Papers - Hori, Satoko

Classification of Patient Characteristics Associated with Reported Adverse Drug Events to Neuraminidase Inhibitors：An Applicability Study of Latent Class Analysis in Pharmacovigilance

Okada T, Hashiguchi M, Hori S

International Journal of Clinical Pharmacy  2022.09

Research paper (scientific journal), Accepted

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全国大学医学部における医薬品・医療機器等安全性情報報告制度に関わる授業内容の実態

佐藤倫広、目時弘仁、堀里子、小原拓 、眞野成康

臨床薬理 53 ( 4 ) 121 - 127 2022.07

Research paper (scientific journal), Accepted

臨床研究コーディネーターが治験における被験者ケアにおいて抱える課題の抽出：フォーカスグループインタビュー法を用いた研究

木崎速人，角田望，大島央子，石﨑雅人，野呂幾久子，飯岡緒美，中野重行，堀里子

臨床薬理 53 ( 4 ) 137 - 145 2022.07

Research paper (scientific journal), Last author, Corresponding author, Accepted

人口動態統計に基づいたセルフメディケーション税制に関する実態調査と課題抽出

田口和明, 榎木裕紀, 堀里子, 山浦克典, 松元一明

医療薬学 48 ( 7 ) 276 - 283 2022.07

Research paper (scientific journal), Accepted

Latent Class Analysis of Patients’ Background Factors Affecting the Risk of Specific Adverse Drug Reactions to Dipeptidyl Peptidase 4 Inhibitors

Kaseda D, Hashiguchi M, Kizaki H, Hori S.

Int. J. Clin. Pharmacol. Ther.  2022.06

Research paper (scientific journal), Accepted,  ISSN  0946-1965

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Extracting Multiple Worries from Breast Cancer Patient Blogs Using MultiLabel Classification with a Natural Language-Processing Model Bidirectional Encoder Representations from Transformers: Infodemiology Study of Blogs

Watanabe T, Yada S, Aramaki E, Yajima H, Kizaki H, Hori S

JMIR Cancer ({JMIR} Publications Inc.)  8 ( 2 ) e37840 2022.06

Research paper (scientific journal), Last author, Corresponding author, Accepted

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多様な進路・働き方における薬剤師のキャリアパスに対する意識調査

土屋雅美，河添　仁，大西友美子，島田美樹，堀　里子

医療薬学 48 ( 6 ) 249 - 258 2022.06

Research paper (scientific journal), Accepted

Identification of hand-foot syndrome from cancer patients’ blog posts: BERT-based deep-learning approach to detect potential adverse drug reaction symptoms

Nishioka S, Watanabe T, Asano M, Yamamoto T, Kawakami K, Yada S, Aramaki E, Yajima H, Kizaki H, Hori S

PLoS One 17 ( 5 ) e0267901 2022.05

Research paper (scientific journal), Last author, Corresponding author, Accepted

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保険薬局の薬剤師によるがん薬物療法に関する疑義照会の実態調査

明貝怜美、澤井夏海、須藤洋行、佐藤宏樹、藤田行代志、三島八重子、木崎速人、堀里子、澤田康文

医薬品情報学 24 ( 1 ) 11 - 16 2022.05

Research paper (scientific journal), Accepted

Analysis of contributory factors to incidents related to medication assistance for residents taking medicines in residential care homes for the elderly: a qualitative interview survey with care home staff

Kizaki H,Yamamoto D, Satoh H, Masuko K Maki H, Konishi Y, Hori S, Sawada Y.

BMC Geriatrics 22 ( 352 ) 352 2022.04

Research paper (scientific journal), Accepted

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Estimating the range of incremental cost-effectiveness thresholds for healthcare based on willingness to pay and GDP per capita: A systematic review

Iino H, Hashiguchi M, Hori S

PLoS One (Public Library of Science ({PLoS}))  17 ( 4 ) e0266934 2022.04

Research paper (scientific journal), Accepted

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Characteristics of single-channel electroencephalogram in depression during conversation with noise reduction technology

Mitsukura Y, Tazawa Y, Nakamura R, Sumali B, Nakagawa T, Hori S, Mimura M, Kishimoto T

PLoS One 17 ( 4 ) e0266518 2022.04

Research paper (scientific journal), Accepted

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Development of Risk Prediction Model for Grade 2 or Higher Hypocalcemia in Bone Metastasis Patients Treated with Denosumab plus Cholecalciferol (Vitamin D3)/Ca Supplement

Ikegami K, Hashiguchi M, Kizaki H, Yasumuro O, Funakoshi R, Hori S

J Clin Pharmacol  2022.04

Research paper (scientific journal), Last author, Corresponding author, Accepted

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Information provision and retrieval by registered salespersons from consumers during over-the-counter drug sales – a questionnaire survey

Kizaki H, Mochizuki M, Yoshida Y, Ishikawa K, Ohishi M, Satoh H, Sawada Y, Hori S

BMC Health Serv. Res.  21 ( 1333 ) 1333 2021.12

Research paper (scientific journal), Last author, Corresponding author, Accepted

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Telepharmacy in mountainous depopulated areas of Japan: an exploratory interview study of patients’ perspectives

Matsumoto Y, Kizaki H, Ikeda Y, Nakamura S, Kina S, Nagai T, Nasu T, Miyamoto K, Hori S

Drug Discov Ther 15 ( 6 ) 337 - 340 2021.12

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted,  ISSN  0306-5251

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Questionnaire Survey Investigation of the Present Status of Dietetic Consultation at Community Pharmacies from the Perspectives of Registered Dietitians and Pharmacists

Kizaki H, Ota T, Mashima S, Nakamura Y, Kiyokawa S, Kominato H, Satoh H, Sawada Y, Hori S

BMC Health Serv. Res. 21 ( 935 ) 935 2021.09

Research paper (scientific journal), Last author, Corresponding author, Accepted

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<h4>Background</h4>Registered dietitians are rarely employed at community pharmacies in Japan, even though dietetic advice might benefit some patients.<h4>Objective</h4>To clarify the present status of dietetic consultation provided by registered dietitians and their collaboration with pharmacists in community pharmacies.<h4>Methods</h4>We conducted a cross-sectional questionnaire-based survey of pharmacists and registered dietitians who work in community pharmacies. The surveyed items were: frequency of dietetic consultation, awareness of one's knowledge and ability to conduct dietetic consultation, concerns, pharmacists' recognition of the need for nutritional support at community pharmacies, and cooperation between registered dietitians and pharmacists.<h4>Results</h4>Sixty-six registered dietitians, 53 pharmacists in pharmacies with registered dietitians/dietitians, and 110 pharmacists in pharmacies without registered dietitians/dietitians responded. The frequency of dietetic consultation regarding obesity and hypertension was significantly higher for registered dietitians than for pharmacists. The ability to conduct dietetic consultation regarding diseases/conditions such as kidney disease not requiring dialysis, hyperuricemia, gout, obesity and hypertension was also significantly higher for dietitians than pharmacists. More than 70% of pharmacists recognized the importance of nutritional support at community pharmacies, while 56.1% of registered dietitians noted that they were not able to fully utilize their occupational abilities. Registered dietitians were divided into two groups: registered dietitians who answered that they were able to utilize their occupational abilities and those that answered they were not. The former group was more likely to ask pharmacists about patients' medication for dietetic consultation and to be asked to provide dietetic consultation to patients. The latter group was more likely to find difficulty in scheduling dietetic consultation.<h4>Conclusion</h4>Our results suggest that registered dietitians in community pharmacies have a greater explanatory ability than pharmacists concerning nutritional and dietary management for patients. It may be important for pharmacists to improve cooperation with registered dietitians by providing more opportunities for dietetic consultation.

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Risk factors for severe neutropenia in pancreatic cancer patients treated with gemcitabine/nab-paclitaxel combination therapy

Ito G, Kawakami K, Aoyama T, Yokokawa T, Nakamura M, Ozaka M, Sasahira N, Hashiguchi M, Kizaki H, Hama T, Hori S

PLOS ONE 16 ( 7 ) e0254726 2021.07

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

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<h4>Aim</h4>Combination therapy with gemcitabine and nanoparticle albumin-bound paclitaxel (nab-paclitaxel), known as GnP therapy, significantly prolongs the survival of pancreatic cancer patients compared with gemcitabine monotherapy. However, it may cause severe neutropenia, requiring discontinuation of treatment. This study aimed to clarify the risk factors for Grade 3/4 neutropenia during GnP therapy.<h4>Methods</h4>Clinical data of pancreatic cancer patients who underwent GnP therapy at the Cancer Institute Hospital of the Japanese Foundation for Cancer Research from December 2014 to December 2016 were retrospectively collected. The relationship of Grade 3/4 neutropenia onset to laboratory values and patient background factors was investigated by multivariate logistic regression analysis.<h4>Results</h4>Clinical data of 222 patients were analyzed. Grade 3/4 neutropenia occurred in 118 patients (53.2%) in the first cycle of GnP therapy. Multivariate analysis identified low absolute neutrophil count (ANC), high total bilirubin (T-Bil), and low C-reactive protein (CRP) as risk factors for Grade 3/4 neutropenia. Age was not a risk factor. The incidence of neutropenia was 85.7% in patients with all three risk factors, but only 27.7% in patients with none of them.<h4>Conclusion</h4>Low ANC, high T-Bil, and low CRP may be risk factors for Grade 3/4 neutropenia in patients receiving GnP therapy, even if these laboratory values are within normal reference ranges. Patients with these risk factors should be carefully monitored for adverse events.

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セルフメディケーション税制に対する新人薬局薬剤師の認知・見解実態把握調査

田口和明, 榎木裕紀, 有賀聡美, 榊原幹夫, 堀里子, 山浦克典, 松元一明

医療薬学 ((一社)日本医療薬学会)  47 ( 7 ) 358 - 363 2021.07

Research paper (scientific journal), Accepted,  ISSN  1346-342X

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ドラッグストアまたはドラッグストア併設の保険薬局に勤務し、在学中にセルフメディケーション税制(以下、本税制)が施行されていた薬剤師を対象に、本税制に関する認知・見解実態把握調査(アンケート)を実施した。調査対象者は、男性138名(44.5%)、女性172名(55.5%)の合計310名であった。本税制の認知度と理解度について調査したところ、284名(91.6%)の調査対象者が「よく知っている(説明できる)」または「聞いたことはあるが、内容はよく知らない」と回答し、理解度に差はあるものの、ほとんどの調査対象者が本税制について見聞があった。これらの調査対象者は、主に「テレビ」、「雑誌本」、「インターネット」などのメディアを通して本税制に関する情報を得ていた。また、教育現場や職場で本税制について知った調査対象者も多かった。調査対象者の97名(31.3%)が本税制に関する講義を受講したと回答した。本税制の認知度を集計した結果、大学で本税制の講義を受けたことのあると回答した調査対象者において、「よく知っている(説明できる)」と回答した割合が顕著に高かった。今後、薬剤師として働くうえで、多くの調査対象者(86.4%)が本税制の知識が必要だと感じており、半数の調査対象者が本税制に関する情報を収集するうえで携帯アプリを活用したいと回答した。

健康セミナー参加者におけるセルフメディケーション税制に関する実態調査と税制改定に向けた課題の抽出

田口和明, 榎木裕紀, 有賀聡美, 榊原幹夫, 堀里子, 山浦克典, 松元一明

医療薬学 ((一社)日本医療薬学会)  47 ( 5 ) 256 - 263 2021.05

Research paper (scientific journal), Accepted,  ISSN  1346-342X

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健康セミナー参加者247名を対象に、セルフメディケーション税制に対する認知、理解度や関心などの実情に関するアンケートを実施し、本税制を取り巻く国民の実状と本税制の課題を明らかにすることを目的とした。調査の結果、過半数の調査対象者がドラッグストアを1ヵ月間に複数回利用しており、ドラッグストアを頻繁に利用している現状が示された。しかし、1年間のOTC医薬品の合計購入額が1万2千円以上10万円未満の調査対象者は11.8%(29人)と少なく、1年間のOTC医薬品の合計購入額が10万円以上の調査対象者はいなかった。セルフメディケーション税制の認知度について調査したところ、理解度に差はあるものの60%以上の調査対象者が本税制を認知していた。さらに、OTC医薬品の年間合計購入金額別に認知度を集計した。その結果、合計購入金額が1万2千円未満の調査対象者と合計購入金額が1万2千円以上の調査対象者で認知度は変わらなかったものの、合計購入金額が1万2千円以上の調査対象者のほうがセルフメディケーション税制について「知っている」と回答した割合が多かった。しかし、認知度に比べて申告件数は著しく少なかった。セルフメディケーション税制については、約50%(43人)が興味を示すとともに申告要件が揃っていれば控除を受けたいと回答した。

Experimental study on patient preferences regarding the shape and size of medical tablets and capsules using three-dimensionally printed plastic model formulations.

Kabeya K, Satoh H, Hori S, Sawada Y.

Patient Prefer Adherence 15   863 - 870 2021.04

Research paper (scientific journal), Joint Work, Accepted

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