OHE Tomoyuki

写真a

Affiliation

Faculty of Pharmacy, Department of Pharmaceutical Sciences 医薬品化学講座 (Shiba-Kyoritsu)

Position

Associate Professor

E-mail Address

E-mail address

External Links

Career 【 Display / hide

  • 1996.04
    -
    1997.03

    日本学術振興会 特別研究員

  • 1997
    -
    1999

    万有製薬株式会社(MSD) つくば研究所 創薬研究所

  • 1999
    -
    2000

    Merck Research Laboratories(West Point, PA, USA)

  • 2000
    -
    2009

    万有製薬株式会社(MSD) つくば研究所 薬物動態研究所

  • 2009
    -
    2011

    大鵬薬品工業株式会社 創薬センター 分子標的薬研究所

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Academic Background 【 Display / hide

  • 1992.03

    The University of Tokyo, Faculty of Pharmaceutical Science, 製薬化学科

    University, Graduated

  • 1994.03

    The University of Tokyo, Graduate School, Division of Pharmaceutical Sciences, 生命薬学

    Graduate School, Completed, Master's course

  • 1997.03

    The University of Tokyo, Graduate School, Division of Pharmaceutical Sciences, 生命薬学

    Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide

  • PhD, The University of Tokyo, Coursework, 1997.03

Licenses and Qualifications 【 Display / hide

  • 薬剤師, 1992

 

Research Areas 【 Display / hide

  • Chemical pharmacy (Chemical Pharmaceutical Science)

  • Physical pharmacy

  • Drug development chemistry (Drug Development Chemistry)

  • Environmental and hygienic pharmacy

Research Keywords 【 Display / hide

  • 創薬化学

  • drug metabolism

  • 分析化学

  • pharmacokinetics

  • antioxidant

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Research Themes 【 Display / hide

  • Strategic Drug Design to Eliminate Metabolic Activation of Hapatotoxic Drugs, 

    2011
    -
    Present

  • Lead optimization considering drug metabolism, 

    2012
    -
    Present

  • 反応性代謝物を捕捉する新規トラッピング剤の開発, 

    2017
    -
    Present

  • 臓器標的型プロドラッグ戦略の開発, 

    2018
    -
    Present

  • Synthesis of fullerene derivatives and their biological activities, 

    2011
    -
    Present

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Books 【 Display / hide

Papers 【 Display / hide

  • Development of a Fluorescent-Labeled Trapping Reagent to Detect Reactive Acyl Glucuronides

    Shibazaki, C., Mashita O.,Takahashi K., Nakamura, S., Mashino T., Ohe T.

    Chemical Research in Toxicology 34 ( 11 ) 2343 - 2352 2021.11

    Research paper (scientific journal), Joint Work, Accepted

  • Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor infiltrating CD8T lymphocytes

    Nishida M, Yamashita N, Ogawa T, Koseki K, Warabi E, Ohe T, Komatsu M, Kawakami E, Shiroguchi K, Udono H

    J Immunotherapy of Cancer  9 ( 9 ) e002954 2021.10

    Research paper (scientific journal), Joint Work, Accepted

  • Development of Fluorescent-Labeled Trapping Reagents Based on Cysteine to Detect Soft and Hard Electrophilic Reactive Metabolites

    Shibazaki C., Ohe T,. Takahashi K., Nakamura S., Mashino T.

    Drug Metabolism and Pharmacokinetics 39   100386 2021.08

    Research paper (scientific journal), Joint Work, Accepted

  • Novel pyridinium-type fullerene derivatives as multitargeting inhibitors of HIV-1 reverse transcriptase, HIV-1 protease, and HCV NS5B polymerase

    Kobayashi T, Yasuno T, Takahashi K, Nakamura S, Mashino T, Ohe T

    Bioorganic & Medicinal Chemistry Letters in press 2021.08

    Research paper (scientific journal), Joint Work, Accepted

  • p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response

    Kageyama, S., Gudmundsson, S., Sou, Y., Ichimura, Y.,, Tamura, N., Kazuno, S., Ueno, T., Miura, Y.,Noshiro, D., Abe, M., Mizushima, T., Miura, N., Okuda, S., Motohashi, H., Lee, J-A., Sakimura, K., Ohe, T., Noda, N., Waguri, S., Eskelinen, E-L., Komatsu, M.

    Nature Communications (Nature Communications)  12 ( 1 ) 16 2021.01

    Research paper (scientific journal), Joint Work, Accepted

     View Summary

    © 2021, The Author(s). Autophagy contributes to the selective degradation of liquid droplets, including the P-Granule, Ape1-complex and p62/SQSTM1-body, although the molecular mechanisms and physiological relevance of selective degradation remain unclear. In this report, we describe the properties of endogenous p62-bodies, the effect of autophagosome biogenesis on these bodies, and the in vivo significance of their turnover. p62-bodies are low-liquidity gels containing ubiquitin and core autophagy-related proteins. Multiple autophagosomes form on the p62-gels, and the interaction of autophagosome-localizing Atg8-proteins with p62 directs autophagosome formation toward the p62-gel. Keap1 also reversibly translocates to the p62-gels in a p62-binding dependent fashion to activate the transcription factor Nrf2. Mice deficient for Atg8-interaction-dependent selective autophagy show that impaired turnover of p62-gels leads to Nrf2 hyperactivation in vivo. These results indicate that p62-gels are not simple substrates for autophagy but serve as platforms for both autophagosome formation and anti-oxidative stress.

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • Drug discovery of safer benzbromarone derivatives

    Tomoyuki Ohe

    BIO Clinica (北隆館)  35 ( 2 ) 59 - 62 2020.02

    Introduction and explanation (scientific journal)

  • Drug discovery of safer drugs by eliminating metabolic activation of existing drugs

    Tomoyuki Ohe

    Precision Medicine (北隆館)  2 ( 9 ) 47 - 51 2019.08

    Introduction and explanation (scientific journal), Single Work

  • 反応性代謝物とその評価.

    Ohe T.

    日本薬理学雑誌 (日本薬理学会)  134   338-341 2009.12

    Introduction and explanation (scientific journal), Single Work

  • Evaluation of drug interactions with P-glycoprotein in drug discovery: in vitro assessment of the potential for drug-drug interactions with P-glycoprotein.

    Hochman JH, Yamazaki M, Ohe T, Lin JH.

    Curr Drug Metab (Bentham Science Publishers)  3   257-273 2002.06

    Introduction and explanation (scientific journal), Joint Work

Presentations 【 Display / hide

  • TC-HepG2 細胞を用いた反応性代謝物の毒性評価と創薬への応用

    大江知之

    第2回 Cell Based Assay Workshop(オンライン), 2021.09, Public discourse, seminar, tutorial, course, lecture and others

  • ADMET研究への有機化学的アプローチ

    大江知之

    第20回ケムステVシンポ(オンライン), 2021.07, Public discourse, seminar, tutorial, course, lecture and others

  • Nrf2活性を制御するタンパク質間相互作用阻害剤の創成

    安田大輔, 今村理世, 小島宏建, 岡部隆義, 高橋恭子, 熊谷直哉,一村義信, 小松雅明, 山本雅之, 長野哲雄, 増野匡彦, 大江知之

    日本ケミカルバイオロジー学会第15回年会, 2021.06, Poster (general)

  • p62-Keap1-Nrf2 系を標的とした抗がん剤感受性増強剤の創製

    安田大輔, 吉田逸平, 高橋恭子, 熊谷直哉, 増野匡彦, 今村理世, 小島宏建, 岡部隆義, 一村義信, 小松雅明, 山本雅之, 長野哲雄, 大江知之

    第74回日本酸化ストレス学会, 2021.05, Oral Presentation(general)

  • 代謝活性化の回避を目指したトファシチニブ類縁体の合成と評価

    立石 泰寛、大江 知之、高橋 恭子、中村 成夫、増野 匡彦

    日本薬学会第141年会 (広島(オンライン)) , 2021.03, Oral Presentation(general)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 新型コロナウイルス感染症治療薬を目指した新規フラーレン誘導体の創製

    2021.04
    -
    2024.03

    文部科学省, 挑戦的研究(萌芽), 大江知之, Research grant, Principal Investigator

  • 既存薬を基盤とした臓器標的型プロドラッグの創製

    2021.04
    -
    2022.03

    福澤基金研究補助, 大江知之, Research grant, Principal Investigator

  • 探索段階における反応性代謝物リスク評価法の開発

    2020.10
    -
    2021.09

    旭化成ファーマ株式会社, A-COMPASS, 大江知之, Joint research, Principal Investigator

  • 抗真菌薬を基盤とした胆道・膵臓がんに対する新規治療薬の創製

    2020.04
    -
    2023.03

    Grant-in-Aid for Scientific Research, 齋藤義正, Co-investigator

  • 既存薬のADMET 特性を変換することによる新規医薬品の創製研究

    2019.04
    -
    2020.03

    慶應義塾, 福澤基金研究補助, 大江知之, Research grant, Principal Investigator

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Intellectual Property Rights, etc. 【 Display / hide

  • パーキンソン病治療薬

    Application No.: PCT/JP2020/003462  2020.01 

    Patent, Joint, PCT international application

  • パーキンソン病治療薬

    Application No.: 特願2019-014281  2019.01 

    Patent, Joint, National application

  • 潰瘍性大腸炎の予防または治療剤と新規フラーレン誘導体

    Application No.: PCT/JP2014/053950  2014.02 

    Announcement No.: WO2014/129513  2014.08 

    Patent, Joint, PCT international application

  • 潰瘍性大腸炎の予防または治療剤と新規フラーレン誘導体

    Application No.: 特願2013-030455  2013.02 

    Patent, Joint

Awards 【 Display / hide

  • 2019年度学部長賞(教育)

    2020.03, 慶應義塾大学薬学部

    Type of Award: Keio commendation etc.

  • 2017年度学部長賞(運営)

    2018.03, 慶應義塾大学薬学部

    Type of Award: Keio commendation etc.

  • Merck Award for Excellence

    2008.07

  • Drug Metabolism of Disposition Best Paper of the Year 1997

    1997

 

Courses Taught 【 Display / hide

  • STUDY OF MAJOR FIELD (MOLECULAR DESIGN)

    2021

  • SEMINAR (MOLECULAR DESIGN)

    2021

  • RESEARCH FOR BACHELOR'S THESIS 1

    2021

  • RESEARCH APPARATUS LABORATORY COURSE

    2021

  • PHARMACEUTICAL-ENGLISH SEMINAR

    2021

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Courses Previously Taught 【 Display / hide

  • C4(4)化学物質の構造決定

    Keio University, 2015, Autumn Semester, Major subject, Lecture, Within own faculty, 200people

  • C5(1)官能基の導入・変換

    Keio University, 2015, Spring Semester, Major subject, Lecture, Within own faculty, 200people

  • C5(2)複雑な化合物の合成

    Keio University, 2015, Autumn Semester, Major subject, Lecture, Within own faculty, 200people

  • C6(1)生体分子のコアとパーツB

    Keio University, 2015, Spring Semester, Major subject, Lecture, Within own faculty, 200people

  • 精密有機合成

    Keio University, 2015, Autumn Semester, Major subject, Lecture, Within own faculty, 60people

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Educational Activities and Special Notes 【 Display / hide

  • スタンダード薬学シリーズⅡ 化学系薬学 Ⅱ生体分子・医薬品の化学による理解 日本薬学会編 東京化学同人 

    2016.04

    , Development of Textbook and Teaching Material

 

Social Activities 【 Display / hide

  • 薬学協議会薬科学担当教員会議

    2020.12
    -
    Present
  • 芳香族アミン取扱事業所で発生した膀胱がんの業務上外に関する検討会検討委員

    厚生労働省

    2020.02
    -
    2021.03
  • 日本薬学会代議員

    2019.03
    -
    Present
  • 日本薬物動態学会評議員

    2014.04
    -
    Present

Memberships in Academic Societies 【 Display / hide

  • 日本分析化学会, 

    2016
    -
    Present
  • 日本酸化ストレス学会, 

    2012
    -
    Present
  • 日本薬物動態学会, 

    2008
    -
    Present
  • 日本薬学会(医薬化学部会), 

    1992
    -
    Present

Committee Experiences 【 Display / hide

  • 2013.10
    -
    2015.09

    学生交換・在外研修委員, 慶應義塾国際センター

  • 2013.10
    -
    2015.09

    学習指導主任, 慶應義塾国際センター

  • 2017.04
    -
    Present

    学生相談室芝共立キャンパス兼担カウンセラー, 慶應義塾

  • 2017.10
    -
    2021.09

    芝共立キャンパスITC所長, 慶應義塾

  • 2014.04
    -
    Present

    CBT実施委員長, 慶應義塾大学薬学部

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