部学術大会 (東京) ,
2011.12 -
薬物代謝酵素シトクロムP450によるフェノール類の代謝と機構解析.
○増野匡彦, 大江知之, 中村成夫.
第15回生体触媒化学シンポジウム (東京) ,
2011.12 -
シトクロムP450によるipso位代謝反応の医薬品への応用研究.
○大江知之, 清水香往, 土門周, 高橋恭子, 中村成夫, 増野匡彦.
第15回生体触媒化学シンポジウム (東京) ,
2011.12 -
Characterization of Reactive Metabolites by High-Resolution Mass Spectrometry in Drug Discovery.
Ohe T.
25th JSSX Meeting (Tokyo) ,
2010.10 -
Brain Penetration in Monkeys: Is P-gp-mediated efflux an important limiting factor?.
○T, Ohe, C, Tang.
Banyu Drug Metabolism and Pharmacokinetics Forum (Tsukuba) ,
2008.05 -
Design and Synthesis of the Potent, Orally Available, Brain-Penetrable Triarylimidazoline Class of Neuropeptide Y5 Receptor Antagonists.
N, Sato, M, Ando, S, Ishikawa, M, Jitsuoka, K, Nagai, T, Nagase, H, Takahashi, A, Sakuraba, H, Tsuge, H, Iwaasa, A, Ishihara, T, Ohe, Y, Ishii, A, Kanatani, T, Fukami.
Frontiers in CNS and Oncology Medicinal Chemistry (Siena, Italy) ,
2007.10 -
What is the best strategy to apply transporter research to drug discovery and development?.
○T, Ohe.
JSSX 11th Danwakai Seminar (Tsukuba) ,
2007.08 -
Discovery and optimization of imidazoline derivatives, a potent, orally active neuropeptide Y Y5 receptor antagonist.
M, Ando, N, Sato, S, Ishikawa, M, Jitsuoka, K, Nagai, T, Nagase, H, Takahashi, A, Sakuraba, H, Tsuge, M, Hirayama, J, Ito, H, Iwaasa, H, Natsushita, A, Gomori, S, Mashiko, A, Ishihara, N, Fujino, S, Tanaka, T, Ohe, K, Tadano, T, Fukuroda, Y, Ishii, A, Kanatani, T, Fukami.
234th ACS National Meeting (Boston) ,
2007.08 -
How can we predict absorption in human? impact of drug transporters on intestinal absorption.
○T, Ohe, H, Sato.
Banyu Drug Metabolism and Pharmacokinetics Forum (Tsukuba) ,
2007.06 -
RNA Interference of Na+/taurocholate Co-transporting Polypeptide in Primary Cultured Rat Hepatocytes.
K, Wakayama, A, Nakajima, N, Morita, K, Imagaki, Y, Tamai, T, Ohe, M, Chiba, Y, Ishii.
14th North American ISSX Meeting (Puerto Rico) ,
2006.10 -
RNA Interference of Na+/taurocholate Co-transporting Polypeptide in Primary Cultured Rat Hepatocytes.
K, Wakayama, A, Nakajima, N, Morita, K, Imagaki, Y, Tamai, T, Ohe, M, Chiba, Y, Ishii.
8th Seizai Forum (Kyoto) ,
2006.09 -
Involvement of P-Glycoprotein in the Intestinal Secretion.
○T, Ohe, N, Fujino, M, Sato, S, Tanaka, N, Morita, N, Takenaga, M, Chiba, Y, Ishii.
13th North American ISSX Meeting/20th JSSX Meeting (Hawaii) ,
2005.10 -
Effect of P-Glycoprotein on CSF/Plasma Concentration Ratio.
○T, Ohe, M, Sato, S, Tanaka, N, Fujino, M, Hata, Y, Shibata, Y, Sawazaki, A, Kanatani, T, Fukami, M, Yamazaki, M, Chiba, Y, Ishii.
5th Seizai Forum (Tokyo) ,
2003.09 -
Effect of P-Glycoprotein on CSF/Plasma Concentration Ratio.
○T, Ohe, M, Sato, S, Tanaka, N, Fujino, M, Hata, Y, Shibata, Y, Sawazaki, A, Kanatani, T, Fukami, M, Yamazaki, M, Chiba, Y, Ishii.
AAPS Annual Meeting (Toronto) ,
2002.11 -
Effect of P-Glycoprotein on CSF/Plasma Concentration Ratio.
○T, Ohe, M, Yamazaki, M, Sato, N, Fujino, M, Hata, Y, Shibata, Y, Sawazaki, T, Fukami, M, Chiba, Y, Ishii.
6th International ISSX Meeting (Munich) ,
2001.10 -
Strategy for In Vitro Identification of Substrates/Inhibitors of P-Glycoprotein: A Case Study for a Carbapenem Antibiotic, MK-0826, with Poor Membrane Permeability.
○T, Ohe, M, Yamazaki, W, E, Neway, J, H, Hochman, Y, Ishii, M, Chiba, J, H, Lin.
Pharmaceutical Sciences Millennial World Congress (San Francisco) ,
2000.04