Tago, Megumi

写真a

Affiliation

Faculty of Pharmacy, Department of Pharmacy 衛生化学講座 （Shiba-Kyoritsu）

Position

Professor

E-mail Address

E-mail address

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Career 【 Display / hide 】

  • 2006.06
    -
    Present

    2003年4月～2006年5月 米国留学 2006年6月 共立薬科大学薬学部生化学講座　助手 (2007年４月より助教） 2008年4月 慶應義塾大学薬学部生化学講座　助教 2009年4月 慶應義塾大学薬学部生化学講座　専任講師 2014年4月 慶應義塾大学薬学部衛生化学講座 准教授

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Academic Background 【 Display / hide 】

  • 1998.03

    共立薬科大学, 薬学部, 薬学科

    JAPAN, University, Graduated

  • 2003.03

    共立薬科大学大学院, 薬学研究科, 分子生物学、生化学

    JAPAN, Graduate School, Completed, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 博士（薬学）, 共立薬科大学, Coursework, 2003.03

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Research Areas 【 Display / hide 】

  • Biological pharmacy (Biological System Pharmaceutical Science)

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Research Keywords 【 Display / hide 】

  • JAK2、STAT、erythropoietin、NF-kappaB

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Research Themes 【 Display / hide 】

  • Analysis of cytokine signaling pathway, 

    2006
    -
    Present

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Books 【 Display / hide 】

  • IL-33レセプターのシグナル伝達.

    笠原 忠、多胡めぐみ., 科学評論社, 2011.03

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Papers 【 Display / hide 】

  • Oral consumption of α-glucosyl-hesperidin could prevent lens hardening, which causes presbyopia

    Nakazawa Y., Aoki M., Doki Y., Morishita N., Endo S., Nagai N., Funakoshi-Tago M., Tamura H.

    Biochemistry and Biophysics Reports （Biochemistry and Biophysics Reports)  25 2021.03

    Research paper (scientific journal), Joint Work, Accepted

    　View Summary

    © 2020 The Authors Presbyopia is one of the most well-known diseases of the eye, predominantly affecting the adult population after 50 years’. Due to hardening of the lens and failure of accommodative change, patients lose the ability to focus on near objects. This eye symptom is reported to be an early symptom of age-related nuclear cataract, and we have previously reported that hesperetin treatment could delay the onset of nuclear cataractogenesis induced by sodium selenite. In this study, we examined whether oral intake of α-glucosyl-hesperidin (G-Hsd), which has greater water solubility than hesperetin, could delay the onset of presbyopia. G-Hsd treatment protected lens elasticity, upregulated the mRNA expression of anti-oxidative enzymes like glutathione reductase and thioredoxin reductase 1 in the plasma and lens, and prevented premature cataract symptoms in selenite-induced cataract rat lens. Thus, the anti-presbyopic effects of G-Hsd were attributed, at least in part, to its antioxidant effects. G-Hsd represents the first oral treatment agent with anti-presbyopia and/or anti-cataract properties.

  • EBP2, a novel NPM-ALK-interacting protein in the nucleolus, contributes to the proliferation of ALCL cells by regulating tumor suppressor p53.

    Uchihara Y, Tago K, Tamura H, Funakoshi-Tago M.

    Mol Oncol.  15 （ 1 ） 167 - 197 2021.01

    Research paper (scientific journal), Joint Work, Accepted

  • Pyrocatechol, a component of coffee, suppresses LPS-induced inflammatory responses by inhibiting NF-κB and activating Nrf2

    Funakoshi-Tago M., Nonaka Y., Tago K., Takeda M., Ishihara Y., Sakai A., Matsutaka M., Kobata K., Tamura H.

    Scientific Reports （Scientific Reports)  10 （ 1 ）  2020.12

    Research paper (scientific journal), Joint Work, Accepted

    　View Summary

    © 2020, The Author(s). Coffee is a complex mixture of many bioactive compounds possessing anti-inflammatory properties. However, the mechanisms by which coffee exerts anti-inflammatory effects remains unclear and the active ingredients have not yet been identified. In this study, we found that coffee extract at more than 2.5%(v/v) significantly inhibited LPS-induced inflammatory responses in RAW264.7 cells and that anti-inflammatory activity of coffee required the roasting process. Interestingly, we identified pyrocatechol, a degradation product derived from chlorogenic acid during roasting, as the active ingredient exhibiting anti-inflammatory activity in coffee. HPLC analysis showed that 124 μM pyrocatechol was included in 100% (v/v) roasted coffee. A treatment with 5%(v/v) coffee extract and more than 2.5 μM pyrocatechol inhibited the LPS-induced activation of NF-κB and also significantly activated Nrf2, which acts as a negative regulator in LPS-induced inflammation. Furthermore, intake of 60% (v/v) coffee extract and 74.4 μM pyrocatechol, which is the concentration equal to contained in 60% (v/v) coffee, markedly inhibited the LPS-induced inflammatory responses in mice. Collectively, these results demonstrated that pyrocatechol, which was formed by the roasting of coffee green beans, is one of the ingredients contributing to the anti-inflammatory activity of coffee.

  • Coffee decoction enhances tamoxifen proapoptotic activity on MCF-7 cells.

    Funakoshi-Tago M, Tago K, Li C, Hokimoto S, Tamura H.

    Sci Rep. 10 （ 1 ） 19588 2020.11

    Research paper (scientific journal), Joint Work, Accepted

  • Kampo medicines, Rokumigan, Hachimijiogan, and Goshajinkigan, significantly inhibit glucagon-induced CREB activation

    Funakoshi-Tago M., Yu S., Kushida A., Takeuchi K., Tamura H.

    Heliyon （Heliyon)  6 （ 3 ）  2020.03

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  24058440

    　View Summary

    © 2020 The Author(s) The pathophysiology of type 2 diabetes mellitus (T2DM) is characterized by not only insulin resistance, but also the abnormal regulation of glucagon secretion, suggesting that antagonizing the glucagon-induced signaling pathway has therapeutic potential in the treatment of T2DM. Although various Kampo medicines (traditional herbal medicines) are often utilized to ameliorate the symptoms of T2DM, their effects on glucagon signaling have not yet been clarified. In the present study, we examined the effects of nine types of representative Kampo formulations prescribed for T2DM on glucagon-induced CREB activation in HEK293T cells stably expressing glucagon receptor (Gcgr) and a hepatic cell line HepG2. Among these Kampo medicines, Rokumigan, Hachimijiogan, and Goshajinkigan significantly suppressed the glucagon-induced transactivation of the cAMP-responsive element (CRE)-binding protein (CREB) by inhibiting its interaction with CREB-binding protein (CBP), which led to a reduction in the expression of phosphoenolpyruvate carboxykinase (PEPCK) mRNA. Furthermore, among the crude drugs commonly contained in these three Kampo medicines, Rehmannia Root (Jio), Moutan Bark (Botampi), and Cornus Fruit (Shanzhuyu) exerted inhibitory effects on glucagon-induced CREB activation. Collectively, the present results provide a novel mechanism, the inhibition of glucagon signaling, by which Rokumigan, Hachimijiogan, and Goshajinkigan improve the symptoms of T2DM.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • 炎症メディエーターと細胞 IL-1.

    笠原 忠、多胡めぐみ.

    炎症・再生医学事典(松島綱治、西脇徹編) (朝倉書店)  0   52-54 2009.04

    Introduction and explanation (scientific journal), Joint Work

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Presentations 【 Display / hide 】

  • Anti-cataract effect of coffee intake on selenite-induced cataract in rat

    TAGO Megumi

    日本薬学会第136年会（横浜）, 2016.03, Poster (general)

  • Inhibitory effect of ParvifloronE on TNFa signaling pathway

    TAGO Megumi

    日本薬学会第136年会（横浜）, 2016.03, Poster (general)

  • Anti-inflammatory activity of Coffee extract

    TAGO Megumi

    日本薬学会第136年会（横浜）, 2016.03, Poster (general)

  • The role of DDX5 in JAK2 V617F mutant – induced transformation.

    TAGO Megumi

    日本薬学会第136年会（横浜）, 2016.03, Poster (general)

  • Mechanism of NPM-ALK positive cells apoptosis induced by crizotinib

    TAGO Megumi

    日本薬学会第136年会（横浜）, 2016.03, Poster (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • エリスロポエチン受容体結合分子を介した慢性骨髄増殖性腫瘍の発症機序の解明

    2020.04
    -
    2023.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 多胡 めぐみ, Grant-in-Aid for Scientific Research (C), Principal Investigator

  • エリスロポエチン受容体のリン酸化を介した慢性骨髄増殖性腫瘍の発症機序の解明

    2017.04
    -
    2020.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 多胡　めぐみ, Grant-in-Aid for Scientific Research (C), Principal Investigator

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Awards 【 Display / hide 】

  • 柿内三郎記念奨励研究賞第11回（2014年）

    多胡　めぐみ, 2014.10, 日本生化学会, 「定量的リン酸化プロテオミクスによる慢性骨髄増殖性腫瘍の発症機構の解析」

    Type of Award： Awards of National Conference, Council and Symposium

  • 第11回(2014年）柿内三郎記念奨励研究賞

    多胡　めぐみ, 2014.10, 日本生化学会, 定量的リン酸化プロテオミクスによる慢性骨髄増殖性腫瘍の発症機構の解析

  • 平成22年度関東支部奨励賞

    Tago M., 2012.10, 日本薬学会, JAK2 変異体のシグナル伝達解析による真性赤血球増加症発症機構の解明.

  • FEBS Letters Young Group Leader Award 2011

    Tago M., 2012.09, FEBS Letters, FEBS Letters Young Group Leader Award 2012.

  • 2012 FEBS Letters Young Group Leader Award

    TAGO MEGUMI, 2012.09, FEBS, Aurora kinase A critically contributes to the resistance to anti-cancer drug cisplatin in JAK2 V617F mutant-induced transformed cells

    Type of Award： International Academic Awards

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Courses Taught 【 Display / hide 】

  • TOXICOLOGICAL SCIENCES

    2021

  • STUDY OF MAJOR FIELD: (HYGIENIC CHEMISTRY)

    2021

  • SEMINAR: (HYGIENIC CHEMISTRY)

    2021

  • RESEARCH FOR BACHELOR'S THESIS 1

    2021

  • PUBLIC HEALTH

    2021

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Memberships in Academic Societies 【 Display / hide 】

  • 日本薬学会、日本生化学会、日本分子生物学会

    　
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Committee Experiences 【 Display / hide 】

  • 2012.04
    -
    2014.03

    トピックス小委員, 日本薬学会

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