Papers - YAMAURA Katsunori

Expression of precipitating factors of pruritus found in humans in an imiquimod-induced psoriasis mouse model

Oishi N., Iwata H., Kambe N., Kobayashi N., Fujimoto K., Sato H., Hisaka A., Ueno K., Yamaura K.

Heliyon (Heliyon)  5 ( 6 )  2019.06

Research paper (scientific journal), Joint Work, Accepted,  ISSN  24058440

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© 2019 The Authors Aims: To use a mouse model of imiquimod-induced psoriasis to investigate the relationship between pruritus and mast cells, nerve growth factor (NGF) and endogenous pruritogenic peptides, which are highly expressed in the skin of psoriasis patients. Main methods: We developed a mouse model of imiquimod-induced psoriasis and measured the frequency and duration of the model animals’ self-scratching behavior using the SCLABA®-Real real-time scratch counting system. We then harvested the ears and subjected them to toluidine blue staining and real-time PCR. Key findings: Topical application of imiquimod increased the Psoriasis Area and Severity Index score as well as the frequency and duration of self-scratching. Regarding internal factors, increases in mast cells number and mRNA expression of NGF and endogenous pruritogenic peptide precursor were confirmed. Significance: Self-scratching behavior is accompanied by increased number of mast cells and expression of NGF and endogenous pruritogenic peptides in our imiquimod-induced psoriasis model. The expression of these factors was consistent with the features in patients with pruritic psoriasis, suggesting that our model reflects at least some of the precipitating factors of pruritus found in humans.

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中学生に対する医薬品の適正使用教育と薬物乱用防止教育の在り方と他職種からの視点

YAMAURA KATSUNORI

社会薬学 36 ( 1 ) 1 - 12 2017.06

Research paper (scientific journal), Joint Work, Accepted

検体測定室の未申請薬局における簡易血液検査の普及を阻害する要因の調査　－検体測定室の普及・継続に向けた全国調査研究（第２報）－

宮崎 源生、岩田 紘樹、小林 典子、藤本 和子、吉田 加奈、岡崎 光洋、山浦 克典

医療薬学 43 ( 1 ) 34 - 40 2017.01

Research paper (scientific journal), Joint Work, Accepted

脂質異常症の早期発見における検体測定の有用性および地域住民の病識に関する研究

岩田 紘樹, 増尾 涼, 岡﨑 光洋, 福本 正勝, 藤本 和子, 小林典子, 山浦 克典

社会薬学 35 ( 2 ) 80 - 86 2016.12

Research paper (scientific journal), Joint Work, Accepted

うつ病患者に対する薬局薬剤師の対応に関与する要因の検討

岸本 桂子, 秋谷 正浩, 大岩 眞二, 山浦 克典, 福島,紀子

医療薬学 42 ( 12 ) 795 - 808 2016.12

Research paper (scientific journal), Joint Work, Accepted

Whether Visual Information Loss of Expression by Community Pharmacist Masks to Effect a Cchange in Feeling of Trust among Help-seeker?

岸本桂子, 羽坂亜希子, 山浦克典, 福島紀子

YAKUGAKU ZASSHI (日本薬学会)  136 ( 10 ) 1401 - 1413 2016.10

Research paper (scientific journal), Accepted

50歳以上の薬局来局者の在宅医療への薬剤師関与の希望と在宅医療における薬剤師業務に対する認識との関連性

岸本 桂子, 寺田亜里沙, 後藤知良, 山浦 克典, 福島紀子

医療薬学 42 ( 8 ) 582 - 595 2016.08

Research paper (scientific journal), Joint Work, Accepted

検体測定室届出薬局における簡易血液検査の継続を阻止する要因の解明

吉田 加奈, 岩田紘樹, 小林典子, 藤本和子, 岡崎光洋, 山浦 克典

医療薬学 42 ( 7 ) 543 - 549 2016.07

Research paper (scientific journal), Joint Work, Accepted

Effect of enhanced expression of connexin 43 on sunitinib-induced cytotoxicity in mesothelioma cells.

Miaki Uzu, Hiromi Sato, Ryota Yamada, Tatsuro Kashiba, Yukihiro Shibata, Katsunori Yamaura, Koichi Ueno

J Pharmacol Sci. 128   17 - 26 2015

Research paper (scientific journal), Joint Work, Accepted

Protective Effect of Young Green Barley Leaf (Hordeum vulgare L.) on Restraint Stress-Induced Decrease in Hippocampal BDNF in Mice.

Katsunori Yamaura, Riho Tanaka, Yuanyuan Bi, Hideki Fukata, Nobuo Oishi, Hiromi Sato, Chisato Mori, Koichi Ueno.

Pharmacognosy Mag. 11   S86 - S92 2015

Research paper (scientific journal), Joint Work, Accepted

Elacridar enhances the cytotoxic effects of sunitinib and prevents multidrug resistance in renal carcinoma cells.

Hiromi Sato, Sana Siddig, Miaki Uzu; Sayumi Suzuki; Yuki Nomura; Tatsuro Kashiba; Keisuke Gushimiyagi; Yuko Sekine, Tomoya Uehara, Yasushi Arano,Katsunori Yamaura, Koichi Ueno

Eur. J. Pharmacol. 746   258 - 266 2015

Research paper (scientific journal), Joint Work, Accepted

Sex-related differences in SLIGRL-induced pruritus in mice.

Yamaura K, Tomono A, Suwa E, Ueno K.

Life Sciences. 94   54 - 57 2014

Research paper (scientific journal), Joint Work, Accepted

Increased expression of the histamine H4 receptor following differentiation and mediation of the H4 receptor on interleukin-8 mRNA expression in HaCaT keratinocytes.

Suwa E, Yamaura K (co-first author), Sato S, Ueno K.

Exp Dermatol. 23   138 - 140 2014

Research paper (scientific journal), Joint Work, Accepted

高齢者投与禁忌薬に対する薬局薬剤師の認識及びその処方実態に関する研究

重森 梓, 山浦 克典(co-first author), 諏訪 映里子, 小川 雅教, 中野 英治, 野本 禎, 上野 光一

医薬品医療機器レギュラトリーサイエンス 44 ( 5 ) 446 - 451 2013.05

Topical royal jelly alleviates symptoms of pruritus in a murine model of allergic contact dermatitis.

Yamaura K, Tomono A, Suwa E, Ueno K.

Pharmacognosy Mag. 9   9 - 13 2013

Research paper (scientific journal), Joint Work, Accepted

Sex differences in stress reactivity of hippocampal BDNF in mice are associated with the female preponderance of decreased locomotor activity in response to restraint stress.

Yamaura K, Bi Y, Ishiwatari M, Oishi N, Fukata H, Ueno K.

Zoolog Sci. 30   1019 - 1024 2013

Research paper (scientific journal), Joint Work, Accepted

Difficulty for consumers in choosing commercial bilberry supplements by relying only on product label information.

Yamamoto M, Yamaura K (co-first author), Ishiwatari M, Ueno K.

Pharmacognosy Res 5   212 - 215 2013

Research paper (scientific journal), Joint Work, Accepted

Degradation Index for Quality Evaluation of Commercial Dietary Supplements of Bilberry Extract.

Yamamoto M, Yamaura K (co-first author), Ishiwatari M, Shimada M, Kado S, Seki H, Shimada N, Ueno K.

J Food Sci. 78   S477 - 483 2013

Research paper (scientific journal), Joint Work, Accepted

Anthocyanins, but not anthocyanidins, from bilberry (Vaccinium myrtillus L.) alleviate pruritus via inhibition of mast cells degranulation.

Yamaura K, Ishiwatari M, Yamamoto M, Shimada M, Bi Y, Ueno K.

J Food Sci. 77   H262 - 267 2012

Research paper (scientific journal), Joint Work, Accepted

Repeated application of glucocorticoids exacerbate pruritus via inhibition of prostaglandin D2 production of mast cells in a murine model of allergic contact dermatitis.

Yamaura K, Doi R, Suwa E, Ueno K.

J Toxicol Sci. 37   1127 - 1134 2012

Research paper (scientific journal), Joint Work, Accepted