Details of a Researcher - OHE Tomoyuki

OHE Tomoyuki

写真a

Affiliation: Faculty of Pharmacy, Department of Pharmaceutical Sciences 医薬品化学講座（Shiba-Kyoritsu）

Position: Associate Professor

E-mail Address

External Links

Career 【 Display / hide 】

1996.04

-

1997.03

日本学術振興会　特別研究員
1997

-

1999

万有製薬株式会社（MSD）　つくば研究所　創薬研究所
1999

-

2000

Merck Research Laboratories（West Point, PA, USA）
2000

-

2009

万有製薬株式会社（MSD)　つくば研究所薬物動態研究所
2009

-

2011

大鵬薬品工業株式会社創薬センター分子標的薬研究所

Academic Background 【 Display / hide 】

1992.03

The University of Tokyo, Faculty of Pharmaceutical Science, 製薬化学科

University, Graduated
1994.03

The University of Tokyo, Graduate School, Division of Pharmaceutical Sciences, 生命薬学

Graduate School, Completed, Master's course
1997.03

The University of Tokyo, Graduate School, Division of Pharmaceutical Sciences, 生命薬学

Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide 】

PhD, The University of Tokyo, Coursework, 1997.03

Licenses and Qualifications 【 Display / hide 】

薬剤師, 1992

Research Areas 【 Display / hide 】

Chemical pharmacy (Chemical Pharmaceutical Science)
Physical pharmacy
Drug development chemistry (Drug Development Chemistry)
Environmental and hygienic pharmacy

Research Keywords 【 Display / hide 】

創薬化学
drug metabolism
分析化学
pharmacokinetics
antioxidant

Research Themes 【 Display / hide 】

Strategic Drug Design to Eliminate Metabolic Activation of Hapatotoxic Drugs,

2011

-

Present
Lead optimization considering drug metabolism,

2012

-

Present
反応性代謝物を捕捉する新規トラッピング剤の開発,

2017

-

Present
臓器標的型プロドラッグ戦略の開発,

2018

-

Present
Synthesis of fullerene derivatives and their biological activities,

2011

-

Present

Books 【 Display / hide 】

Fullerene derivatives as antiviral and anticancer agents, in Handbook of Fullerene Science and Technology

Ohe, T., Mashino, T., Springer, 2021.06, Page： 1-10

Contact page： 1-10
フラーレン誘導体・内包技術の最前線.

Ohe T, Mashino T., シーエムシー出版, 東京, 2014.04

Scope: 237-247
創薬研究のストラテジー.

岩尾洋, 飯野正光, 赤池昭紀監修., 金芳堂, 日本, 2012.02

Scope: 232-239

Papers 【 Display / hide 】

Development of a Fluorescent-Labeled Trapping Reagent to Detect Reactive Acyl Glucuronides

Shibazaki, C., Mashita O.,Takahashi K., Nakamura, S., Mashino T., Ohe T.

Chemical Research in Toxicology 34 （ 11 ） 2343 - 2352 2021.11

Research paper (scientific journal), Joint Work, Accepted
Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor infiltrating CD8T lymphocytes

Nishida M, Yamashita N, Ogawa T, Koseki K, Warabi E, Ohe T, Komatsu M, Kawakami E, Shiroguchi K, Udono H

J Immunotherapy of Cancer 9 （ 9 ） e002954 2021.10

Research paper (scientific journal), Joint Work, Accepted
- Access to Document (DOI)
Development of Fluorescent-Labeled Trapping Reagents Based on Cysteine to Detect Soft and Hard Electrophilic Reactive Metabolites

Shibazaki C., Ohe T,. Takahashi K., Nakamura S., Mashino T.

Drug Metabolism and Pharmacokinetics 39 100386 2021.08

Research paper (scientific journal), Joint Work, Accepted
- Access to Document (DOI)
Novel pyridinium-type fullerene derivatives as multitargeting inhibitors of HIV-1 reverse transcriptase, HIV-1 protease, and HCV NS5B polymerase

Kobayashi T, Yasuno T, Takahashi K, Nakamura S, Mashino T, Ohe T

Bioorganic & Medicinal Chemistry Letters in press 2021.08

Research paper (scientific journal), Joint Work, Accepted
- Access to Document (DOI)
p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response

Kageyama, S., Gudmundsson, S., Sou, Y., Ichimura, Y.,, Tamura, N., Kazuno, S., Ueno, T., Miura, Y.,Noshiro, D., Abe, M., Mizushima, T., Miura, N., Okuda, S., Motohashi, H., Lee, J-A., Sakimura, K., Ohe, T., Noda, N., Waguri, S., Eskelinen, E-L., Komatsu, M.

Nature Communications （Nature Communications) 12 （ 1 ） 16 2021.01

Research paper (scientific journal), Joint Work, Accepted

　View Summary

© 2021, The Author(s). Autophagy contributes to the selective degradation of liquid droplets, including the P-Granule, Ape1-complex and p62/SQSTM1-body, although the molecular mechanisms and physiological relevance of selective degradation remain unclear. In this report, we describe the properties of endogenous p62-bodies, the effect of autophagosome biogenesis on these bodies, and the in vivo significance of their turnover. p62-bodies are low-liquidity gels containing ubiquitin and core autophagy-related proteins. Multiple autophagosomes form on the p62-gels, and the interaction of autophagosome-localizing Atg8-proteins with p62 directs autophagosome formation toward the p62-gel. Keap1 also reversibly translocates to the p62-gels in a p62-binding dependent fashion to activate the transcription factor Nrf2. Mice deficient for Atg8-interaction-dependent selective autophagy show that impaired turnover of p62-gels leads to Nrf2 hyperactivation in vivo. These results indicate that p62-gels are not simple substrates for autophagy but serve as platforms for both autophagosome formation and anti-oxidative stress.
- Access to Document (DOI)

Papers, etc., Registered in KOARA 【 Display / hide 】

Strategic drug design to avoid metabolic activation of hapatotoxic drugs

Ōe, Tomoyuki

科学研究費補助金研究成果報告書 2018
Biological applications of azafulleroids as novel nanomaterials

Oe, Tomoyuki

学事振興資金研究成果実績報告書（慶應義塾大学) 2017
Diagnostic and therapeutic strategies targeting microRNAs and epigenome alterations in biliary tract and pancreatic cancer stem cells

Ooe, Tomoyuki

科学研究費補助金研究成果報告書 2016

Reviews, Commentaries, etc. 【 Display / hide 】

Drug discovery of safer benzbromarone derivatives

Tomoyuki Ohe

BIO Clinica (北隆館) 35 ( 2 ) 59 - 62 2020.02

Introduction and explanation (scientific journal)
Drug discovery of safer drugs by eliminating metabolic activation of existing drugs

Tomoyuki Ohe

Precision Medicine (北隆館) 2 ( 9 ) 47 - 51 2019.08

Introduction and explanation (scientific journal), Single Work
反応性代謝物とその評価.

Ohe T.

日本薬理学雑誌 (日本薬理学会) 134 338-341 2009.12

Introduction and explanation (scientific journal), Single Work
Evaluation of drug interactions with P-glycoprotein in drug discovery: in vitro assessment of the potential for drug-drug interactions with P-glycoprotein.

Hochman JH, Yamazaki M, Ohe T, Lin JH.

Curr Drug Metab (Bentham Science Publishers) 3 257-273 2002.06

Introduction and explanation (scientific journal), Joint Work

Presentations 【 Display / hide 】

TC-HepG2 細胞を用いた反応性代謝物の毒性評価と創薬への応用

大江知之

第2回 Cell Based Assay Workshop（オンライン）, 2021.09, Public discourse, seminar, tutorial, course, lecture and others
ADMET研究への有機化学的アプローチ

大江知之

第20回ケムステVシンポ（オンライン）, 2021.07, Public discourse, seminar, tutorial, course, lecture and others
Nrf2活性を制御するタンパク質間相互作用阻害剤の創成

安田大輔, 今村理世, 小島宏建, 岡部隆義, 高橋恭子, 熊谷直哉,一村義信, 小松雅明, 山本雅之, 長野哲雄, 増野匡彦, 大江知之

日本ケミカルバイオロジー学会第15回年会, 2021.06, Poster (general)
p62-Keap1-Nrf2 系を標的とした抗がん剤感受性増強剤の創製

安田大輔, 吉田逸平, 高橋恭子, 熊谷直哉, 増野匡彦, 今村理世, 小島宏建, 岡部隆義, 一村義信, 小松雅明, 山本雅之, 長野哲雄, 大江知之

第74回日本酸化ストレス学会, 2021.05, Oral Presentation(general)
代謝活性化の回避を目指したトファシチニブ類縁体の合成と評価

立石泰寛、大江知之、高橋恭子、中村成夫、増野匡彦

日本薬学会第141年会 (広島（オンライン）) , 2021.03, Oral Presentation(general)

Research Projects of Competitive Funds, etc. 【 Display / hide 】

新型コロナウイルス感染症治療薬を目指した新規フラーレン誘導体の創製

2021.04

-

2024.03

文部科学省, 挑戦的研究（萌芽）, 大江知之, Research grant, Principal Investigator
既存薬を基盤とした臓器標的型プロドラッグの創製

2021.04

-

2022.03

福澤基金研究補助, 大江知之, Research grant, Principal Investigator
探索段階における反応性代謝物リスク評価法の開発

2020.10

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2021.09

旭化成ファーマ株式会社, A-COMPASS, 大江知之, Joint research, Principal Investigator
抗真菌薬を基盤とした胆道・膵臓がんに対する新規治療薬の創製

2020.04

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2023.03

Grant-in-Aid for Scientific Research, 齋藤義正, Co-investigator
既存薬のADMET 特性を変換することによる新規医薬品の創製研究

2019.04

-

2020.03

慶應義塾, 福澤基金研究補助, 大江知之, Research grant, Principal Investigator

Intellectual Property Rights, etc. 【 Display / hide 】

パーキンソン病治療薬

Application No.： PCT/JP2020/003462 2020.01

Patent, Joint, PCT international application
パーキンソン病治療薬

Application No.：特願2019-014281 2019.01

Patent, Joint, National application
潰瘍性大腸炎の予防または治療剤と新規フラーレン誘導体

Application No.： PCT/JP2014/053950 2014.02

Announcement No.： WO2014/129513 2014.08

Patent, Joint, PCT international application
潰瘍性大腸炎の予防または治療剤と新規フラーレン誘導体

Application No.：特願2013-030455 2013.02

Patent, Joint

Awards 【 Display / hide 】

2019年度学部長賞（教育）

2020.03, 慶應義塾大学薬学部

Type of Award： Keio commendation etc.
2017年度学部長賞（運営）

2018.03, 慶應義塾大学薬学部

Type of Award： Keio commendation etc.
Merck Award for Excellence

2008.07
Drug Metabolism of Disposition Best Paper of the Year 1997

1997

Courses Taught 【 Display / hide 】

STUDY OF MAJOR FIELD (MOLECULAR DESIGN)

2021
SEMINAR (MOLECULAR DESIGN)

2021
RESEARCH FOR BACHELOR'S THESIS 1

2021
RESEARCH APPARATUS LABORATORY COURSE

2021
PHARMACEUTICAL-ENGLISH SEMINAR

2021

Courses Previously Taught 【 Display / hide 】

Ｃ４（４）化学物質の構造決定

Keio University, 2015, Autumn Semester, Major subject, Lecture, Within own ｆaculty, 200people
Ｃ５（１）官能基の導入・変換

Keio University, 2015, Spring Semester, Major subject, Lecture, Within own ｆaculty, 200people
Ｃ５（２）複雑な化合物の合成

Keio University, 2015, Autumn Semester, Major subject, Lecture, Within own ｆaculty, 200people
Ｃ６（１）生体分子のコアとパーツＢ

Keio University, 2015, Spring Semester, Major subject, Lecture, Within own ｆaculty, 200people
精密有機合成

Keio University, 2015, Autumn Semester, Major subject, Lecture, Within own ｆaculty, 60people

Educational Activities and Special Notes 【 Display / hide 】

スタンダード薬学シリーズⅡ　化学系薬学　Ⅱ生体分子・医薬品の化学による理解　日本薬学会編東京化学同人　

2016.04

, Development of Textbook and Teaching Material

Social Activities 【 Display / hide 】

薬学協議会薬科学担当教員会議

2020.12

-

Present
芳香族アミン取扱事業所で発生した膀胱がんの業務上外に関する検討会検討委員

厚生労働省

2020.02

-

2021.03
日本薬学会代議員

2019.03

-

Present
日本薬物動態学会評議員

2014.04

-

Present

Memberships in Academic Societies 【 Display / hide 】

日本分析化学会,

2016

-

Present
日本酸化ストレス学会,

2012

-

Present
日本薬物動態学会,

2008

-

Present
日本薬学会（医薬化学部会）,

1992

-

Present

Committee Experiences 【 Display / hide 】

2013.10

-

2015.09

学生交換・在外研修委員, 慶應義塾国際センター
2013.10

-

2015.09

学習指導主任, 慶應義塾国際センター
2017.04

-

Present

学生相談室芝共立キャンパス兼担カウンセラー, 慶應義塾
2017.10

-

2021.09

芝共立キャンパスITC所長, 慶應義塾
2014.04

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Present

CBT実施委員長, 慶應義塾大学薬学部