Matsumoto, Kazuaki

写真a

Affiliation

Faculty of Pharmacy, Department of Pharmacy 薬効解析学講座 (Shiba-Kyoritsu)

Position

Professor
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Career 【 Display / hide 】

  • 2003.04
    -
    2007.03

    鹿児島大学医学部・歯学部附属病院, 薬剤部, 医療職員

  • 2007.04
    -
    2014.03

    鹿児島大学医学部・歯学部附属病院, 薬剤部, 主任

  • 2014.04
    -
    2017.03

    慶應義塾大学薬学部, 実務薬学講座, 准教授

  • 2017.04
    -
    Present

    慶應義塾大学薬学部, 薬効解析学講座, 教授

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Academic Background 【 Display / hide 】

  • 1994.04
    -
    1998.03

    Kumamoto University, 薬学部, 薬学科

    University, Graduated

  • 1998.04
    -
    2000.03

    Kumamoto University, 薬学研究科

    Graduate School, Completed, Master's course

  • 2000.04
    -
    2003.03

    Kumamoto University, 薬学研究科

    Graduate School, Completed, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 博士（薬学）, Kumamoto University, Coursework, 2003.03

    α1-酸性糖蛋白質の生理作用と動態特性に関する研究

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Licenses and Qualifications 【 Display / hide 】

  • 薬剤師免許証, 1998.07

  • 日本薬剤師研修センター認定薬剤師, 2006.03

  • 日本医療薬学会認定薬剤師, 2009.01

  • インフェクションコントロールドクター, 2009.01

  • 感染制御専門薬剤師, 2009.03

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Research Areas 【 Display / hide 】

  • Life Science / Clinical pharmacy

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Research Keywords 【 Display / hide 】

  • Pharmacokinetics/Pharmacodynamics

  • Therapeutic drug monitoring

  • 抗菌化学療法

  • 高齢者医療

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Research Themes 【 Display / hide 】

  • 医薬品の薬効評価と副作用解析に基づいた薬物療法の最適化に関する研究, 

    2014.04
    -
    Present

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Books 【 Display / hide 】

  • 今日の治療薬2025

    松元一明, 南江堂, 2025.01

  • 今日の治療指針2025

    松元一明, 医学書院, 2025.01

    Scope: 市中肺炎/急性中耳炎 服薬指導・薬剤情報

  • ベーシック薬学教科書シリーズ 薬物治療学（第2版増補版）

    松元一明, 化学同人, 2024.03

    Scope: 第13章感染症と薬物治療.

  • 外来・薬局感染症学

    松元一明, じほう, 2024.03

    Scope: β-ラクタム系薬.

  • ケースで学ぶ老年薬学

    松元一明, 日経BP, 2024.01

    Scope: 感染症.

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Papers 【 Display / hide 】

  • Influence factors of metronidazole-related CNS disorders: an analysis of the Japan adverse drug event report and FDA adverse event reporting system.

    Takada K, Enoki Y, Samura M, Igarashi Y, Taguchi K, Tanikawa K, Matsumoto K

    Expert opinion on drug safety    1 - 7 2025.04

    Joint Work,  ISSN  1474-0338

  • Development and validation of a population pharmacokinetic model of vancomycin for patients of advanced age.

    Takada K, Samura M, Igarashi Y, Suzuki A, Ishigo T, Fujii S, Ibe Y, Yoshida H, Tanaka H, Ebihara F, Maruyama T, Hamada Y, Komatsu T, Tomizawa A, Takuma A, Chiba H, Yagi Y, Nishi Y, Enoki Y, Taguchi K, Tanikawa K, Kunishima H, Matsumoto K

    Journal of pharmaceutical health care and sciences 11 ( 1 ) 18 2025.03

    Joint Work,  ISSN  2055-0294

    　View Summary

    Background: Population pharmacokinetic (PPK) models of vancomycin (VCM) commonly use creatinine clearance (CLcr) as a covariate for clearance (CL). However, relying on CLcr in patients of advanced age may lead to inaccuracies in estimating VCM clearance. Therefore, this study aimed to develop and validate a new PPK model specifically for patients aged 75 years and older. Methods: PPK analysis was performed based on the blood concentrations of VCM (n = 159 patients). The predictive performance of the developed model was compared with that of previous models using mean absolute error (MAE) and mean squared error (MSE) for another dataset. Results: The PPK analysis optimized a two-compartment model using CLcr and the Alb levels as covariates at the central compartment of VCM clearance. The final model was as follows: CL (L/h) = 1.96 × (CLcr/3.09) 0.63 × (Serum albumin (Alb) /2.3) 0.22 × exponential (0.11). Clearance between the central and peripheral compartments (L/h) = 4.86. Central compartment volume of distribution (L) = 31.78. Peripheral compartment volume of distribution (L) = 53.64. The validation study revealed that compared with those of previous models (ranging from 0.67 to 0.79 L/h and from 0.81 to 1.11 (L/h)2, respectively), the final model demonstrated the smallest MAE of 0.60 L/h and MSE of 0.65 (L/h)2 for patients of advanced age with serum creatinine levels of < 0.6 mg/dL. Conclusion: The PPK model of VCM for patients of advanced age was optimized by adding the Alb levels and CLcr as covariates for CL. The predictive accuracy of the PPK model for patients with an SCr of < 0.6 mg/dL tended to be higher than those of previous models based just on CLcr. Thus, dosage is suggested to be adjusted based on CLcr and Alb levels for patients with an SCr of < 0.6 mg/dL.

  • Carbon monoxide alleviates endotoxin-induced acute lung injury via NADPH oxidase inhibition in macrophages and neutrophils

    Watabe Y., Giam Chuang V.T., Sakai H., Ito C., Enoki Y., Kohno M., Otagiri M., Matsumoto K., Taguchi K.

    Biochemical Pharmacology 233   116782 2025.03

    Joint Work,  ISSN  00062952

    　View Summary

    Sepsis is a life-threatening condition caused by severe infection and often complicates acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) due to the collapse of the oxidative and inflammatory balance induced by microbial pathogens, including lipopolysaccharides (LPS). In sepsis-related ARDS/ALI, NADPH oxidase (NOX) and toll-like receptors (TLR) in neutrophils and macrophages are key players in initiating oxidative and inflammatory imbalances. Although NOX and TLR activation has been linked to carbon monoxide (CO), the mechanism by which CO affects sepsis-related ARDS/ALI through NOX and TLR remains unknown. Here, we demonstrate that CO reduces sepsis-related ARDS/ALI by inhibiting NOX in neutrophils and macrophages, which in turn suppresses the production of reactive oxygen species (ROS), TLR4-associated inflammatory responses, and macrophage polarization toward M1-like macrophages. CO-bound hemoglobin vesicle (CO-HbV) therapy, a hemoglobin-based CO donor, exerts a protective effect against LPS-induced ALI by suppressing exaggerated oxidative and inflammatory responses and neutrophil and M1-like macrophage infiltration in the bronchoalveolar lavage fluid (BALF). Through suppression of NOX activity, CO decreased ROS generation, the TLR4/NF-κB signaling pathway, and macrophage polarization toward M1-like macrophages, according to cellular experiments conducted with peripheral neutrophils, BALF cells, and Raw264.7 cells. Moreover, ALI was found to be more severe in Hmox1+/- mice (mice with decreased endogenous CO production) than in the wild-type mice. Our findings suggest that both endogenously generated and exogenously supplied CO inhibit NOX-associated ROS generation, the TLR4/NF-κB signaling pathway, and macrophage polarization, thereby eliciting antioxidant and anti-inflammatory responses that prevent the onset and progression of LPS-induced ALI.

  • The combined dual β-lactams and diazabicyclooctane β-lactamase inhibitor is highly effective against Mycobacterium abscessus species in vitro.

    Misawa K, Nishimura T, Yoshikawa M, Shimamura R, Kashimura S, Enoki Y, Taguchi K, Matsumoto K, Hasegawa N

    Journal of global antimicrobial resistance 42   142 - 150 2025.02

    Joint Work,  ISSN  2213-7165

    　View Summary

    Objective: Mycobacterium abscessus pulmonary disease is a refractory infectious disease. Developing an effective treatment is urgent as the number of patients infected with M. abscessus species (MABS) is increasing worldwide. We previously reported that nacubactam, a diazabicyclooctane (DBO) β-lactamase inhibitor, could inhibit MABS β-lactamase. Few reports have indicated that dual β-lactams are effective with a DBO β-lactamase inhibitor against MABS. The objective of this study was to determine which dual β-lactams have high antibacterial activity against MABS in the presence and absence of nacubactam. Methods: Antimicrobial susceptibility tests were conducted through a checkerboard assay of 27 β-lactams using the broth microdilution method for three subspecies-type strains and 20 clinical isolates of MABS. The number of intracellular and extracellular bacteria was measured using human macrophages infected with M. abscessus treated with effective combinations confirmed in susceptibility tests. Results: In antimicrobial susceptibility tests, 91 combinations of dual β-lactams with nacubactam exhibited synergistic effects on M. abscessus JCM13569. Among them, the combination of cefazolin, cefotiam, cefoxitin, or cefuroxime with imipenem and nacubactam exhibited highly synergistic effects, resulting in low MICs against MABS clinical isolates. Without nacubactam, the combination of imipenem and cefoxitin showed the lowest MIC. In experiments using human macrophages infected with M. abscessus, these dual β-lactam combinations reduced the number of intracellular and extracellular bacteria compared with those of single β-lactams. Conclusions: The combination of cefazolin, cefotiam, cefoxitin, or cefuroxime with imipenem and nacubactam was highly effective against MABS. Without nacubactam, the combination of cefoxitin and imipenem was effective.

  • In Vitro Activity of Aztreonam in Combination with Relebactam against Gram-Negative Pathogens Producing Various Serine and Metallo-β-Lactamases.

    Hayashi K, Suzuki M, Ishii Y, Matsumura Y, Matsumoto K, Saito S, Doi Y

    Journal of global antimicrobial resistance 42   73 - 79 2025.02

    Joint Work,  ISSN  2213-7165

    　View Summary

    Objectives: Infections caused by carbapenemase-producing Gram-negative pathogens have become a significant global public health challenge due to limited treatment options. Pathogens producing metallo-β-lactamase are particularly problematic since they are not inhibited by conventional β-lactamase inhibitors. Herein, we assess the in vitro activity of aztreonam in combination with relebactam against a collection carbapenemase producing organisms, including strains producing both serine‑β-lactamase and IMP-type metallo-β-lactamase that are commonly encountered in Japan. Methods: A total of 119 carbapenemase-producing clinical isolates were used in this study. Minimum inhibitory concentrations (MICs) of aztreonam and imipenem alone and aztreonam/relebactam, aztreonam/avibactam and imipenem/relebactam combinations were determined by the broth microdilution method. Results: Aztreonam MICs were reduced in combination with relebactam for strains producing ESBL or AmpC in addition to IMP-type, NDM-type, GES-type or OXA-48 carbapenemases and for Stenotrophomonas spp. Additionally, aztreonam/relebactam combination MICs were significantly lower than MICs of aztreonam alone among IMP producers, NDM producers and Stenotrophomonas spp. Significant differences between aztreonam/relebactam and aztreonam MICs were also observed for strains of E. coli, K. pneumoniae and Enterobacter spp., many of which produced both metallo-β-lactamase and serine‑β-lactamase. The aztreonam/relebactam combination showed comparable to higher MICs compared with the aztreonam/avibactam combination. Conclusion: The addition of relebactam has a potential to restore the activity of aztreonam against strains that produce metallo-β-lactamase and serine‑β-lactamase. The combination may have a role in the treatment of infections due to these strains in countries without access to ceftazidime-avibactam.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • Reply to Mitsuboshi, “Enhancing result reliability by addressing potential confounding factors”

    Ishigo T., Matsumoto K., Yoshida H., Tanaka H., Ibe Y., Fujii S., Fukudo M., Fujihara H., Yamaguchi F., Ebihara F., Maruyama T., Hamada Y., Samura M., Nagumo F., Komatsu T., Tomizawa A., Takuma A., Chiba H., Nishi Y., Enoki Y., Taguchi K., Suzuki A.

    Microbiology Spectrum 13 ( 3 ) e0149924 2025.03

  • 小児消化管感染症診療ガイドライン2024

    日本小児感染症学会／日本小児消化管感染症・免疫アレルギー研究会

     2024.11

  • MRSA感染症の診療ガイドライン2024

    光武 耕太郎, 松本 哲哉, 植田 貴史, 内山 勝文, 小澤 俊幸, 唐牛 春香, 菅井 基行, 関 雅文, 高橋 聡, 竹末 芳生, 中嶋 一彦, 中嶋 秀人, 中南 秀将, 畑 啓昭, 藤倉 雄二, 藤村 茂, 松下 和彦, 松元 一明, 三鴨 廣繁, 宮入 烈, 柳原 克紀, 山岸 由佳, 山口 哲央, 山田 浩司, 山本 善裕, 吉田 耕一郎, 池田 信介, 岩田 栄一朗, 大野 久美子, 大野 智裕, 加勢田 富士子, 加藤 秀雄, 加茂野 絵美, 川崎 洋平, 川筋 仁史, 小林 直実, 坂 なつみ, 瀬戸 良教, 高野 昇太郎, 浜田 幸宏, 松本 浩, 荒川 創一, 岩田 敏, 金光 敬二, 公益社団法人日本化学療法学会, 一般社団法人日本感染症学会MRSA感染症の診療ガイドライン作成委員会

    日本化学療法学会雑誌 ((公社)日本化学療法学会)  72 ( 3 ) 251 - 321 2024.05

    ISSN  1340-7007

  • 呼吸器及び尿路感染症におけるブレイクポイント　新規抗菌薬の追加(2023)

    平松 和史, 青木 弘太郎, 荒岡 秀樹, 猪川 和朗, 石井 良和, 大塚 喜人, 大谷 真理子, 柴山 恵吾, 舘田 一博, 松永 直久, 松元 一明, 冨山 直樹, 三学会合同ブレイクポイント臨床応用検討委員会, 日本化学療法学会, 日本感染症学会, 日本臨床微生物学会

    日本臨床微生物学会雑誌 ((一社)日本臨床微生物学会)  33 ( 4 ) 253 - 254 2023.09

    ISSN  2434-866X

  • 三学会合同ブレイクポイント　臨床応用検討委員会報告　呼吸器及び尿路感染症におけるブレイクポイント　新規抗菌薬の追加(2023)

    平松 和史, 松元 一明, 青木 弘太郎, 荒岡 秀樹, 猪川 和朗, 石井 良和, 大塚 喜人, 大谷 真理子, 柴山 恵吾, 舘田 一博, 松永 直久, 三学会合同ブレイクポイント臨床応用検討委員会

    日本化学療法学会雑誌 ((公社)日本化学療法学会)  71 ( 4 ) 349 - 351 2023.07

    ISSN  1340-7007

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Presentations 【 Display / hide 】

  • 抗菌薬曝露時におけるMycobacterium abscessusのコロニー形態変化.

    島村莉奈、西村知泰、三澤可奈、吉川万衣子、柏村祥子、矢野大和、矢野郁也、榎木裕紀、田口和明、松元一明、長谷川直樹.

    第55回結核・非定型抗酸菌症治療研究会 (東京都) , 

    2024.11
    , 

    Oral presentation (general)

  • Mycobacterium aviumとMycobacterium intracellulareの臨床分離株を用いたβ-ラクタム系抗菌薬2剤併用の有効性評価.

    吉川万衣子、西村知泰、三澤可奈、島村莉奈、鈴木健太、柏村祥子、榎木裕紀、田口和明、松元一明、長谷川直樹.

    第55回結核・非定型抗酸菌症治療研究会 (東京都) , 

    2024.11
    , 

    Oral presentation (general)

  • 非発熱時または発熱時におけるニューキノロン系抗菌薬の体温低下.

    原量平、榎木裕紀、田口和明、松元一明.

    第34回日本医療薬学会年会 (千葉県) , 

    2024.11
    , 

    Oral presentation (general)

  • 日本医療薬学会賞・学術賞・奨励賞受賞講演：抗感染症薬の個別最適化を目指した基礎・臨床研究

    松元一明.

    第34回日本医療薬学会年会 (千葉県) , 

    2024.11
    , 

    Public lecture, seminar, tutorial, course, or other speech

  • 免疫抑制マウス肺部S. pneumoniae感染モデルを用いたcefditoren pivoxilのPK/PD解析及び臨床用量評価.

    五十嵐裕貴，小島菜奈，髙田啓介, 榎木裕紀，田口和明，谷川浩司, 松元一明.

    第34回日本医療薬学会年会 (千葉県) , 

    2024.11
    , 

    Oral presentation (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 新規肺MABC症治療薬の開発と革新的非臨床PK/PD評価法の構築

    2024.04
    -
    2028.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

  • 薬剤耐性淋菌・緑膿菌に有効な新規抗菌剤の開発

    2023.08
    -
    2024.03

    国立研究開発法人日本医療研究開発機構（AMED）, 新興・再興感染症に対する革新的医薬品等開発推進研究事業, Joint research, Coinvestigator(s)

  • ホローファイバー感染モデルを用いたカルバペネム耐性菌感染症の抗菌薬併用療法に関する橋渡し研究

    2022.04
    -
    2025.03

    国立研究開発法人国立国際医療研究センター, 国際医療研究開発事業, Joint research, Coinvestigator(s)

  • マウス肺感染モデルを用いたOP0595の臨床有効性予測

    2022.01
    -
    2024.03

    Meiji Seikaファルマ株式会社, Commissioned ｒesearch, Principal investigator

  • Investigation of the effectiveness of imeglimin as a potential therapeutic agent for sarcopenia

    2021.09
    -
    2023.08

    大日本住友製薬株式会社, Commissioned ｒesearch, Principal investigator

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Intellectual Property Rights, etc. 【 Display / hide 】

  • メトヘモグロビン小胞体を有効成分として含む医薬およびその使用

    Date applied： 特願2020-144044  2020.08 

    Patent, Joint

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Awards 【 Display / hide 】

  • 2024年度日本医療薬学会学術賞

    松元一明., 2024.11, 抗感染症薬の個別最適化を目指した基礎・臨床研究.

  • 第36回微生物シンポジウム優秀発表賞（ポスター発表）

    林侑孝、髙橋実秀、佐々木萌、劉小茜、榎木裕紀、田口和明、松元一明., 2024.08, In vivoおよびIn vitro感染モデルを用いた腸球菌感染症に対するバンコマイシンのPK/PD評価.

  • MRSAフォーラム2024一般演題優秀賞

    高橋実秀、佐々木萌、劉小茜、林侑孝、榎木裕紀、田口和明、松元一明., 2024.07, In vivo実験から得られた腸球菌感染症に対するバンコマイシンの目標PK/PDパラメータ値.

  • 第7回フレッシャーズ・カンファランス優秀演題発表賞

    三原貴之、田口和明、榎木裕紀、松元一明., 2024.06, デキストラン硫酸ナトリウム誘発性炎症性腸疾患マウスモデルにおけるfidaxomicinの抗炎症効果の評価と腸内細菌叢の解析.

  • 第44回日本臨床薬理学会学術総会優秀発表賞

    並木孝哉、横山雄太、枦秀樹、織田錬太郎、地引綾、河添仁、松元一明、鈴木小夜、中村智徳., 2023.12, 基質特異性拡張型β-ラクタマーゼ産生腸内細菌目細菌感染患者に対する遊離形セフメタゾール濃度を用いたPPK/PD解析と最適投与法の構築.

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Courses Taught 【 Display / hide 】

  • ENGLISH EXERCISES FOR PHARMACEUTICAL SCIENCES

    2025

  • DRUG INFORMATION AND PHARMACODYNAMICS

    2025

  • DOCTORAL LECTURE ON CLINICAL PHARMACY 1

    2025

  • CLINICAL PHARMACOLOGY AND PHARMACEUTICS

    2025

  • CLINICAL PHARMACOLOGY

    2025

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Social Activities 【 Display / hide 】

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Memberships in Academic Societies 【 Display / hide 】

  • 日本医真菌学会, 

    2019.02
    -
    Present

  • 日本DDS学会, 

    2018.05
    -
    Present

  • 日本臨床微生物学会, 

    2018.03
    -
    Present

  • 日本老年薬学会　理事・評議員, 

    2016.04
    -
    Present

  • 日本薬剤学会　代議員, 

    2015.12
    -
    Present

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